RU2018143004A - METHOD FOR NEO-ADJUVANT THERMOCHEMI-RADIATION TREATMENT OF DIRECT GUT CANCER - Google Patents

METHOD FOR NEO-ADJUVANT THERMOCHEMI-RADIATION TREATMENT OF DIRECT GUT CANCER Download PDF

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Publication number
RU2018143004A
RU2018143004A RU2018143004A RU2018143004A RU2018143004A RU 2018143004 A RU2018143004 A RU 2018143004A RU 2018143004 A RU2018143004 A RU 2018143004A RU 2018143004 A RU2018143004 A RU 2018143004A RU 2018143004 A RU2018143004 A RU 2018143004A
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Russia
Prior art keywords
thermochemi
days
neo
adjuvant
hyperthermia
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RU2018143004A
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Russian (ru)
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RU2018143004A3 (en
RU2704205C2 (en
Inventor
Андрей Дмитриевич Каприн
Сергей Анатольевич Иванов
Леонид Олегович Петров
Игорь Александрович Гулидов
Дмитрий Валерьевич Ерыгин
Александр Анатольевич Карпов
Людмила Николаевна Титова
Александр Иванович Кобец
Original Assignee
Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России)
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Priority to RU2018143004A priority Critical patent/RU2704205C2/en
Publication of RU2018143004A publication Critical patent/RU2018143004A/en
Publication of RU2018143004A3 publication Critical patent/RU2018143004A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Radiation-Therapy Devices (AREA)

Claims (1)

Способ неоадъювантного термохимиолучевого лечения рака прямой кишки, включающий дистанционную лучевую гамма-терапию на фоне введения химиопрепаратов и локальной гипертермии, отличающийся тем, что проводят конвенциональную лучевую терапию с фракционированием дозы в РОД 2 Гр до СОД 50 Гр в течение 5 недель на фоне химиотерапии: оксалиплатин 50 мг/м2 внутривенно капельно в 1, 8, 22, 29 дни и капецитабин в дозе 825 мг/м2 прием внутрь 2 раза в день с 1 по 14 и с 22 по 33 дни лучевой терапии в сочетании с локальной электромагнитной гипертермией, причем локальную гипертермию 4-6 сеансов проводят в 1-й, 3-й, 8-й, 10-й и 12-й дни лечения за 30-40 минут до лучевого воздействия, при температуре в опухоли 41-44°С частоте 13,56 МгГц, время экспозиции 50-70 минут.A method of neoadjuvant thermo-chemoradiation treatment of colorectal cancer, including remote radiation gamma therapy with the introduction of chemotherapy and local hyperthermia, characterized in that they carry out conventional radiation therapy with dose fractionation in the genus 2 Gy to SOD 50 Gy for 5 weeks on the background of chemotherapy: oxaliplatin 50 mg / m 2 intravenously in drops on days 1, 8, 22, 29 and capecitabine at a dose of 825 mg / m 2 by mouth 2 times a day from 1 to 14 and from 22 to 33 days of radiation therapy in combination with local electromagnetic hyperthermia, moreover, the locale hyperthermia of 4-6 sessions is carried out on the 1st, 3rd, 8th, 10th and 12th days of treatment 30-40 minutes before radiation exposure, at a temperature in the tumor of 41-44 ° С, frequency 13, 56 MHz, exposure time 50-70 minutes.
RU2018143004A 2018-12-05 2018-12-05 Method of neoadjuvant thermochemoradiation treatment of rectal cancer RU2704205C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2018143004A RU2704205C2 (en) 2018-12-05 2018-12-05 Method of neoadjuvant thermochemoradiation treatment of rectal cancer

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RU2018143004A RU2704205C2 (en) 2018-12-05 2018-12-05 Method of neoadjuvant thermochemoradiation treatment of rectal cancer

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RU2018143004A true RU2018143004A (en) 2019-01-14
RU2018143004A3 RU2018143004A3 (en) 2019-07-17
RU2704205C2 RU2704205C2 (en) 2019-10-24

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2748635C1 (en) * 2020-06-30 2021-05-28 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Method for combined treatment of rectal cancer with lesions of upper ampullar rectum with intermediate and moderate risk of developing locoregional relapse
RU2740361C1 (en) * 2020-07-31 2021-01-13 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) Method for organ-preserving treatment of operable rectal cancer
RU2770989C2 (en) * 2021-12-16 2022-04-25 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Method for combined treatment of patients with locally advanced rectal cancer using neoadjuvant radiation therapy and consolidating chemotherapy

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RU2289459C1 (en) * 2005-12-01 2006-12-20 ФГУ "МНИОИ им. П.А. Герцена Росздрава" Method for thermo-radio-therapy of malignant tumors
RU2414936C1 (en) * 2009-08-06 2011-03-27 Учреждение Российской академии медицинских наук Российский онкологический научный центр имени Н.Н. Блохина РАМН Method of treating rectal cancer
RU2590866C1 (en) * 2015-04-14 2016-07-10 Федеральное государственное бюджетное научное учреждение "Томский научно-исследовательский институт онкологии" (Томский НИИ онкологии") Method of combination treatment of operable non-small cell lung cancer stage iii
RU2599043C1 (en) * 2015-08-03 2016-10-10 Федеральное государственное бюджетное научное учреждение "Томский научно-исследовательский институт онкологии" (Томский НИИ онкологии) Method of combination treatment of locally advanced rectal cancer
RU2636869C1 (en) * 2017-01-31 2017-11-28 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр" Российской академии наук ("Томский НИМЦ") Method for combined treatment of stage ii-iii non-small-cell lung cancer

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RU2018143004A3 (en) 2019-07-17
RU2704205C2 (en) 2019-10-24

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