RU2026681C1 - Method of forming microflora of neonate's intestine in prenatal preparation of woman in childbirth - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: this method prescribes vaginally administering bifido- and lactobacteria, perorally administering bifidum-containing medicine prepared from bacteria inherent in organisms of nursing babies and rectally administering complex immunoglobulin preparation. EFFECT: greater simplicity and efficiency; shorter period of formation of normal intestinal microflora in neonates and prevention of emergence of infectious diseases in infants by carrying out antepartum preparation of pregnant women of vulnerable group with use of complex of biological medicines. 1 tbl

Description

 The invention relates to medicine, in particular to pediatrics, and can be used to increase the resistance of the newborn to colonization by microorganisms that can have an adverse effect on the newborn's body.

 The indigenous anaerobic form forms in the human intestine a natural barrier to bacterial defense called colonization resistance. The leading role in creating its mechanism belongs to bifidobacteria, which make up 90% of the total intestinal microbiocenosis; 1 g of feces contains 1-10 and more than billions of bifidobacteria.

 The microorganisms that make up the normal human microflora perform the most important physiological functions: they produce vitamins, other biologically active compounds such as antibiotics, hormones, secrete enzymes that metabolize various endogenous and exogenous substrates, exhibit anticarcinogenic activity, etc.

 It is known that a child is born sterile and from the first minutes of life it is seeded with microbes from the environment and especially those that are present in the genital, intestinal tract, mucous membranes and skin of the mother.

 If the mother’s microbial homeostasis is optimal for the human and microflora systems, then the microorganisms that enter the body of the newborn baby from the mother will quickly form their microbial status and will be resistant to the introduction of pathogenic and conditionally pathogenic bacteria, and the necessary microorganism, microbial metabolites, the microflora of the child will actively detoxify harmful chemical compounds, optimally support immunobiological reactivity.

 And on the contrary, if the mother has microbial homeostasis, the colonization resistance of the newborn child will be insufficient, microorganisms that are not characteristic of healthy children with all the ensuing consequences for health and life will be stored in the body of such a child for a long time.

 Thus, the need for the early formation of normal intestinal microflora in newborns is an essential condition for maintaining its health both in the first days after birth and for its subsequent life.

Known methods that allow the formation of newborn children favorable for them microflora. They include:
- early application to the mother’s breast so that antibodies introduced with colostrum prevent the colonization of the body by microbes that can cause diseases;
- the appointment from the first hours of life of bifidumbacterin to newborn children at risk, prematurely born or with signs of prematurity, who received antibiotics in the early neonatal period, children whose mothers suffered severe pregnancy toxicosis, extragenital pathology (Methodological recommendations. The use of bacterial biological preparations in the treatment of patients with intestinal infections , diagnosis and treatment of intestinal dysbiosis, M., 1986);
- joint stay of the mother of the child in one ward from the moment of birth;
- the appointment of pregnant women suffering from purulent-inflammatory diseases of antibiotics directed against the causative agents of these diseases.

 The disadvantage of these methods is that they do not take into account the microecological status of the mother, which leads to the fact that the unfavorable microflora of the mother, colonizing the body of the newborn, will impede the formation of normal microflora of the intestines of the child.

 The appointment of specific antimicrobial compounds to combat a specific pathogen indirectly affects the normal microflora of the mother, reduces its colonization resistance and, subsequently, the colonization resistance of the child.

 Closest to the claimed is a method of prenatal preparation of pregnant women at risk for biological bacterial drugs bifidumbacterin, lactobacterin.

 The method consists in the fact that bifidumbacterin or lactobacterin is prescribed 5-6 doses 1 time per day for 5-8 days intravaginally under the control of restoring the purity of the vaginal secretion to the I-II degree of purity and the disappearance of the clinical symptoms of inflammation.

 The disadvantage of this method is that it is aimed at normalizing only vaginal microflora. Meanwhile, it is known that the microflora of a newborn child is formed not only due to the vaginal microflora, but also largely due to the microflora of the gastrointestinal tract. In addition, the timing of the formation of normal intestinal microflora in newborns with this method is long - up to 15-20 days of life.

 The purpose of the invention is to reduce the formation of intestinal microflora of the optimal composition for healthy newborn babies.

 This goal is achieved in that the prenatal preparation of pregnant women at risk, starting from the gestational age of 32-34 weeks, is carried out with a complex of biological preparations with the simultaneous administration of them intravaginally, orally and rectally. Moreover, for the correction of vaginal microflora, bifidumbacterin or lactobacterin according to the prototype are used. Orally for the correction of the microflora of the gastrointestinal tract, a bifid-containing preparation prepared from the types of bifidobacteria inherent in the body of infants is prescribed. Supplements - 30 g per day, bifidumbacterin 10 doses per day for 5-8 days under the control of intestinal microflora. In parallel, a complex immunoglobulin preparation (CIP) is administered rectally at a dose of 400 mg (2 suppositories) 1 time per day during the same time.

 CIP is a complex preparation containing immunoglobulins of class M, I, A and is intended to increase the immune status of the child's body, prevents colonization of the gastrointestinal tract with potentially pathogenic gram-negative and gram-positive aerobic and facultative anaerobic bacteria that are not characteristic of a healthy body.

 PRI me R. Under supervision were 50 pregnant women at risk with non-specific inflammatory diseases of the genitals. During prenatal preparation (during pregnancy 32-34 weeks), they all received a complex of biological preparations, including lactobacterin or bifidumbacterin, intravaginally in 5 doses for 5-8 days. At the same time, all women received a per os bifid-containing preparation, prepared on the basis of the species B. bifidum and B. longum, characteristic of the infant's body. The drug was administered per os 1 time per day for 5-8 days, bifidumbacterin in 10 doses, dietary supplement - in a dose of 30 g of dry matter dissolved in a glass of milk. In parallel, a complex immunoglobulin preparation (CIP) was administered per rectum in the form of suppositories in a dose of 400 mg once a day during the same time.

Evaluation of the effectiveness of the method of prenatal preparation was carried out according to the timing of the formation of the optimal level of bifidoflora of newborns and the infectious morbidity of newborns in the first month of life. At the same time, the microflora composition was considered optimal if the quantitative level of bifidobacteria is 10 ⁹ per 1 g of feces, and the total number of bifidobacteria in the microbiocenosis reaches 90% and the prevailing types of bifidobacteria are B. bifidum and B.longum.

 As a control, a similar group of pregnant women at risk in the amount of 50 people was used, the prenatal preparation of which was carried out in accordance with the prototype only with the intravaginal administration of lactobacterin or bifidumbacterin at 5 doses per day for 5-8 days.

 Comparative data on the overall assessment of the effectiveness of various methods of directed formation of the intestinal microflora of newborns are presented in the table.

 The data obtained indicate that the proposed method of prenatal preparation of pregnant women at risk provides for the formation of optimal bifidoflora in newborns at an earlier date compared to the prototype, while the optimal level of bifidoflora in 60% of newborns is formed on the 5-6th day of life. Infectious incidence of children in this group is 4 times lower than the incidence of children in the control group.

 Thus, the proposed method of prenatal preparation is simple, physiological, harmless, affordable, effective and can be used in wide healthcare practice both in outpatient conditions and in a day hospital. In addition, the proposed method avoids the need for the appointment of live bacterial eubiotics to newborn children.

Claims (1)

 METHOD FOR FORMING THE INTESTINAL INTESTINAL MICROFLORA IN THE PRE-PRE-PREPARATION OF THE MOTHER, including the intravaginal administration of bifidumbacterin and lactobacterin in case of non-specific inflammatory diseases of the genitalia, additionally administering an antibacterial drug containing bifid bacteria to the children.

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