RU2008150065A - N- AND C-SUBSTITUTED TETREPEPTIDES WITH ANTIVIRAL ACTIVITY - Google Patents

N- AND C-SUBSTITUTED TETREPEPTIDES WITH ANTIVIRAL ACTIVITY Download PDF

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Publication number
RU2008150065A
RU2008150065A RU2008150065/04A RU2008150065A RU2008150065A RU 2008150065 A RU2008150065 A RU 2008150065A RU 2008150065/04 A RU2008150065/04 A RU 2008150065/04A RU 2008150065 A RU2008150065 A RU 2008150065A RU 2008150065 A RU2008150065 A RU 2008150065A
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RU
Russia
Prior art keywords
substituted
antiviral activity
tetrepeptides
glya2
glycine
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RU2008150065/04A
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Russian (ru)
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RU2402563C2 (en
Inventor
Людмила Сергеевна Королева (RU)
Людмила Сергеевна Королева
Валентин Викторович Власов (RU)
Валентин Викторович Власов
Елена Павловна Гончарова (RU)
Елена Павловна Гончарова
Марина Аркадьевна Зенкова (RU)
Марина Аркадьевна Зенкова
Николай Алексеевич Ковалев (RU)
Николай Алексеевич Ковалев
Михаил Павлович Ковпак (RU)
Михаил Павлович Ковпак
Владимир Николаевич Сильников (RU)
Владимир Николаевич Сильников
Николай Вячеславович Тамкович (RU)
Николай Вячеславович Тамкович
Original Assignee
Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) (RU)
Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН)
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Application filed by Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) (RU), Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) filed Critical Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) (RU)
Priority to RU2008150065/04A priority Critical patent/RU2402563C2/en
Publication of RU2008150065A publication Critical patent/RU2008150065A/en
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Publication of RU2402563C2 publication Critical patent/RU2402563C2/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

N- и С-замещенные тетрапептиды, общей формулы A1D-Glu-AK1-AK2-GlyA2 (соединения 1, 2 и 3), где A1D=1-тетрадецил-1,4-диазониабицикло[2.2.2]окт-4-ил для 1 и 2 и =Н для 3; АК1=глицин для 1 и β-аланин для 2 и 3; АК2=лизин для 1 и 3 и аргинин для 2; GlyA2=н-дециловый эфир глицина, обладающие противовирусной активностью. N- and C-substituted tetrapeptides of the general formula A1D-Glu-AK1-AK2-GlyA2 (compounds 1, 2 and 3), where A1D = 1-tetradecyl-1,4-diazoniabicyclo [2.2.2] oct-4-yl for 1 and 2 and = H for 3; AK1 = glycine for 1 and β-alanine for 2 and 3; AK2 = lysine for 1 and 3 and arginine for 2; GlyA2 = n-decyl ester of glycine with antiviral activity.

Claims (1)

N- и С-замещенные тетрапептиды, общей формулы A1D-Glu-AK1-AK2-GlyA2 (соединения 1, 2 и 3), где A1D=1-тетрадецил-1,4-диазониабицикло[2.2.2]окт-4-ил для 1 и 2 и =Н для 3; АК1=глицин для 1 и β-аланин для 2 и 3; АК2=лизин для 1 и 3 и аргинин для 2; GlyA2=н-дециловый эфир глицина, обладающие противовирусной активностью. N- and C-substituted tetrapeptides of the general formula A1D-Glu-AK1-AK2-GlyA2 (compounds 1, 2 and 3), where A1D = 1-tetradecyl-1,4-diazoniabicyclo [2.2.2] oct-4-yl for 1 and 2 and = H for 3; AK1 = glycine for 1 and β-alanine for 2 and 3; AK2 = lysine for 1 and 3 and arginine for 2; GlyA2 = n-decyl ester of glycine with antiviral activity.
RU2008150065/04A 2008-12-17 2008-12-17 Agent having antiviral activity RU2402563C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2008150065/04A RU2402563C2 (en) 2008-12-17 2008-12-17 Agent having antiviral activity

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Application Number Priority Date Filing Date Title
RU2008150065/04A RU2402563C2 (en) 2008-12-17 2008-12-17 Agent having antiviral activity

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RU2008150065A true RU2008150065A (en) 2010-06-27
RU2402563C2 RU2402563C2 (en) 2010-10-27

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RU2008150065/04A RU2402563C2 (en) 2008-12-17 2008-12-17 Agent having antiviral activity

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2480478C1 (en) * 2012-02-29 2013-04-27 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Agent for inactivating dna viruses

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Effective date: 20181218