RU2017129539A - Устройство нейромодуляции - Google Patents
Устройство нейромодуляции Download PDFInfo
- Publication number
- RU2017129539A RU2017129539A RU2017129539A RU2017129539A RU2017129539A RU 2017129539 A RU2017129539 A RU 2017129539A RU 2017129539 A RU2017129539 A RU 2017129539A RU 2017129539 A RU2017129539 A RU 2017129539A RU 2017129539 A RU2017129539 A RU 2017129539A
- Authority
- RU
- Russia
- Prior art keywords
- signal
- patient
- nerve
- paragraphs
- vagal nerve
- Prior art date
Links
- 230000004007 neuromodulation Effects 0.000 title claims 10
- 210000005036 nerve Anatomy 0.000 claims 45
- 238000000034 method Methods 0.000 claims 43
- 230000001515 vagal effect Effects 0.000 claims 30
- 230000000694 effects Effects 0.000 claims 18
- 230000002685 pulmonary effect Effects 0.000 claims 13
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 8
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 8
- 239000002260 anti-inflammatory agent Substances 0.000 claims 8
- 239000008280 blood Substances 0.000 claims 8
- 210000004369 blood Anatomy 0.000 claims 8
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 7
- 230000036982 action potential Effects 0.000 claims 7
- 208000006673 asthma Diseases 0.000 claims 7
- 230000001734 parasympathetic effect Effects 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 6
- 206010006482 Bronchospasm Diseases 0.000 claims 5
- 230000007885 bronchoconstriction Effects 0.000 claims 5
- 239000000835 fiber Substances 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 4
- 239000001569 carbon dioxide Substances 0.000 claims 4
- 210000004072 lung Anatomy 0.000 claims 4
- 230000008035 nerve activity Effects 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 150000003431 steroids Chemical group 0.000 claims 4
- 206010011224 Cough Diseases 0.000 claims 3
- 208000013116 chronic cough Diseases 0.000 claims 3
- 238000002513 implantation Methods 0.000 claims 3
- 230000003447 ipsilateral effect Effects 0.000 claims 3
- 230000036387 respiratory rate Effects 0.000 claims 3
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 2
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 2
- 229940092705 beclomethasone Drugs 0.000 claims 2
- 229960004436 budesonide Drugs 0.000 claims 2
- 230000008859 change Effects 0.000 claims 2
- -1 cyclesonide Chemical compound 0.000 claims 2
- 230000001066 destructive effect Effects 0.000 claims 2
- 229960000676 flunisolide Drugs 0.000 claims 2
- 229960000289 fluticasone propionate Drugs 0.000 claims 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 229960001664 mometasone Drugs 0.000 claims 2
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 2
- 230000001537 neural effect Effects 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 230000002085 persistent effect Effects 0.000 claims 2
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims 2
- 229960002117 triamcinolone acetonide Drugs 0.000 claims 2
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 claims 1
- 230000006872 improvement Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003227 neuromodulating effect Effects 0.000 claims 1
- 230000011514 reflex Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
Classifications
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surgical Instruments (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562119998P | 2015-02-24 | 2015-02-24 | |
| US62/119,998 | 2015-02-24 | ||
| PCT/US2016/019234 WO2016138066A1 (en) | 2015-02-24 | 2016-02-24 | Neuromodulation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2017129539A true RU2017129539A (ru) | 2019-03-25 |
Family
ID=56789175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017129539A RU2017129539A (ru) | 2015-02-24 | 2016-02-24 | Устройство нейромодуляции |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10441787B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3261711B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018508329A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180008397A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107847740A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016222825A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017018068A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2977517A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2855799T3 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2017129539A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016138066A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10029101B2 (en) | 2013-01-09 | 2018-07-24 | Mayo Foundation For Medical Education And Research | Systems for the detection and delivery of neurochemical and electrical signals for functional restoration |
| CA2944056A1 (en) * | 2014-03-27 | 2015-10-01 | Circuit Therapeutics, Inc. | System and method for therapeutic management of cough |
| EA201892008A1 (ru) | 2016-04-21 | 2019-06-28 | Астросайт Фармасьютикалс, Инк. | Соединения и способы лечения неврологических и сердечно-сосудистых состояний |
| US11040197B2 (en) * | 2017-06-22 | 2021-06-22 | Mayo Foundation For Medical Education And Research | Voltammetric neurochemical detection in whole blood |
| CN109199359A (zh) * | 2018-10-15 | 2019-01-15 | 暨南大学 | 光电联合刺激系统和光电联合刺激神经纤维方法 |
| US11077314B1 (en) * | 2020-04-29 | 2021-08-03 | Multi Radiance Medical | System and method for treating patients requiring mechanical ventilation |
| DE102020114745A1 (de) * | 2020-06-03 | 2021-12-09 | NeuroCare Group GmbH | Körperzustandsabhängige Stimulation mit Echtzeitkommunikation zwischen einem Aktions- und einem Erfassungsmodul |
| WO2025079630A1 (ja) * | 2023-10-13 | 2025-04-17 | 帝人ファーマ株式会社 | 咳嗽治療装置 |
| EP4635557A1 (en) | 2024-04-16 | 2025-10-22 | Merck Patent GmbH | System for inhibiting action potential conduction in a nerve |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7389145B2 (en) | 2001-02-20 | 2008-06-17 | Case Western Reserve University | Systems and methods for reversibly blocking nerve activity |
| US6928320B2 (en) * | 2001-05-17 | 2005-08-09 | Medtronic, Inc. | Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated |
| US20060200219A1 (en) * | 2005-03-01 | 2006-09-07 | Ndi Medical, Llc | Systems and methods for differentiating and/or identifying tissue regions innervated by targeted nerves for diagnostic and/or therapeutic purposes |
| US8660647B2 (en) * | 2005-07-28 | 2014-02-25 | Cyberonics, Inc. | Stimulating cranial nerve to treat pulmonary disorder |
| CN101674862A (zh) * | 2005-11-10 | 2010-03-17 | 电子核心公司 | 支气管收缩的电刺激治疗 |
| US8874227B2 (en) * | 2009-03-20 | 2014-10-28 | ElectroCore, LLC | Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient |
| US9037247B2 (en) * | 2005-11-10 | 2015-05-19 | ElectroCore, LLC | Non-invasive treatment of bronchial constriction |
| AU2006337679A1 (en) * | 2006-02-10 | 2007-08-16 | Electrocore, Inc. | Methods and apparatus for treating anaphylaxis using electrical modulation |
| US9579506B2 (en) * | 2008-01-25 | 2017-02-28 | Flint Hills Scientific, L.L.C. | Contingent cardio-protection for epilepsy patients |
| CA2723806C (en) * | 2008-05-09 | 2022-05-31 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US8918178B2 (en) | 2009-03-20 | 2014-12-23 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| US9833621B2 (en) * | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| US20110301587A1 (en) * | 2010-04-06 | 2011-12-08 | Innovative Pulmonary Solutions, Inc. | System and method for pulmonary treatment |
| US9358381B2 (en) * | 2011-03-10 | 2016-06-07 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| CA2834180C (en) * | 2011-05-19 | 2019-04-30 | Neuros Medical, Inc. | High-frequency electrical nerve block |
| US9398933B2 (en) * | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
| US20140324129A1 (en) * | 2013-04-30 | 2014-10-30 | Case Western Reserve University | Systems and methods for temporary, incomplete, bi-directional, adjustable electrical nerve block |
| US10413731B2 (en) * | 2014-01-17 | 2019-09-17 | Cardiac Pacemakers, Inc. | Selective nerve stimulation using presynaptic terminal depletion block |
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2016
- 2016-02-24 JP JP2017562969A patent/JP2018508329A/ja active Pending
- 2016-02-24 KR KR1020177026793A patent/KR20180008397A/ko not_active Withdrawn
- 2016-02-24 BR BR112017018068-5A patent/BR112017018068A2/pt not_active Application Discontinuation
- 2016-02-24 ES ES16756233T patent/ES2855799T3/es active Active
- 2016-02-24 EP EP16756233.9A patent/EP3261711B1/en not_active Not-in-force
- 2016-02-24 RU RU2017129539A patent/RU2017129539A/ru not_active Application Discontinuation
- 2016-02-24 EP EP20212912.8A patent/EP3808407A1/en not_active Withdrawn
- 2016-02-24 CN CN201680023560.6A patent/CN107847740A/zh active Pending
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- 2016-02-24 AU AU2016222825A patent/AU2016222825A1/en not_active Abandoned
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2019
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| KR20180008397A (ko) | 2018-01-24 |
| CA2977517A1 (en) | 2016-09-01 |
| BR112017018068A2 (pt) | 2018-04-10 |
| EP3808407A1 (en) | 2021-04-21 |
| CN107847740A (zh) | 2018-03-27 |
| US20200009384A1 (en) | 2020-01-09 |
| EP3261711A4 (en) | 2019-02-20 |
| EP3261711A1 (en) | 2018-01-03 |
| US20180043162A1 (en) | 2018-02-15 |
| WO2016138066A1 (en) | 2016-09-01 |
| AU2016222825A1 (en) | 2017-09-07 |
| US10441787B2 (en) | 2019-10-15 |
| JP2018508329A (ja) | 2018-03-29 |
| ES2855799T3 (es) | 2021-09-24 |
| EP3261711B1 (en) | 2020-12-16 |
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