RU2069566C1 - Method for improving organism resistance - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves administering vegetable biostimulation agents at a daily subtherapeutic doses. The daily dose is determined according to random number distribution law from the range of their variation, each differing in the preparation amount contained in one drop of the preparation tincture. The variations used begin with subtherapeutic doses for men not older than 65, with a dose 1.5 times as low as the subtherapeutic dose for men older than 65 and women of any age. 1/10 of the start dose is applied to children older than from 1 to 4, 1/5 of the start dose is applied to children from 4 to 6, 1/4 of the start dose is applied to children from 6 to 10 years. 1/3 of the start dose is applied to children from 10 to 14 years. 1/2 of the start dose is applied to children from 14 to 16 years. The organism state being satisfactory, 16 doses variation is applied. The organism state being weakened, 8 doses variation is applied. The organism state being weakened to a great extent, 4 doses variation is applied. EFFECT: enhanced effectiveness of treatment. 3 cl, 2 tbl

Description

 The invention relates to medicine, in particular to the therapeutic correction of functional abnormalities, characterized as a decrease in body resistance, and can be used to prevent, improve and increase the body's resistance to various stresses and diseases.

 There is a method of increasing the body's resistance by taking various biostimulants, for example, eleutherococcus, ginseng, etc. (Brekhman N.N. Man and biological active substances. L. 1976; Dardymov I.V. Ginseng, eleutherococcus. M. Science, 1976).

 However, the known method does not take into account gender and age. Reception of biostimulants, which are xenobiotics, in relatively large doses leads to a breakdown in stress, especially in weakened individuals.

 A known method of increasing the resistance of an organism (in the book "Adaptation reactions and resistance of an organism." Garkavi L. Kh. Kvakina EB B. Ukolova MA 1990, Rostov-on-Don, p. 45), including the development of an activation reaction by a correctly selected dose of a biostimulant and its systematic change (strength of exposure) in the direction of increase or decrease.

 However, this method has certain disadvantages: the selection of doses is carried out in a cybernetic way according to the signal indicator of the reaction - the percentage of lymphocytes in the leukocyte formula. Therefore, the previously proposed method requires frequent blood tests, which complicates its mass use. In addition, a blood test takes time, the desired dose change is delayed, which reduces the effectiveness of the method.

 The purpose of the invention is to increase the effectiveness of therapeutic effects to increase the body's resistance, resistance to damaging effects and diseases.

 The goal is achieved in that patients are given daily varying subtherapeutic doses of biostimulants, use tincture of biostimulants of plant origin, the daily dose is determined according to the law of random numbers from the range of their variations, each of which differs in the amount of the drug contained in one drop of tincture. For men under 65, use variations starting from the lower subtherapeutic dose; for men over 65 years old and for women of any age, variations are selected starting from a dose 1.5 times less than the subtherapeutic; for children aged 1 to 4 years - start from 1/10, from 4 to 6 years from 1/5, from 6 to 10 years from 1/4, from 10 to 14 years 1/3, from 14 to 16 years with 1/2 subtherapeutic dose and in a satisfactory condition of the body, variations of 16 doses are used, in a weakened state of 8 doses, and in a sharply weakened of 4 doses; treatment is continued for a month.

 As a random number generator, four or three times, or two times tossing a coin is used, for each value of the obtained combinations a certain dose of the biostimulator is fixed. To prepare doses of less than one drop, an extract diluted with water 10 times is used.

 The invention is new, since it is not known from the level of medicine in the field of therapeutic correction of functional deviations, characterized by a decrease in the body's resistance. The proposed method differs from the known ones in that the daily applied individual subtherapeutic dose of the stimulator is determined according to the law of random numbers and is made dependent on gender and age. A random number generator with a uniform distribution of four-fold and three-fold or two-fold coin throwing is used, for each value of which a certain sub-therapeutic dose of the stimulator is fixed.

 Thus, the proposed method of increasing the resistance of the organism is significantly different from the known one, meets the criteria of the invention of "novelty."

 The invention has an inventive step, since for a specialist (a doctor of any specialty) it does not explicitly follow from the level of development of medicine in the field of increasing the body's resistance to various stresses and diseases and for prevention.

 The advisability of changing the dosage according to the law of random numbers is explained by the need to maintain the informational value of stimulation, that is, the need to maintain the "novelty" factor during the course of exposure. Novelty is reduced due to the development of the “waiting reaction”: with daily use of the dose according to a known scheme (in a known manner), the body is as if warned about the dose. The “novelty” factor leads to a predominance of the excitation process in the brain, and since the stimulus is small (subtherapeutic doses), the excitation does not develop excessive, but moderate, physiological. The validity of this approach is also confirmed by many years of experimental research (Garkavi L. Kh. Kvakina E. B. Ukolova M. A. 1990). It is this nature of changes in the central nervous system, as was shown earlier, that is observed during the development of an activation reaction that most significantly reduces the body's resistance (Garkavi L. Kh. 1969; Kvakina Ye. B. 1972; Garkavi L. Kh. Kvakina Ye. B. Ukolova M A. A. 1979). Using the law of random numbers to establish the daily dose, determines the randomness of the dose change, which prevents the development of addiction and helps to maintain the "factor of novelty."

 Thus, the proposed technical solution is not obvious, since it does not follow from the level of development in this field of medicine, it is not known either in the world or in the Russian (CIS) medical literature.

 The invention is industrially applicable, since the technical result achieved by using it increases the body's resistance, contributing to an increase in the level of health, the prevention of various diseases, their easier course, greater treatment effectiveness, allow us to consider the method industrially applicable in various fields of medicine: for prevention, recovery, relief course of the disease.

 The feasibility of taking into account gender and age is associated with a high sensitivity of the body of women and an increase in sensitivity during aging.

 The dose selection according to the law of random numbers (Monte Carlo method) will be considered using the example of eleutherococcus, whose single therapeutic dose is 30 25 drops of the extract. Starting with the maximum subtherapeutic dose, for example, with 24 drops for men under the age of 65, for example, 16 lower doses are prescribed with an interval of 1 drop (this interval is taken for practical use). In this case, each dose is numbered by a serial number, starting with N 1. Thus, each serial number corresponds to its own dose (Table 1).

 For women of any age and men over 65, the maximum sub-therapeutic dose is 1.5 times less than for men under 65. Then the dose is signed with the preservation of the interval of 1 drop. For doses smaller than a drop, an extract diluted with water 10 times (E / 10) is used. To select a daily dose according to the Monte Carlo method, a "random number generator" with a uniform distribution is used. Such a generator can be: an automatic machine for obtaining random numbers, a table of random numbers, or coin flipping accessible to everyone. When tossing a coin, two options can be obtained: “eagle” (O) or “tails” (P). To ensure the necessary randomness of the dose distribution, triple throwing of moments is enough, which gives 8 possible combinations of 3. Each of the 8 combinations is associated with one of the 8 selected subtherapeutic doses. A four-fold coin toss provides even more randomness, as it gives 16 dose options (Table 1), and a two-fold smaller one, as it gives 4 dose options. In old age and in weakened people, one should start with a 3-fold throwing of a coin and use the 8 minimum doses for a given gender and age of the dose values, and in especially severe cases, even with a 2-fold throwing a coin and use the four minimum doses. Considering the circadian rhythm of the called “activation reaction”, it is necessary to take the biostimulant once a day, preferably from 7 to 9 hours, when the informational effect is enough to form the named reaction. Before each use of the biostimulant (daily, on an empty stomach, 1 time per day), it is necessary, by throwing a coin 2, 3 or 4 times, to fix the sequence of the “eagles” and “tails” drawn and then determine the value of the corresponding dose according to table 1.

 The criterion for the selection of doses, their individualization depending on age and gender, evaluation of effectiveness, all this is based on the theory and practice of adaptive reactions that we have been developing for many years. Highly informative and well correlating with changes in the neuroendocrine and immune systems, a signal response indicator of a specially calculated leukocyte formula and the total number of leukocytes is an important criterion for both the state of the body and the assessment of the effectiveness and correctness of the selected doses.

 The percentage of lymphocytes determines the type of reaction (training, activation, stress), and deviations from the norm of the percentage of other elements of the blood formula (eosinophils, basophils, nuclear neutrophils, monocytes) and the total number of leukocytes (leukopenia or leukocytosis) indicate the presence of tension, non-physiological activation reactions or training. This indicator and a change in well-being, a decrease or disappearance of complaints, and in the presence of objectively determined signs of impairment, their normalization (for example, blood pressure), a decrease in the number of pathogenic colonies in the skin autoflora in the complex, make it possible to judge the effectiveness of the effects. It should be noted that the listed symptoms in the vast majority of cases (at least 90) correlate well. The fact that in the selected prototype the doses of the biostimulant "can lead to the development of stress" is proved simply: the parameters of the leukocyte formula become characteristic of stress, as the author of stress G. Salier found. The fact that "taking the same doses" leads to the development of a waiting response that reduces the therapeutic effectiveness of the biostimulator is due to the fact that under any severe regime of dose variation (strength) of the acting factor, the body is capable of extrapolation. Specifically, this is manifested by the fact that after the first change in the nature of the reaction (it can last from 2 days to a week), in the case of taking the same dose or changing the dose according to the rigid scheme, there is a return to the initial state (in terms of blood counts), with which a return to the initial state of well-being, i.e., the therapeutic effectiveness of the biostimulator is reduced or removed.

 The activation reaction was judged by the percentage of lymphocytes in the leukocyte formula. In some people (25 people in each group), the development of an activation reaction was also judged by the autoflora of the skin. According to the proposed method, this was carried out not for dose selection, but to control (evidence) the development of the activation reaction before the onset of exposure and at the end of exposure lasting for a month.

 The choice of a known or proposed method for obtaining an activation reaction was carried out on the basis of randomization: even dates of the onset of impacts — a known method, odd proposed.

The results of comparing the prototype and the proposed method showed that the proposed method effectively increases resistance in people with reduced resistance (in prenosological conditions) and causes the development of an activation reaction in a significantly larger percentage of cases. A high percentage of lymphocytes, oil, the number of pathogenic colonies in the autoflora of the skin, the disappearance of persistent complaints, an improvement in general condition and an increase in working capacity indicate the usefulness of the developing activation reaction (Table 2)
As an example of a specific implementation of the proposed method, the following extracts from outpatient cards.

 1. Card N 3.

 A 46-year-old woman, subjectively complaining of headaches, poor sleep, poor working capacity, fatigue, depressed mood. Objectively: the percentage of lymphocytes in the leukocyte formula is 18.5, which corresponds to the stress reaction, the number of pathogenic autoflora colonies of the skin is 42, which is also characteristic of stress. The patient underwent a medical examination and no specific disease was detected.

Appointment: Eleutherococcus in a dose of 16 to 1 drop. Daily dose selection was carried out using a four-fold coin toss and then determined in accordance with the attached table. 1. In this case, for example, as a result of daily throwing, coins received:
Day Number of drops
First OROR 10
Second PPOO 3
Third PPPO -1
Fourth ORRO 9
Fifth LLCP 14
Sixth ROOR 6
Seventh PPPP 15
Eighth PPPO 1
Ninth ORRO 9
Tenth ROOR 6
Eleventh OOPP -12
Twelfth LLCP 14
Thirteenth OROO 11
Fourteenth PPOO 3
Fifteenth OOPP 12
Sixteenth ASPO 13
Seventeenth ROOR 6
Eighteenth ORRP 8
Nineteenth POPP 4
Twentieth PPP 2
Twenty-first ASPO 13
After 3 weeks of daily intake of Eleutherococcus in the indicated doses, subjectively improvement of the condition, disappearance of complaints, increase of working capacity. The percentage of lymphocytes in the leukocyte formula became 35, which corresponds to the activation reaction, the number of pathogenic skin colonies in autoflora decreased to three, which is also characteristic of the activation reaction.

2. Card N 15
A man aged 52 years, subjectively complaining of pain in the region of the heart, headaches, general weakness, poor sleep, irritability, a sense of fear and anxiety, self-doubt, impotence, impaired performance. Objectively: the number of lymphocytes in the leukocyte formula is 17 which corresponds to stress, the number of pathogenic colonies in the autoflora of the skin is 40, which is also characteristic of stress.

The alcohol extract of pantocrine was treated for 21 days at a dose of 20 to 5 drops. The daily dose was selected according to the law of random numbers with the help of a four-fold coin toss in accordance with Table. 1:
Day Number of drops
First LLCP 20
Second PPOO 13
Third ROOR 11
Fourth PPPO 8
Fifth RORO 9
Sixth ORRR 5
Seventh POPP 6
Eighth PPPP 19
Ninth TOC 18
Tenth OROR 10
Eleventh ORRO -12
Twelfth LLCP 18
Thirteenth ORRO 12
Fourteenth PPOO 13
Fifteenth POPP 11
Sixteenth PPPP 19
Seventeenth OOPP 14
Eighteenth OOPOR 10
Nineteenth RROR 7
Twentieth OOPP 14
Twenty-first ROOO 15
Three weeks later, persistent complaints disappeared, increased efficiency, increased sexual potency, improved mood. Objectively: HELL
125/30, the number of lymphocytes in the leukocyte formula 33, which corresponds to the activation reaction, the number of pathogenic colonies in autoflora decreased to 5, which is also characteristic of activation.

3. Card N 37
A man aged 32 years. When handling, subjectively complaints of pain in the epigastric region that occur immediately after eating, a feeling of heaviness in this area, belching of air, poor sleep, decreased performance, fatigue, lethargy. It has been treated for a long time and continues to be treated for hypoacid gastritis without a lasting effect. Objectively: the number of lymphocytes in the leukocyte formula is 15; the number of colonies of pathogenic microbes is 48, which is typical (for lymphocytes and autoflora) for the stress reaction. Treatment with Leuzea liquid extract was prescribed in a dose of 19 to 4 drops. Choosing a daily dose according to the law of random numbers using coin toss:
Day Number of drops
First ROOR 10
Second OOOP 17
Third ROOR 10
Fourth PPPP 18
Fifth ASPO 16
Sixth OOOR 17
Seventh OOOR 17
Seventh PPOO 12
Eighth LLCP 17
Ninth OOOO 19
Tenth ORRR 3
Eleventh ASPO -16
Twelfth ORRO 11
Thirteenth PPPO 7
Fourteenth ASPO 16
Fifteenth OROO -15
Sixteenth RPOO 12
Seventeenth ORRR 3
Eighteenth ROOR 10
Nineteenth PPPO 7
Twentieth PPPP 18
Twenty-first OROO 11
Twenty-second ROOO 14
Twenty-third PPOO 12
Twenty-fourth PPPO 7
25th ORRO 11
Twenty-sixth PPPO 7
Twenty-seventh ASPO 16
Twenty-eighth OOOO 19
After 28 days, persistent complaints disappeared, only occasionally there is an indefinite feeling of discomfort in the epigastric region, increased performance, improved sleep and appetite, mood. The percentage of lymphocytes in the leukocyte formula 40 pathogenic colonies in autoflora are single, which is typical for the activation reaction.

Map N 7
Woman aged 49. When handling complaints of pain in the heart, interruptions, weakness, fatigue, poor sleep. Objectively: HELL 80/65. On an ECG right ventricular extrasystole. The number of lymphocytes in the leukocyte formula is 25, which corresponds to the training reaction, the number of pathogenic colonies is 9. An alcohol tincture of ginseng root was prescribed for 28 days in the dose range from 7 drops of undiluted tincture to 1 drop of tincture diluted with water 10 times. To select a daily dose, a four-fold coin toss was used, the dosage was carried out in accordance with table. 1:
Day -
First OOPP 1
Second OOOP 5
The third ORRR 1 r-ra 1/10
Fourth OROO 3
Fifth PPPO 4
Sixth POPP 5 r-1/10
Seventh ROOO 2
Eighth OOOO 7
Ninth ROOO 2
Tenth RORO 5 solutions 1/100
Eleventh PPPO 4 r-1/10
Twelfth RRRP 6
Thirteenth PPOO 9
Fourteenth OOOO 7
Fifteenth PPPO 4 r-1/10
Sixteenth ASPO 4
Seventeenth PPPP 6
Eighteenth PPPO 4 r-1/10
Nineteenth RROR 3 solutions 1/10
Twentieth OOPP 1
Twenty-first LLC 5
Twenty-second ROOR 7 r-1/10
Twenty-third RORO 5 r-1/10
Twenty-Four PPPP 6
Twenty-fifth OROR 6 rd 1/10
Twenty-sixth PPPO 4 r-ra 1/10
Twenty-seventh ROOO 2
Twenty-eighth RORO 5 r-1/10
After 3 weeks, the complaints disappeared, extrasystole on the ECG was not determined, blood pressure - 115/70, the number of lymphocytes in the leukocyte formula 43, which corresponds to the activation reaction, the pathogenic flora is absent.

Map N 10
A man at the age of 65. When handling complaints of weakness, dizziness, pain in the heart, poor sleep, memory impairment. Objectively: HELL 145/90, the number of lymphocytes in the leukocyte formula is 18, the number of pathogenic colonies in the autoflora of the skin is 64, which corresponds to stress.

The treatment was carried out with the extract of the golden root (Rhodiola rosea), at a dose of 9 drops of undiluted extract to 3 drops of the extract, diluted with water 10 times during the month. The choice of daily dose was carried out using a four-fold coin toss and was determined in accordance with the table, built on the same principle as the table. 1 for eleutherococcus. In this case:
Day Number
First RFOO 2
Second OOPR 3
Third OOOO 8
Fourth ASPO 6
Fifth POPP 4 solutions 1/10
Sixth OROO 5
Seventh POPP 7 r. 1/10
Eighth ROOR 9
Ninth RRRP 8
Tenth OOOO 9
Eleventh RROO 2
Twelfth ORRO 1
Thirteenth ROOO 4
Fourteenth OROO 5
Fifteenth OROO 5
Sixteenth PPPO 6 r-1/10
Seventeenth ASPA 6
The eighteenth PPPO 6 r-1/10
Nineteenth OROO 5
Twentieth ORRO 1
Twenty-first OROO 5
Twenty-second OOPP 3
Twenty-third PPOO 2
Twenty-fourth LLCP 7
Twenty-fifth PPOO 2
Twenty-sixth OROO 5
Twenty-seventh ROOR 9 r-1/10
The twenty-eighth POPP 4 solutions of 1/10
After treatment, the patient felt a surge of strength, noted an improvement in memory, mood; heart pain and dizziness disappeared. HELL 125/80, the number of lymphocytes 33, the number of pathogenic colonies in the autoflora of the skin 7, which corresponds to the activation reaction.

 In order to increase the body's resistance, the method was tested on the faces of male and female high school students daily, for 15 days. The daily dose was determined by the proposed method of increasing the body's resistance according to the law of random numbers, which caused a challenge to the activation reaction. A quadruple coin toss was used as a random number generator, for each value of which (a sequence of four combinations of “heads” and “tails”) a certain dose of biostimulant was recorded. The subjects were divided into 2 groups. The first group received exposure with a dose selection according to the law of random numbers, and the second was standardized for the same dose 2 times a day.

 In total, for the prevention of colds, 166 people were tested. of which the proposed method 116, the prototype of 50 people.

 After a preventive effect during the autumn-winter period for 4 months of colds in the first group (exposure to the proposed method) was from 116 to 14 people. (12), from the prototype group of 50, 10 people fell ill. (20).

 Thus, the use of biostimulants in the dosage selection mode according to the law of random numbers can increase the body's resistance to a greater extent than in the prototype group when using the standard exposure mode.

 The technical and economic effectiveness of the proposed method of increasing the body's resistance lies in the fact that the use of the method allows to increase the body's resistance to external influences, morbidity. In addition, the method is effective for carrying out preventive and recreational work among the mass contingents of the population, as it is simple, affordable and does not require large material costs, as well as time.

Claims (3)

 1. A method of increasing the body's resistance, including the introduction of daily changing subtherapeutic doses of biostimulants, characterized in that they use tincture of biostimulants of plant origin, the daily dose is determined by the law of random numbers from the range of their variations, each of which differs in the amount of the drug contained in one drop of tincture, while for men up to 65 years of age, variations are used, starting from the lower sub-therapeutic dose, for men over 65 and for women of any age, variations they are selected, starting with a dose 1.5 times less than the subtherapeutic, for children aged 1 to 4 years, start from 1/10, from 4 to 6 years from 1/5, from 6 to 10 years from 1/4, from 10 up to 14 years with 1/3, from 14 to 16 years of 1.2 sub-therapeutic dose and in a satisfactory condition of the body, use variations of 16 doses, in a weakened state of 8 doses, and in a sharply weakened of 4 doses, treatment continues for a month.  2. The method according to p. 1, characterized in that as a random number generator, four, three, or two coin flips are used, a specific dose of the biostimulator is fixed for each value of the obtained combinations.  3. The method according to PP. 1 and 2, characterized in that for the preparation of doses of less than one drop using an extract diluted with water 10 times.

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