RU2014141093A - A method of producing cephalosporin antibiotic nanocapsules in human serum albumin - Google Patents

A method of producing cephalosporin antibiotic nanocapsules in human serum albumin Download PDF

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Publication number
RU2014141093A
RU2014141093A RU2014141093A RU2014141093A RU2014141093A RU 2014141093 A RU2014141093 A RU 2014141093A RU 2014141093 A RU2014141093 A RU 2014141093A RU 2014141093 A RU2014141093 A RU 2014141093A RU 2014141093 A RU2014141093 A RU 2014141093A
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RU
Russia
Prior art keywords
serum albumin
human serum
cephalosporin antibiotic
producing cephalosporin
nanocapsules
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RU2014141093A
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Russian (ru)
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RU2619332C2 (en
Inventor
Александр Александрович Кролевец
Илья Александрович Богачев
Original Assignee
Александр Александрович Кролевец
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Application filed by Александр Александрович Кролевец filed Critical Александр Александрович Кролевец
Priority to RU2014141093A priority Critical patent/RU2619332C2/en
Publication of RU2014141093A publication Critical patent/RU2014141093A/en
Application granted granted Critical
Publication of RU2619332C2 publication Critical patent/RU2619332C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

Способ получения нанокапсул цефалоспориновых антибиотиков в альбумине человеческом сывороточном, отличающийся тем, что в качестве оболочки нанокапсул используется альбумин сывороточный человеческий при их получении физико-химическим методом осаждения нерастворителем с использованием осадителя - петролейного эфира.A method of producing cephalosporin antibiotic nanocapsules in human serum albumin, characterized in that human serum albumin is used as the nanocapsule shell by their physicochemical precipitation with a non-solvent using a precipitating agent - petroleum ether.

Claims (1)

Способ получения нанокапсул цефалоспориновых антибиотиков в альбумине человеческом сывороточном, отличающийся тем, что в качестве оболочки нанокапсул используется альбумин сывороточный человеческий при их получении физико-химическим методом осаждения нерастворителем с использованием осадителя - петролейного эфира. A method of producing cephalosporin antibiotic nanocapsules in human serum albumin, characterized in that human serum albumin is used as the nanocapsule shell by their physicochemical precipitation with a non-solvent using a precipitating agent - petroleum ether.
RU2014141093A 2014-10-10 2014-10-10 Method of producing nanocapsules of cephalosporin antibiotics in human serum albumin RU2619332C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2014141093A RU2619332C2 (en) 2014-10-10 2014-10-10 Method of producing nanocapsules of cephalosporin antibiotics in human serum albumin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2014141093A RU2619332C2 (en) 2014-10-10 2014-10-10 Method of producing nanocapsules of cephalosporin antibiotics in human serum albumin

Publications (2)

Publication Number Publication Date
RU2014141093A true RU2014141093A (en) 2016-05-10
RU2619332C2 RU2619332C2 (en) 2017-05-15

Family

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Family Applications (1)

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RU2014141093A RU2619332C2 (en) 2014-10-10 2014-10-10 Method of producing nanocapsules of cephalosporin antibiotics in human serum albumin

Country Status (1)

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RU (1) RU2619332C2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2134967C1 (en) * 1997-05-30 1999-08-27 Шестаков Константин Алексеевич Method of preparing microcapsulated preparations containing pyrethroid insecticides
WO2010004594A1 (en) * 2008-07-08 2010-01-14 S.I.F.I. Societa' Industria Farmaceutica Italiana S.P.A. Ophthalmic compositions for treating pathologies of the posterior segment of the eye

Also Published As

Publication number Publication date
RU2619332C2 (en) 2017-05-15

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20171011