RU2010143359A - METHOD FOR DIFFERENTIAL DIAGNOSTICS OF SKIN DISEASES - Google Patents
METHOD FOR DIFFERENTIAL DIAGNOSTICS OF SKIN DISEASES Download PDFInfo
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- RU2010143359A RU2010143359A RU2010143359/15A RU2010143359A RU2010143359A RU 2010143359 A RU2010143359 A RU 2010143359A RU 2010143359/15 A RU2010143359/15 A RU 2010143359/15A RU 2010143359 A RU2010143359 A RU 2010143359A RU 2010143359 A RU2010143359 A RU 2010143359A
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Abstract
Способ дифференциальной диагностики заболеваний кожи, включающий анализ взятого у больного биологического материала из очага поражения, определение планиметрических характеристик ядер лимфоцитов, их оценку и выставление диагноза на их основании, отличающийся тем, что анализ проводят путем компьютерной морфометрии, в качестве биологического материала используют ядра лимфоцитов дермы в гистологическом срезе кожи, дополнительно определяют удельную плотность ядер лимфоцитов на единицу площади имиджа среза, периметр и усредненный диаметр ядра, фактор формы и при удельной средней плотности ядер лимфоцитов на единицу площади более 0,0141±0,0016 (ДИ 0,01301; 0,01932), средней площади ядер более 13,661±0,0802 (ДИ 12,912; 14,9934), среднего периметра ядер более 15,05±0,089 (ДИ 14,5178; 17,2189), среднего диаметра Фере более 4,59±0,014 (ДИ 4,48790; 4,9745), среднего значения фактора формы менее 0,8452±0,005 (ДИ 0,8311; 0,8423) диагностируют грибовидный микоз, а при отсутствии у диагностируемого больного указанных векторов изменений параметров и присутствия статистически значимых различий менее 0,05 по сравнению с цифровыми значениями параметров грибовидного микоза диагностируют хронический доброкачественный дерматоз. A method for differential diagnosis of skin diseases, including analysis of biological material taken from a patient from the lesion site, determination of the planimetric characteristics of lymphocyte nuclei, their assessment and diagnosis based on them, characterized in that the analysis is carried out by computer morphometry, using the derma lymphocyte nuclei as biological material in the histological section of the skin, additionally determine the specific density of the nuclei of lymphocytes per unit area of the image of the section, perimeter and average diameter nuclear core, shape factor and at a specific average density of lymphocyte nuclei per unit area of more than 0.0141 ± 0.0016 (CI 0.01301; 0.01932), average area of nuclei more than 13.661 ± 0.0802 (CI 12.912; 14.9934 ), the average perimeter of nuclei is more than 15.05 ± 0.089 (CI 14.5178; 17.2189), the average diameter of Fere is more than 4.59 ± 0.014 (CI 4.48790; 4.9745), the average value of the form factor is less than 0.8452 ± 0.005 (CI 0.8311; 0.8423), fungal mycosis is diagnosed, and in the absence of the indicated vectors of parameter changes and the presence of statistically significant differences less than 0.05 in comparison with the numerical values of the pairs meters of fungal mycosis are diagnosed with chronic benign dermatosis.
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RU2010143359/15A RU2466398C2 (en) | 2010-10-22 | 2010-10-22 | Differential diagnostic technique for skin diseases |
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RU2010143359/15A RU2466398C2 (en) | 2010-10-22 | 2010-10-22 | Differential diagnostic technique for skin diseases |
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RU2010143359A true RU2010143359A (en) | 2012-04-27 |
RU2466398C2 RU2466398C2 (en) | 2012-11-10 |
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RU2010143359/15A RU2466398C2 (en) | 2010-10-22 | 2010-10-22 | Differential diagnostic technique for skin diseases |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2498301C1 (en) * | 2012-09-10 | 2013-11-10 | Эльмира Фанисовна Гарифуллина | Differential diagnostic technique for sezary's syndrome and erythroderma accompanying benign inflammatory dermatoses as shown by morphometric profile of antigen-presenting cells |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2526180C1 (en) * | 2013-08-14 | 2014-08-20 | Эльмира Фанисовна Гарифуллина | Method of differential morphometric diagnostics of erythrodermal form of mycosis fungoides and syndrome of skin pseudolymphoma by relative volume of epidermis and mitotic index of epidermal cells |
RU2612007C2 (en) * | 2014-12-26 | 2017-03-01 | федеральное государственное автономное образовательное учреждение высшего профессионального образования "Национальный исследовательский ядерный университет МИФИ" (НИЯУ МИФИ) | Method for automated blood cells analysis through leukocytes description based on optical features of nuclei structures |
RU2687274C1 (en) * | 2018-07-05 | 2019-05-13 | государственное бюджетное учреждение Свердловской области "Уральский научно-исследовательский институт дерматовенерологии и иммунопатологии" | Method for differential diagnosis of fungous mycosis from chronic dermatoses |
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RU2104526C1 (en) * | 1995-05-05 | 1998-02-10 | Эммануил Маркович Коган | Method for diagnosing t-cellular lymphomae of skin |
RU2286570C2 (en) * | 2004-08-30 | 2006-10-27 | Николай Васильевич Кунгуров | Differential diagnosis method for diagnosing erythrodermic malignant t-cell skin lymphoma and other erythrodermatitis cases |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2498301C1 (en) * | 2012-09-10 | 2013-11-10 | Эльмира Фанисовна Гарифуллина | Differential diagnostic technique for sezary's syndrome and erythroderma accompanying benign inflammatory dermatoses as shown by morphometric profile of antigen-presenting cells |
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RU2466398C2 (en) | 2012-11-10 |
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