RU2021114345A - Способ для диагностики/скрининга колоректального рака - Google Patents
Способ для диагностики/скрининга колоректального рака Download PDFInfo
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- RU2021114345A RU2021114345A RU2021114345A RU2021114345A RU2021114345A RU 2021114345 A RU2021114345 A RU 2021114345A RU 2021114345 A RU2021114345 A RU 2021114345A RU 2021114345 A RU2021114345 A RU 2021114345A RU 2021114345 A RU2021114345 A RU 2021114345A
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- RU
- Russia
- Prior art keywords
- blood
- concentration
- colorectal cancer
- urea
- dbil
- Prior art date
Links
- 201000011231 colorectal cancer Diseases 0.000 title claims 6
- 238000003745 diagnosis Methods 0.000 title claims 2
- 210000004369 Blood Anatomy 0.000 claims 10
- 239000008280 blood Substances 0.000 claims 10
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 8
- 239000004202 carbamide Substances 0.000 claims 4
- 102100015724 CRP Human genes 0.000 claims 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 2
- 108010082126 Alanine Transaminase Proteins 0.000 claims 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims 1
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims 1
- NNUSCVFWUPARGJ-UHFFFAOYSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=NC(CC=2[C](C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N=2)CCC(O)=O)=C(CCC(O)=O)[C]1C NNUSCVFWUPARGJ-UHFFFAOYSA-N 0.000 claims 1
- 102000025380 C-Reactive Protein Human genes 0.000 claims 1
- 108010074051 C-Reactive Protein Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 238000008789 Direct Bilirubin Methods 0.000 claims 1
- 102100010966 GPT Human genes 0.000 claims 1
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 1
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Claims (6)
- Способ скринингового исследования для диагностики колоректального рака, характеризующийся тем, что у пациентов с подозрением на колоректальный рак определяют показатели биохимического анализа венозной крови, затем с использованием линейного дискриминантного анализа рассчитывают диагностические коэффициенты, оценивающие вероятность наличия колоректального рака по формулам:
- F1 = 1,2332⋅TP + 0,0591⋅CRP + 1,3239⋅Urea + 4,43231⋅HDL + 2,2370⋅Glu + Dbil⋅1,2618 + 1,197⋅Bil + ALT⋅0,1703 + AST⋅0,0871 – 74,5821
- F2 = 1,4980⋅TP + 0,0079⋅CRP + 0,69⋅Urea + 3,7407⋅HDL + 1,7054⋅Glu + Dbil⋅1,5711 + 0,9943⋅Bil + ALT⋅0,1135 + AST⋅0,1443 - 80,7422
- где F1 - значение диагностического коэффициента, указывающее на наличие колоректального рака,
- F2 - значение диагностического коэффициента, указывающее на отсутствие колоректального рака,
- TP - концентрация общего белка в крови, г/л; СRP - концентрация С-реактивного белка в крови, мг/л; Urea - концентрация мочевины в крови, ммоль/л; HDL - концентрация липопротеинов высокой плотности в крови, ммоль/л; Glu - концентрация глюкозы в крови, ммоль/л; Dbil - концентрация прямого билирубина в крови, мкмоль/л; Bil - концентрация общего билирубина в крови, мкмоль/л; ALT - концентрация аланинаминотрансферазы в крови, МЕ/л; AST - концентрация аспартатаминотрансферазы в крови, МЕ/л.
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2021114345A true RU2021114345A (ru) | 2022-11-21 |
| RU2798058C2 RU2798058C2 (ru) | 2023-06-14 |
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