RU2016104199A - Method for non-invasive determination of glucose concentration in blood by glucose - Google Patents

Method for non-invasive determination of glucose concentration in blood by glucose Download PDF

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RU2016104199A
RU2016104199A RU2016104199A RU2016104199A RU2016104199A RU 2016104199 A RU2016104199 A RU 2016104199A RU 2016104199 A RU2016104199 A RU 2016104199A RU 2016104199 A RU2016104199 A RU 2016104199A RU 2016104199 A RU2016104199 A RU 2016104199A
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glucose
diffusion
parameters
current
concentration
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RU2016104199A
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Russian (ru)
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RU2644501C2 (en
Inventor
Анна Павловна Бабашкина
Елена Викторовна Власова
Ксения Евгеньевна Шверева
Юлия Владимировна Суслова
Евгений Иванович Глинкин
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Федеральное государственное бюджетное образовательное учреждение высшего образования "Тамбовский государственный технический университет" (ФГБОУ ВО ТГТУ)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Claims (7)

1. Способ неинвазивного определения концентрации глюкозы в крови человека по глюкограмме, характеризующийся тем, что измеряют посредством четырехэлектродных датчиков, закрепленных на поверхности тела человека, электрические характеристики протекающего по ткани тока, затем обрабатывают измерения четырехэлектродных датчиков по предварительно откалиброванной математической модели путем сравнения результатов предлагаемого способа определения глюкозы в крови человека и любого другого известного метода определения глюкозы в крови человека, после чего определяют концентрацию глюкозы в крови человека, отличающийся тем, что определяют действительное значение концентрации глюкозы крови по калибровочной глюкосименсграмме (ГСГ), тождественной экспериментальному эквиваленту за счет оптимизации ее предельных параметров: глюкозы Р0 и проводимости Y0 структуры, - нормированными значениями границ адаптивного диапазона известных пациентов: глюкозы Pi, для i=1,2, и диффузионными проводимостями с кратным отношением Y1 и Y2=nY1, для n>1,1-3, вольтамперных характеристик (ВАХ) ii(u) с оптимальными параметрами: диффузионным напряжением Ui и диффузионным током Ii, которые калибруют по измеренным токам iij, для j=1,2, заданным двумя напряжениями u1 и бинарным u2=2u1, по которым находят диффузионные проводимости Yi пациентов как отношение диффузионных параметров Yi=Ii/Ui их вольтамперных характеристик i(u)1. A non-invasive method for determining the concentration of glucose in human blood from a glucogram, characterized in that the electrical characteristics of the current flowing through the tissue are measured by means of four-electrode sensors mounted on the surface of the human body, then the measurements of the four-electrode sensors are processed by a pre-calibrated mathematical model by comparing the results of the proposed method for determining glucose in human blood and any other known method for determining glucose in human blood oveka, after which the concentration of human blood glucose, characterized in that the determined actual value of the blood glucose concentration from the calibration glyukosimensgramme (GHA) identical experimental equivalent by optimizing its limiting parameters: glucose P0 and conduction Y 0 structure - normalized values the boundaries of the adaptive range of known patients: glucose P i , for i = 1.2, and diffusion conductivities with a multiple ratio of Y 1 and Y 2 = nY 1 , for n> 1.1-3, current-voltage characteristics (CVC) i i (u ) with wholesale mal parameters: voltage U i diffusion and the diffusion current I i, which is calibrated according to the measured currents i ij, for j = 1,2, specify the two voltages u 1 and u 2 binary 1 = 2u, which are diffusive conductance Y i patients as a the ratio of the diffusion parameters Y i = I i / U i their current-voltage characteristics i (u)
Figure 00000001
Figure 00000001
 с тождественными границам диапазона параметрами: диффузионными током Ii, напряжением Ui и проводимостью Yi=Ii/Ui with identical parameters of the range: diffusion current I i , voltage U i and conductivity Y i = I i / U i
Figure 00000002
Figure 00000003
Figure 00000002
Figure 00000003
 2. Способ по п. 1, отличающийся тем, что глюкосименсграмма P=Poexp(Y/Yo) отражает физику натурного эксперимента, с тождественными границам диапазона параметрами: проводимостью Y0 и глюкозой Р0 структуры2. The method according to p. 1, characterized in that the glucosimetric P = P o exp (Y / Y o ) reflects the physics of the full-scale experiment, with parameters identical to the limits of the range: conductivity Y 0 and glucose P 0 structure
Figure 00000004
,
Figure 00000005
,
Figure 00000004
,
Figure 00000005
, где n=Y2/Y1.where n = Y 2 / Y 1 .
RU2016104199A 2016-02-09 2016-02-09 Method for non-invasive determination of blood glucose concentration in glucogram RU2644501C2 (en)

Priority Applications (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2587656A (en) * 2019-10-04 2021-04-07 Etouch Medical Inc Non-Invasive system for testing blood sugar and method of the same

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2230485C2 (en) * 2001-05-29 2004-06-20 Общество с ограниченной ответственностью "Алгоритм" Method for determination of blood glucose concentration in humans
RU2342071C2 (en) * 2007-01-29 2008-12-27 Игорь Алексеевич Новиков Method of glucose concentration definition in human blood
US20110004080A1 (en) * 2008-04-11 2011-01-06 Glucovista, Llc Method for non-invasive analysis of a substance concentration within a body
RU2444279C1 (en) * 2010-07-21 2012-03-10 Государственное образовательное учреждение высшего профессионального образования "Тамбовский государственный технический университет" (ГОУ ВПО ТГТУ) Method of determining glucose concentration in blood
RU2518134C2 (en) * 2012-02-24 2014-06-10 Хилби Корпорейшн Method for determining individual's blood glucose concentration

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2587656A (en) * 2019-10-04 2021-04-07 Etouch Medical Inc Non-Invasive system for testing blood sugar and method of the same
GB2587656B (en) * 2019-10-04 2021-09-22 Etouch Medical Inc Non-Invasive system for testing blood glucose and method of the same

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