RU2032415C1 - Method of prophylaxis and treatment of pigs with balantidiasis - Google Patents

Abstract

FIELD: veterinary. SUBSTANCE: three days before piglet removal from sows they were given drink containing bioactive substance - condensed alfalfa extract together with trichopol (2 times per a day) at the dose: condensed alfalfa extract 0.3-0.5 g/kg of animal mass, and trichopol 0.2-0.3 g/head. Condensed alfalfa extract is dissolved in 20-30 ml distilled water. EFFECT: improved method of prophylaxis and treatment. 2 cl, 2 tbl

Description

 The invention relates to methods for the prevention and treatment of swine balantidiosis and may find application in veterinary medicine.

 Pig balantidiosis is caused by the infusoria Balantidium coli, which lives mainly in the large intestine of the pig’s intestines. The disease occurs with the phenomena of catarrhal colitis or catarrhal-hemorrhagic enterocolitis, accompanied by diarrhea, emaciation, there is blood in the stool. Losses in mass usually continue after treatment.

 The diagnosis is made according to clinical signs and the results of studies of feces, crushed by a drop, where a large number of motile balantidia and cysts are detected.

To treat balantidiosis, orasol is usually used in a dose: for animals 2-3 months. 0.1-0.2; 3-4 months 0.2-0.3; 4-8 months 0.3-0.4; 8-12 months, 0.4-0.5; over 12 months 0.5-0.7;
Tilan is prescribed at a dose of 0.00125 g / kg 2 times a day for three days in a row. After a three-day break, the treatment is repeated. The drug is mixed in water for 20 minutes, and then mixed with food;
metronidazole is given to piglets at a dose of 0.25 g 2 times a day for three days in a row; after 3-7 days, repeat 2-3 times;
Vetdipasphen for the treatment of piglets up to 30 days is used in a dose of 0.125 g from 31 days to the 60th 0.25 g, from 61 to 120 days 0.375 g and older than 120 days 0.725 g daily once a day three days in a row;
furazolidone is prescribed at a dose of 0.01 g / kg 3 times a day for 3-5 days;
iodinol is recommended for 4-6 month old piglets of 20-25 ml per dose 2 times a day for 7-10 days with a small portion of the feed.

 MIX-10 (a complex preparation containing 150 kg of robodet, 100 g of lecocept, 100 g of dimetridizole and 650 g of excipient in 1 kg) is given to piglets under the age of 40 days with food for 3-4 kg / t for 7-10 days. Food mixed with MIX-10, do not heat up (see Veterinary formulation with the basics of therapy and prevention, M. Agropromizdat, 1988).

 The use of Trichopol (Trichopol) for the treatment of balantidiosis is known. Trichopol anti-trichomonas, used orally at 0.25 g 2 times a day for 7-10 days. The total dose for the course of treatment can be 5 g. The drug is produced in Poland and Hungary (see Medicines used in medical practice in the USSR, 1989 prototype).

 Known means and methods for treating swine balantidiosis are expensive, not always effective, some of the considered methods and drugs have side effects.

 For the prevention of balantidiosis, usually in farms it is necessary to observe the requirements of pet hygiene: to clean and disinfect walls, floors, and feeders with a 2-3% solution of NaOH or KOH, a 4% solution of formalin. It is necessary to add vitamins A, D, C and others to the feed, as well as ABA, PABA, and whey.

 For chemoprophylaxis, furazolidone with soap in a ratio of 1: 1000 is usually used, which is diluted with water to a creamy state and laid out in piglets machines 2-3 days before weaning. They give MICS-10, for example, Osarcoli 0.25, Natii hydrocorbonats 1.0, Aqnac destillate 100 me, 4 ml 2 times a day three days in a row are prescribed for weaning. A piglet at the age of 40 days is prescribed Vetdipaspheni 2.5, Aquae coctal 50 me, internal at one time. A suckling pig is prescribed Tilani 2.5, Aquae coctal 1000 me, internal, 1 ml / kg once a day for three days in a row or Furasolidoni 0.3 is mixed with half the norm of food and given 3 times a day, or Todinoli 300 me, internal 20 ml 2 times a day with a small portion of the feed (see Veterinary formulation with the basics of therapy and prevention, M. Agropromizdat, 1988).

 It is known that prophylactic Trichopol (Trichopol) is used antitrichomonas, inside of 0.5 g 2 times a day for 7-10 days (see Medicines used in medical practice in the USSR, 1989).

 The aim of the invention is to increase the therapeutic and prophylactic effect and, as a result, the provision of stable gains in treated animals.

 To this end, the Trinity Veterinary Institute (Department of Parasitology and Invasive Diseases) together with the Zheltinsky State Farm of the Agapovsky District of the Chelyabinsk Region tested the therapeutic and prophylactic effect of the Condensed Vegetable Extract (Erakonda) in case of swine balantidiosis.

 Of the spontaneously infected balantidiosis piglets of three months of age, 2 experimental groups of 10 animals were formed in each group, and group I of the piglets was the control. The experiment lasted 30 days.

 Experimental animals of group I for 3 days individually 2 times a day were asked Trichopolum in a dose of 0.5 g per head.

 Experimental animals of group II for 3 days were given Trichopolum in a dose of 0.5 g per head, together with Herakond at a dose of 0.5 g / kg, dissolved in 20-30 ml of water.

 Experimental animals of group III (control) were not prescribed any drugs.

 Before the start of the experiment and at the end of the experiment, animals were weighed and coprologically examined using native smear and fulleburn methods.

 The results of the use of drugs were evaluated according to the indicators of extensibility (EE), the safety and weight gain of piglets at the end of the experiment.

 The research results are given in table 1.

As can be seen from Table 1, the most effective was the use of heraconda with Trichopolum, which provided, with a slightly higher initial intensity of invasion, the effect of release from balantidia and the maximum average daily gain. If in the first experimental group after the use of Trichopolum the average daily gain in body weight of piglets increased by 4.7% compared with the control group, while in the second experimental group after giving Trichopolum simultaneously with the Heracond, this indicator was higher by 22.1% Accordingly, the increase in live body weight of animals increased; moreover, in the second experimental group it was 1.1 kg higher than in the first. Extensibility in the I and II experimental groups was 100%
In the control group of sick animals during the experiment, the intensity of invasion increased slightly from 3-13 to 4-25 specimens.

 Thus, the increase in body weight and the average daily increase in piglets when used for the treatment of piglets, patients with balantidiosis, trichopolum against the background of heraconda is greater than when treated with trichopolum alone.

 Testing the prophylactic action of trichopolum in combination with heracond in swine balantidiosis. Spontaneously infected piglets were taken into the experiment; 2 experimental and 1 control groups of 10 animals each were formed.

 Experimental animals of group I for 3 days individually 2 times a day were asked Trichopolum in a dose of 0.25 g per head.

 Experimental animals of group II for 3 days individually 2 times a day were asked trichopol in a dose of 0.25 g per head and heracond at a dose of 0.5 g / kg, dissolved in 20-30 ml of water.

 Experimental animals of group III for 3 days 2 times a day were asked only heracond at a dose of 0.5 g / kg, dissolved in 20-30 ml of water.

 Piglets were prescribed 3 days after weaning from sows.

 The animals of the control group were not given drugs.

 In the period and after the administration of the preparations, the pigs were monitored. Before the start, after 30 days and at the end of the experiment, the animals were weighed and coprologically examined using native smear and fulleborn methods.

 The results of the studies are presented in table.2.

An analysis of the data showed that the increase in body weight per animal in the experimental group I after 30 days averaged 5.3 kg, and after 60 days 11.4 kg, which is 1.1 and 0.7 kg, respectively, more than in the control group of animals. EE in this group 80.0%
When trichopolum was used for the chemoprophylaxis of swine balantidiosis at the same time as the heracond (group II), body weight gain after 30 and 60 days was 7.4 and 13.9 kg, respectively, which is 3.2 kg more than in the control group of animals. The average daily gain for the same period in experimental animals is also greater by 72.73 and 28.89%, respectively, than in animals of the control group. EE 90.0%
The average daily weight gain of piglets in the II experimental group for 30 and 60 days was 1.4 and 1.2 times, respectively, more than in the I experimental group. Over the same period, the increase in live body weight of animals increased, and in the II experimental group it was 2.1 and 2.5 kg more than in the first group.

The safety of piglets in the control group (III) was 90.0% whereas in the experimental groups 100.0%
Thus, the increase in body weight and the average daily increase in piglets when using trichopol for chemoprophylaxis against the background of heraconda is greater than when using trichopol alone.

 Thus, in a comparative aspect, the test of Trichopolum and Trichopolum with Heraconda showed that the use of Trichopolum against the background of Heraconda is more effective. The combination with heracond enhances the preventive effect and increases the productivity of animals.

 Condensed plant extract (Erakond) is an aqueous extract of alfalfa grass (hay) obtained by treatment with an extractant containing a mixture of trace elements, mg / kg of plant mass: Mo 8.0; Ba 10.0, Pb 20.0, Co 1.05, V 1.0, Cz 0.5, Zn 200.0, Fe 300.0, Sn 40.0.

 The method of preparation and composition of Heraconda is as follows (application N 4736234 / 30-15).

 Prepare a solution of salts of trace elements based on the steam condensate of distilled water, including, mg: Mo 8.0; Ba 10.0; Pb 20.0, Co 1.05; V 1.0; Cz 0.5; Zn 200.0; Fe 300.0; Sn 40.0.

Alfalfa grass (hay) is crushed and placed in an autoclave, poured with a prepared solution in a ratio of 1: 5, the autoclave is sealed, heated to 120 ^° C and held for 10 minutes. The autoclave is depressurized, the primary extract is poured into the storage tank, and the raffinate remaining in the autoclave is again poured with the extracting mixture in the same ratio and heated to 180 ^° C for 10 minutes. The secondary extract is poured into the storage tank and mixed with the primary extract. The resulting mixture was evaporated until numerous bubbles appeared on the mirror. Then the extract is filtered through a cotton-gauze filter. The resulting filtrate was placed on a baking sheet covered with a polyethylene film, and continue to evaporate in an oven at 60 ° ^C to form a resinous mass throughout the thickness poured onto a baking extract. The resulting resinous mass is formed into a lump for further use (or storage).

 A sterile heraconda aqueous solution was prepared. The original preparation of Heraconda was dissolved in distilled water until completely dissolved by vigorous stirring. The solution was filtered through several layers of gauze and used immediately after preparation (it is possible to ampoule the solution for long-term storage).

 Trichopolum was introduced into the heraconda solution. The drug was given with food during drinking (for example, when giving a warm solution during drinking).

Claims (2)

 1. METHOD FOR PREVENTION AND TREATMENT OF PIG BALANTIDIOSIS, including giving a drink to piglets before weaning biologically active substances from a sow, characterized in that the biologically active substance is given three days before weaning from a sow 2 times a day, and the biologically active substance at a dose of 0 , 3 0.5 g / kg of the animal’s mass is dissolved in 20 30 ml of distilled water and set together with Trichopolum in a dose of 0.2 0.5 g per head. 2. The method according to claim 1, characterized in that as a biologically active substance, a herbal preparation is used, including a plant extract, for example alfalfa hay, containing soluble metal salts, mg / kg of plant mass:
Mo 8.0
VA 10.0
Rv 20.0
V 1.0
Cz 0.5
Zn 200.0
Fe 300.0
Sn 40.0

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