RU2017112352A - SOLID MEDICINAL FORM INDOL-3-CARBINOL - Google Patents

SOLID MEDICINAL FORM INDOL-3-CARBINOL Download PDF

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Publication number
RU2017112352A
RU2017112352A RU2017112352A RU2017112352A RU2017112352A RU 2017112352 A RU2017112352 A RU 2017112352A RU 2017112352 A RU2017112352 A RU 2017112352A RU 2017112352 A RU2017112352 A RU 2017112352A RU 2017112352 A RU2017112352 A RU 2017112352A
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RU
Russia
Prior art keywords
carbinol
indole
pharmaceutical composition
starch
stearic acid
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Application number
RU2017112352A
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Russian (ru)
Other versions
RU2680967C2 (en
RU2017112352A3 (en
Inventor
Алексей Павлович Кисилев
Наталья Викторовна Рогова
Original Assignee
Акционерное общество "МираксБиоФарма"
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Application filed by Акционерное общество "МираксБиоФарма" filed Critical Акционерное общество "МираксБиоФарма"
Priority to RU2017112352A priority Critical patent/RU2680967C2/en
Publication of RU2017112352A3 publication Critical patent/RU2017112352A3/ru
Publication of RU2017112352A publication Critical patent/RU2017112352A/en
Application granted granted Critical
Publication of RU2680967C2 publication Critical patent/RU2680967C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (6)

1. Фармацевтическая композиция, обладающая противоопухолевой активностью, содержащая индол-3-карбинол и вспомогательные вещества лактозу, крахмал кукурузный модифицированный, микрокристаллическую целлюлозу, соли стеариновой кислоты кальциевую или магниевую, в виде капсул, отличающаяся тем, что содержит микронизированный индол-3 карбинол и натрий крахмала гликолят в следующем количестве в одной капсуле, г1. A pharmaceutical composition having antitumor activity, containing indole-3-carbinol and excipients lactose, modified corn starch, microcrystalline cellulose, calcium or magnesium stearic acid salts, in the form of capsules, characterized in that it contains micronized indole-3 carbinol and sodium starch glycolate in the following quantity in one capsule, g Индол-3 карбинолIndole-3 carbinol 0,15-0,200 г0.15-0.200 g Вспомогательные вещества:Excipients: ЛактозаLactose 0,110-0,140 г0.110-0.140 g Целлюлоза микрокристаллическаяMicrocrystalline cellulose 0,034-0,064 г0.034-0.064 g Крахмал кукурузный модифицированный Starch 1500Modified corn starch Starch 1500 0,06-0,095 г0.06-0.095 g Натрий крахмала гликолятSodium Starch Glycolate 0,03-0,05 г0.03-0.05 g Соли стеариновой кислоты кальциевая или магниеваяStearic Acid Salts Calcium or Magnesium 0,001-0,04 г0.001-0.04 g
2. Фармацевтическая композиция по п. 1, отличающаяся тем, что размер частиц микронизированного индол-3 карбинола 87-90 микрон2. The pharmaceutical composition according to claim 1, characterized in that the particle size of the micronized indole-3 carbinol is 87-90 microns 3. Фармацевтическая композиция, обладающая противоопухолевой активностью, содержащая индол-3-карбинол и вспомогательные вещества лактозу, крахмал кукурузный модифицированный, микрокристаллическую целлюлозу, соли стеариновой кислоты кальциевую или магниевую, в виде капсул, отличающаяся тем, что содержит микронизированный индол-3 карбинол и кроскармеллозу натрия в следующем количестве в одной капсуле, г:3. A pharmaceutical composition having antitumor activity, containing indole-3-carbinol and excipients lactose, modified corn starch, microcrystalline cellulose, calcium or magnesium stearic acid salts, in the form of capsules, characterized in that it contains micronized indole-3 carbinol and croscarmell sodium in the following amount in one capsule, g: Индол-3 карбинолIndole-3 carbinol 0,15-0,200 г0.15-0.200 g Вспомогательные вещества:Excipients: ЛактозаLactose 0,110-0,140 г0.110-0.140 g Целлюлоза микрокристаллическаяMicrocrystalline cellulose 0,034-0,064 г0.034-0.064 g Кроскармелоза натрияCroscarmellose sodium 0.030-0,004 г0.030-0.004 g Крахмал кукурузный модифицированный Starch 1500Modified corn starch Starch 1500 0,06-0,095 г0.06-0.095 g Соли стеариновой кислоты кальциевая или магниеваяStearic Acid Salts Calcium or Magnesium 0,001-0,04 г0.001-0.04 g
4. Фармацевтическая композиция по п. 3, отличающееся тем, что размер частиц микронизированного ИЗК 87-90 микрон.4. The pharmaceutical composition according to p. 3, characterized in that the particle size of the micronized IZK is 87-90 microns.
RU2017112352A 2017-04-11 2017-04-11 Solid pharmaceutical form of indole-3-carbinol RU2680967C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2017112352A RU2680967C2 (en) 2017-04-11 2017-04-11 Solid pharmaceutical form of indole-3-carbinol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2017112352A RU2680967C2 (en) 2017-04-11 2017-04-11 Solid pharmaceutical form of indole-3-carbinol

Publications (3)

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RU2017112352A3 RU2017112352A3 (en) 2018-10-11
RU2017112352A true RU2017112352A (en) 2018-10-11
RU2680967C2 RU2680967C2 (en) 2019-03-01

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RU2017112352A RU2680967C2 (en) 2017-04-11 2017-04-11 Solid pharmaceutical form of indole-3-carbinol

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2760000C1 (en) * 2021-03-24 2021-11-22 Общество с ограниченной ответственностью "Научно-внедренческий центр Агроветзащита" Method for producing indole-3-carbinol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010125572A1 (en) * 2009-04-29 2010-11-04 Hetero Research Foundation Compressed tablets and capsules containing efavirenz
RU2540519C2 (en) * 2013-02-05 2015-02-10 Общество с ограниченной ответственностью "Трейдсервис" Dosage form of clopidogrel
EA024165B1 (en) * 2013-10-31 2016-08-31 Ооо "Тева" Pharmaceutical dosage form of n-carbamoylmethyl-4-phenyl-2-pyrrolidone, method for preparing the same and application

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RU2017112352A3 (en) 2018-10-11

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