RU2069561C1 - Method of plague treatment in dogs - Google Patents

Abstract

FIELD: veterinary. SUBSTANCE: method involves parenteral administration of biseptol (2.5 ml per 8-10 kg weight, 2-3 times per 24 h at 8-12 h intervals), oral administration of streptocid (1.5-2 g per 20 kg weight, 2-3 times per 24 h) and parenteral administration of vitamins B₁,B₁₂,B₆,B₂, C (1 ml, once per 24 h). At pulmonary disease form the following drugs were administrated to animal: aloe (0.5 ml, once per 24 h, subcutaneously) and calcium chloride (1 spoonful, 3 times per a day, orally). At nervous disease form the following drugs were administrated to animal: dibasol (1-2 tablets, 1-2 times per a day), aethaperazin (10 ml), triftazin (2-5 mg) and biseptol. At intestine disease form vitamins B₁,B₆,B₁₂,B₂ and C, K, U and glucose were administrated additionally, except for basic preparation, to animal. EFFECT: enhanced effectiveness of plague treatment. 4 cl

Description

 The invention relates to veterinary medicine and is used to treat plague in animals.

 As you know, the plague is an acute viral disease characterized by fever, catarrh of the mucous membranes, pneumonia, as well as damage to the nervous system.

There are various methods of treating plague in animals [1]
According to this method, treatment by administering tetracycline antibiotics is most preferred. In this case, tetracycline is administered orally at a dose of 200 thousand units, and orally 100 thousand 2 times a day. Oxytetracycline is administered orally at a dose of 100 thousand units 2 3 times a day and intramuscularly (oxytetracycline hydrochloride) 50 thousand units 2 times a day.

 For disorders of the gastrointestinal tract, chloramphenicol is prescribed at a dose of 5 mg per 1 kg of animal weight, as well as furazolidone at a dose of 7 mg per 1 kg of body weight 2 times a day.

 The main disadvantage of this method of treatment is its low therapeutic efficacy due to the low bacteriostatic activity of the antibiotics used.

There is also a method of treating plague in animals [2]
This method is the closest to the claimed and can serve as a prototype.

 According to this method, in case of a plague disease in animals, antibiotics and sulfonamide drugs are administered for the prevention of pneumonia, and levomycetin, furazolidone, phthalazole are prescribed inside to normalize the gastrointestinal tract. At the same time, vitamins of groups B and A are introduced into the animal organism at the same time. In case of nervous form, animals are prescribed luminal or potassium bromide.

 The main disadvantage of this method is also the low therapeutic effectiveness of the method, since, as you know, the plague is a disease of viral etiology, and the combination of means used in this case does not have a virocidal effect.

 The known method only helps to increase the overall tone of the animal’s body and serves mainly for the prevention of bacterial infections.

 The main objective of the proposed method is to increase the therapeutic effectiveness of treatment, as well as reducing the recovery time of animals.

This is achieved by the fact that in the treatment of plague in animals by administering sulfonamide drugs in combination with B vitamins, animals, regardless of the form of the disease, are additionally intramuscularly injected with biseptol at a rate of 2.5 ml for every 8 10 kg of animal weight 2 3 times a day s with an interval of 8 to 12 hours and vitamin C also intramuscularly at 1 ml per day, and streptocide is used as a sulfonamide preparation, and streptocide is administered orally to animals at the rate of 1.5 to 2 kg of live weight 2 3 times a day, and vitamins B ₁ , B ₁₂ , B _6, B ₂ administered subcutaneously, Jun Blowing each of 1 ml, once a day.

 Streptocide itself is an analogue of para-aminobenzoic acid (PBC), but it only works if its amount (streptocide) is five times the quantitative presence of PBC in the body.

 Biseptol, having bactericidal properties, inhibits bacterial infections in animals, and also blocks enzymes that accelerate the biosynthesis of folic acid in microorganisms, thus concomitant microflora is inhibited, while streptocid acts directly on viruses.

 In the pulmonary form of the disease, in addition to the above animals, aloe and calcium chloride are administered, moreover, aloe is administered subcutaneously once a day at the rate of 0.5 ml of aloe and 0.5 ml of FIBS in one syringe, and calcium chloride is administered orally by 1 tbsp. spoon 3 times a day.

 At high temperature, camphor oil for injection subcutaneously is used, 0.5 to 1.0 ml 1 2 times a day.

 To prevent cracking, the animal’s nose and paw pads are lubricated with Vaseline 2 3 times a day. For conjunctivitis, tetracycline ophthalmic ointment is used 2 3 times a day. The course of treatment is 15 days.

 In the nervous form of the disease, in addition to streptocide, Biseptolum, B vitamins, the animal is additionally injected with dibazole, stazirazin or triftazin and one of the calcium preparations. Dibazole is used to relieve intracranial pressure, 1 2 tablets 1 2 times a day. To relieve seizures, 10 mg of phyrazine is introduced 1 2 times a day. When the animal is in a nervous form, they are given calcium preparations, gluconate or glycerophosphate, 5 6 tablets 3 times a day. To relieve intoxication from sulfonamides, animals are given multivitamins with biotin and pantothenic acid. In addition, the animal is given sedative and hypnotic drugs, for example, elenium or diphenhydramine 0.5 1 tablet 1 2 times a day. The course of treatment is 40 days with a 5 7-day break.

 To relieve intoxication and improve brain function, the animal is injected with glucose, a 40% solution in the amount of 10 ml, 10 ml or more of saline or Ringer's solution subcutaneously once a day. With severe dehydration, the amount of saline is brought up to 60 ml of 20 ml per injection. With intestinal bleeding, the animal is injected with vitamin K inside, 1 tablet per day, or parenterally, 1 ampoule per day. To restore intestinal function, vitamin U is administered at the rate of 1 tablet for every 12 kg of live weight 3 times a day. With severe depletion or prolonged refusal of feed, the animal is injected with hydrolysin or casein hydrolyzate 20-60 ml subcutaneously once a day. Before eating, it is recommended to give raw egg protein. During the treatment period, a diet is observed. The animal is given broths, as well as slightly salted chicken or ground beef. The course of treatment, as with the pulmonary form of the disease, is 15 days.

Example 1. To a sick animal, a Caucasian shepherd puppy, 5.5 months old, having symptoms of plague, such as high body temperature (39 ^o C), sharp, foamy vomiting, liquid, fetid orange stool, watery discharge from the nose, dryness last one. Parenteral administration: Biseptolum (intramuscularly) 10 ml 2 times a day with an interval of 12 hours, and also gave streptocide in tablets, 6 tablets 3 times a day. In addition to the above preparations, the animal was administered serum 3-valent 10 ml subcutaneously 1 time per day, two days in a row; vitamin C intramuscularly 1 ml once a day: vitamins B ₁ , B ₁₂ , B ₆ , B ₂ also subcutaneously 1 ml per day, alternating up to 4 injections of each vitamin; 40% glucose of 10 ml + 10 ml or more of saline subcutaneously 1 time. In addition to the above treatment, the animal was prescribed a diet (broths and slightly salted minced meat). Before eating, the animal was given raw egg protein, and streptocide tablets 30 minutes before the raw protein. After 3 days, the puppy was clinically healthy. Further treatment was carried out by the owners of the animal. After 15 days, the course of treatment was discontinued.

Example 2. A sick animal, male, boxer, age 1.1 g, weight 25 kg, had the following signs of the disease: fever, cough, wheezing, rhinitis, yellow feces. The animal was injected intramuscularly with Biseptol 7.5 ml 2 times a day; streptocide inside 3 tablets 3 times a day; Aloe subcutaneously once a day, at the rate of 0.5 ml of aloe and 0.5 ml of FIBS in one syringe; vitamins C, B ₁ , B ₁₂ , B ₆ , B ₂ subcutaneously, 1 ml per day, alternating up to 4 injections of each vitamin; calcium chloride for 1 tbsp. spoon 3 times a day. The diet is the same as in example 1. After four days, the animal was clinically healthy, and after 15 days the course of treatment was discontinued.

Example 3. A sick animal, a puppy of a shepherd dog, age 3 months, weight 15 kg. Signs of the disease: epileptic seizures, foam from the mouth, clattering teeth, whining. Temperature 39 ^o C. The following treatment was carried out: biseptol intramuscularly in 4 ml 2 times a day; streptocid inside 4 tablets 3 times a day until anxiety disappears; gamma globulin 1 ampoule intramuscularly for 4 days in a row; Dibazole 1 tablet per day; calcium gluconate also inside 4 tablets 3 times a day; vitamins C, B ₁ , B ₁₂ , B ₆ , B ₂ , intramuscularly, vitamin C 1 ml once a day, B vitamins one at a time, alternating. The course of treatment lasted 40 days. Moreover, after 20 days of treatment, a break of 5 7 days was made, then the course of treatment was continued for another 20 days. By the end of treatment, the nerve tics in the animal disappeared.

 For the period from September 3, 1992 to February 3, 1993, the author examined 78 animals (dogs) suffering from plague. Of this number, 40 animals had an intestinal form of the disease, 19 had a pulmonary form, and 19 had a nervous form. Sick animals were prescribed a course of treatment as described above, taking into account the form of the disease. It was established that out of 78 sick animals, only 2 dogs fell, the remaining 76 recovered, that is, the percentage of their treatment was 97.5%, including 40 dogs recovered from 40 animals with an intestinal form of the disease, 1 fell.

 Of the 19 dogs with pulmonary disease, after the course of treatment as described above, all animals recovered. Relapses and side complications were not observed.

 Of the 19 animals with a nervous form of the disease, 18 recovered, 1 dog fell. Moreover, in animals with convulsive twitching of the limbs, these phenomena were reduced, but their traces remained, and in animals with epileptic seizures, health was fully restored.

 Thus, the claimed method of treatment of animals suffering from plague has the following advantages: refusal to use antibiotics, including imported ones; shortening the recovery time of animals; high therapeutic effectiveness of treatment without impaired body functions.

Claims (4)

1. A method of treating plague in dogs, including the introduction of sulfonamide preparations in combination with vitamins of group B, characterized in that animals, regardless of the form of the disease, are additionally parenterally administered biseptol at a rate of 2.5 ml per 8 10 kg of animal weight 2 3 times a day s an interval of 8 to 12 hours, and streptocide is used as a sulfonamide preparation, which is administered orally to animals at the rate of 1.5 to 2.0 g per 20 kg of animal weight 2 3 times a day, with vitamins B ₁ , B ₁₂ , B ₆ , B ₂ and C is administered 1 ml 1 time per day.  2. The method according to claim 1, characterized in that in the pulmonary form of the disease, the animal is additionally injected with aloe and calcium chloride, moreover, aloe is administered subcutaneously once a day at the rate of 0.5 ml of aloe and 0.5 ml of FIBS in one syringe, and calcium chloride is administered orally at 1 tbsp. spoon 3 times a day.  3. The method according to claim 1, characterized in that, in case of a nervous form of the disease, the animal is additionally orally administered with dibazole, stepsirazine or triftazine, moreover, dibazole is administered 1 2 tablets 1 2 times a day, stepsirazine 10 mg, tryptazine 2 5 mg and Ca gluconate 4 tablets 3 times a day.  4. The method according to claim 1, characterized in that when the intestinal form of the disease, the animal is additionally injected with 40% glucose of 10 ml 1 time per day in a mixture with saline, as well as vitamin K parenterally 1 ampoule per day or orally 1 tablet per day and vitamin U orally 3 times a day at the rate of 1 tablet per 12 kg of animal weight.