RU2013146906A - PHARMACEUTICAL COMPOSITION IN THE FORM OF NASAL SPRAY BASED ON NALOXONE HYDROCHLORIDE AND METHOD FOR PRODUCING IT - Google Patents
PHARMACEUTICAL COMPOSITION IN THE FORM OF NASAL SPRAY BASED ON NALOXONE HYDROCHLORIDE AND METHOD FOR PRODUCING IT Download PDFInfo
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- RU2013146906A RU2013146906A RU2013146906/15A RU2013146906A RU2013146906A RU 2013146906 A RU2013146906 A RU 2013146906A RU 2013146906/15 A RU2013146906/15 A RU 2013146906/15A RU 2013146906 A RU2013146906 A RU 2013146906A RU 2013146906 A RU2013146906 A RU 2013146906A
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- RU
- Russia
- Prior art keywords
- naloxone hydrochloride
- pharmaceutical composition
- nasal spray
- macrogol
- poloxamer
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Фармацевтическая композиция в виде назального спрея для быстрого купирования острого отравления опиоидами на основе налоксона гидрохлорида, отличающаяся тем, что дополнительно содержит пропиленгликоль, макрогол 400, полоксамер 407, моногидрат лимонной кислоты, воду очищенную, при этом соотношение компонентов следующее (мас.%):2. Способ получения фармацевтической композиции в виде назального спрея на основе налоксона гидрохлорида, отличающийся тем, что в воду очищенную, содержащую лимонную кислоту, последовательно загружают пропиленгликоль и макрогол 400, полоксамер 407, налоксона гидрохлорид и после каждой загрузки перемешивают под вакуумом глубиной от минус 0,05 до минус 0,07 МПа, полученный раствор расфасовывают в баллоны, вставляют насос-дозатор и герметизируют баллоны.1. A pharmaceutical composition in the form of a nasal spray for the rapid relief of acute opioid poisoning based on naloxone hydrochloride, characterized in that it further contains propylene glycol, macrogol 400, poloxamer 407, citric acid monohydrate, purified water, with the following ratio of components (wt.%) : 2. A method of obtaining a pharmaceutical composition in the form of a naloxone hydrochloride-based nasal spray, characterized in that propylene glycol and macrogol 400, poloxamer 407, naloxone hydrochloride are successively loaded into purified water containing citric acid and, after each loading, they are mixed under vacuum from a depth of minus 0.05 to minus 0.07 MPa, the resulting solution is packaged in cylinders, a metering pump is inserted and the cylinders are sealed.
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Application Number | Priority Date | Filing Date | Title |
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RU2013146906/15A RU2572217C2 (en) | 2013-10-21 | 2013-10-21 | Pharmaceutical composition in form of naloxone hydrochloride-based nasal spray and method of obtaining thereof |
Applications Claiming Priority (1)
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RU2013146906/15A RU2572217C2 (en) | 2013-10-21 | 2013-10-21 | Pharmaceutical composition in form of naloxone hydrochloride-based nasal spray and method of obtaining thereof |
Publications (2)
Publication Number | Publication Date |
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RU2013146906A true RU2013146906A (en) | 2015-04-27 |
RU2572217C2 RU2572217C2 (en) | 2015-12-27 |
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RU2013146906/15A RU2572217C2 (en) | 2013-10-21 | 2013-10-21 | Pharmaceutical composition in form of naloxone hydrochloride-based nasal spray and method of obtaining thereof |
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RU (1) | RU2572217C2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20180193332A1 (en) * | 2017-10-09 | 2018-07-12 | Adapt Pharma Operations Limited | Low-temperature stable opioid antagonist solutions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101036651A (en) * | 2006-03-16 | 2007-09-19 | 薛京 | Naloxone hydrochloride spraying agent for mouth and nose |
RU2344822C2 (en) * | 2006-04-05 | 2009-01-27 | Алексей Валентинович Надеждин | Method of heroine addiction treatment |
CN101057830A (en) * | 2007-05-10 | 2007-10-24 | 北京天川军威医药技术开发有限公司 | Naloxone hydrochloride sublingual spraying drug delivery system or composition and its preparation method |
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- 2013-10-21 RU RU2013146906/15A patent/RU2572217C2/en active
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Publication number | Publication date |
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RU2572217C2 (en) | 2015-12-27 |
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