RU2013131870A - METHOD FOR DETECTING AVAILABILITY, SEVERITY, RISK AND POSITION FOR RECIDIENTS, AND ALSO TREATMENT AND REACTION TO TREATMENT OF URINARY INFLAMMATION AND KITS FOR ITS DESCRIPTION - Google Patents

METHOD FOR DETECTING AVAILABILITY, SEVERITY, RISK AND POSITION FOR RECIDIENTS, AND ALSO TREATMENT AND REACTION TO TREATMENT OF URINARY INFLAMMATION AND KITS FOR ITS DESCRIPTION Download PDF

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RU2013131870A
RU2013131870A RU2013131870/15A RU2013131870A RU2013131870A RU 2013131870 A RU2013131870 A RU 2013131870A RU 2013131870/15 A RU2013131870/15 A RU 2013131870/15A RU 2013131870 A RU2013131870 A RU 2013131870A RU 2013131870 A RU2013131870 A RU 2013131870A
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eosinophilic peroxidase
detecting
eosinophilic
peroxidase
sample
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RU2013131870/15A
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Павлов Владимир Игоревич
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Priority to PCT/RU2014/000422 priority patent/WO2015005823A1/en
Publication of RU2013131870A publication Critical patent/RU2013131870A/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5428—IL-10
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5437—IL-13
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/908—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
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  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1. Способ обнаружения воспаления мочевыводящих путей у пациента, содержащий: а) обеспечение образца от пациента; и б) обнаружение в указанном образце экспрессии по меньшей мере одного из биомаркеров, выбранных из группы, содержащей ИЛ-33, ИЛ-13, ИЛ-10 и эозинофильную пероксидазу.2. Способ по п. 1, включающий обнаружение присутствия мРНК для ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы.3. Способ по п. 2, включающий взаимодействие указанных мРНК для ИЛ-33 и/или ИЛ-13, и/или ИЛ-10, и/или эозинофильной пероксидазы с зондом из нуклеиновой кислоты, комплементарным к указанной мРНК для ИЛ-33 и/или ИЛ-13, и/или ИЛ-10 и/или эозинофильной пероксидазы.4. Способ по п. 1, включающий обнаружение присутствия полипептидов ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы.5. Способ по п. 4, включающий взаимодействие указанных полипептидов ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы с антителом, специфичным к указанному полипептиду ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы и обнаружение связывания указанного антитела с указанным полипептидом ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы.6. Способ по п. 1, в котором испытуемым является человек.7. Способ по п. 1, где образец включает мочу, кровь, и/или клетки или ткань мочевого пузыря.8. Способ лечения обнаруженного в соответствии со способом по п. 1 воспаления мочевыводящих путей, включающий: а) обеспечение образца от исследуемого; б) обнаружение экспрессии ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы в указанном образце; в) на основании указанной экспрессии ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы подавление воспаления с пом1. A method for detecting inflammation of the urinary tract in a patient, comprising: a) providing a sample from the patient; and b) detecting in said sample expression of at least one of the biomarkers selected from the group consisting of IL-33, IL-13, IL-10 and eosinophilic peroxidase. 2. A method according to claim 1, comprising detecting the presence of mRNA for IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase. 3. The method of claim 2, comprising reacting said mRNA for IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase with a nucleic acid probe complementary to said mRNA for IL-33 and / or IL-13, and / or IL-10 and / or eosinophilic peroxidase. 4. A method according to claim 1, comprising detecting the presence of IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase polypeptides. The method of claim 4, comprising reacting said IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase polypeptides with an antibody specific for said IL-33 and / or IL-13 and / or IL -10 and / or eosinophilic peroxidase and detecting binding of the indicated antibody to the indicated IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase polypeptide. 6. The method of claim 1, wherein the test person is a human. The method of claim 1, wherein the sample includes urine, blood, and / or cells or tissue of the bladder. A method of treating an inflammation of the urinary tract detected in accordance with the method of claim 1, comprising: a) providing a sample from the subject; b) detecting the expression of IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase in the specified sample; c) based on the indicated expression of IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase, suppression of inflammation with

Claims (14)

1. Способ обнаружения воспаления мочевыводящих путей у пациента, содержащий: а) обеспечение образца от пациента; и б) обнаружение в указанном образце экспрессии по меньшей мере одного из биомаркеров, выбранных из группы, содержащей ИЛ-33, ИЛ-13, ИЛ-10 и эозинофильную пероксидазу.1. A method for detecting inflammation of the urinary tract in a patient, comprising: a) providing a sample from the patient; and b) detecting in said sample expression of at least one of the biomarkers selected from the group consisting of IL-33, IL-13, IL-10 and eosinophilic peroxidase. 2. Способ по п. 1, включающий обнаружение присутствия мРНК для ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы.2. The method of claim 1, comprising detecting the presence of mRNA for IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase. 3. Способ по п. 2, включающий взаимодействие указанных мРНК для ИЛ-33 и/или ИЛ-13, и/или ИЛ-10, и/или эозинофильной пероксидазы с зондом из нуклеиновой кислоты, комплементарным к указанной мРНК для ИЛ-33 и/или ИЛ-13, и/или ИЛ-10 и/или эозинофильной пероксидазы.3. The method according to p. 2, comprising the interaction of these mRNAs for IL-33 and / or IL-13, and / or IL-10, and / or eosinophilic peroxidase with a probe from a nucleic acid complementary to the specified mRNA for IL-33 and / or IL-13, and / or IL-10 and / or eosinophilic peroxidase. 4. Способ по п. 1, включающий обнаружение присутствия полипептидов ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы.4. The method according to p. 1, comprising detecting the presence of IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase polypeptides. 5. Способ по п. 4, включающий взаимодействие указанных полипептидов ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы с антителом, специфичным к указанному полипептиду ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы и обнаружение связывания указанного антитела с указанным полипептидом ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы.5. The method according to p. 4, comprising the interaction of these polypeptides IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase with an antibody specific for the specified polypeptide IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase and the detection of binding of the indicated antibodies to the specified polypeptide of IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase. 6. Способ по п. 1, в котором испытуемым является человек.6. The method according to p. 1, in which the subject is a person. 7. Способ по п. 1, где образец включает мочу, кровь, и/или клетки или ткань мочевого пузыря.7. The method of claim 1, wherein the sample includes urine, blood, and / or cells or tissue of the bladder. 8. Способ лечения обнаруженного в соответствии со способом по п. 1 воспаления мочевыводящих путей, включающий: а) обеспечение образца от исследуемого; б) обнаружение экспрессии ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы в указанном образце; в) на основании указанной экспрессии ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы подавление воспаления с помощью моноклональных антител и/или растворимых рецепторов и/или ингибиторов протеаз против, соответственно, полипептида или гена ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы.8. A method of treating an inflammation of the urinary tract detected in accordance with the method of claim 1, comprising: a) providing a sample from the subject; b) detecting the expression of IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase in the specified sample; c) based on the indicated expression of IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase, suppression of inflammation with monoclonal antibodies and / or soluble receptors and / or protease inhibitors against, respectively, the IL polypeptide or gene -33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase. 9. Способ по п. 8, дополнительно включающий определение ИЛ-33 и лактатдегидрогеназы (ЛДГ) у испытуемого и лечение испытуемого на основании дифференциального диагноза рака и инфекции мочевыводящих путей.9. The method of claim 8, further comprising determining IL-33 and lactate dehydrogenase (LDH) in the subject and treating the subject based on a differential diagnosis of cancer and urinary tract infection. 10. Набор для описания в испытуемом обнаруженного в соответствии со способом по п. 1 воспаления мочевыводящих путей, включающий: а) реагент, обладающий способностью специфически обнаруживать присутствие или отсутствие экспрессии ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы; и б) инструкцию по использованию указанного набора для описания воспаления мочевыводящих путей в указанном испытуемом.10. A kit for describing in a test subject a urinary tract inflammation detected in accordance with the method of claim 1, comprising: a) a reagent capable of specifically detecting the presence or absence of expression of IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase; and b) instructions for using the indicated kit to describe urinary tract inflammation in the test subject. 11. Набор по п. 10, в котором указанный реагент включает в себя зонд из нуклеиновой кислоты, комплементарный к ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы мРНК.11. The kit of claim 10, wherein said reagent includes a nucleic acid probe complementary to IL-33 and / or IL-13 and / or IL-10 and / or eosinophilic peroxidase mRNA. 12. Набор по п. 10, в котором указанный реагент включает в себя антитело, специфически связывающееся с полипептидом ИЛ-33 и/или ИЛ-13 и/или ИЛ-10 и/или эозинофильной пероксидазы.12. The kit of claim 10, wherein said reagent includes an antibody specifically binding to an IL-33 and / or IL-13 and / or IL-10 polypeptide and / or eosinophilic peroxidase. 13. Набор по п. 10, дополнительно включающий антитело, специфически связывающееся с лактатдегидрогеназой (ЛДГ), и нуклеотидный зонд, специфически узнающий мРНК лактатдегидрогеназы (ЛДГ).13. The kit of claim 10, further comprising an antibody specifically binding to lactate dehydrogenase (LDH), and a nucleotide probe specifically recognizing lactate dehydrogenase mRNA (LDH). 14. Набор по пункту 10, дополнительно включающий в себя опросник для испытуемого на наличие боли. 14. The kit of claim 10, further comprising a questionnaire for the subject for pain.
RU2013131870/15A 2013-07-11 2013-07-11 METHOD FOR DETECTING AVAILABILITY, SEVERITY, RISK AND POSITION FOR RECIDIENTS, AND ALSO TREATMENT AND REACTION TO TREATMENT OF URINARY INFLAMMATION AND KITS FOR ITS DESCRIPTION RU2013131870A (en)

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RU2013131870/15A RU2013131870A (en) 2013-07-11 2013-07-11 METHOD FOR DETECTING AVAILABILITY, SEVERITY, RISK AND POSITION FOR RECIDIENTS, AND ALSO TREATMENT AND REACTION TO TREATMENT OF URINARY INFLAMMATION AND KITS FOR ITS DESCRIPTION
PCT/RU2014/000422 WO2015005823A1 (en) 2013-07-11 2014-06-06 Methods for detecting, treating and preventing urinary tract inflammation/infection

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RU2013131870/15A RU2013131870A (en) 2013-07-11 2013-07-11 METHOD FOR DETECTING AVAILABILITY, SEVERITY, RISK AND POSITION FOR RECIDIENTS, AND ALSO TREATMENT AND REACTION TO TREATMENT OF URINARY INFLAMMATION AND KITS FOR ITS DESCRIPTION

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RU2115124C1 (en) * 1994-05-17 1998-07-10 Михаил Иосифович Коган Method of diagnosis of pyelonephritis acute stage
RU2153672C1 (en) * 1999-10-22 2000-07-27 Московский областной научно-исследовательский клинический институт Method for performing differential diagnosis of inflammatory processes in male urogenital paths
RU2215534C2 (en) * 2002-01-08 2003-11-10 Государственное унитарное предприятие "Иммунопрепарат" Method for treatment of inflammatory diseases of organs of urinary system
GB0423974D0 (en) * 2004-10-28 2004-12-01 Ares Trading Sa Proteins
WO2008127271A2 (en) * 2006-09-08 2008-10-23 Abbott Laboratories Interleukin -13 binding proteins

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