RU2021112315A - METHOD FOR FUNCTIONALIZATION OF CALCIUM PHOSPHATE MATERIAL WITH CISPLATIN PREPARATION IN AQUEOUS SOLUTION - Google Patents

METHOD FOR FUNCTIONALIZATION OF CALCIUM PHOSPHATE MATERIAL WITH CISPLATIN PREPARATION IN AQUEOUS SOLUTION Download PDF

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Publication number
RU2021112315A
RU2021112315A RU2021112315A RU2021112315A RU2021112315A RU 2021112315 A RU2021112315 A RU 2021112315A RU 2021112315 A RU2021112315 A RU 2021112315A RU 2021112315 A RU2021112315 A RU 2021112315A RU 2021112315 A RU2021112315 A RU 2021112315A
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RU
Russia
Prior art keywords
calcium phosphate
phosphate material
aqueous solution
functionalization
preparation
Prior art date
Application number
RU2021112315A
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Russian (ru)
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RU2021112315A3 (en
RU2765465C2 (en
Inventor
Екатерина Алексеевна Кувшинова
Ярослав Дмитриевич Шанский
Наталья Валерьевна Петракова
Юлия Олеговна Никитина
Ирина Константиновна Свиридова
Владимир Сергеевич Комлев
Наталья Сергеевна Сергеева
Андрей Дмитриевич Каприн
Original Assignee
Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России)
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Application filed by Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) filed Critical Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России)
Priority to RU2021112315A priority Critical patent/RU2765465C2/en
Publication of RU2021112315A publication Critical patent/RU2021112315A/en
Publication of RU2021112315A3 publication Critical patent/RU2021112315A3/ru
Application granted granted Critical
Publication of RU2765465C2 publication Critical patent/RU2765465C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (1)

Способ функционализации кальцийфосфатного материала препаратом цисплатина в водном растворе, обеспечивающий его пролонгированный выход, отличающийся тем, что в качестве кальцийфосфатного материала используют октакальцийфосфат, а для пролонгирования выхода химиотерапевтического лекарственного средства в насыщающий кальцийфосфатный материал раствор препарата добавляют золедроновую кислоту в массовом соотношении с препаратом соответственно от 1:0,2 до 1:1.A method of functionalizing a calcium phosphate material with a cisplatin preparation in an aqueous solution, providing its prolonged release, characterized in that octacalcium phosphate is used as a calcium phosphate material, and zoledronic acid is added to a solution of the preparation saturating calcium phosphate material in a mass ratio of 1 to the preparation, respectively, to prolong the release of a chemotherapeutic drug. : 0.2 to 1: 1.
RU2021112315A 2021-04-28 2021-04-28 Method for functionalisation of calcium phosphate material with cisplatin preparation in aqueous solution RU2765465C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2021112315A RU2765465C2 (en) 2021-04-28 2021-04-28 Method for functionalisation of calcium phosphate material with cisplatin preparation in aqueous solution

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2021112315A RU2765465C2 (en) 2021-04-28 2021-04-28 Method for functionalisation of calcium phosphate material with cisplatin preparation in aqueous solution

Publications (3)

Publication Number Publication Date
RU2021112315A true RU2021112315A (en) 2021-06-28
RU2021112315A3 RU2021112315A3 (en) 2021-10-21
RU2765465C2 RU2765465C2 (en) 2022-01-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2021112315A RU2765465C2 (en) 2021-04-28 2021-04-28 Method for functionalisation of calcium phosphate material with cisplatin preparation in aqueous solution

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RU (1) RU2765465C2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105030823B (en) * 2015-06-19 2017-12-26 合肥工业大学 A kind of calcium phosphate nanoparticles for embedding cis-platinum and its preparation method and application
JP2020169146A (en) * 2019-04-04 2020-10-15 株式会社ナノビヨンド Agent for enhancing antitumor effect of polymer type anticancer agent

Also Published As

Publication number Publication date
RU2021112315A3 (en) 2021-10-21
RU2765465C2 (en) 2022-01-31

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