RU2012119658A - RECOMBINANT PLASMAID DNA pCI-UB-POLYEPI, CONTAINING EPITOPS OF TUMOR-ASSOCIATED ANTIGENS FOR COLORECTAL CANCER, AND METHOD OF ITS APPLICATION FOR STIMULATION OF SPECIFIC ANTIVECIOLOMATIS - Google Patents
RECOMBINANT PLASMAID DNA pCI-UB-POLYEPI, CONTAINING EPITOPS OF TUMOR-ASSOCIATED ANTIGENS FOR COLORECTAL CANCER, AND METHOD OF ITS APPLICATION FOR STIMULATION OF SPECIFIC ANTIVECIOLOMATIS Download PDFInfo
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- RU2012119658A RU2012119658A RU2012119658/10A RU2012119658A RU2012119658A RU 2012119658 A RU2012119658 A RU 2012119658A RU 2012119658/10 A RU2012119658/10 A RU 2012119658/10A RU 2012119658 A RU2012119658 A RU 2012119658A RU 2012119658 A RU2012119658 A RU 2012119658A
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Abstract
1. Рекомбинантная плазмидная ДНК pCI-UB-POLYEPI, содержит 11 эпитопов опухоль-ассоциированных антигенов колоректального рака, имеет размер 6 355 п.н. и экспрессирует следующую аминокислотную последовательность:DYKDDDDK-LLGVGTFVV-ADRIW-GLKAGVIAV-AAYARY-VLAFGLLLA-ADRIW-YQLDPKFITSI-AAYARY-IMIGVLVGV-ADRIW-YLSGADLNL-AAYARY-CGIQNSVSA-AAYARY-LLLLTVLTV-ADRIW-QYIKANSKFIGITEL-ANIY-SIINFEKL-ARY-SASFDGWATVSVIAL-ARY-SERVRTYWIIIELKHKARE-ARY-IQNDTGFYTLHVIKSDLVNEEрекомбинантная плазмида pCI-UB-POLYEPI содержит CMV энхансер (5251-5910 п.н.), CMV промотор (5919-6001), Т7 промотор (6317-6336 п.н.), убиквитин (1-229), так же содержит уникальные сайты рестрикции EcoRI (233), XbaI(891), NotI (908), BamHI (3164), NdeI (5638), SacI (5980), XhoI (6342).2. Способ генерации антиген-специфических противоопухолевых цитотоксических клеток, заключающийся в совместном культивировании мононуклеарных клеток (МНК) периферической крови больных колоректальным раком с дендритными клетками (ДК), активированными опухолевыми антигенами, отличающийся тем, что для культивирования используют зрелые ДК, полученные добавлением к незрелым ДК провоспалительного цитокина ФНО-α, активированные путем трансфекции в них рекомбинантной плазмидной ДНК pCI-UB-POLYEPI, заявленной в п.1.1. Recombinant plasmid DNA pCI-UB-POLYEPI, contains 11 epitopes of tumor-associated antigens of colorectal cancer, has a size of 6 355 bp and expresses the following amino acid sequence: DYKDDDDK-LLGVGTFVV-ADRIW-GLKAGVIAV-AAYARY-VLAFGLLLA-ADRIW-YQLDPKFITSI-AAYARY-IMIGVLVGV-ADRIW-YLSGADLNL-AAYARY-CGIQNSVSA-AAYARY-LLLLTVLTV-ADRIW-QYIKANSKFIGITEL-ANIY-SIINFEKL-ARY-SASFDGWATVSVIAL- ARY-SERVRTYWIIIELKHKARE-ARY-IQNDTGFYTLHVIKSDLVNEE recombinant plasmid pCI-UB-POLYEPI contains a CMV enhancer (5251-5910 bp), CMV promoter (5919-6001), T7 promoter (6317n.p. 1bp. 229), also contains unique restriction sites EcoRI (233), XbaI (891), NotI (908), BamHI (3164), NdeI (5638), SacI (5980), XhoI (6342) .2. A method for generating antigen-specific antitumor cytotoxic cells, which consists in co-culturing mononuclear cells (MNCs) of peripheral blood of patients with colorectal cancer with dendritic cells (DCs) activated by tumor antigens, characterized in that mature DCs obtained by adding proinflammatory DCs to immature DC are used for cultivation TNF-α cytokine activated by transfection of pCI-UB-POLYEPI recombinant plasmid DNA therein as claimed in claim 1.
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RU2012119658/10A RU2507265C2 (en) | 2012-05-12 | 2012-05-12 | RECOMBINANT PLASMID DNA pCI-UB-POLYEPI CONTAINING EPITOPES OF TUMOUR-ASSOCIATED ANTIGENS FOR COLORECTAL CANCER AND METHOD OF ITS APPLICATION FOR STIMULATION OF SPECIFIC ANTITUMOUR IMMUNE RESPONSE AGAINST COLORECTAL CANCER CELLS |
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RU2012119658/10A RU2507265C2 (en) | 2012-05-12 | 2012-05-12 | RECOMBINANT PLASMID DNA pCI-UB-POLYEPI CONTAINING EPITOPES OF TUMOUR-ASSOCIATED ANTIGENS FOR COLORECTAL CANCER AND METHOD OF ITS APPLICATION FOR STIMULATION OF SPECIFIC ANTITUMOUR IMMUNE RESPONSE AGAINST COLORECTAL CANCER CELLS |
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RU2725493C2 (en) * | 2018-12-28 | 2020-07-02 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | System for stable expression of tumor-associated antigens based on lentiviral vector |
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RU2684235C2 (en) * | 2016-11-29 | 2019-04-04 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фундаментальной и клинической иммунологии" (НИИФКИ) | Polyepitope anti-tumour vaccine structure containing epitopes of tumor-associated antigens, pharmaceutical composition and its application for stimulating specific anti-tumor immune response |
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ITRM20050064A1 (en) * | 2005-02-16 | 2006-08-17 | Univ Siena | POLIEPITOPIC PEPTIDE DERIVED FROM TIMIDILATO SINTETASI WITH IMMUNOLOGICAL AND ANTITUMORAL ACTIVITY AND RELATIVE PHARMACEUTICAL COMPOSITIONS. |
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Publication number | Priority date | Publication date | Assignee | Title |
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RU2725493C2 (en) * | 2018-12-28 | 2020-07-02 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | System for stable expression of tumor-associated antigens based on lentiviral vector |
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