RU2103002C1 - Pectoral species - Google Patents

Abstract

FIELD: chemical-pharmaceutical industry, phytotherapy. SUBSTANCE: invention proposes pectoral species containing wild rosemary sprouts, violet tricolor herb or thyme herb, or marjoram herb, matricary flowers, licorice roots or elfwort roots, peppermint leaves, flax seeds and pot-marigold flowers. Species is used as an expectorant, antiinflammatory, spasmolytic, antibacterial agent at respiratory organ diseases. EFFECT: enhanced effectiveness of species.

Description

 The invention relates to the chemical-pharmaceutical industry, namely, to the creation of medicinal preparations from plant materials, which in the future can be used to treat bronchopulmonary diseases.

 Known collection of medicinal herbs for the treatment of chronic bronchitis (RF patent N 2013095, class A 61 K 35/78), containing herbs of oregano, coltsfoot, ledum and licorice root in patients with obstructive forms of the disease. And for the treatment of patients with non-obstructive forms of the disease, the collection contains pine buds, a leaf of plantain and sage, licorice root and elderberry flowers.

 Known collection with bronchodilator effect (RF patent N 2002465, class A 61 K 35/78), including anise lofant, elsgolt Patren, myrtle, savory, sage and lavender. The collection is effective for acute respiratory infections, bronchitis, tonsillitis, stabilizes the immune status, has high organoleptic characteristics, but in its composition contains plants that do not grow in central Russia.

 Known collection for the treatment of bronchitis (RF patent N 2008013, class A 61 K 35/88), including Ledum grass, coltsfoot, tricolor violet grass, etc. (40 components).

 The disadvantage of the collection is the complexity of its composition, the presence of components not approved for medical use.

 Known collection of medicinal plants recommended for respiratory diseases, containing in its composition marsh rosemary grass, coltsfoot leaves, tricolor violet grass, pharmacy chamomile flowers and medicinal calendula, licorice roots smooth and elecampane high, anise ordinary, mint grass pepper, leaves of a large plantain, taken in equal proportions Sokolov S.Ya., Zamotaev IP Handbook of medicinal plants (herbal medicine). M .: 1987, p. 478).

 The drawback is the poor therapeutic effect in acute inflammatory conditions.

 The objective of the invention is to create a collection of plant materials that have an expectorant, anti-inflammatory, antispasmodic, antimicrobial effect in the treatment of respiratory diseases.

The problem is solved by the medicinal collection, consisting of shoots of Labrador tea, tricolor violet grass or thyme grass, or oregano grass, calendula and chamomile flowers, licorice roots or elecampane roots, peppermint leaves, flax seeds in the following ratio of components, wt.%:
Ledum shoots - 15 - 20
Tricolor violet herb or thyme herb or oregano herb - 20 - 25
Pharmacy chamomile flowers - 15 - 20
Licorice roots or elecampane roots - 10 - 15
Peppermint leaves - 5 - 10
Flax Seed - 0.5 - 5
Calendula Flowers - Else
As part of the collection, plant components containing phenolic compounds: violet grass or thyme grass, or oregano grass, as well as plant components containing terpenoids: licorice roots or elecampane roots can be used as alternatives.

 All types of raw materials included in the collection are included in the State Pharmacopoeia of the USSR X1 edition, vol. 2. General methods of analysis. Medicinal plant materials (M. Medicine, 1989).

 The proposed collection is prepared as follows.

 Each type of medicinal plant material that is part of the collection is crushed separately to the size of the particles passing through a sieve according to TU 23-2-2068-89 with openings with diameters of 5 mm and through a sieve with openings with a diameter of 2 mm. The raw materials crushed to 5 mm are mixed, packaged in packs of 50 and 75 g and packaged. The raw materials crushed to 2 mm are mixed, 2 g each are packed in filter bags from heat-sealable porous non-wetting paper, corresponding to TU 13-7308001-770-88, in packs of 20 pieces. Store in a cool, dry place. The shelf life of the collection is 2 g.

 Microscopic analysis of the collection is carried out according to the method described in the State Pharmacopoeia of the X1 edition (issue 1) M .: Medicine, 1987

 The collection is used to prepare the infusion, used as an expectorant, anti-inflammatory and antispasmodic for respiratory diseases.

 The method of preparation of the infusion. 10 g (2 tablespoons) of the mixture consisting of rosemary shoots, tricolor violet grass or thyme grass, or oregano grass, pharmacy chamomile flowers, licorice root or elecampane root, peppermint leaves, flaxseed, marigold flowers are placed in an enameled dish, poured 200 ml of boiled water, heated in a boiling water bath for 15 minutes, then infused at room temperature for at least 45 minutes, filtered. The remaining raw materials are squeezed. The volume of the resulting infusion is adjusted with boiled water to 2000 ml. Shake the infusion before use. The infusion is taken orally in a warm form, 1/3 cup 3 times a day for 20 to 30 minutes before meals for 2 to 3 weeks. The prepared infusion is stored in a cool place for no more than 2 to 3 days.

 We give specific examples of the preparation of the collection and water extraction from it.

 Example 1. 10 g (2 tablespoons) of a mixture consisting of 1.5 g rosemary shoots, tricolor violet grass 2.0 g, chamomile flowers 1.5 g, licorice root 1.0 g, peppermint leaves 0.5 g, flaxseed 0.05 g, marigold flowers 3.45 g, placed in an enamel bowl, pour 200 ml (1 cup) boiled water, heated in a boiling water bath for 15 minutes, then insist at room temperature for at least 45 minutes filter. The remaining raw materials are squeezed. The volume of the resulting infusion was adjusted with boiled water to 200 ml. Shake the infusion before use.

 Example 2. 10 g of the Mixture consisting of shoots of rosemary 2.9 g, thyme grass 2.5 g, chamomile flowers 2.0 g, elecampane root 1.5 g, peppermint leaves 1.0 g, flax seed 0.5 g, calendula flowers 0.5 g, placed in an enamel bowl, pour 200 ml of boiled water and prepare the infusion, as described in example 1.

 Example 3. 10 g of a mixture consisting of shoots of rosemary 1.5 g, oregano grass 2.0 g, chamomile flowers 1.5 g, licorice root 1.0 g, peppermint leaves 0.5 g, flax seed 0, 05 g, marigold flowers 3.45 g, placed in an enamel bowl, pour 200 ml of boiled water and prepare the infusion, as in example 1.

 We present the results of clinical trials of the proposed collection.

 Clinical trials of the proposed collection were conducted at the Department of Traditional Medicine of the Russian Medical Academy of Postgraduate Education on the basis of the 6th Central Military Clinical Hospital.

 Patients received a breast anti-inflammatory collection in the form of water extract - an infusion prepared according to the rules of the Pharmacopoeia of the 11th edition: 2 tablespoons of the collection, consisting of shoots of wild rosemary, three-colored violet grass or thyme grass, or oregano grass, pharmacy chamomile flowers, licorice root or elecampane root, peppermint leaves, flaxseed, marigold flowers were placed in an enameled bowl, filled with 200 ml of boiled water, heated in a water bath for 15 minutes, insisted at room temperature for 45 minutes, filtering wali, squeezed, adjusted to the initial volume of boiled water. Patients took an infusion of 1/2 - 1/3 cup 2 - 3 times a day. The course of treatment was 7-14 days.

 The study group consisted of 29 people: 15 men and 14 women, whose age ranged from 19 to 66 years. Eleven patients were diagnosed with acute uncomplicated bronchitis, 18 people suffered from chronic bronchitis in the acute stage, and 6 of them had obstructive bronchitis with shortness of breath, prolonged expiration, dry voiced whistling and buzzing wheezing, paroxysmal coughing at night, 16 patients smoked. The disease is provoked by adenovirus infection or cooling. For the treatment of patients, with their consent, only thoracic anti-inflammatory collection in the form of aqueous extraction was used. In 12 patients with bronchitis associated with coronary heart disease, appropriate treatment for coronary artery disease was performed.

 As the main criteria for the effectiveness of treatment, the clinical phenomenon of bronchitis subsidence was used: cessation or weakening of cough (in chronicles) and a change in the average number of leukocytes in sputum 7-10 days after the start of treatment. We used the technique of counting the number of leukocytes in three fields of view and the total number was divided by 3.

 When analyzing the results of treatment in the studied group of patients, the following data were obtained. All patients, some of whom were treated on an outpatient basis, showed a rapid improvement in their condition and cessation of cough in the first 3 to 5 days. Sputum in these patients was not investigated, as patients could not collect it. Patients independently stopped taking the collection a week after the start of treatment, as they considered themselves to have recovered. When examined during this period, the physical data did not cause anxiety. After the end of the collection, the cough did not resume.

 In the group of patients with chronic bronchitis, the timing of improvement ranged from 2 to 10 days. The fastest effect was observed in patients with rare exacerbations of the disease without symptoms of bronchial obstruction when the collection was prescribed in the first days of the onset of symptoms of exacerbation. A later weakening of symptoms of exacerbation of bronchitis was noted in patients with a long-term course of bronchitis with the development of bronchial obstruction syndrome. In these patients, only by 8 to 10 days there was a reduction in coughing, coughing at night, and easier sputum discharge.

 Without exception, all patients noted satisfactory palatability and tolerance of aqueous extraction from breast anti-inflammatory collection.

 When analyzing the results of sputum examination before and after treatment, a significant decrease in the number of leukocytes after the appointment of the collection (p <0.05) was noted. If we take into account the fact that patients did not take other antibacterial drugs, we can conclude that this collection has an antimicrobial effect, which explains its anti-inflammatory property.

 Thus, the proposed collection has an expectorant, anti-inflammatory, antispasmodic, antimicrobial effect and can be used as an expectorant and anti-inflammatory agent for respiratory diseases.

Claims (1)

 Breast collection, including rosemary, chamomile flowers, medicinal calendula flowers, peppermint and plant components containing phenolic compounds and terpenoids, characterized in that it additionally contains flax seed, as a plant component containing phenolic compounds, tricolor violet grass, or thyme grass, or oregano grass, and as a plant component containing terpenoids, licorice roots or elecampane roots in the following ratio of components, wt. Ledum shoots 15 20
Tricolor violet grass, or thyme grass, or oregano grass 20 25
Chamomile flowers pharmacy 15 20
Licorice roots or elecampane roots 10 15
Peppermint leaves 5 10
Flax Seed 0.5 5.0
Calendula Flowers