RU2015125548A - Синбиотическая композиция и ее использование - Google Patents
Синбиотическая композиция и ее использование Download PDFInfo
- Publication number
- RU2015125548A RU2015125548A RU2015125548A RU2015125548A RU2015125548A RU 2015125548 A RU2015125548 A RU 2015125548A RU 2015125548 A RU2015125548 A RU 2015125548A RU 2015125548 A RU2015125548 A RU 2015125548A RU 2015125548 A RU2015125548 A RU 2015125548A
- Authority
- RU
- Russia
- Prior art keywords
- bifidobacterium
- strain
- synbiotic
- oligosaccharides
- composition according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 23
- 235000019722 synbiotics Nutrition 0.000 title claims 12
- 229920001542 oligosaccharide Polymers 0.000 claims 10
- 241000186000 Bifidobacterium Species 0.000 claims 8
- 235000013305 food Nutrition 0.000 claims 8
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims 6
- 229940009289 bifidobacterium lactis Drugs 0.000 claims 6
- 235000013339 cereals Nutrition 0.000 claims 4
- 150000002482 oligosaccharides Chemical class 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 239000006041 probiotic Substances 0.000 claims 3
- 230000000529 probiotic effect Effects 0.000 claims 3
- 235000018291 probiotics Nutrition 0.000 claims 3
- 241000186012 Bifidobacterium breve Species 0.000 claims 2
- 241001608472 Bifidobacterium longum Species 0.000 claims 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 2
- 229940009291 bifidobacterium longum Drugs 0.000 claims 2
- 210000002429 large intestine Anatomy 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- LGQKSQQRKHFMLI-SJYYZXOBSA-N (2s,3r,4s,5r)-2-[(3r,4r,5r,6r)-4,5,6-trihydroxyoxan-3-yl]oxyoxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)CO[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)OC1 LGQKSQQRKHFMLI-SJYYZXOBSA-N 0.000 claims 1
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims 1
- LGQKSQQRKHFMLI-UHFFFAOYSA-N 4-O-beta-D-xylopyranosyl-beta-D-xylopyranose Natural products OC1C(O)C(O)COC1OC1C(O)C(O)C(O)OC1 LGQKSQQRKHFMLI-UHFFFAOYSA-N 0.000 claims 1
- 235000007319 Avena orientalis Nutrition 0.000 claims 1
- 244000075850 Avena orientalis Species 0.000 claims 1
- 229920002498 Beta-glucan Polymers 0.000 claims 1
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims 1
- 241001134770 Bifidobacterium animalis Species 0.000 claims 1
- 241001213452 Bifidobacterium longum NCC2705 Species 0.000 claims 1
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims 1
- SQNRKWHRVIAKLP-UHFFFAOYSA-N D-xylobiose Natural products O=CC(O)C(O)C(CO)OC1OCC(O)C(O)C1O SQNRKWHRVIAKLP-UHFFFAOYSA-N 0.000 claims 1
- 240000005979 Hordeum vulgare Species 0.000 claims 1
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 241000209056 Secale Species 0.000 claims 1
- 235000007238 Secale cereale Nutrition 0.000 claims 1
- 240000006394 Sorghum bicolor Species 0.000 claims 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 244000098338 Triticum aestivum Species 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims 1
- 125000000089 arabinosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)CO1)* 0.000 claims 1
- 235000008452 baby food Nutrition 0.000 claims 1
- 229940118852 bifidobacterium animalis Drugs 0.000 claims 1
- 229940004120 bifidobacterium infantis Drugs 0.000 claims 1
- 235000015496 breakfast cereal Nutrition 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical group COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 1
- 235000011868 grain product Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 239000011265 semifinished product Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Pediatric Medicine (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (17)
1. Синбиотическая композиция для использования в подавлении патогенной инфекции в толстом кишечнике, содержащая (i) пробиотический микроорганизм штамм Bifidobacterium и (ii) олигосахаридный компонент, содержащий арабино-ксило-олигосахариды.
2. Синбиотическая композиция по п. 1, в которой упомянутый штамм Bifidobacterium выбран из Bifidobacterium longum, Bifidobacterium lactis, Bifidobacterium animalis, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium adolescentis и их смесей.
3. Синбиотическая композиция по п. 2, в которой упомянутый штамм Bifidobacterium выбран из Bifidobacterium longum NCC 3001, Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, Bifidobacterium lactis NCC 2818 и их смеси.
4. Синбиотическая композиция по п. 1, в которой упомянутые арабино-ксило-олигосахариды (АКОС) имеют среднюю степень полимеризации (СП) в интервале от 2 до 50, предпочтительно от 2 до 15 и отношение арабиноза/ксилоза (отношение А/К) в интервале от 0,18 до 0,30.
5. Синбиотическая композиция по п. 1, в которой остаток феруловой кислоты присоединен к упомянутым арабино-ксило-олигосахаридам (АКОС) через сложноэфирную связь, предпочтительно к остатку арабинозы.
6. Синбиотическая композиция по п. 1, в которой упомянутый олигосахаридный компонент дополнительно содержит бета-глюкан, ксило-олигосахариды, ксилобиозу и смеси из них.
7. Синбиотическая композиция, содержащая (i) пробиотический микроорганизм штамм Bifidobacterium и (ii) олигосахаридный компонент, содержащий арабино-ксило-олигосахариды.
8. Синбиотическая композиция по п. 7, в которой упомянутый штамм Bifidobacterium представляет собой штамм Bifidobacterium lactis, причем предпочтительно упомянутый пробиотический микроорганизм преимущественно состоит из Bifidobacterium lactis NCC 2818.
9. Синбиотическая композиция по п. 7, в которой упомянутые арабино-ксило-олигосахариды извлечены из зерновых культур, предпочтительно выбранных из пшеницы, риса, кукурузы, овса, ячменя, сорго, ржи.
10. Пищевая композиция, содержащая синбиотическую композицию по п. 7.
11. Пищевая композиция по п. 10, которая выбрана из зернового продукта для детского питания, сухой зерновой смеси, полуфабриката для каши, зернового завтрака, порошкообразного диетического продукта, зернового батончика, порошкообразного напитка, продукта на молочной основе и корма для домашних животных.
12. Пищевая композиция по п. 10, которая содержит
от 100 мг до 10 г олигосахаридного компонента в дневной дозе, и/или
от 106 до 1012 КОЕ штамма Bifidobacterium на грамм пищевой композиции.
13. Пищевая композиция по п. 12, в которой упомянутый штамм Bifidobacterium представляет собой штамм Bifidobacterium lactis, причем предпочтительно упомянутый штамм Bifidobacterium состоит преимущественно из Bifidobacterium lactis NCC 2818.
14. Пищевая композиция по п. 10 для использования в подавлении патогенной инфекции в толстом кишечнике.
15. Синбиотическая композиция по п. 7 или 9 или пищевая композиция по любому одному из пп. 10-13 для использования в лечении патогенной инфекции в толстом кишечнике.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12194905 | 2012-11-29 | ||
| EP12194905.1 | 2012-11-29 | ||
| PCT/EP2013/075117 WO2014083166A1 (en) | 2012-11-29 | 2013-11-29 | Synbiotic composition and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015125548A true RU2015125548A (ru) | 2017-01-11 |
Family
ID=47263168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015125548A RU2015125548A (ru) | 2012-11-29 | 2013-11-29 | Синбиотическая композиция и ее использование |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20150290258A1 (ru) |
| EP (1) | EP2925334A1 (ru) |
| CN (1) | CN104902910A (ru) |
| BR (1) | BR112015012220A2 (ru) |
| CA (1) | CA2891860A1 (ru) |
| CL (1) | CL2015001457A1 (ru) |
| IL (1) | IL238531A0 (ru) |
| MX (1) | MX2015006312A (ru) |
| PH (1) | PH12015501147A1 (ru) |
| RU (1) | RU2015125548A (ru) |
| WO (1) | WO2014083166A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE051052T2 (hu) * | 2015-04-30 | 2021-03-01 | Carbiotix Ab | Arabinoxilo-oligoszacharidokat tartalmazó készítmény |
| IT201800020383A1 (it) * | 2018-12-20 | 2020-06-20 | Dom Terry Int S R L | XOS derivati della pannocchia del mais per potenziare la biodisponibilità e la stabilità delle materie prime nella produzione dei nutraceutici |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0414655D0 (en) * | 2004-06-30 | 2004-08-04 | Leuven K U Res & Dev | Prebiotic |
| US20100092429A1 (en) | 2006-12-11 | 2010-04-15 | Danisco A/S | Composition |
| DK2106215T3 (da) * | 2007-01-16 | 2020-09-28 | Puratos Nv | Brød med forhøjet arabinoxylo-oligosaccharid-indhold |
| GB0718974D0 (en) | 2007-09-28 | 2007-11-07 | Univ Leuven Kath | oligosaccharides derived from arabinoxylan for prevention of gastrointestinal infection |
| GB0805360D0 (en) | 2008-03-25 | 2008-04-30 | Univ Leuven Kath | Arabinoxylan oligosaccharide preparation |
| ES2416086T3 (es) | 2008-12-10 | 2013-07-30 | Katholieke Universiteit Leuven | Alimento que contiene arabinoxilano y oligosacáridos |
| WO2010071421A1 (en) | 2008-12-17 | 2010-06-24 | N.V. Nutricia | Probiotics for the treatment and/or prevention of pulmonary hypertension |
| GB0902018D0 (en) | 2009-02-09 | 2009-03-11 | Fugeia | Method for making pentoses and pentose-based oligosaccharides from cereals |
| EP2251022A1 (en) | 2009-05-11 | 2010-11-17 | Nestec S.A. | Non-replicating micro-organisms and their immune boosting effect |
| JP2012526752A (ja) | 2009-05-11 | 2012-11-01 | ネステク ソシエテ アノニム | ビフィドバクテリウム・ロンガムｎｃｃ２７０５（ｃｎｃｍｉ−２６１８）及び免疫障害 |
| EP2251020A1 (en) | 2009-05-11 | 2010-11-17 | Nestec S.A. | Short-time high temperature treatment generates microbial preparations with anti-inflammatory profiles |
-
2013
- 2013-11-29 EP EP13798337.5A patent/EP2925334A1/en not_active Withdrawn
- 2013-11-29 CN CN201380061438.4A patent/CN104902910A/zh not_active Withdrawn
- 2013-11-29 MX MX2015006312A patent/MX2015006312A/es unknown
- 2013-11-29 WO PCT/EP2013/075117 patent/WO2014083166A1/en active Application Filing
- 2013-11-29 CA CA2891860A patent/CA2891860A1/en not_active Abandoned
- 2013-11-29 US US14/646,141 patent/US20150290258A1/en not_active Abandoned
- 2013-11-29 RU RU2015125548A patent/RU2015125548A/ru not_active Application Discontinuation
- 2013-11-29 BR BR112015012220A patent/BR112015012220A2/pt not_active IP Right Cessation
-
2015
- 2015-04-29 IL IL238531A patent/IL238531A0/en unknown
- 2015-05-22 PH PH12015501147A patent/PH12015501147A1/en unknown
- 2015-05-28 CL CL2015001457A patent/CL2015001457A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL238531A0 (en) | 2015-06-30 |
| CN104902910A (zh) | 2015-09-09 |
| EP2925334A1 (en) | 2015-10-07 |
| PH12015501147A1 (en) | 2015-08-10 |
| WO2014083166A1 (en) | 2014-06-05 |
| BR112015012220A2 (pt) | 2017-07-11 |
| US20150290258A1 (en) | 2015-10-15 |
| MX2015006312A (es) | 2015-09-07 |
| CL2015001457A1 (es) | 2015-09-21 |
| CA2891860A1 (en) | 2014-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20161130 |