RU2053795C1 - Composition for dressing material - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: before application on the wound the components were mixed at the following ratio, mas. p.: high-molecular oligoethertriol 100; low-molecular oligoetherdiol 1-5; water 2.3-4.0; catalyst of urethan-formation 0.4-0.5, and isocyanate complex 35.3-54.1. Composition can also contain low-molecular triol at concentration 0.3-1.5 mas. p. per 100 mas. p. high-molecular oligoethertriol. EFFECT: enhanced quality of composition. 2 cl

Description

 The invention relates to polymer compositions used for the preparation of dressings applied to burns and other wounds, and can be used in medicine.

 Polyurethane compositions are known for use in the preparation of dressings.

 Closest to the proposed is a known composition for a dressing material, consisting of a polyol as one component containing oligoester polyol based on ethylene oxide and propylene oxide in a ratio of 60:40 to 75: 25 (referred to in the description of the composition as a surface active agent and a urethane formation catalyst mainly of the amine type, and an isocyanate component representing an oligoester urethane isocyanate. The oligoester urethanisocyanate used in this composition is obtained from an molecular weight oligoester polyol from 200 to 20,000 (preferably 600-6000, in example 1500) and OH functionality from 2 to 6 and an excess of isocyanate (toluene diisocyanate, diphenylmethane diisocyanate, polyphenylene polymethylene polyisocyanates, etc.); 1 g of oligoester urethaneisocyanate contains from 0.33 to 3.05 m -groups, i.e. the content of NCO-groups is from 1.4 to 12.8 wt. A dressing material based on the composition is obtained by mixing the polyol and isocyanate components and curing the resulting mixture on a paper substrate by heating, followed by sterilization and packaging. The obtained dressing has a porous layered structure, is able to adsorb exudate from the wound and prevent its passage through the material, while maintaining a moist microclimate necessary for wound healing.

 When using dressings obtained on the basis of the known composition, its tight fit to the wound surface is not ensured and the development of infection under the dressing is not excluded.

 To create dressings that provide sealing of the wound and optimal healing conditions, a composition for dressings is proposed, consisting of a polyol as one component, including an oligoester polyol based on ethylene oxide and propylene oxide, and an isocyanate component, including oligourethanisocyanate based on oligourethane polyol and diphenylmethylene polyisocyanate characterized in that the polyol as one component contains high molecular weight oligoesterriol, low molecular weight ol ioetherdiol, water and a urethane formation catalyst, and the isocyanate component contains the named oligourethane anisocyanate and an excess of diphenylmethanediisocyanate and / or polyphenylene polymethylene polyisocyanates and has an NCO content of 19.2-26.0 wt. in the following ratio of ingredients, wt. h

High Molecule
oligoester triol 100
Low molecular weight oligoesterdiol 1.0-5.0 Water 2.3-4.0
Urethane catalyst 0.4-0.5
Isocyanate component 35.3-54.1
The polyol as one component of the composition may also optionally contain a low molecular weight triol in an amount of 0.3-1.5 parts by weight per 100 parts by weight high molecular weight oligoesterriol.

The composition is chosen so that the formation of flexible polyurethane foam takes place at ambient temperature and humidity environment, without the use of special types of blowing agents and fluorocarbons as the temperature rises as a result of the reaction is not more than up to 40-41 ° ^C. This allows the formation of a porous polyurethane dressings directly on the wound surface, as a result of applying a mixed composition to this surface in the stage of gel formation with its subsequent hardening m in the form of an elastic polyurethane foam, which provides sealing of the wound and absorption of exudate, well retained on the wound without the use of additional fixing means.

 In the composition of the proposed composition as high molecular weight oligoethertriol can be used having an average molecular weight (M) of from 1000 to 6000 polyaddition products of ethylene oxide and / or propylene oxide to trihydric alcohols, such as glycerin, trimethylolpropane, etc. Examples of such oligoesterriols are products commercially available under the name Laprol, having, for example, grades 1003, 3003, 3203, 3503, 3603, 4003, 5003, 6003.

 As low molecular weight oligoesters, linear polyaddition products of ethylene oxide and / or propylene oxide to ethylene and / or propylene glycol having M from 200 to 1000 are used. Examples of such oligoesters are products commercially available under the name Laprol having, for example, grade 202 , 402, 502, 702, 1052.

 As a catalyst in the proposed composition can be used various known catalysts for urethane formation: tertiary amines, organotin compounds, metal acetylacetonates, etc. Examples of such catalysts are triethylenediamine (diazabicyclooctane-DABCO), tin dibutyldylaurinate, tin (II) octoate, manganese acetylacetonate, nickel acetylacetonate, etc.

 As a low molecular weight triol, which can be additionally incorporated into the polyol as one component, triols such as glycerol, trimethylolpropane or low molecular weight products of addition of ethylene oxide and / or propylene oxide to them, for example, such as Laprol 503, are used.

 The polyol component is prepared by thoroughly mixing all of its constituent ingredients with a high molecular weight oligoesterriol, a low molecular weight oligoesterdiol, water, a urethane formation catalyst and, if necessary, a low molecular weight triol. The quantities of ingredients are selected in such a way as to ensure optimal speed of the stages of the foaming process and the necessary physical and mechanical properties and structure of the resulting polyurethane foam.

 As the isocyanate component (oligourethanisocyanate) in the proposed composition, the condensation products of oligoester polyols with an excess of diphenylmethanediisocyanate (MDI) and / or polyphenylene polymethylene polyisocyanates are used. Examples of oligoester polyols are low molecular weight or high molecular weight diols and triols, such as Laprol 202, 503, 1052, 5003 and others. Examples of isocyanates are 4,4'-MDI, mixtures of 4,4'-and 2,4'-MDI, a mixture of polyphenylene-polymethylene polyisocyanates containing 40-75% MDI and known as "crude MDI", "polymer MDI", "polyisocyanate" . An oligourethanisocyanate is prepared by reacting the oligoester polyol with the whole amount of isocyanate necessary to achieve the above content of NCO groups in the isocyanate component, or with part of this amount, then mixing the reaction product with the rest of the isocyanate.

 The composition is prepared by mixing the polyol and isocyanate components immediately before use. The prepared composition is applied to the wound surface at the stage of gel formation (0.5-1.5 minutes after mixing).

 The invention is illustrated by the following examples.

PRI me R 1. The polyol as one component of the composition is prepared by mixing 100 wt. including oligoesterriol based on glycerol, ethylene oxide and propylene oxide (Laprol 5003-2B-10, TU 6-05-1513-76), 3.04 wt.h. oligoetherdiol based on ethylene oxide (Laprol 402-2-100, TU 6-05-1986-85), 3.19 parts by weight water and 0.5 wt. h. DABCO. The isocyanate component was prepared by adding under stirring for 60 min at 70 ° ^C 3.68 pbw oligoetherdiol based on ethylene oxide (Laprol 202-3-100, TU 6-05-221-826-86) to 23.0 parts by weight 4,4'-diphenylmethanediisocyanate, followed by exposure of the reaction mixture for 70 minutes at 70 ^about C, and then adding to the resulting product 26.68 wt.h. polyisocyanate grade B (TU 113-03-375-75) and thoroughly stirring the mixture for 30 minutes at 40 ^C. The resulting isocyanate component comprises 26 wt. NCO groups; its total amount is 53.36 parts by weight per 100 parts by weight Laprol 5003-2B-10. The composition is prepared by adding the isocyanate component to the polyol as one and mixing the components manually. After 30 s from the moment the isocyanate component was added (foam rise begins (start time), gel formation begins after 55 s (gel formation time), foam rise ends after 80 s (foam rise time). The composition is applied to the wound surface (after it has been thoroughly washed) ) after the onset of gelation and before the end of the foam rise period Within 1.5-2 minutes after the end of application, the composition turns into a porous sponge that is firmly held on the wound surface for 7 days until it is completely epithelized.

 PRI me R 2. Polyol and isocyanate components are prepared analogously to example 1 with the difference that the composition of the polyol as one component is additionally introduced 1.52 wt.h. a low molecular weight triol based on glycerol and propylene oxide (Laprol 503B, TU 6-05-1679-83), and the isocyanate component is prepared and used in an amount of 54.12 parts by weight per 100 parts by weight Laprol 5003-2B-10. The composition is prepared and used analogously to example 1. Foaming parameters: start 25 s, gelation 50 s, foam rise 90 s.

 PRI me R 3. Polyol and isocyanate components are prepared analogously to example 1 with the difference that 0.3 wt.h. glycerol, and the isocyanate component is prepared and used in an amount of 53.52 parts by weight per 100 parts by weight Laprol 5003-2B-10. The composition is prepared and used analogously to example 1. Foaming parameters: start 25 s, gelation 50 s, foam rise 80 s.

PRI me R 4. The polyol as one component is prepared analogously to example 1 with the difference that water is used in an amount of 2.39 wt.h. The isocyanate component was prepared by adding under stirring for 60 min at 70 ° ^C, 4.87 wt. including oligoesteriol Laprol 202-3-100 to 30.44 parts by weight 4,4'-diphenylmethane diisocyanate, followed vyderzh- Coy reaction mass for 70 minutes at 70 ^C. The resulting isocyanate component contains 22.8 wt. NCO groups; its total amount is 35.31 parts by weight per 100 parts by weight Laprol 5003-2B-10. The composition is prepared and used analogously to example 1. Foaming parameters: start 35 s, gelation 60 s, foam rise 85 s.

 PRI me R 5. The polyol as one component is prepared analogously to example 1, with the difference that DABCO is used in an amount of 0.4 wt.h. and the isocyanate component is analogous to example 4, but in an amount of 35.58 parts by weight per 100 parts by weight Laprol 5003-2B-10. The composition is prepared and used analogously to example 1. Foaming parameters: start 30 s, gelation 70 s, foam rise 100 s.

EXAMPLE Example 6. The polyol component was prepared similarly to Example 3. The isocyanate component was prepared by adding under stirring for 90 minutes at 40-45 ^{° C,} 11.10 parts by weight Laprol 5003-2B-10 to 31.71 parts by weight brand B. polyisocyanate. Then the reaction mass is maintained at 75 ° C. ^for another 60 minutes. The obtained isocyanate component (42.81 parts by weight) contains 21.8 wt. NCO groups. The composition is prepared and used analogously to example 1. Foaming parameters: start 35 s, gelation 60 s, foam rise 80 s.

EXAMPLE EXAMPLE 7 The polyol component was prepared similarly to Example 3. The isocyanate component was prepared by adding under stirring for 90 minutes at 40 ^C. 7.93 wt. including oligoetherdiol based on propylene oxide (Laprol 1052, TU 6-05-021-266-80) to 34.88 parts by weight polyisocyanate grade B, then at ⁷⁵ ° C the reaction mixture was kept another 60-90 min. The obtained isocyanate component (42.81 parts by weight) contains 22.7% of NCO groups. The composition is prepared and used analogously to example 1. Foaming parameters: start 35 s, gelation 60 s, foam rise 85 s.

EXAMPLE EXAMPLE 8. The polyol component was prepared as in Example 2. The isocyanate component was prepared by adding under stirring for 90 minutes ^at 40 ° C 0.83 pbw Laprol 5003-2B-10 and 3.32 parts by weight Laprol 503 to 31.77 parts by weight polyisocyanate mark B. Then, at ⁷⁵ ° C, the reaction mass was kept for another 60 min. The obtained isocyanate component (35.92 parts by weight) contains 19.2 wt. NCO groups. The composition is prepared and used analogously to example 1. Foaming parameters: start 35 s, gel formation 40 s, foam rise 80 s.

 PRI me R 9. The polyol component is prepared analogously to example 1 with the difference that oligoester based on ethylene oxide (Laprol 402-2-100, TU 6-05-1986-85) is used in an amount of 1.40 wt.h . and the isocyanate component is prepared analogously to example 1. The composition is prepared and used analogously to example 1. Foaming parameters: start 27 s, gelation 54 s, foam rise 85 s.

 PRI me R 10. The composition is prepared and used analogously to example 9 with the difference that oligoetherdiol (Laprol 402-2-100) is used in an amount of 5.0 wt. h. Foaming parameters: start 29 s, gel formation 57 s, foam rise 80 s.

 PRI me R 11. The composition is prepared and used analogously to example 9 with the difference that oligoetherdiol (Laprol 402-2-100) is used in an amount of 1.0 wt. hours and water in the amount of 4 parts by weight Foaming parameters: start 29 s, gel formation 54 s, foam rise 80 s.

Claims (1)

1. COMPOSITION FOR BANDING MATERIAL, consisting of a polyol as one component, comprising an oligoester polyol based on ethylene oxide and propylene oxide, and an isocyanate component including oligourethanisocyanate based on oligoester polyols and diphenylmethylene diolipolyene polyolene polyolene polyolene , water and a urethane formation catalyst, and the isocyanate component contains the named oligourethanisocyan and an excess of a diphenylmethane diisocyanate and / or polyphenylenepolymethylene and has an isocyanate content of 19.2 - 26.0% by weight with the following ratio of ingredients in parts by weight .:.
High molecular weight oligoesterriol - 100
Low molecular weight oligoesterdiol - 1 - 5
Water - 2.3 - 4.0
Urethane catalyst - 0.40 - 0.50
Isocyanate component - 35.3 - 54.1
2. The composition according to claim 1, characterized in that the polyol as one component further comprises a low molecular weight triol in an amount of 0.3 to 1.5 wt.h. per 100 parts by weight high molecular weight oligoesterriol.