RU2015106123A - THERMOSENSITIVE AMPHIPHILIC POLYURETHANE AND AQUEOUS SOLUTION INJECTED ON THE BASIS OF THIS MATTER - Google Patents

THERMOSENSITIVE AMPHIPHILIC POLYURETHANE AND AQUEOUS SOLUTION INJECTED ON THE BASIS OF THIS MATTER Download PDF

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RU2015106123A
RU2015106123A RU2015106123A RU2015106123A RU2015106123A RU 2015106123 A RU2015106123 A RU 2015106123A RU 2015106123 A RU2015106123 A RU 2015106123A RU 2015106123 A RU2015106123 A RU 2015106123A RU 2015106123 A RU2015106123 A RU 2015106123A
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Джанлука ЧАРДЕЛЛИ
Сузанна САРТОРИ
Моника БОФФИТО
Пьеро СЕРАФИНИ
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Джельтис С.Р.Л.
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Abstract

1. Термочувствительная золь-гель композиция, вводимая путем инъекции, состоящая из водного раствора по меньшей мере одного амфифильного полиуретана, отличающаяся тем, что указанный амфифильный полиуретан является таким, что его можно синтезировать посредством полимеризации в реакционной смеси, содержащей по меньшей мере:- первое количество (Q) по меньшей мере одного и максимум двух макродиолов, содержащих по меньшей мере один блок, состоящий из полиэтиленгликоля (PEG) в форме олигомера или полимера;- второе количество (Q) по меньшей мере одного диизоцианата с формулой OCN-R-NCO, где R представляет собой алифатическую группу, содержащую от 4 до 26 атомов углерода.2. Композиция по п. 1, отличающаяся тем, что указанная реакционная смесь содержит по меньшей мере один растворитель.3. Композиция по п. 2, отличающаяся тем, что указанный растворитель выбран из 1,2-дихлорметана, тетрагидрофурана, N,N-диметилформамида, 1,2-дихлорэтана.4. Композиция по п. 1, отличающаяся тем, что указанная реакционная смесь содержит по меньшей мере один катализатор.5. Композиция по п. 4, отличающаяся тем, что указанный катализатор выбран из третичных аминов или металлоорганических соединений.6. Композиция по п. 1, отличающееся тем, что указанное первое количество (Q) макродиола составляет от 20 масс. % до 90 масс. % указанной реакционной смеси, и указанное второе количество (Q) диизоцианата составляет от 80 масс. % до 10 масс. % указанной реакционной смеси.7. Композиция по п. 1, отличающаяся тем, что молекулярная масса указанного блока полиэтиленгликоля (PEG) имеет M(среднечисловая молекулярная масса - от англ. the number average molecular weight), составляющую от 200 до 5000 Да.8. Композиция по п. 1, отличающаяся тем, что указанный диизоцианат выбран из 1,6-эзаметилен-диизоцианата,1. Heat-sensitive sol-gel composition, administered by injection, consisting of an aqueous solution of at least one amphiphilic polyurethane, characterized in that the amphiphilic polyurethane is such that it can be synthesized by polymerization in a reaction mixture containing at least: the amount (Q) of at least one and a maximum of two macrodiols containing at least one block consisting of polyethylene glycol (PEG) in the form of an oligomer or polymer; - a second amount (Q) of at least one diisocyanate with the formula OCN-R-NCO, where R is an aliphatic group containing from 4 to 26 carbon atoms. 2. A composition according to claim 1, characterized in that said reaction mixture contains at least one solvent. A composition according to claim 2, wherein said solvent is selected from 1,2-dichloromethane, tetrahydrofuran, N, N-dimethylformamide, 1,2-dichloroethane. 4. A composition according to claim 1, characterized in that said reaction mixture contains at least one catalyst. A composition according to claim 4, characterized in that said catalyst is selected from tertiary amines or organometallic compounds. The composition of claim 1, wherein said first amount (Q) of macrodiol is from 20 mass. % to 90 mass. % of the specified reaction mixture, and the specified second quantity (Q) of diisocyanate is from 80 wt. % to 10 mass. % of the specified reaction mixture. 7. The composition according to claim 1, characterized in that the molecular weight of the indicated block of polyethylene glycol (PEG) has M (number average molecular weight) from 200 to 5000 Da. The composition of claim 1, wherein said diisocyanate is selected from 1,6-esamethylene diisocyanate,

Claims (22)

1. Термочувствительная золь-гель композиция, вводимая путем инъекции, состоящая из водного раствора по меньшей мере одного амфифильного полиуретана, отличающаяся тем, что указанный амфифильный полиуретан является таким, что его можно синтезировать посредством полимеризации в реакционной смеси, содержащей по меньшей мере:1. Heat-sensitive sol-gel composition, administered by injection, consisting of an aqueous solution of at least one amphiphilic polyurethane, characterized in that the amphiphilic polyurethane is such that it can be synthesized by polymerization in a reaction mixture containing at least: - первое количество (Q1) по меньшей мере одного и максимум двух макродиолов, содержащих по меньшей мере один блок, состоящий из полиэтиленгликоля (PEG) в форме олигомера или полимера;- a first quantity (Q 1 ) of at least one and a maximum of two macrodiols containing at least one block consisting of polyethylene glycol (PEG) in the form of an oligomer or polymer; - второе количество (Q2) по меньшей мере одного диизоцианата с формулой OCN-R-NCO, где R представляет собой алифатическую группу, содержащую от 4 до 26 атомов углерода.- a second amount (Q 2 ) of at least one diisocyanate of the formula OCN-R-NCO, where R is an aliphatic group containing from 4 to 26 carbon atoms. 2. Композиция по п. 1, отличающаяся тем, что указанная реакционная смесь содержит по меньшей мере один растворитель.2. The composition according to p. 1, characterized in that the reaction mixture contains at least one solvent. 3. Композиция по п. 2, отличающаяся тем, что указанный растворитель выбран из 1,2-дихлорметана, тетрагидрофурана, N,N-диметилформамида, 1,2-дихлорэтана.3. The composition according to p. 2, characterized in that the solvent is selected from 1,2-dichloromethane, tetrahydrofuran, N, N-dimethylformamide, 1,2-dichloroethane. 4. Композиция по п. 1, отличающаяся тем, что указанная реакционная смесь содержит по меньшей мере один катализатор.4. The composition according to p. 1, characterized in that the reaction mixture contains at least one catalyst. 5. Композиция по п. 4, отличающаяся тем, что указанный катализатор выбран из третичных аминов или металлоорганических соединений.5. The composition according to p. 4, characterized in that said catalyst is selected from tertiary amines or organometallic compounds. 6. Композиция по п. 1, отличающееся тем, что указанное первое количество (Q1) макродиола составляет от 20 масс. % до 90 масс. % указанной реакционной смеси, и указанное второе количество (Q2) диизоцианата составляет от 80 масс. % до 10 масс. % указанной реакционной смеси.6. The composition according to p. 1, characterized in that the said first quantity (Q 1 ) of macrodiol is from 20 mass. % to 90 mass. % of the specified reaction mixture, and the specified second quantity (Q 2 ) of diisocyanate is from 80 mass. % to 10 mass. % of the specified reaction mixture. 7. Композиция по п. 1, отличающаяся тем, что молекулярная масса указанного блока полиэтиленгликоля (PEG) имеет Mn (среднечисловая молекулярная масса - от англ. the number average molecular weight), составляющую от 200 до 5000 Да.7. The composition according to p. 1, characterized in that the molecular weight of the indicated block of polyethylene glycol (PEG) has M n (number average molecular weight from the English. The number average molecular weight), comprising from 200 to 5000 Da. 8. Композиция по п. 1, отличающаяся тем, что указанный диизоцианат выбран из 1,6-эзаметилен-диизоцианата, 1,4-бутандиизоцианата или 1,4-циклоэзаметилен-диизоцианата, L-лизин-диизоцианата.8. The composition according to claim 1, characterized in that said diisocyanate is selected from 1,6-esamethylene diisocyanate, 1,4-butanediisocyanate or 1,4-cycloesamethylene diisocyanate, L-lysine diisocyanate. 9. Композиция по п. 1, представляющая собой физический или обратимый гель.9. The composition according to p. 1, which is a physical or reversible gel. 10. Композиция по п. 1, отличающаяся тем, что указанная реакционная смесь содержит по меньшей мере одно третье количество (Q3) по меньшей мере одного удлинителя цепи, содержащего соответствующие гидроксильные или аминогруппы.10. The composition according to p. 1, characterized in that the said reaction mixture contains at least one third amount (Q 3 ) of at least one chain extender containing the corresponding hydroxyl or amino groups. 11. Композиция по п. 10, отличающаяся тем, что указанный удлинитель цепи выбран из диолов или диаминов, содержащих аминокислотные последовательности, диолов или диаминов, состоящих из аминокислотных производных, диолов или диаминов, содержащих защищенную функциональную группу, циклических диолов или диаминов.11. The composition according to p. 10, wherein said chain extender is selected from diols or diamines containing amino acid sequences, diols or diamines consisting of amino acid derivatives, diols or diamines containing a protected functional group, cyclic diols or diamines. 12. Композиция по п. 10, отличающаяся тем, что массовое процентное содержание указанного третьего количества (Q3) удлинителя цепи в указанной реакционной смеси составляет от 0% до 65%.12. The composition according to p. 10, characterized in that the mass percentage of the specified third quantity (Q 3 ) of the chain extender in the specified reaction mixture is from 0% to 65%. 13. Композиция по п. 10, отличающаяся тем, что указанное первое количество (Q1) макродиола, указанное второе количество (Q2) диизоцианата и указанное третье количество (Q3) удлинителя цепи находятся в указанной смеси в молярном соотношении Q1:Q2:Q3, которое может находится в интервале от 1:2:1 до 3:8:5.13. The composition according to p. 10, characterized in that said first amount (Q 1 ) of macrodiol, said second amount (Q 2 ) of diisocyanate and said third amount (Q 3 ) of chain extender are in said mixture in a molar ratio of Q 1 : Q 2 : Q 3 , which may be in the range from 1: 2: 1 to 3: 8: 5. 14. Композиция по п. 1, отличающаяся тем, что жидкая фаза, в которой растворяют указанный полимер, представляет собой дистиллированную воду или физиологический раствор, или раствор глюкозы, или физиологический раствор, содержащий глюкозу.14. The composition according to p. 1, characterized in that the liquid phase in which the specified polymer is dissolved is a distilled water or physiological solution, or glucose solution, or physiological solution containing glucose. 15. Композиция по п. 1, отличающаяся тем, что вводимая путем инъекции композиция содержит по меньшей мере одно шестое количество (Q6) по меньшей мере одного лекарственного средства или биологически активной молекулы.15. The composition according to p. 1, characterized in that the injectable composition contains at least one sixth amount (Q 6 ) of at least one drug or biologically active molecule. 16. Композиция по п. 15, отличающаяся тем, что указанное шестое количество (Q6) составляет от 0 масс./об. % до 30 масс./об. %, более предпочтительно от 0% до 20% указанного раствора.16. The composition according to p. 15, characterized in that the sixth amount (Q 6 ) is from 0 wt./about. % up to 30 wt./about. %, more preferably from 0% to 20% of the specified solution. 17. Применение композиции по любому из пп. 1-16 для регенерации тканей и в области эстетической медицины и протезирования.17. The use of a composition according to any one of paragraphs. 1-16 for tissue regeneration and in the field of aesthetic medicine and prosthetics. 18. Применение по п. 17 указанной композиции в качестве наполнителя или в качестве носителя лекарственных средств, ростовых факторов или клеток.18. The use according to claim 17 of the specified composition as a filler or as a carrier of drugs, growth factors or cells. 19. Раствор полиуретана, содержащий по меньшей мере одну композицию по любому из пп. 1-16, отличающийся тем, что раствор содержит четвертое количество (Q4) полиуретана, составляющее от 1 масс./об. % до 99 масс./об. %, более предпочтительно от 1 масс./об. % до 50 масс./об. % указанного раствора.19. A polyurethane solution containing at least one composition according to any one of paragraphs. 1-16, characterized in that the solution contains a fourth amount (Q 4 ) of polyurethane, comprising from 1 wt./about. % to 99 wt./about. %, more preferably from 1 wt./about. % to 50 wt./about. % of the specified solution. 20. Раствор по п. 19, отличающийся тем, что раствор содержит пятое количество (Q5) по меньшей мере одного природного полимера и/или углеводов и/или белков.20. The solution according to claim 19, characterized in that the solution contains a fifth amount (Q 5 ) of at least one natural polymer and / or carbohydrates and / or proteins. 21. Раствор по п. 20, отличающийся тем, что указанный природный полимер и/или углеводы и/или белки выбраны из гиалуроновой кислоты, желатина, коллагена.21. The solution according to p. 20, characterized in that the said natural polymer and / or carbohydrates and / or proteins are selected from hyaluronic acid, gelatin, collagen. 22. Раствор по п. 20, отличающийся тем, что указанное пятое количество (Q5) составляет от 0 масс./об. % до 99 масс./об. %, более предпочтительно от 1 масс./об. % до 20 масс./об. % указанного раствора. 22. The solution according to p. 20, characterized in that the specified fifth quantity (Q 5 ) is from 0 wt./about. % to 99 wt./about. %, more preferably from 1 wt./about. % up to 20 wt./about. % of the specified solution.
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