RU2010130899A - METHOD FOR PRODUCING NEOSTIGMINE METHYL SULPHATE AND NEOSTIGMINE IODIDE - Google Patents
METHOD FOR PRODUCING NEOSTIGMINE METHYL SULPHATE AND NEOSTIGMINE IODIDE Download PDFInfo
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- RU2010130899A RU2010130899A RU2010130899/04A RU2010130899A RU2010130899A RU 2010130899 A RU2010130899 A RU 2010130899A RU 2010130899/04 A RU2010130899/04 A RU 2010130899/04A RU 2010130899 A RU2010130899 A RU 2010130899A RU 2010130899 A RU2010130899 A RU 2010130899A
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- neostigmine
- sodium
- iodide
- producing
- dimethylaminophenolate
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Abstract
Способ получения неостигмина йодида и неостигмина метилсульфата, включающий получение 3-диметиламинофенолята натрия, последующее его взаимодействие с хлорангидридом диметилкарбомаиловой кислоты и взаимодействие полученного 3-((диметилкарбомоилокси)фенил)-диметиламина с соответствующим алкилирующим агентом (йодметан, диметилсульфат), отличающийся тем, что получение 3-диметиламинофенолята натрия проводят взаимодействием 3-диметиламинофенола с металлическим натрием в среде толуола при температуре кипения растворителя, 3-((диметилкарбомоилокси)фенил)-диметиламин используют на следующей стадии без выделения и целевой продукт получают в среде диэтилового эфира. A method of producing neostigmine iodide and neostigmine methyl sulfate, including the preparation of sodium 3-dimethylaminophenolate, its subsequent interaction with dimethylcarbomoyloic acid chloride and the interaction of the obtained 3 - ((dimethylcarbomoyloxy) phenyl) dimethylamine with an appropriate alkylating agent (iodomethane, which is dimethyl Sodium 3-dimethylaminophenolate is carried out by reacting 3-dimethylaminophenol with metallic sodium in toluene at a boiling point of the solvent, 3 - ((dimethylcarb omoyloxy) phenyl) dimethylamine is used in the next step without isolation and the desired product is obtained in diethyl ether.
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RU2010130899/04A RU2458050C2 (en) | 2010-07-23 | 2010-07-23 | Method for preparing methylulphate neostigmine and iodide neostigmine |
Applications Claiming Priority (1)
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RU2010130899/04A RU2458050C2 (en) | 2010-07-23 | 2010-07-23 | Method for preparing methylulphate neostigmine and iodide neostigmine |
Publications (2)
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RU2010130899A true RU2010130899A (en) | 2012-01-27 |
RU2458050C2 RU2458050C2 (en) | 2012-08-10 |
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RU2010130899/04A RU2458050C2 (en) | 2010-07-23 | 2010-07-23 | Method for preparing methylulphate neostigmine and iodide neostigmine |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11389420B2 (en) | 2017-07-25 | 2022-07-19 | Das-Mg, Inc. | Pharmaceutical compositions and methods utilizing neostigmine and an NK-1 antagonist for treating myasthenia gravis |
CN115353465A (en) * | 2022-10-24 | 2022-11-18 | 云南先施药业有限公司 | Synthesis method of neostigmine methylsulfate |
CN115353466A (en) * | 2022-10-24 | 2022-11-18 | 云南先施药业有限公司 | Preparation and purification method of neostigmine methosulfate |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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GB342237A (en) * | 1930-05-30 | 1931-01-29 | Hoffmann La Roche | Process for the manufacture of products for destroying animals |
US1905990A (en) * | 1931-01-02 | 1933-04-25 | Hoffmann La Roche | Disubstituted carbamic acid esters of phenols containing a basic constituent |
CH208883A (en) * | 1937-04-24 | 1940-02-29 | Hoffmann La Roche | Process for the preparation of the dimethylcarbamic acid ester of m-dimethylaminophenol. |
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2010
- 2010-07-23 RU RU2010130899/04A patent/RU2458050C2/en not_active IP Right Cessation
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11389420B2 (en) | 2017-07-25 | 2022-07-19 | Das-Mg, Inc. | Pharmaceutical compositions and methods utilizing neostigmine and an NK-1 antagonist for treating myasthenia gravis |
CN115353465A (en) * | 2022-10-24 | 2022-11-18 | 云南先施药业有限公司 | Synthesis method of neostigmine methylsulfate |
CN115353466A (en) * | 2022-10-24 | 2022-11-18 | 云南先施药业有限公司 | Preparation and purification method of neostigmine methosulfate |
CN116082193A (en) * | 2022-10-24 | 2023-05-09 | 云南先施药业有限公司 | Preparation and purification method of neostigmine methosulfate |
CN115353466B (en) * | 2022-10-24 | 2023-08-01 | 云南先施药业有限公司 | Preparation and purification method of neostigmine methosulfate |
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RU2458050C2 (en) | 2012-08-10 |
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MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20120728 |