RU2088254C1 - Medicinal species for treatment and prophylaxis of vessel diseases - Google Patents

Abstract

FIELD: medicine, phytotherapy. SUBSTANCE: species has the following components, mas. p. p.: horse chestnut seeds, 1; rose fruits, 1; citrus peel, 1; Jacob's ladder roots and rhizomes, 1; and catchfly herb, 1. EFFECT: enhanced effectiveness of treatment and prophylaxis.

Description

 The invention relates to medicine, namely to phytotherapeutic agents for the treatment and prevention of vascular diseases, used alone, and also in combination with a vasodilator, antispasmodic, anti-inflammatory, capillary-strengthening, non-specific immunocorrection therapy and physiotherapy.

 The tool has capillary-strengthening, anti-inflammatory, venotonic, analgesic, antithrombotic activity.

 It is known to use herbal remedies used for a similar purpose, for example: glivenol, eskusan, esflazide, rutin, horse chestnut, etc. (1). However, their number is extremely small and with a constantly increasing number of patients with vascular diseases, they cannot satisfy the needs of medical practice. In addition, most of these drugs are imported and therefore quite expensive. It should also be noted a relatively narrow range of therapeutic effects of them.

 The search for drugs of this group is also important because the most pronounced therapeutic effect is achieved with the combined use of various drugs (2). It is also recommended to use instead of individual plants plant collections, in particular, containing rose hips (3), since in this case it is possible to significantly expand the ranges of therapeutic action with a significant increase in individual sides of this action. In the collection, you can enter components that potentiate and diversify the influence of the main ones, which will beneficially affect the treatment.

 The basis of the invention is the creation of such a drug collection for the treatment and prevention of vascular diseases, which would be highly effective, had no undesirable side effects, contained affordable and relatively inexpensive components, a preparation from which could be obtained at home.

The problem is solved in that the claimed fee has the following composition, in parts:
Chestnut Seed 1
Rosehip 1
Citrus Peel 1
Rhizome with the roots of cyanosis blue 1
Grass pitching Tatar or drooping 1
The collection is invited to assign the name Citrosipol.

 The components of the collection are not potent, do not have contraindications in therapeutic doses. The plants and raw materials included in the collection are available, relatively inexpensive. All work on the layout of the collection, its preparation, treatment of patients and interpretation of treatment results was carried out by specialists with special education and extensive experience. Given the chemical composition of the plants and the expected therapeutic effect, we prepared 40% alcohol extraction from the collection as follows: 250 g of the collection was poured into 1000 ml of 40% alcohol, insisted for 3 days, the extraction was drained, the raw materials were squeezed, 500 ml of 40% alcohol was added to it and insisted 3 days, after which the raw materials were squeezed, and the extraction was combined. Received 1250 ml of the drug, which was filtered (through cotton wool or 2-3 layers of gauze). At home, extraction can be made with vodka. The extract is a clear liquid, orange-brown in color, bitter taste, spicy aromatic smell. Patients took 30-50 drops 3 times daily before meals with water.

 Citrosipol was used to treat patients with thrombophlebitis of the superficial and deep veins of the lower extremities, atherosclerosis obliterans of the arteries of the lower extremities, obliterating endarteritis and in the postoperative period after vascular surgery. In clinical conditions, 15 patients with the indicated types of pathology were treated. The treatment was carried out both in complex and in pure form only with Citrosipol.

Example 1. Patient K., 32 years old, was admitted to the Department of Vascular Surgery on April 4, 1994 with a diagnosis of acute ilofemoral venous thrombosis on the left. Sick 8 days On admission, edema of the left thigh and lower leg was noted (volume difference with a healthy limb was ^o C 4 and + 1.5 cm, respectively), moderate cyanosis, soreness along the vascular bundle on the thigh. Analysis of April 5; fibrinogen 4.8 g / l recalcification time 160 s, heparin tolerance 12 min, thrombin activity 93% fibrinolytic activity 9 min, prothrombin 0.98, bilirubin 8.8 μm / l, cholesterol 4.38 mm / l, clotting time 2 , 2 3.5 minutes Started treatment with Citrosipol 1 tbsp. l 3 p. in days, ointment compresses. No other treatment was performed. After 7 days, the swelling began to subside. Pain lasted 5 days. Allowed to walk in elastic bandages. At 14 days, the edema is insignificant, worse by the end of the day. The difference in the circumference of the thigh and lower leg, respectively, compared with a healthy limb is ^o C 1 and + 0.5 cm. Blood tests as of April 19: fibrinogen 3.8, recalcification time 120 s, heparin tolerance 10 min, thrombin activity 89% fibrinolytic activity 7 min, prothrombin 0.8, bilirubin 8.2 μm / l, cholesterol 4.38 mm / l, clotting time 3.6-4.5 min.

 Example 2. Patient E., 58 years old, was admitted to the Department of Vascular Surgery on May 10, 1994 with a diagnosis of acute sural phlebitis on the right. Sick 5 days Upon admission, an increase in the right lower leg in volume is noted (a difference of 3 cm compared with a healthy lower leg), pain during palpation along the vascular bundle, a positive symptom of Goman's. May 11 analyzes: fibrinogen 5.08 g / l, recalcification time 120 s, heparin tolerance 12 min, thrombin activity 86% fibrinolytic activity 8 min, prothrombin 0.92, cholesterol 3.56 mm / l, bilirubin 8.2 μm / l, coagulation time start 2, end 3.2 minutes Treatment: Citrosipol 1 tbsp. 3 times a day Within 10 days, the condition improved significantly. The swelling was asleep. The pain is gone. Discharged for 12 days. Tests of May 20: fibrinogen 4.58, recalcification time 110 s, heparin tolerance 10 min, thrombin activity 90% fibrinolytic activity 7 min, prothrombin 0.82, bilirubin 8.8 μm / l, cholesterol 3.38 mm / l . coagulation time start 3, end 3.5 min.

 Thus, it can be argued that the drug collection of Citrosipol is effective for the treatment and prevention of vascular diseases both in the treatment of only one collection, and in combination with other drugs of this purpose. It can and should be used both before surgery and in the postoperative period.

 Patients took the drug with apparent pleasure and confidence.

Sources of information
1. Mashkovsky M.D. Medicines, ed. 10, part 1, "Medicine", M. 1987, p. 400-409.

 2. Kudrin A. M. Pharmacology with the basics of pathophysiology. M. "Medicine", 1977, p. 84.

 3. Ladynina EA Morozova R.S. Phytotherapy. L. "Medicine", 1990, p. 22.

Claims (1)

 A drug collection for the treatment and prevention of vascular diseases, including rose hips, characterized in that it additionally contains chestnut seed, citrus peel, rhizome with blue cyanosis roots, Tatar or wilting grass, taken in the following proportions, parts by weight Chestnut Seed 1
Rose hips 1
Rhizome with the roots of cyanosis blue 1
Grass of tar of the Tatar or drooping 1p