RU2012104984A - METHOD FOR PHARMACOLOGICAL CORRECTION OF SKELETAL ISCHEMIA ISCHEMIA SILDENAFIL, INCLUDING L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY - Google Patents
METHOD FOR PHARMACOLOGICAL CORRECTION OF SKELETAL ISCHEMIA ISCHEMIA SILDENAFIL, INCLUDING L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY Download PDFInfo
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- RU2012104984A RU2012104984A RU2012104984/14A RU2012104984A RU2012104984A RU 2012104984 A RU2012104984 A RU 2012104984A RU 2012104984/14 A RU2012104984/14 A RU 2012104984/14A RU 2012104984 A RU2012104984 A RU 2012104984A RU 2012104984 A RU2012104984 A RU 2012104984A
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- ischemia
- sildenafil
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- nitric oxide
- oxide deficiency
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Abstract
Способ фармакологической коррекции ишемии скелетной мышцы силденафилом, в том числе при L-NAME-индуцированном дефиците оксида азота, отличающийся тем, что коррекцию ишемии скелетной мышцы, в том числе при моделировании дефицита оксида азота внутрибрюшинным введением лабораторному животному в течение 7 суток блокатора синтеза оксида азота N-нитро-L-аргинин метилового эфира в дозе 25 мг/кг ежедневно, осуществляют путем внутрибрюшинного введения силденафила в дозе 2,2 мг/кг на первые, третьи и пятые сутки эксперимента.A method for the pharmacological correction of skeletal muscle ischemia with sildenafil, including with L-NAME-induced nitric oxide deficiency, characterized in that the correction of skeletal muscle ischemia, including with modeling nitric oxide deficiency, by an intraperitoneal administration of a nitric oxide synthesis blocker to a laboratory animal for 7 days N-nitro-L-arginine methyl ester at a dose of 25 mg / kg daily, is carried out by intraperitoneal injection of sildenafil at a dose of 2.2 mg / kg on the first, third and fifth days of the experiment.
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RU2012104984/14A RU2497203C2 (en) | 2012-02-13 | 2012-02-13 | Method of pharmacological correction of sceletal muscle ischemia with silnedafil including in l-name induced nitrogen oxide deficiency |
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RU2012104984/14A RU2497203C2 (en) | 2012-02-13 | 2012-02-13 | Method of pharmacological correction of sceletal muscle ischemia with silnedafil including in l-name induced nitrogen oxide deficiency |
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RU2012104984A true RU2012104984A (en) | 2013-08-20 |
RU2497203C2 RU2497203C2 (en) | 2013-10-27 |
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RU2012104984/14A RU2497203C2 (en) | 2012-02-13 | 2012-02-13 | Method of pharmacological correction of sceletal muscle ischemia with silnedafil including in l-name induced nitrogen oxide deficiency |
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Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2547692C1 (en) * | 2014-02-13 | 2015-04-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Method for stimulating neoangiogenesis in ischemic skeletal muscle |
RU2618621C1 (en) * | 2016-03-22 | 2017-05-04 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный университет" | Method for skeletal muscle experimental ischemia pharmacological correction using sildenafil and pentoxifylline in combined therapy |
RU2618622C1 (en) * | 2016-03-22 | 2017-05-04 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный университет" | Method for skeletal muscle experimental ischemia pharmacological correction using vardenafil and pentoxifylline in combined therapy |
RU2618620C1 (en) * | 2016-03-22 | 2017-05-04 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный университет" | Method for skeletal muscle experimental ischemia pharmacological correction using tadalafil and pentoxifylline in combined therapy |
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US20030105108A1 (en) * | 2002-12-19 | 2003-06-05 | Wood Ralph E. | Method of treating peripheral vascular diseases, peripheral neuropathies, and autonomic neuropathies |
ATE445402T1 (en) * | 2004-03-05 | 2009-10-15 | Nycomed Gmbh | NEW USE OF PDE5 INHIBITORS |
DE102004038328A1 (en) * | 2004-08-06 | 2006-03-16 | Bayer Healthcare Ag | New uses of 2-phenyl-substituted imidazotriazinone derivatives |
EP2107556A1 (en) * | 2008-04-04 | 2009-10-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Audio transform coding using pitch correction |
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Effective date: 20140214 |