RU2010130899A - METHOD FOR PRODUCING NEOSTIGMINE METHYL SULPHATE AND NEOSTIGMINE IODIDE - Google Patents

METHOD FOR PRODUCING NEOSTIGMINE METHYL SULPHATE AND NEOSTIGMINE IODIDE Download PDF

Info

Publication number
RU2010130899A
RU2010130899A RU2010130899/04A RU2010130899A RU2010130899A RU 2010130899 A RU2010130899 A RU 2010130899A RU 2010130899/04 A RU2010130899/04 A RU 2010130899/04A RU 2010130899 A RU2010130899 A RU 2010130899A RU 2010130899 A RU2010130899 A RU 2010130899A
Authority
RU
Russia
Prior art keywords
neostigmine
sodium
iodide
producing
dimethylaminophenolate
Prior art date
Application number
RU2010130899/04A
Other languages
Russian (ru)
Other versions
RU2458050C2 (en
Inventor
Павел Викторович Ругаев (RU)
Павел Викторович Ругаев
Сергей Павлович Алтухов (RU)
Сергей Павлович Алтухов
Евгений Михайлович Дородных (RU)
Евгений Михайлович Дородных
Наталья Ивановна Кузнецова (RU)
Наталья Ивановна Кузнецова
Игорь Аликович Нельга (RU)
Игорь Аликович Нельга
Игорь Викторович Медвецкий (RU)
Игорь Викторович Медвецкий
Алексей Анатольевич Шевелев (RU)
Алексей Анатольевич Шевелев
Original Assignee
Федеральное Государственное Учреждение "33 Центральный Научно-Исследовательский Испытательный Институт Министерства Обороны Российск
Федеральное государственное учреждение "33 Центральный научно-исследовательский испытательный институт Министерства обороны Российской Федерации"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное Государственное Учреждение "33 Центральный Научно-Исследовательский Испытательный Институт Министерства Обороны Российск, Федеральное государственное учреждение "33 Центральный научно-исследовательский испытательный институт Министерства обороны Российской Федерации" filed Critical Федеральное Государственное Учреждение "33 Центральный Научно-Исследовательский Испытательный Институт Министерства Обороны Российск
Priority to RU2010130899/04A priority Critical patent/RU2458050C2/en
Publication of RU2010130899A publication Critical patent/RU2010130899A/en
Application granted granted Critical
Publication of RU2458050C2 publication Critical patent/RU2458050C2/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Способ получения неостигмина йодида и неостигмина метилсульфата, включающий получение 3-диметиламинофенолята натрия, последующее его взаимодействие с хлорангидридом диметилкарбомаиловой кислоты и взаимодействие полученного 3-((диметилкарбомоилокси)фенил)-диметиламина с соответствующим алкилирующим агентом (йодметан, диметилсульфат), отличающийся тем, что получение 3-диметиламинофенолята натрия проводят взаимодействием 3-диметиламинофенола с металлическим натрием в среде толуола при температуре кипения растворителя, 3-((диметилкарбомоилокси)фенил)-диметиламин используют на следующей стадии без выделения и целевой продукт получают в среде диэтилового эфира. A method of producing neostigmine iodide and neostigmine methyl sulfate, including the preparation of sodium 3-dimethylaminophenolate, its subsequent interaction with dimethylcarbomoyloic acid chloride and the interaction of the obtained 3 - ((dimethylcarbomoyloxy) phenyl) dimethylamine with an appropriate alkylating agent (iodomethane, which is dimethyl Sodium 3-dimethylaminophenolate is carried out by reacting 3-dimethylaminophenol with metallic sodium in toluene at a boiling point of the solvent, 3 - ((dimethylcarb omoyloxy) phenyl) dimethylamine is used in the next step without isolation and the desired product is obtained in diethyl ether.

Claims (1)

Способ получения неостигмина йодида и неостигмина метилсульфата, включающий получение 3-диметиламинофенолята натрия, последующее его взаимодействие с хлорангидридом диметилкарбомаиловой кислоты и взаимодействие полученного 3-((диметилкарбомоилокси)фенил)-диметиламина с соответствующим алкилирующим агентом (йодметан, диметилсульфат), отличающийся тем, что получение 3-диметиламинофенолята натрия проводят взаимодействием 3-диметиламинофенола с металлическим натрием в среде толуола при температуре кипения растворителя, 3-((диметилкарбомоилокси)фенил)-диметиламин используют на следующей стадии без выделения и целевой продукт получают в среде диэтилового эфира. A method of producing neostigmine iodide and neostigmine methyl sulfate, including the preparation of sodium 3-dimethylaminophenolate, its subsequent interaction with dimethylcarbomoyloic acid chloride and the interaction of the obtained 3 - ((dimethylcarbomoyloxy) phenyl) dimethylamine with an appropriate alkylating agent (iodomethane, which is dimethyl Sodium 3-dimethylaminophenolate is carried out by reacting 3-dimethylaminophenol with metallic sodium in toluene at a boiling point of the solvent, 3 - ((dimethylcarb omoyloxy) phenyl) dimethylamine is used in the next step without isolation and the desired product is obtained in diethyl ether.
RU2010130899/04A 2010-07-23 2010-07-23 Method for preparing methylulphate neostigmine and iodide neostigmine RU2458050C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2010130899/04A RU2458050C2 (en) 2010-07-23 2010-07-23 Method for preparing methylulphate neostigmine and iodide neostigmine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2010130899/04A RU2458050C2 (en) 2010-07-23 2010-07-23 Method for preparing methylulphate neostigmine and iodide neostigmine

Publications (2)

Publication Number Publication Date
RU2010130899A true RU2010130899A (en) 2012-01-27
RU2458050C2 RU2458050C2 (en) 2012-08-10

Family

ID=45786300

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2010130899/04A RU2458050C2 (en) 2010-07-23 2010-07-23 Method for preparing methylulphate neostigmine and iodide neostigmine

Country Status (1)

Country Link
RU (1) RU2458050C2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11389420B2 (en) 2017-07-25 2022-07-19 Das-Mg, Inc. Pharmaceutical compositions and methods utilizing neostigmine and an NK-1 antagonist for treating myasthenia gravis
CN115353465A (en) * 2022-10-24 2022-11-18 云南先施药业有限公司 Synthesis method of neostigmine methylsulfate
CN115353466A (en) * 2022-10-24 2022-11-18 云南先施药业有限公司 Preparation and purification method of neostigmine methosulfate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB342237A (en) * 1930-05-30 1931-01-29 Hoffmann La Roche Process for the manufacture of products for destroying animals
US1905990A (en) * 1931-01-02 1933-04-25 Hoffmann La Roche Disubstituted carbamic acid esters of phenols containing a basic constituent
CH208883A (en) * 1937-04-24 1940-02-29 Hoffmann La Roche Process for the preparation of the dimethylcarbamic acid ester of m-dimethylaminophenol.

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11389420B2 (en) 2017-07-25 2022-07-19 Das-Mg, Inc. Pharmaceutical compositions and methods utilizing neostigmine and an NK-1 antagonist for treating myasthenia gravis
CN115353465A (en) * 2022-10-24 2022-11-18 云南先施药业有限公司 Synthesis method of neostigmine methylsulfate
CN115353466A (en) * 2022-10-24 2022-11-18 云南先施药业有限公司 Preparation and purification method of neostigmine methosulfate
CN116082193A (en) * 2022-10-24 2023-05-09 云南先施药业有限公司 Preparation and purification method of neostigmine methosulfate
CN115353466B (en) * 2022-10-24 2023-08-01 云南先施药业有限公司 Preparation and purification method of neostigmine methosulfate

Also Published As

Publication number Publication date
RU2458050C2 (en) 2012-08-10

Similar Documents

Publication Publication Date Title
RU2012138259A (en) METHOD FOR OBTAINING RIVAROXABAN
MX2013011257A (en) Process for preparation of dronedarone by n-butylation.
JP2010095546A5 (en)
MY197904A (en) Method for producing substituted 5-fluoro-1h-pyrazolopyridines
MY182905A (en) Process for preparing a titanium-containing zeolitic material having an mww framework structure
MX2013003764A (en) Methods of making l-ornithine phenyl acetate.
JP2013532130A5 (en)
MX2014006992A (en) Malonic acid di-salts and a method for preparing malonyl dihalides.
NZ601805A (en) Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
CY1121055T1 (en) METHOD FOR THE MANUFACTURE OF CHARGED INTERCONNECTORS
PT2462098E (en) Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
TW201129535A (en) Alcoholic hydroxyl-containing compounds and making method
RU2010130899A (en) METHOD FOR PRODUCING NEOSTIGMINE METHYL SULPHATE AND NEOSTIGMINE IODIDE
EA201200820A1 (en) METHOD OF SYNTHESIS OF INTERMEDIATE PRODUCTS APPLICABLE FOR OBTAINING SUBSTITUTED INDAZOLES AND AZAINDAZOLES
UA108126C2 (en) A METHOD FOR OBTAINING THE Copolymer of Sodium Carboxymethylcellulose and Gosipol
MX337997B (en) New method for synthesising ivabradine and its added salts with a pharmaceutically acceptable acid.
DE602006014001D1 (en) Preparation of 2-aminothiazole-5-carboxylic acid derivatives
CY1117612T1 (en) A METHOD FOR THE PREPARATION OF THE DETERMINATED ESTE OF DY- (2-THYNYLYL) GLUCIC ACID, AN INTERMEDIATE UNION IN THE SYNTHESIS OF BROOM
MY170662A (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
FR2981068B1 (en) PROCESS FOR THE PREPARATION OF GLYCEROL DERIVATIVES, USE AND COMPOSITION COMPRISING SAID GLYCEROL DERIVATIVES
RU2011123582A (en) METHOD FOR PRODUCING 3- (o-, m-, p-METHOXYPHENYL) -TETRAHYDRO-2H-1, 5, 3-DIOXAZEPINES
JO3189B1 (en) Novel method for SYNTHESISING (2E)-3-(3,4-DIMETHOXYPHENYL)PROP-2-ENENITRILE, AND USE FOR SYNTHESISING IVABRADINE AND THE ADDED SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID
MX2013002656A (en) New process.
CL2012001528A1 (en) Process to prepare the crystalline form a of ilaprazole from an inorganic salt of ilaprazole and subsequent neutralization of the salt with an acid in a reaction solvent; and process for preparing the crystalline form b of ilaprazole into the crystalline form a of ilaprazole.
WO2011151442A3 (en) Process for producing aliskiren

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20120728