RU205146U1 - PORTABLE THERMOSTAT FOR COMBINED MEDICAL AND BIOLOGICAL EXPERIMENTS - Google Patents

Abstract

The utility model refers to devices for thermostating biological samples during radiobiological research under conditions of strictly specified thermal regimes and can be used to conduct combined experiments on the simultaneous effect of ionizing radiation and hyperthermia on cells of different types. It can also be used for transportation and storage of biological objects that require maintaining thermal conditions within strictly specified limits. The thermally insulated housing with a working chamber and a lid is made of materials permeable to ionizing radiation and includes a ventilation module, a heating element and a contact thermometer, as well as a switch that controls the change in operating modes of the heating element, a power supply unit located separately from the housing containing a 220 V voltage conversion step-down transformer 24 V, built-in rechargeable battery to maintain uninterrupted operation during experiments, and the lid contains an additional hole for a monitoring thermometer. The utility model is intended for reusable use, it allows to increase the heat-shielding properties of the container, the thermostating time, increase hyperthermia, protect against sudden power outages, and carry out combined experiments with several influencing factors. 2 ill.

Description

The utility model refers to devices for thermostating biological samples during radiobiological research under conditions of strictly specified thermal regimes and can be used to conduct combined experiments of simultaneous exposure of cells to various types of ionizing radiation and hyperthermia. It can also be used for transportation and storage of biological objects that require maintaining thermal conditions within strictly specified limits.

To increase the effectiveness of radiation therapy, the combined action of ionizing radiation and various inhibitors of cell regeneration from radiation damage is often used. The synergistic effect, best achieved with the simultaneous action of agents, is most effective in suppressing tumor cell regeneration. Research on synergistic effects is relevant and promising. The proposed device should help in carrying out the necessary experiments on the simultaneous exposure of cells to radiation and elevated temperatures.

A thermostat for biomedical research (RU 142802 U1, July 10, 2014) is known from the existing prior art, containing a closable thermostatic chamber with heat-insulating walls, a means for accommodating biological samples under study, equipped with flat electric heaters, a temperature controller, temperature sensors, and the means to accommodate the biological samples under study is made in the form of a holder made of a heat-conducting material, consisting of two halves, the inner surface of which has recesses for the shape of test tubes intended for placing biological samples in them, and the holder itself is equipped with spring-loaded guides for connecting its halves and piezoelements, at the same time, temperature sensors, flat electric heaters and piezoelectric elements are located on the outer surface of the cage and are equipped with a means of connection to the control and recording unit, which acts as a temperature regulator for the studied biological images ts and a control device for piezoelectric elements, providing shaking of the holder with test tubes.

The disadvantage of this device for specific tasks is its complexity and additional structural elements required in zero gravity conditions, which is not necessary in our case. Also, the disadvantages include increased power consumption due to additional devices. The material from which this device is supposed to be made may distort the results of the combined (radiation) effects we use.

Also known is a thermal container (RU 197942 U1, 03/20/2020), which includes a body and a lid with a handle, made of heat-insulating and heat-reflecting layers. The thermal container is equipped with latches, and the body is made of polypropylene in the form of a parallelepiped or a truncated pyramid, is impact-resistant and contains a hinged lid fixed to the body with hinges, the body is a multilayer structure consisting of a polypropylene body shell, heat-insulating layers with a closed loop in the form of polyurethane foam and vacuum insulation panels. The operating time while maintaining the required thermal mode is up to 170 hours.

The disadvantage of this model can be attributed to the small amount of time required to hold a given temperature. The time required for experiments with radiation sometimes exceeds a week or more.

The closest to the proposed device is a portable thermostat for transportation and storage of biological substances (RU 130377 U1, July 20, 2013), containing a thermally insulated housing with a working chamber and a lid, made of foamed polyurethane foam, a thermoblock including a thermoelectric module, a radiator and a fan, an automatic control system, while the automatic control system includes a control board and a power board. The temperature difference is offered from -30 to + 40 ° С.

The disadvantage of this thermostat is insufficient heating, planned in experiments, which is necessary to achieve the best result of action on biological substances, as well as the absence of the need to maintain negative temperatures in the working chamber.

The technical result is the creation of a compact thermostat that ensures the formation of a uniform temperature field in the area of placement of samples of the studied biological materials with the maintenance of a precisely specified controlled elevated temperature under conditions of the unhindered influence of additional physical parameters, such as irradiation from sources of ionizing radiation.

The technical result is achieved by the fact that the thermostat is made of materials permeable to ionizing radiation and contains a switch that controls the change in operating modes of the heating element, a power supply unit located separately from the case, equipped with a 220 ° V to 24 V voltage conversion transformer and a built-in battery to maintain uninterrupted operation during time of experiments, and the side cover of the chamber is pressed with a plug, and there is an additional hole in the cover for a controlling thermometer.

When solving the technical result, by expanding the capabilities of the contact thermometer, increasing the power of the power supply and increasing the battery capacity, heating capabilities will be increased and the required elevated temperatures will be maintained for long periods of time.

The utility model is illustrated by a detailed description and illustrations, which depict:

FIG. 1 - Diagram of a portable thermostatic device for combined biomedical research; front view: 1- body; 2- transport handle; 3- thermal insulation; 4- working chamber; 8- working shelf; 9- shelf for contact thermometer; 10- thermoblock fasteners; 11- outlet for the power cable; 13-pin thermometer; 14- heating element; 15- ventilation module; 16- switch.

FIG. 2 - Diagram of a portable thermostatic device; side view: 1- body; 2-transport handles; 3- thermal insulation; 4- working chamber; 5- cover; 6- plug; 7- hole for a control thermometer; 8 - working shelf; 9- shelf for contact thermometer; 10- thermoblock fasteners; 11- outlet for the power cable; 12 - power cable; 13-pin thermometer; 17- thermoblock; 18- power supply unit; 19- step-down transformer; 20- battery; 21- on / off button.

Description of the utility model.

The thermostat (Fig. 1, 2) for carrying out combined biomedical experiments on biological objects is completely made of materials permeable to ionizing radiation - polymethyl methacrylate. The thermostat contains an impact-resistant body 1 in the form of a parallelepiped and is equipped with transport handles 2. Between the body 1 and the chamber 4 there is a multilayer thermal insulation 3 (foam). Chamber 4 is equipped with a side cover 5, which is pressed with a plug 6. In the center of the cover 5 there is a hole 7 for a control thermometer. Inside chamber 4 there is a working shelf 8 (for installing a container with biological objects under study). A thermoblock 17, a heating element 14, a ventilation module 15 and a switch 16, which controls the change in the operating modes of the heating element, are rigidly mounted near the rear wall of the chamber 4 using fasteners 10. A contact thermometer 13 is installed on shelf 9. Chamber 4 in the rear wall is equipped with an outlet 11 for power cable 12, connected to power supply 18. Power supply 18 is equipped with a transformer 19 to convert 220V to 24V voltage, built-in battery 20 to maintain uninterrupted operation devices during experiments and the on / off button 21.

The device is used as follows.

The thermostat (Fig. 1, 2) for carrying out combined radiobiological experiments, with a housing 1 made of polymethyl methacrylate, is taken by the transport handles 2 and transferred to an appropriate place near the source of ionizing radiation involved in the work. The power supply unit 18 is turned on using the on / off button 21. The contact thermometer 13 is adjusted to the temperature planned for the experiment. Cover 5 with plug 6 is closed. After some time, when the required temperature is reached, the plug 6 is removed and a control thermometer is inserted through the technological hole 7 in the cover 5. If the temperature has reached the values planned for the work, and coincides with the control, then the experiment is started. The access to the chamber 4 is carried out through the cover 5, pushing back the plug 6 and a regime object with the cell suspension is installed on the working shelf 8. The cover 5 is put in place and tightly pressed down with the plug 6. After that, the effect of ionizing radiation is started, timing the experiment. A 20 battery is used to ensure smooth operation.

The device is intended for carrying out combined experiments of simultaneous exposure to objects of different types of ionizing radiation and hyperthermia. The thermostat is compact, lightweight, mobile and easy to operate, which allows, during experiments, to simultaneously influence cells by two controlled physical factors. The advantage of the model also lies in the fact that there is complete control and long-term maintenance of the set temperature.

The utility model is intended for reusable use, it allows to increase the heat-shielding properties of the container, the thermostating time, increase hyperthermia, protect against sudden power outages, and carry out combined experiments with several influencing factors.

Claims (1)

Portable thermostat for carrying out combined biomedical experiments, including a thermally insulated housing with a working chamber and a lid, a ventilation module, a heating element and a contact thermometer, characterized in that the thermostat is made of materials permeable to ionizing radiation and contains a switch that controls the change in operating modes of the heating element a power supply unit located separately from the case, equipped with a 220 V to 24 V voltage conversion transformer and a built-in battery to maintain uninterrupted operation during experiments, and the side cover of the chamber is pressed with a plug, and the cover has an additional hole for a controlling thermometer.

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