RU2018143895A - FORMATED BY MEDIUM-RADIATED FATTY ACIDS, COMPLEXES OF BETA HYDROXIBUTIRATE AND BUTANDIOL, AND COMPOSITIONS AND METHODS ON THEIR BASIS - Google Patents
FORMATED BY MEDIUM-RADIATED FATTY ACIDS, COMPLEXES OF BETA HYDROXIBUTIRATE AND BUTANDIOL, AND COMPOSITIONS AND METHODS ON THEIR BASIS Download PDFInfo
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- RU2018143895A RU2018143895A RU2018143895A RU2018143895A RU2018143895A RU 2018143895 A RU2018143895 A RU 2018143895A RU 2018143895 A RU2018143895 A RU 2018143895A RU 2018143895 A RU2018143895 A RU 2018143895A RU 2018143895 A RU2018143895 A RU 2018143895A
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- alkyl
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- unsubstituted
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- 239000000203 mixture Substances 0.000 title claims 17
- 238000000034 method Methods 0.000 title claims 11
- 235000014113 dietary fatty acids Nutrition 0.000 title 1
- 229930195729 fatty acid Natural products 0.000 title 1
- 239000000194 fatty acid Substances 0.000 title 1
- 150000004665 fatty acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 45
- 125000000217 alkyl group Chemical group 0.000 claims 24
- 210000004556 brain Anatomy 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 230000001787 epileptiform Effects 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 5
- 235000020887 ketogenic diet Nutrition 0.000 claims 5
- 230000001154 acute effect Effects 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 235000014633 carbohydrates Nutrition 0.000 claims 4
- 235000015872 dietary supplement Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 2
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 238000002637 fluid replacement therapy Methods 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 231100000516 lung damage Toxicity 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 201000005962 mycosis fungoides Diseases 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
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Claims (80)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662346975P | 2016-06-07 | 2016-06-07 | |
US62/346,975 | 2016-06-07 | ||
PCT/US2017/035826 WO2017213999A1 (en) | 2016-06-07 | 2017-06-02 | Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same |
Publications (3)
Publication Number | Publication Date |
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RU2018143895A true RU2018143895A (en) | 2020-07-09 |
RU2018143895A3 RU2018143895A3 (en) | 2021-03-11 |
RU2761829C2 RU2761829C2 (en) | 2021-12-13 |
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RU2018143895A RU2761829C2 (en) | 2016-06-07 | 2017-06-02 | Esters of beta-hydroxybutyrate and butanediol formed by medium-chain fatty acids and compositions and methods based on them |
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US (4) | US10889538B2 (en) |
EP (1) | EP3465335A4 (en) |
JP (3) | JP7058610B2 (en) |
KR (2) | KR102638807B1 (en) |
CN (2) | CN109477993B (en) |
AU (2) | AU2017278099B2 (en) |
CA (1) | CA3026621A1 (en) |
CO (1) | CO2018014167A2 (en) |
IL (2) | IL263561B (en) |
MX (2) | MX2021009806A (en) |
RU (1) | RU2761829C2 (en) |
SG (1) | SG11201810765PA (en) |
WO (1) | WO2017213999A1 (en) |
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AU2017278099B2 (en) | 2016-06-07 | 2021-03-11 | Ithaca College | Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same |
CN111050764A (en) | 2017-07-21 | 2020-04-21 | 巴克老年研究所 | β -hydroxybutyrate and butanediol S enantiomers and methods of use thereof |
WO2019161047A1 (en) * | 2018-02-14 | 2019-08-22 | Bickman Benjamin | Oral supplements of fatty acid and amino acid ketone esters to improve metabolic, physical and cognitive health |
JP7391096B2 (en) * | 2019-01-17 | 2023-12-04 | ケトリピックス セラポーティクス ゲーエムベーハー | Method for producing polyol-based esters of optionally acylated hydroxycarboxylic acids |
WO2020147981A1 (en) * | 2019-01-17 | 2020-07-23 | Ioi Oleo Gmbh | Process for preparing capped 3-hydroxycarboxylic acids and their salts and esters |
BR112021014015A2 (en) * | 2019-01-17 | 2021-09-21 | Ioi Oleo Gmbh | METHOD FOR THE PRODUCTION OF FATTY ALCOHOL ESTERS OF HYDROXYCARBOXYLIC ACIDS |
CN110372502A (en) * | 2019-07-25 | 2019-10-25 | 润泰化学(泰兴)有限公司 | A kind of double esterification synthetic method of 1,3- glycol |
GB201918657D0 (en) | 2019-12-17 | 2020-01-29 | Tdeltas Ltd | Compounds for new use |
CN116917264A (en) * | 2020-07-13 | 2023-10-20 | 凯托利皮克斯治疗有限责任公司 | Process for preparing hydroxybutyric acid carboxylic ester |
CN112341542B (en) * | 2021-01-08 | 2021-05-14 | 清华大学 | 3-hydroxybutyrylated modified protein medicine and preparation method and application thereof |
WO2022164755A1 (en) * | 2021-01-26 | 2022-08-04 | Buck Institute For Research On Aging | Use of exogenous ketone esters to induce weight loss in mammals |
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