RU2018129876A - Композиции и их применение в регенерации костей - Google Patents
Композиции и их применение в регенерации костей Download PDFInfo
- Publication number
- RU2018129876A RU2018129876A RU2018129876A RU2018129876A RU2018129876A RU 2018129876 A RU2018129876 A RU 2018129876A RU 2018129876 A RU2018129876 A RU 2018129876A RU 2018129876 A RU2018129876 A RU 2018129876A RU 2018129876 A RU2018129876 A RU 2018129876A
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- Prior art keywords
- microns
- composition
- particles
- porous
- particle size
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 27
- 230000010478 bone regeneration Effects 0.000 title claims 2
- 239000002245 particle Substances 0.000 claims 21
- 239000005313 bioactive glass Substances 0.000 claims 8
- 239000007943 implant Substances 0.000 claims 8
- 239000000463 material Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 239000004568 cement Substances 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000000017 hydrogel Substances 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 2
- 229940045110 chitosan Drugs 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229940014259 gelatin Drugs 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000003178 glass ionomer cement Substances 0.000 claims 1
- 239000007788 liquid Chemical group 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Ceramic Engineering (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550706P | 2011-10-24 | 2011-10-24 | |
| US61/550,706 | 2011-10-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014121023A Division RU2665361C2 (ru) | 2011-10-24 | 2012-10-24 | Композиции и их применение в регенерации костей |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018129876A true RU2018129876A (ru) | 2019-03-20 |
| RU2018129876A3 RU2018129876A3 (enExample) | 2020-07-03 |
Family
ID=47144146
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014121023A RU2665361C2 (ru) | 2011-10-24 | 2012-10-24 | Композиции и их применение в регенерации костей |
| RU2018129876A RU2018129876A (ru) | 2011-10-24 | 2012-10-24 | Композиции и их применение в регенерации костей |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014121023A RU2665361C2 (ru) | 2011-10-24 | 2012-10-24 | Композиции и их применение в регенерации костей |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8871235B2 (enExample) |
| EP (1) | EP2771041B1 (enExample) |
| JP (2) | JP6169585B2 (enExample) |
| CN (1) | CN103957951B (enExample) |
| AU (1) | AU2012329012B2 (enExample) |
| BR (1) | BR112014009794B8 (enExample) |
| CA (1) | CA2853457C (enExample) |
| DK (1) | DK2771041T3 (enExample) |
| ES (1) | ES2825423T3 (enExample) |
| PL (1) | PL2771041T3 (enExample) |
| PT (1) | PT2771041T (enExample) |
| RU (2) | RU2665361C2 (enExample) |
| WO (1) | WO2013063033A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7567129B2 (en) * | 2007-06-29 | 2009-07-28 | Intel Corporation | Monolithic flexible power amplifier using integrated tunable matching networks |
| US11225430B2 (en) * | 2012-03-26 | 2022-01-18 | Steven Jung | Bioactive glass scaffolds, and method of making |
| US9045362B2 (en) * | 2013-03-15 | 2015-06-02 | Mosci Corp. | Bioactive glass scaffolds, and method of making |
| US10207027B2 (en) | 2012-06-11 | 2019-02-19 | Globus Medical, Inc. | Bioactive bone graft substitutes |
| US9381274B2 (en) | 2013-03-14 | 2016-07-05 | Prosidyan, Inc. | Bone graft implants containing allograft |
| US8889178B2 (en) | 2013-03-14 | 2014-11-18 | Prosidyan, Inc | Bioactive porous bone graft compositions in synthetic containment |
| US8883195B2 (en) | 2013-03-14 | 2014-11-11 | Prosidyan, Inc. | Bioactive porous bone graft implants |
| US9775853B2 (en) * | 2013-03-15 | 2017-10-03 | Biomet Manufacturing, Llc. | Hemostatic compositions and methods |
| US9486483B2 (en) | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
| US9539286B2 (en) | 2013-10-18 | 2017-01-10 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
| TWI651103B (zh) | 2013-12-13 | 2019-02-21 | 萊特醫技股份有限公司 | 多相骨移植替代材料 |
| US9579421B2 (en) | 2014-02-07 | 2017-02-28 | Globus Medical Inc. | Bone grafts and methods of making and using bone grafts |
| US9463264B2 (en) | 2014-02-11 | 2016-10-11 | Globus Medical, Inc. | Bone grafts and methods of making and using bone grafts |
| EP3206633A4 (en) * | 2014-10-13 | 2018-07-18 | Novabone Products LLC | Irrigation resistant compositions for regeneration of hard tissues and methods and kits of using the same |
| US10238507B2 (en) | 2015-01-12 | 2019-03-26 | Surgentec, Llc | Bone graft delivery system and method for using same |
| US11426489B2 (en) | 2015-06-10 | 2022-08-30 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
| US10016529B2 (en) | 2015-06-10 | 2018-07-10 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
| PL3522944T3 (pl) * | 2016-10-05 | 2024-09-16 | Bonalive Biomaterials Oy | Wszczep kostny |
| DE102017220710A1 (de) * | 2017-11-20 | 2019-05-23 | Aesculap Ag | Implantat und Kit zum Behandeln und/oder biologischen Rekonstruieren eines Knochendefekts |
| US10687828B2 (en) | 2018-04-13 | 2020-06-23 | Surgentec, Llc | Bone graft delivery system and method for using same |
| US11116647B2 (en) | 2018-04-13 | 2021-09-14 | Surgentec, Llc | Bone graft delivery system and method for using same |
| CN108721702B (zh) * | 2018-06-29 | 2021-06-29 | 江西理工大学 | 一种镁/左旋聚乳酸复合骨支架的制备方法 |
| US11090412B2 (en) * | 2018-12-21 | 2021-08-17 | Zavation Medical Products Llc | Bone repair composition and kit |
| IT201900003947A1 (it) * | 2019-03-19 | 2020-09-19 | Mt Ortho S R L | Granulo in materiale metallico biocompatibile per vertebroplastica. |
| US11191868B2 (en) | 2019-07-10 | 2021-12-07 | Synergy Biomedical, Llc | Implantable bodies comprising a regional composite |
| US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
| WO2024049993A2 (en) * | 2022-08-31 | 2024-03-07 | Biogennix, Llc | Tissue regeneration particles with a controlled structure |
| CN115554468B (zh) * | 2022-09-20 | 2023-12-01 | 中科硅骨(东莞)医疗器械有限公司 | 含生物活性玻璃的骨水泥及其制备方法和应用 |
| FR3160884A1 (fr) | 2024-04-06 | 2025-10-10 | Noraker | Pâte injectable à base de verre bioactif |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775646A (en) | 1984-04-27 | 1988-10-04 | University Of Florida | Fluoride-containing Bioglass™ compositions |
| US4851046A (en) | 1985-06-19 | 1989-07-25 | University Of Florida | Periodontal osseous defect repair |
| FR2646084B1 (fr) | 1989-04-20 | 1994-09-16 | Fbfc International Sa | Materiau bioreactif de remplissage de cavites osseuses |
| US5658332A (en) | 1994-06-30 | 1997-08-19 | Orthovita, Inc. | Bioactive granules for bone tissue formation |
| FI101129B (sv) | 1995-01-13 | 1998-04-30 | Vivoxid Oy | Nya bioaktiva glas och deras användning |
| US6190684B1 (en) * | 1996-05-30 | 2001-02-20 | University Of Florida Research Foundation, Inc. | Injectable bio-active glass in a dextran suspension |
| FI103715B1 (fi) * | 1997-04-21 | 1999-08-31 | Heimo Ylaenen | Uusi komposiitti ja sen käyttö |
| US6228386B1 (en) | 1999-04-23 | 2001-05-08 | Unicare Biomedical, Inc. | Compositions and methods to repair osseous defects |
| WO2002079108A1 (en) | 2001-03-30 | 2002-10-10 | King's College London | Use of bioactive glass for cutting bioactive glasses |
| WO2005086706A2 (en) | 2004-03-05 | 2005-09-22 | The Trustees Of Columbia University In The City Of New York | Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone |
| EP1765367A4 (en) * | 2004-06-15 | 2010-08-11 | Therapeutics Inc Encore | PHOSPHOLIPID COMPOSITIONS AND METHOD FOR THEIR PREPARATION AND USE |
| GB0516157D0 (en) * | 2005-08-05 | 2005-09-14 | Imp College Innovations Ltd | Process for preparing bioglass scaffolds |
| US8288344B2 (en) * | 2007-03-15 | 2012-10-16 | Musculoskeletal Transplant Foundation | Ceramic composition for filling bone defects |
| JP2011524324A (ja) * | 2008-05-27 | 2011-09-01 | インペリアル イノベーションズ リミテッド | 低酸素誘導因子（ｈｉｆ）安定化ガラス |
| US8647614B2 (en) | 2009-02-18 | 2014-02-11 | Orthovita, Inc. | Method for stabilizing vertebral body architecture |
| CN102596102A (zh) * | 2009-10-29 | 2012-07-18 | 普罗斯蒂安公司 | 骨移植物材料 |
| EP2322134B1 (en) * | 2009-11-12 | 2012-09-12 | BonAlive Biomaterials Oy | Implantable paste and its use |
| US8778378B2 (en) | 2009-12-21 | 2014-07-15 | Orthovita, Inc. | Bioactive antibacterial bone graft materials |
| US9950096B2 (en) * | 2010-01-12 | 2018-04-24 | Vanderbilt University | Particle/polyurethane composites and methods thereof |
| US20110243913A1 (en) | 2010-04-06 | 2011-10-06 | Orthovita, Inc. | Biomaterial Compositions and Methods of Use |
-
2012
- 2012-10-24 ES ES12783472T patent/ES2825423T3/es active Active
- 2012-10-24 PL PL12783472T patent/PL2771041T3/pl unknown
- 2012-10-24 JP JP2014538902A patent/JP6169585B2/ja active Active
- 2012-10-24 PT PT127834729T patent/PT2771041T/pt unknown
- 2012-10-24 AU AU2012329012A patent/AU2012329012B2/en active Active
- 2012-10-24 RU RU2014121023A patent/RU2665361C2/ru active
- 2012-10-24 WO PCT/US2012/061574 patent/WO2013063033A1/en not_active Ceased
- 2012-10-24 CN CN201280058570.5A patent/CN103957951B/zh active Active
- 2012-10-24 EP EP12783472.9A patent/EP2771041B1/en active Active
- 2012-10-24 US US13/659,095 patent/US8871235B2/en active Active
- 2012-10-24 BR BR112014009794A patent/BR112014009794B8/pt active IP Right Grant
- 2012-10-24 DK DK12783472.9T patent/DK2771041T3/da active
- 2012-10-24 CA CA2853457A patent/CA2853457C/en active Active
- 2012-10-24 RU RU2018129876A patent/RU2018129876A/ru not_active Application Discontinuation
-
2013
- 2013-04-23 US US13/868,388 patent/US8506981B1/en active Active
-
2017
- 2017-05-09 JP JP2017092997A patent/JP6463880B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2665361C2 (ru) | 2018-08-29 |
| US8506981B1 (en) | 2013-08-13 |
| CA2853457A1 (en) | 2013-05-02 |
| AU2012329012B2 (en) | 2016-04-07 |
| PT2771041T (pt) | 2020-09-17 |
| CN103957951A (zh) | 2014-07-30 |
| CA2853457C (en) | 2020-03-24 |
| JP2014530744A (ja) | 2014-11-20 |
| DK2771041T3 (da) | 2020-08-24 |
| JP6463880B2 (ja) | 2019-02-06 |
| RU2018129876A3 (enExample) | 2020-07-03 |
| BR112014009794B8 (pt) | 2020-02-11 |
| EP2771041A1 (en) | 2014-09-03 |
| CN103957951B (zh) | 2017-07-28 |
| BR112014009794B1 (pt) | 2019-10-15 |
| BR112014009794A2 (pt) | 2017-04-25 |
| PL2771041T3 (pl) | 2020-11-16 |
| US8871235B2 (en) | 2014-10-28 |
| US20130101673A1 (en) | 2013-04-25 |
| AU2012329012A1 (en) | 2014-06-12 |
| JP6169585B2 (ja) | 2017-07-26 |
| WO2013063033A1 (en) | 2013-05-02 |
| RU2014121023A (ru) | 2015-12-10 |
| EP2771041B1 (en) | 2020-05-20 |
| ES2825423T3 (es) | 2021-05-17 |
| JP2017176844A (ja) | 2017-10-05 |
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