RU2018110163A - PEPTIDE SUBSTRATES OF CYSTEINE PEPTIDASES OF THE PAPAIN FAMILY - Google Patents

PEPTIDE SUBSTRATES OF CYSTEINE PEPTIDASES OF THE PAPAIN FAMILY Download PDF

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Publication number
RU2018110163A
RU2018110163A RU2018110163A RU2018110163A RU2018110163A RU 2018110163 A RU2018110163 A RU 2018110163A RU 2018110163 A RU2018110163 A RU 2018110163A RU 2018110163 A RU2018110163 A RU 2018110163A RU 2018110163 A RU2018110163 A RU 2018110163A
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RU
Russia
Prior art keywords
gly
ala
group
proteinogenic
phe
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RU2018110163A
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Russian (ru)
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RU2018110163A3 (en
RU2717689C2 (en
Inventor
Ирина Юрьевна Филиппова
Елена Николаевна Элпидина
Николай Иванович Соколенко
Анна Олеговна Лобанова
Елена Александровна Дворякова
Валерия Феликсовна Терещенкова
Яков Ефимович Дунаевский
Михаил Андреевич Белозерский
Original Assignee
Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ)
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Application filed by Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) filed Critical Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ)
Priority to RU2018110163A priority Critical patent/RU2717689C2/en
Priority to PCT/RU2019/050031 priority patent/WO2019182483A1/en
Publication of RU2018110163A publication Critical patent/RU2018110163A/en
Publication of RU2018110163A3 publication Critical patent/RU2018110163A3/ru
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Publication of RU2717689C2 publication Critical patent/RU2717689C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Claims (10)

1. Пептидный субстрат цистеиновых пептидаз семейства папаина общей формулы (1):1. The peptide substrate of the cysteine peptidases of the papain family of General formula (1): A-Xaa-Gln-B, гдеA-Xaa-Gln-B, where А - N-защитная группа уретанового или ацильного типа;A is the N-protective group of the urethane or acyl type; Хаа - протеиногенная или непротеиногенная аминокислота или дипептид, отвечающие требованиям субстратной специфичности цистеиновых пептидаз семейства семейства С1;Xaa is a proteinogenic or non-proteinogenic amino acid or dipeptide that meets the requirements of the substrate specificity of cysteine peptidases of the C1 family; В - маркерная хромогенная или флуорогенная группировка.B - marker chromogenic or fluorogenic group. 2. Субстрат по п. 1, характеризующийся тем, что N-защитная группа уретанового или ацильного типа выбрана из ряда Z, Boc Glp, Bz, Ac, For, Suc.2. The substrate according to claim 1, characterized in that the N-protective group of the urethane or acyl type is selected from the series Z, Boc Glp, Bz, Ac, For, Suc. 3. Субстрат по п. 1, характеризующийся тем, что протеиногенная или непротеиногенная аминокислота или дипептид выбраны из группы, включающей Phe, Phe-4-Cl, Phe-3,4-Cl2, homoPhe, Phg, Arg, Lys, Val, Tyr, Leu, Val, Ile, Pro, His, Thr(OBzl), Thr(tBu), Ser(OBzl), Ser(tBu), Cys(SBzl), Ala-Ala, Ala-Gly, Gly-Ala, Gly-Gly.3. The substrate according to claim 1, characterized in that the proteinogenic or non-proteinogenic amino acid or dipeptide selected from the group including Phe, Phe-4-Cl, Phe-3,4-Cl 2 , homoPhe, Phg, Arg, Lys, Val, Tyr, Leu, Val, Ile, Pro, His, Thr (OBzl), Thr (tBu), Ser (OBzl), Ser (tBu), Cys (SBzl), Ala-Ala, Ala-Gly, Gly-Ala, Gly -Gly. 4. Субстрат по п. 1, характеризующийся тем, что хромогенная или флуорогенная группировка выбрана из группы, включающей АМС, βNA, AFC, pNA.4. The substrate according to claim 1, characterized in that the chromogenic or fluorogenic group is selected from the group comprising AMC, βNA, AFC, pNA. 5. Применение соединения по п. 1 для создания тест-систем детекции пептидаз.5. The use of a compound according to claim 1 for creating test systems for the detection of peptidases. 6. Применение соединения по п. 5, характеризующееся тем, что детекцию проводят в растворе, в геле после проведения электрофореза в нативных условиях, в системах in vivo.6. The use of a compound according to claim 5, characterized in that the detection is carried out in solution, in a gel after electrophoresis under native conditions, in in vivo systems.
RU2018110163A 2018-03-22 2018-03-22 Peptide substrates of cysteine peptides of family of papain RU2717689C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU2018110163A RU2717689C2 (en) 2018-03-22 2018-03-22 Peptide substrates of cysteine peptides of family of papain
PCT/RU2019/050031 WO2019182483A1 (en) 2018-03-22 2019-03-22 Peptide substrates for papain family cysteine peptidases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2018110163A RU2717689C2 (en) 2018-03-22 2018-03-22 Peptide substrates of cysteine peptides of family of papain

Publications (3)

Publication Number Publication Date
RU2018110163A true RU2018110163A (en) 2019-09-24
RU2018110163A3 RU2018110163A3 (en) 2019-09-24
RU2717689C2 RU2717689C2 (en) 2020-03-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018110163A RU2717689C2 (en) 2018-03-22 2018-03-22 Peptide substrates of cysteine peptides of family of papain

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RU (1) RU2717689C2 (en)
WO (1) WO2019182483A1 (en)

Also Published As

Publication number Publication date
WO2019182483A1 (en) 2019-09-26
RU2018110163A3 (en) 2019-09-24
RU2717689C2 (en) 2020-03-25

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