RU2010142632A - METHOD FOR CORRECTION OF HYPERHOMOCYSTEINE INDUCED NITROGEN OXIDE DEFICIENCY L-NORVALINE IN EXCEPTION - Google Patents
METHOD FOR CORRECTION OF HYPERHOMOCYSTEINE INDUCED NITROGEN OXIDE DEFICIENCY L-NORVALINE IN EXCEPTION Download PDFInfo
- Publication number
- RU2010142632A RU2010142632A RU2010142632/14A RU2010142632A RU2010142632A RU 2010142632 A RU2010142632 A RU 2010142632A RU 2010142632/14 A RU2010142632/14 A RU 2010142632/14A RU 2010142632 A RU2010142632 A RU 2010142632A RU 2010142632 A RU2010142632 A RU 2010142632A
- Authority
- RU
- Russia
- Prior art keywords
- norvaline
- deficiency
- hyperhomocysteine
- correction
- oxide deficiency
- Prior art date
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- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract 11
- 230000007812 deficiency Effects 0.000 title claims abstract 7
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 title claims abstract 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract 4
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims abstract 4
- 210000003038 endothelium Anatomy 0.000 claims abstract 4
- 229930182817 methionine Natural products 0.000 claims abstract 4
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims abstract 2
- 241000700157 Rattus norvegicus Species 0.000 claims abstract 2
- 150000001413 amino acids Chemical class 0.000 claims abstract 2
- 230000001419 dependent effect Effects 0.000 claims abstract 2
- 238000002474 experimental method Methods 0.000 claims abstract 2
- 230000024883 vasodilation Effects 0.000 claims abstract 2
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Способ коррекции гипергомоцистеин индуцированного дефицита оксида азота L-норвалином в эксперименте, отличающийся тем, что белым крысам-самцам линии Wistar с дефицитом оксида азота, моделируемым внутрижелудочным введением аминокислоты метионин в дозе 3 г/кг ежедневно, в течение 7 сут, оценивая степень развития дефицита по отношению показателей эндотелийнезависимой и эндотелийзависимой вазодилатации и повышению концентрации гомоцистеина, внутрижелудочно, через 1 ч после введения метионина, вводят L-норвалин в дозе 10 мг/кг один раз в день, в течение 7 сут. A method for the correction of hyperhomocysteine induced nitric oxide deficiency L-norvaline in an experiment, characterized in that white male Wistar rats with nitric oxide deficiency modeled by intragastric administration of the amino acid methionine at a dose of 3 g / kg daily for 7 days, assessing the degree of development of the deficiency in relation to the indices of endothelium-independent and endothelium-dependent vasodilation and an increase in the concentration of homocysteine, L-norvaline is administered intragastrically, 1 hour after methionine administration, once a day, in echenie 7 days.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010142632/14A RU2453001C1 (en) | 2010-10-18 | 2010-10-18 | Method for l-norvaline correction of hyperhomocystein induced nitrogen oxide deficiency in experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010142632/14A RU2453001C1 (en) | 2010-10-18 | 2010-10-18 | Method for l-norvaline correction of hyperhomocystein induced nitrogen oxide deficiency in experiment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010142632A true RU2010142632A (en) | 2012-04-27 |
| RU2453001C1 RU2453001C1 (en) | 2012-06-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010142632/14A RU2453001C1 (en) | 2010-10-18 | 2010-10-18 | Method for l-norvaline correction of hyperhomocystein induced nitrogen oxide deficiency in experiment |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2453001C1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995022968A1 (en) * | 1994-02-25 | 1995-08-31 | Chugai Seiyaku Kabushiki Kaisha | δ-(S-METHYLISOTHIOUREIDO)-L-NORVALINE AND CEREBROVASCULAR DISORDER REMEDY HAVING NITROGEN MONOXIDE SYNTHASE INHIBITOR ACTIVITY |
| FI107808B (en) * | 1999-08-31 | 2001-10-15 | Biohit Oyj | Procedure for identifying an individual at risk for blood vessel and cancer disease |
| RU2287327C2 (en) * | 2003-10-16 | 2006-11-20 | Юрий Антонович Кошелев | Preparation for treating and preventing atherosclerosis |
| RU2401138C1 (en) * | 2009-07-20 | 2010-10-10 | Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Федерального агентства по здравоохранению и социальному развитию | Method of treating patients with stable exertional angina |
-
2010
- 2010-10-18 RU RU2010142632/14A patent/RU2453001C1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2453001C1 (en) | 2012-06-10 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20121019 |