RU2011112684A - AGENT FACILITATING HAIR GROWTH CONTAINING AN ACTIVE INGREDIENT Derivative 15,15-DIFFOROPROSTAGLANDINE F2α - Google Patents
AGENT FACILITATING HAIR GROWTH CONTAINING AN ACTIVE INGREDIENT Derivative 15,15-DIFFOROPROSTAGLANDINE F2α Download PDFInfo
- Publication number
- RU2011112684A RU2011112684A RU2011112684/15A RU2011112684A RU2011112684A RU 2011112684 A RU2011112684 A RU 2011112684A RU 2011112684/15 A RU2011112684/15 A RU 2011112684/15A RU 2011112684 A RU2011112684 A RU 2011112684A RU 2011112684 A RU2011112684 A RU 2011112684A
- Authority
- RU
- Russia
- Prior art keywords
- group
- agent
- hair growth
- derivative
- general formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Abstract
1. Агент, способствующий росту волос, содержащий в качестве активного ингредиента по меньшей мере одно производное 15,15-дифторпростагландина F2α. ! 2. Агент, способствующий росту волос, по п.1, в котором производное 15,15-дифторпростагландина F2α является соединением, представленным общей формулой (1), или его солью: ! ! где R представляет гидроксиалкильную группу, формильную группу, карбоксигруппу, алкоксикарбонильную группу, арилоксикарбонильную группу, аминокарбонильную группу, алкиламинокарбонильную группу или ариламинокарбонильную группу; причем когда R является арилоксикарбонильной группой или ариламинокарбонильной группой, в его арильном радикале может быть заместитель; в бензольном кольце от одного до трех атомов или групп выбирают из атома галогена и трифторметильной группы в качестве заместителей. ! 3. Агент, способствующий росту волос, по п.2, в котором в общей формуле (1) R является карбоксигруппой или ее сопряженным основанием (карбоксилат анионом) или алкоксикарбонильной группой. ! 4. Агент, способствующий росту волос, по п.3, в котором в общей формуле (1) R является карбоксигруппой или ее сопряженным основанием (карбоксилат анионом) или изопропилоксикарбонильной группой. ! 5. Агент, способствующий росту волос, по любому из пп.1-4, в котором волосы являются ресницами. ! 6. Способ профилактики или лечения заболеваний, затрагивающих волосы, включающий введение в организм пациента фармакологически приемлемого количества по меньшей мере одного производного 15,15-дифторпростагландина F2α. ! 7. Способ профилактики или лечения заболеваний, затрагивающих волосы, по п.6, в котором производное 15,15-дифторпростагландина F2 1. An agent that promotes hair growth, containing as an active ingredient at least one derivative of 15,15-difluoroprostaglandin F2α. ! 2. An agent that promotes hair growth, according to claim 1, in which the derivative of 15,15-difluoroprostaglandin F2α is a compound represented by general formula (1), or a salt thereof:! ! where R represents a hydroxyalkyl group, a formyl group, a carboxy group, an alkoxycarbonyl group, an aryloxycarbonyl group, an aminocarbonyl group, an alkylaminocarbonyl group or an arylaminocarbonyl group; wherein when R is an aryloxycarbonyl group or an arylaminocarbonyl group, there may be a substituent in its aryl radical; in the benzene ring, one to three atoms or groups are selected from the halogen atom and the trifluoromethyl group as substituents. ! 3. An agent that promotes hair growth, according to claim 2, in which, in the general formula (1), R is a carboxy group or its conjugate base (carboxylate anion) or an alkoxycarbonyl group. ! 4. An agent that promotes hair growth, according to claim 3, in which, in the general formula (1), R is a carboxy group or its conjugate base (carboxylate anion) or an isopropyloxycarbonyl group. ! 5. An agent that promotes hair growth, according to any one of claims 1 to 4, in which the hair is eyelashes. ! 6. A method for the prevention or treatment of diseases affecting the hair, comprising introducing into the patient's body a pharmacologically acceptable amount of at least one derivative of 15,15-difluoroprostaglandin F2α. ! 7. A method for the prevention or treatment of diseases affecting the hair according to claim 6, in which the derivative of 15,15-difluoroprostaglandin F2
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008-227066 | 2008-09-04 | ||
JP2008227066 | 2008-09-04 | ||
PCT/JP2009/065462 WO2010027040A1 (en) | 2008-09-04 | 2009-09-04 | HAIR GROWTH PROMOTING AGENT CONTAINING 15,15-DIFLUOROPROSTAGLANDIN F2α DERIVATIVE AS ACTIVE INGREDIENT |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2011112684A true RU2011112684A (en) | 2012-10-10 |
RU2504380C2 RU2504380C2 (en) | 2014-01-20 |
Family
ID=41797206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2011112684/15A RU2504380C2 (en) | 2008-09-04 | 2009-09-04 | AGENT PROMOTING HAIR GROWTH CONTAINING 15, 15-DIFLUOROPROSTAGLAN F2α DERIVATIVE AS ACTIVE INGREDIENT |
Country Status (12)
Country | Link |
---|---|
US (1) | US9089720B2 (en) |
EP (1) | EP2338496A4 (en) |
JP (1) | JP5645381B2 (en) |
KR (1) | KR101628415B1 (en) |
CN (1) | CN102143753B (en) |
AU (1) | AU2009287650B2 (en) |
BR (1) | BRPI0918244A2 (en) |
CA (1) | CA2735825C (en) |
MX (1) | MX2011002383A (en) |
RU (1) | RU2504380C2 (en) |
SG (1) | SG193840A1 (en) |
WO (1) | WO2010027040A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
JP2013534222A (en) * | 2010-08-02 | 2013-09-02 | ファーマ パテント ホールディング インコーポレイテッド | Compositions, methods and kits for enhancing hair |
ES2616089T3 (en) * | 2010-09-21 | 2017-06-09 | S & V Technologies Gmbh | Cosmetic composition |
EP2719383A4 (en) * | 2011-06-08 | 2014-12-17 | Sk Chemicals Co Ltd | Composition for eyelash growth |
US8426471B1 (en) * | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
DE202012003193U1 (en) | 2012-03-29 | 2012-04-30 | S & V Technologies Ag | Cosmetic composition containing tafluprost, cyclodextrin and hyaluronic acid |
JPWO2013180229A1 (en) * | 2012-05-30 | 2016-01-21 | 参天製薬株式会社 | Hair growth composition |
EP3442497B8 (en) | 2015-08-21 | 2021-08-18 | a Novation cosmetics GmbH | Active combinations, compositions and methods for enhancing hair growth |
JP6188837B2 (en) * | 2016-01-29 | 2017-08-30 | エーシー パテント ホールディング インコーポレイテッド | Non-therapeutic hair curl method |
CN111840225B (en) * | 2020-08-12 | 2021-09-14 | 陈丽娜 | Eye drop for treating glaucoma and preparation method thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9303444D0 (en) * | 1993-10-20 | 1993-10-20 | Kabi Pharmacia Ab | New use of prostaglandins |
US5689189A (en) | 1996-04-26 | 1997-11-18 | Picker International, Inc. | Technique for designing distributed radio frequency coils and distributed radio frequency coils designed thereby |
JP3850926B2 (en) | 1996-07-29 | 2006-11-29 | Smc株式会社 | Pilot type switching valve |
JPH10259179A (en) | 1996-09-19 | 1998-09-29 | Santen Pharmaceut Co Ltd | Prostaglandins having multi-substituted aryloxy groups and their use |
JP3480549B2 (en) | 1996-12-26 | 2003-12-22 | 参天製薬株式会社 | Difluoroprostaglandin derivatives and uses thereof |
WO1998033497A1 (en) * | 1997-02-04 | 1998-08-06 | Johnstone Murray A | Method of enhancing hair growth |
JP2000080075A (en) * | 1998-06-25 | 2000-03-21 | Asahi Glass Co Ltd | 15-deoxy-15,15-difluoroprostaglandin derivative, and its salt |
JP2001074315A (en) | 1999-09-01 | 2001-03-23 | Sekisui Chem Co Ltd | Heating system utilizing solar heat |
US7166730B2 (en) * | 2000-01-27 | 2007-01-23 | Fine Tech Laboratories, Ltd | Process for the preparation of prostaglandin derivatives |
JP2003527430A (en) * | 2000-03-24 | 2003-09-16 | スカンポ・アクチェンゲゼルシャフト | Apoptosis inhibitor containing 15-ketoprostaglandin or a derivative thereof |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
JP2002293771A (en) * | 2001-03-30 | 2002-10-09 | Asahi Glass Co Ltd | New ether-type difluoroprostaglandin derivative or its salt |
US7351404B2 (en) * | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
JP2003321442A (en) | 2002-04-24 | 2003-11-11 | Santen Pharmaceut Co Ltd | New difluoroprostaglandin amide derivative |
US20040115234A1 (en) * | 2002-09-24 | 2004-06-17 | Gewirtz Joan T. | Cosmetic composition |
DE602004017477D1 (en) * | 2004-11-09 | 2008-12-11 | Novagali Pharma Sa | Oil-in-water emulsion with low concentration of cationic agent and positive zeta potential |
JP2006187602A (en) * | 2004-12-09 | 2006-07-20 | Santen Pharmaceut Co Ltd | Product containing prostaglandin having fluorine atom in molecule |
JP5100025B2 (en) * | 2005-03-31 | 2012-12-19 | 旭硝子株式会社 | Retinal nerve cell protective agent containing prostaglandin F2α derivative as an active ingredient |
DK1864666T3 (en) | 2005-03-31 | 2012-10-29 | Asahi Glass Co Ltd | Protective agent for a retinal neuronal cell containing prostaglandin F2 alpha derivative as active ingredient |
US20070254920A1 (en) | 2006-04-26 | 2007-11-01 | Aerie Pharmaceuticals, Inc. | Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use |
US7964595B2 (en) | 2008-01-18 | 2011-06-21 | Allergan, Inc. | Thiophenyl prostaglandin derivatives for treating glaucoma and ocular hypertension |
-
2009
- 2009-09-04 KR KR1020117005007A patent/KR101628415B1/en active IP Right Grant
- 2009-09-04 AU AU2009287650A patent/AU2009287650B2/en not_active Ceased
- 2009-09-04 US US13/061,690 patent/US9089720B2/en not_active Expired - Fee Related
- 2009-09-04 SG SG2013065636A patent/SG193840A1/en unknown
- 2009-09-04 WO PCT/JP2009/065462 patent/WO2010027040A1/en active Application Filing
- 2009-09-04 MX MX2011002383A patent/MX2011002383A/en active IP Right Grant
- 2009-09-04 RU RU2011112684/15A patent/RU2504380C2/en not_active IP Right Cessation
- 2009-09-04 EP EP09811565.2A patent/EP2338496A4/en not_active Withdrawn
- 2009-09-04 CN CN2009801346485A patent/CN102143753B/en not_active Expired - Fee Related
- 2009-09-04 BR BRPI0918244A patent/BRPI0918244A2/en not_active Application Discontinuation
- 2009-09-04 CA CA2735825A patent/CA2735825C/en not_active Expired - Fee Related
- 2009-09-04 JP JP2009204174A patent/JP5645381B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2338496A1 (en) | 2011-06-29 |
CA2735825C (en) | 2016-06-21 |
CA2735825A1 (en) | 2010-03-11 |
RU2504380C2 (en) | 2014-01-20 |
AU2009287650A1 (en) | 2010-03-11 |
CN102143753A (en) | 2011-08-03 |
KR101628415B1 (en) | 2016-06-08 |
JP5645381B2 (en) | 2014-12-24 |
AU2009287650B2 (en) | 2014-11-13 |
KR20110050657A (en) | 2011-05-16 |
SG193840A1 (en) | 2013-10-30 |
CN102143753B (en) | 2013-07-03 |
AU2009287650A8 (en) | 2014-11-20 |
BRPI0918244A2 (en) | 2015-12-15 |
MX2011002383A (en) | 2011-04-07 |
US20110152373A1 (en) | 2011-06-23 |
WO2010027040A1 (en) | 2010-03-11 |
JP2010083877A (en) | 2010-04-15 |
US9089720B2 (en) | 2015-07-28 |
EP2338496A4 (en) | 2014-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2011112684A (en) | AGENT FACILITATING HAIR GROWTH CONTAINING AN ACTIVE INGREDIENT Derivative 15,15-DIFFOROPROSTAGLANDINE F2α | |
ATE517882T1 (en) | QUINOLINE DERIVATIVES | |
EA201001669A1 (en) | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | |
EP1857457A3 (en) | Benzimidazole derivative and its use as AII receptor antagonist | |
EA200870193A1 (en) | CYTOTOXIC AGENTS, INCLUDING NEW TOMAMYCIN DERIVATIVES, AND THEIR THERAPEUTIC APPLICATION | |
RU2010144637A (en) | SUBSTITUTED GAMMA-LACTAMS AS THERAPEUTIC AGENTS | |
WO2009063202A3 (en) | Use of crth2 antagonist compounds | |
EA201391263A1 (en) | COMBINED THERAPIES OF HEMATOLOGICAL TUMORS | |
TW200616979A (en) | Non-nucleoside reverse transcriptase inhibitors | |
TR201802944T4 (en) | DERIVATIVES OF AZAINDAZOL OR DIAZAINDAZOL | |
EA201101671A1 (en) | SUBSTITUTED DERIVATIVES OF AMINOPROPIONIC ACID AS NEPRILISIN INHIBITORS | |
EA200970535A1 (en) | ANTIBACTERIAL DERIVATIVES OF QUINOLINE | |
EA201101672A1 (en) | SUBSTITUTED DERIVATIVES OF AMINOISAL ACID AS NEPRILISIN INHIBITORS | |
DE602006006712D1 (en) | THIAZOLYLPIPERIDINE DERIVATIVES USE AS H3 RECEPTOR MODULATORS | |
SE0401971D0 (en) | Piperidne derivatives | |
EA200501820A1 (en) | THERAPEUTIC TOOLS FOR THE TREATMENT OF PAIN | |
RU2011138962A (en) | 4-ISOPROPYLPHENYL GLUCITITE DERIVATIVES AS SGLT1 INHIBITORS | |
TW200700069A (en) | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives | |
MX2009011601A (en) | Therapeutic agents useful for treating pain. | |
DE602008001725D1 (en) | 1- (1-BENZYLPIPERIDIN-4-YL) BENZIMIDAZOLE-5-CARBOXYLENE DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | |
TW200740827A (en) | Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives | |
RU2009144538A (en) | NEW CYCLIC PEPTIDE COMPOUNDS | |
RU2013141559A (en) | METHOD FOR INHIBITING HAMARTOMA TUMOR CELL CELLS | |
ATE449776T1 (en) | PYRROLOÄ2,3-CÜPYRIDINE DERIVATIVES | |
TW200716547A (en) | Piperidin-4-yl-amide derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD4A | Correction of name of patent owner | ||
MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20200905 |