RU2015104027A

RU2015104027A - METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION CONTAINING FUROCUMARINE

Info

Publication number: RU2015104027A
Application number: RU2015104027A
Authority: RU
Inventors: Владимир Владимирович Самородов
Original assignee: Закрытое акционерное общество "Фармцентр ВИЛАР"
Priority date: 2015-02-09
Filing date: 2015-02-09
Publication date: 2016-08-27

Abstract

1. Способ получения фармацевтической композиции, содержащей фурокумарины, предусматривающий трехкратную экстракцию цельного растительного сырья - плодов амми большой с использованием спирта этилового с получением спиртовых извлечений, сгущение первого спиртового извлечения, разделение сгущенного экстракта на осадок суммы фурокумаринов и водный раствор, получение субстанции аммифурин, отличающийся тем, что с одной загрузки сырья получают два продукта: аммифурин и анмарин.2. Способ по п. 1, отличающийся тем, что только первое спиртовое извлечение направляют на сгущение, которое производят до полного отгона спирта этилового, а второе и третье извлечения от каждой загрузки используют в качестве экстрагентов для проведения первой и второй экстракций последующих загрузок сырья, третью экстракцию которых производят спиртом этиловым.3. Способ по п. 1, отличающийся тем, что к сгущенному экстракту приливают трехкратный объем воды и выдерживают при температуре от 0 до 4°C в течение 24 ч.4. Способ по п. 1, отличающийся тем, что по окончании выдержки разбавленного водой сгущенного экстракта при температуре от 0 до 4°C декантируемую жидкую фазу (водный раствор) используют для получения субстанции анмарин.1. A method of obtaining a pharmaceutical composition containing furocoumarins, comprising triple extraction of whole plant material - large ammonium fruits using ethyl alcohol to obtain alcoholic extracts, thickening the first alcoholic extract, separating the condensed extract into a precipitate of the sum of furocoumarins and an aqueous solution, obtaining an ammifurin substance that differs in that two products are obtained from one loading of raw materials: ammifurin and anmarin. 2. The method according to claim 1, characterized in that only the first alcoholic extraction is directed to thickening, which is carried out until the ethyl alcohol is completely distilled off, and the second and third extracts from each load are used as extractants for the first and second extraction of subsequent feeds, the third extraction which are produced with ethyl alcohol. 3. A method according to claim 1, characterized in that a three-fold volume of water is poured onto the condensed extract and kept at a temperature from 0 to 4 ° C for 24 hours. The method according to claim 1, characterized in that upon completion of the exposure to the condensed extract diluted with water at a temperature of 0 to 4 ° C, a decanted liquid phase (aqueous solution) is used to obtain anmarin substance.

Claims

1. A method of obtaining a pharmaceutical composition containing furocoumarins, comprising triple extraction of whole plant material - large ammonium fruits using ethyl alcohol to obtain alcoholic extracts, thickening the first alcoholic extract, separating the condensed extract into a precipitate of the sum of furocoumarins and an aqueous solution, obtaining an ammifurin substance that differs in that two products are obtained from a single loading of raw materials: ammifurin and anmarin.

2. The method according to p. 1, characterized in that only the first alcoholic extraction is directed to thickening, which is carried out until the ethyl alcohol is completely distilled off, and the second and third extracts from each charge are used as extractants for the first and second extraction of subsequent feeds, the third extraction of which is carried out with ethyl alcohol.

3. The method according to p. 1, characterized in that a three-fold volume of water is added to the condensed extract and kept at a temperature of 0 to 4 ° C for 24 hours.

4. The method according to p. 1, characterized in that at the end of the aging of the condensed extract diluted with water at a temperature of 0 to 4 ° C, a decanted liquid phase (aqueous solution) is used to obtain the substance anmarin.