RU2008109929A - METHOD FOR TREATING OR PREVENTING PHYSIOLOGICAL AND / OR PATHYPHYSIOLOGICAL CONDITIONS MEDIATED BY RECEPTORS STIMULATING GROWTH HORMONE SECRETION, TRIAZOLI-ITSOPHYZEMIUM FILM - Google Patents

Abstract

1. The use of a method for the treatment or prevention of physiological and/or pathophysiological conditions mediated by receptors that stimulate the secretion of growth hormone (SSHR receptors) and selected from the group including short-term, medium-term and/or long-term regulation of energy balance; short-term, medium-term and/or long-term regulation (stimulation and/or inhibition) of food intake; adipogenesis, obesity and/or obesity; increase and/or decrease in body weight in mammals, in which the compound covered by the general structural formula (I) is used in the preparation of a medicinal product: ! ! where ! R1 and R2 are independently selected from the group consisting of a hydrogen atom, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and/or heterocyclylalkyl may contain up to 3 substituents independently selected from the group consisting of halogen, -F, -Cl, -Br, -l1 -N3, -CN, -NR7R8, -OH, -NO2, alkyl, aryl, arylalkyl, -O-alkyl, -O-aryl, -O-arylalkyl; and is preferably selected from the group consisting of alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl optionally having up to 3 substituents independently selected from the group consisting of halogen, -F, -Cl, -Br, -I, -N3, -CN, - NR7R8, -OH, -NO2, alkyl, aryl, arylalkyl, -O-alkyl, -O-aryl, -O-arylalkyl; ! one of the radicals R3 and R4 represents a hydrogen atom, and the other radical is selected from the group consisting of a hydrogen atom, alkyl, aryl, heteroaryl, arylalkyl, heteroaryl.

Claims (24)

1. The use of a method for the treatment or prevention of physiological and / or pathophysiological conditions mediated by growth hormone secretion receptors (SSHR receptors) and selected from the group including short-term, medium-term and / or long-term regulation of energy balance; short-term, medium-term and / or long-term regulation (stimulation and / or inhibition) of food intake; adipogenesis, obesity and / or obesity; an increase and / or decrease in body weight in mammals, in which, when preparing a medicine, a compound covered by the general structural formula (I) is used:

Where R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkylsulfonyl, arylalkyl, arylalkyl aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and / or heterocyclylalkyl may contain up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —l1 —N ₃ , —CN, —NR7R8, —OH , -NO _2, alkyl, aryl, arylalkyl, -O-alkyl, -O-aryl, -O-a ylalk; and preferably selected from the group consisting of alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, optionally containing up to 3 substituents, independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N ₃ , —CN, -NR7R8, -OH, -NO ₂ , alkyl, aryl, arylalkyl, -O-alkyl, -O-aryl, -O-arylalkyl; one of the radicals R3 and R4 represents a hydrogen atom, and the other radical is selected from the group consisting of hydrogen atom, alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -alkyl-O-aryl, -alkyl-O-arylalkyl, -alkyl-O-heteroaryl, -alkyl-O-heteroarylalkyl, -alkyl-O-heterocyclyl, alkyl-O-heterocyclylalkyl, -alkyl-CO-aryl, -alkyl-CO-arylalkyl, -alkyl-CO-heteroaryl, -alkyl -CO-heteroarylalkyl, -alkyl-CO-heterocyclyl, -alkyl-CO-heterocyclylalkyl, -alkyl-C (O) O-aryl, -alkyl-C (O) O-arylalkyl, -alkyl-C (O) O- heteroaryl, -alkyl-C (O) O-heteroar Lalka, -alkyl-C (O) O-heterocyclyl, -alkyl-C (O) O-heterocyclylalkyl, -alkyl-CO-NH _2, -alkyl-CO-OH, -alkyl-NH _2, -alkyl-NH- C (NH) -NH ₂ , alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, alkyl-S-alkyl, alkyl-SH, wherein aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and / or heterocyclylalkyl may contain up to 3 substituents independently selected from groups independently selected halogen, —F, —Cl, —Br, —I, —N ₃ , —CN, —NR7R8, —OH, —NO ₂ , alkyl, aryl, arylalkyl, —O-alkyl, —O-aryl, —O- arylalkyl; and is preferably selected from the group consisting of "arylalkyl, heteroarylalkyl, heterocyclylalkyl, -alkyl-O-aryl, -alkyl-O-arylalkyl, -alkyl-O-heteroaryl, -alkyl-O-heteroarylalkyl, -alkyl-O-heterocyclyl, alkyl -O-heterocyclylalkyl, -alkyl-CO-aryl, -alkyl-CO-arylalkyl, -alkyl-CO-heteroaryl, -alkyl-CO-heteroarylalkyl, -alkyl-CO-heterocyclyl, alkyl-CO-heterocyclylalkyl, -alkyl-C (O) O-aryl, - alkyl-C (O) O-arylalkyl, -alkyl-C (O) O-heteroaryl, -alkyl-C (O) O-heteroarylalkyl, -alkyl-C (O) O-heterocyclyl , -alkyl-C (O) O-heterocyclylalkyl, _{-alkyl-CO-NH2,} -alkyl-CO-OH, -alkyl-NH _2, -alk -NH-C (NH) -NH _2, wherein the aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and / or heterocyclylalkyl may comprise up to three substituents independently selected from the group consisting of halogen, -F, -Cl, -Br, -I , -N ₃ , -CN, -NR7R8, -OH, -NO ₂ , alkyl, aryl, arylalkyl, -O-alkyl, -O-aryl, -O-arylalkyl; R5 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -CO-alkyl, -CO-cycloalkyl, -CO-cycloalkylalkyl, -CO-aryl, arylalkyl, -CO-heteroaryl, -CO-heteroarylalkyl, -CO-heterocyclyl, -CO-heterocyclylalkyl, -CO-C * (R9R10) -NH ₂ , -CO-CH ₂ -C * (R9R10) -NH ₂ , - CO-C * (R9R10) -CH ₂ —NH ₂ , alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, which may contain up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N ₃ , -CN, -NR7R8, -OH, -NO _2, alkyl, aryl, arylalkyl, , -O-alkyl, -O-aryl, -O-arylalkyl "; and is preferably selected from the group consisting of hydrogen, -CO-alkyl, -CO-cycloalkyl, -CO-aryl, -CO-heteroaryl, -CO- arylalkyl, -CO-heteroarylalkyl, -CO-heterocyclyl, -CO-C * (R9R10) -NH ₂ , -CO-CH ₂ -C * (R9R10) -NH ₂ , -CO-C * (R9R10) -CH ₂ —NH ₂ which may contain up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N ₃ , —CN, —NR7R8, —OH, —NO ₂ , alkyl, aryl, arylalkyl, -O-alkyl, -O-aryl, -O-arylalkyl; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl and is preferably a hydrogen atom; R7 and R8 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl and preferably represent a hydrogen atom; R9 and R10 are independently selected from the group consisting of hydrogen atom, alkyl, side chain of natural alpha amino acids, side chain of non-natural alpha amino acids, and preferably selected from the group comprising hydrogen atom and alkyl; m corresponds to 0, 1 or 2, and preferably 0; and * means a carbon atom in the R or S configuration, if it is chiral, the treatment is carried out by modulating the SSHR receptors, and antagonists of the SSHR receptors are chosen as the compound. 2. The use according to claim 1, in which R3 is selected from the group consisting of -alkyl-CO-aryl, -alkyl-CO-arylalkyl, -alkyl-CO-heteroaryl, -alkyl-CO-heteroarylalkyl, -alkyl-CO-heterocyclyl , alkyl-CO-heterocyclylalkyl, -alkyl-C (O) O-aryl, -alkyl-C (O) O-arylalkyl, -alkyl-C (O) O-heteroaryl, -alkyl-C (O) O-heteroarylalkyl , -alkyl-C (O) O-heterocyclyl, -alkyl-C (O) O-heterocyclylalkyl, -alkyl-CO-NH ₂ , -alkyl-CO-OH, -alkyl-NH-C (NH) -NH ₂ , alkyl-S-alkyl, alkyl-SH, and is preferably selected from the group consisting of -alkyl-CO-arylalkyl, -alkyl-C (O) O-arylalkyl, -alkyl-CO-NH ₂ , -alkyl-CO -IT. 3. The use according to claim 1, in which R4 represents a hydrogen atom; R5 is selected from the group consisting of hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkylsulfonyl, arylsulfonyl, aryloalkylsulfonyl, -CO-acycloalkyl, -CO-arylalkyl, -CO-heteroaryl, -CO-heteroarylalkyl, -CO-heterocyclyl, -CO-heterocyclylalkyl; moreover, if R5 is —CO-heteroarylalkyl, then heteroaryl is not imidazole; and, if R5 is —CO-heterocyclyl, the heterocyclyl contains only nitrogen atoms as hetero atoms and at least two nitrogen atoms are included in the heterocyclyl; and, if R5 is -CO-heterocyclylalkyl, the heterocyclyl contains only nitrogen atoms as heteroatoms, and if one or two nitrogen atoms enter the heterocyclyl, then the nitrogen atoms are not in position 1 of the heterocyclyl through which the heterocyclyl directly binds to the carbonyl group - CO-; and where alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, -CO-cycloalkyl, -CO-cycloalkyl-alkyl-alkyl , -CO-heteroarylalkyl, -CO-heterocyclyl, and / or -CO-heterocyclylalkyl may contain up to 3 substituents independently selected from the group consisting of halogen, -F, -Cl, -Br, -I, -N ₃ , -CN , -NR7R8, -OH, -NO ₂ , alkyl, aryl, arylalkyl, -O-alkyl, -O-aryl, -O-arylalkyl; moreover, if R5 is —CO-cycloalkyl or —CO-cycloalkylalkyl, then R5 is not substituted with NR7R8 at position 1 of cycloalkyl in which the C atom directly binds cycloalkyl to the carbonyl group —CO— if R5 is —CO-cycloalkyl, or alkyl, if R5 is —CO-cycloalkylalkyl; and if R5 is —CO-aryl or —CO-arylalkyl, and aryl is phenyl / benzene and contains only one substituent, then this substituent cannot be —NR7R8; R6 represents a hydrogen atom; R7 and R8 are independently selected from the group consisting of a hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl and preferably represent a hydrogen atom; and m = 0, 1 or 2, more preferably 0. 4. The use according to claim 1, in which R1 is selected from the group consisting of hydrogen, methyl, (2-methoxyphenyl) methyl, (3-methoxyphenyl) methyl, (4-methoxyphenyl) methyl, (3-methoxyphenyl) - ethyl, (4-methoxyphenyl) ethyl, phenyl, phenyl methyl, phenyl ethyl, (4-ethyl phenyl) methyl, (4-methyl phenyl) methyl, (4-fluorophenyl) methyl, (4-bromophenyl) - methyl, (2,4-dimethoxyphenyl) methyl, (3,5-dimethoxyphenyl) methyl, 2,2-diphenyl-ethyl, naphthalen-1-yl-methyl, 1H-indol-3-yl-methyl, 2- (1H-indol-3-yl) ethyl, 3- (1H-indol-3-yl) propyl, 4-methyl-phenyl, 4-ethyl-phenyl, n-hexyl, (3,4-dichlorophenyl) - methyl, (4-nitro-phenyl) methyl, (pyridin-2-yl) methyl, (pyr idin-3-yl) methyl, (pyridin-4-yl) methyl, (thiophen-2-yl) methyl, (thiophen-3-yl) methyl, (furan-2-yl) methyl, ( furan-3-yl) methyl; R2 is selected from the group consisting of methyl, 1H-indol-3-yl-methyl, 2- (1H-indol-3-yl) -ethyl, 3- (1H-indol-3-yl) -propyl, 2-phenyl- ethyl, 3-phenyl-propyl, 4-phenyl-butyl, 2-methoxy-phenylmethyl, 3-methoxy-phenylmethyl, 4-methoxy-phenylmethyl, 2-methoxy-phenylethyl, 3-methoxy-phenylethyl, 4-methoxy-phenylethyl; R3 is selected from the group consisting of hydrogen, methyl, propan-2-yl, 2-methyl-propan-1-yl, butan-2-yl, butan-1-yl, -CH ₂ -SH, - (CH ₂ ) _2- S-CH ₃ , 1H-indol-3-yl-methyl, phenyl-methyl, 2-phenyl-ethyl, -CH ₂ -O-CH ₂ -phenyl, -CH ₂ -CO-CH ₂ -phenyl, - (CH ₂ ) ₂ -CO-CH ₂ -phenyl, -CH ₂ -C (O) O-phenyl, - (CH ₂ ) ₂ -C (O) O-phenyl, hydroxymethyl, 1-hydroxyethan-1-yl, -CH ₂ -CO-NH ₂ , - (CH ₂ ) ₂ -CO-NH ₂ , (1-hydroxy-benzene-4-yl) methyl, -CH ₂ -CO-OH, - (CH ₂ ) ₂ - CO-OH, - (CH ₂ ) 4-NH ₂ , (1H-imidazol-5-yl) methyl, - (CH ₂ ) ₃ -NH-C (NH) -NH ₂ , - (CH ₂ ) ₃ - NH ₂ , - (CH ₂ ) ₃ —NH — CO — NH ₂ , and is preferably selected from the group consisting of 1H-indol-3-yl-methyl, —CH ₂ —CO — CH ₂ phenyl, - (CH ₂ ) ₂ -CO-CH ₂ -phenyl, -CH ₂ -C (O) O-phenyl, - (CH ₂ ) ₂ -C (O) O-phenyl; R4 represents a hydrogen atom; R5 is selected from the group consisting of a hydrogen atom, —CO — CH ₂ —NH ₂ (residue Gly), —CO — CH ₂ —CH ₂ —NH ₂ (beta-Ala residue), —CO — CHCH ₃ —NH ₂ (residue D- and / or L-alpha-Ala), -CO- (pyrrolidin-2-yl) (residue D- and / or L-Pro), 2-amino-2-carbonyl-propane (residue 2-amino-isobutyric acids / Aib), 4-carbonyl-1H-piperidine, 3-carbonyl-1H-piperidine, R- (3-carbonyl-1H-piperidine), S- (3-carbonyl-1H-piperidine), 2-carbonyl-1H piperidine, R- (2-carbonyl-1H-piperidine), S- (2-carbonyl-1H-piperidine), 1-amino-2-carbonyl-benzene, carbonyl-cyclohexane, 2-acetyl-pyridine, 3-acetyl -pyridine, 4-acetyl-pyridine, 2-propionyl-pyridine, 3-propionyl-pyridine in, 4-propionyl-pyridine, (R-1-amino) -2-carbonyl-cyclohexane, (S-1-amino) -2-carbonyl-cyclohexane, 2-carbonyl-1H-imidazole, 2-carbonyl-pyridine, 3-carbonyl-pyridine, 4-carbonyl-pyridine, 2-amino-3-carbonyl-pyridine, 2-carbonyl-pyrazine, 2-carbonyl-4-hydroxy-1H-pyrrolidine, 4-carbonyl-1H, 3H-diazacyclohexane, methyl sulfonyl, phenylsulfonyl, 1-carbonyl-1-amino-2-phenylethane, phenylmethyl, 1-carbonyl-4-azide-benzene, 2-carbonyl-2,5-dihydro-1H-pyrrole, 2-carbonyl-piperazine, 2-carbonyl-1H-pyrrolidine, 2-aminoethane, carbonyl-benzene, 2-carbonyl-pyrazine, 3-carbonyl-pyrazine, 4-carbonyl-oxacyclog Exane, 4-methyl-phenylsulfonyl, phenylmethyl-sulfonyl; R6 represents a hydrogen atom; and m = 0. 5. The use according to claim 3, in which treat or produce physiological and / or pathophysiological conditions in mammals mediated by SSHR receptors by means of a medicament obtained from an agonist of SSHR receptors, said treatment being carried out by modulating SSHR receptors. 6. The use according to claim 4, which treats or produces physiological and / or pathophysiological conditions in mammals mediated by SSHR receptors by means of a medicament obtained from an agonist of SSHR receptors, said treatment being carried out by modulating SSHR receptors. 7. The use according to claim 4, in which R3 is selected from the group consisting of —CH ₂ —CO — CH ₂ phenyl, - (CH ₂ ) ₂ —CO — CH ₂ phenyl, —CH ₂ —CO — NH ₂ , - (CH ₂ ) ₂ -CO-NH ₂ , -CH ₂ -CO-OH, - (CH ₂ ) ₂ -CO-OH, - (CH ₂ ) ₃ -NH-C (NH) -NH ₂ , -CH ₂ -SH, - (CH ₂ ) ₂ -S-CH ₃ . 8. The use according to claim 4, in which R5 is selected from the group comprising a hydrogen atom, methylsulfonyl, phenylsulfonyl, carbonyl-cyclohexane, (R-1-amino) -2-carbonyl-cyclohexane, (S-1-amino) -2 -carbonyl-cyclohexane, 2-carbonyl-pyridine, 3-carbonyl-pyridine, 4-carbonyl-pyridine, 2-acetyl-pyridine, 3-acetyl-pyridine, 4-acetyl-pyridine, 2-propionyl-pyridine, 3-propionyl -pyridine, 4-propionyl-pyridine, 2-amino-3-carbonyl-pyridine, 2-carbonyl-1H-imidazole, 2-carbonyl-pyrazine, 4-carbonyl-1H, 3H-diazacyclohexane. 9. The use according to claim 1, in which the compound is selected from the group including Compound 1 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 2 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 3 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 4 (R) -N- (1- (5-benzyl-4- (naphthalen-1-ylmethyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 5 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (naphthalen-1-ylmethyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 6 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (3-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 7 (R) -N- (1- (4- (3-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 8 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 9 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 10 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (3-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 11 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (naphthalen-1-ylmethyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 12 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 13 (R) -N- (1- (4- (4-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 14 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (4-bromobenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 15 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-hexyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 16 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4-hexyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 17 (R) -N- (1- (4,5-bis (2- (1H-indol-3-yl) ethyl) -4H-1,2,4-triazol-3-yl) -2- (1H- indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 18 (S) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 19 (R) -N- (1- (4- (3-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 20 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 21 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (3,5-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 22 (R) -N- (1- (4- (4-methoxybenzyl) -5- (3-phenylpropyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indole-3- il) ethyl) -2-amino-2-methylpropanamide, Compound 23 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 24 (R) -N- (1- (4- (2- (1H-indol-3-yl) ethyl) -5- (3- (1H-indol-3-yl) propyl) -4H-1,2, 4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 25 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2-methoxy) benzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 26 (R) -N- (1- (4- (2-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 27 (R) -N- (2- (1H-indol-3-yl) -1- (4- (naphthalen-1-ylmethyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 28 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (3,4-dichlorobenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 29 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-fluorobenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 30 (R) -N- (1- (4- (4-fluorobenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 31 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) piperidin-4-carboxamide, Compound 32 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) piperidin-3-carboxamide, Compound 33 (R) -N- (1- (4- (4-methylbenzyl) -5- (3-phenylpropyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) -2-amino-2-methylpropanamide, Compound 34 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methylbenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 36 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) piperidin-2-carboxamide, Compound 37 (R) -N- (1- (4- (4-methylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 38 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-aminobenzamide, Compound 39 (R) -N- (1- (5-benzyl-4- (pyridin-2-ylmethyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 40 (2S, 4R) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole- 3-yl) ethyl) -4-hydroxypyrrolidin-2-carboxamide, Compound 41 (S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-3-carboxamide, Compound 42 (R) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-3-carboxamide, Compound 43 (R) -N- (1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 44 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperidine-4-carboxamide, Compound 45 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) piperidin-4-carboxamide, Compound 46 (S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) pyrrolidin-2-carboxamide, Compound 47 (R) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) pyrrolidin-2-carboxamide, Compound 48 (S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-2-carboxamide, Compound 49 (R) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-2-carboxamide, Compound 50 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 51 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 52 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-4-yl) acetamide, Compound 53 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) cyclohexanecarboxamide, Compound 54 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) piperidin-4-carboxamide, Compound 55 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) piperidin-3-carboxamide, Compound 56 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -3-aminopropanamide, Compound 57 (S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) -2-aminopropanamide, Compound 58 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-3-yl) acetamide, Compound 59 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -3- (pyridin-3-yl) propanamide, Compound 60 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 61 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 62 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperidine-4-carboxamide, Compound 63 (R) -N - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole- 3-yl) ethyl) piperidin-2-carboxamide, Compound 64 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) picolinamide, Compound 65 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) isonicotinamide, Compound 66 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) pyrazine-2-carboxamide, Compound 67 (R) -N-1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl ) piperazine-2-carboxamide, Compound 68 (S) -N - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole- 3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 69 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 70 (S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazole -3-yl) -2- (1H-indol-3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 71 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) pyrazin-2-carboxamide, Compound 72 (R) -N-1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperazine-2-carboxamide, Compound 73 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) picolinamide, Compound 74 (R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) -2 - (1H-indol-3-yl) ethanamine, Compound 75 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 76 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) pyrazine-2-carboxamide, Compound 77 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) isonicotinamide, Compound 78 (R) -N-1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperazine -2-carboxamide, Compound 79 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) picolinamide Compound 80 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) picolinamide, Compound 81 (R) -N-1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) -2 - (1W-indol-3-yl) ethyl) piperazin-2-carbocamide, Compound 82 (R) -N- (1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 83 (R) -N- (1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperidine-4-carboxamide, Compound 84 (R) -N-1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperazine -2-carboxamide, Compound 85 (R) -N- (1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) pyrazine-2-carboxamide, Compound 86 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-cis-aminocyclohexanecarboxamide, Compound 87 (S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) piperidin-3-carboxamide, Compound 88 (R) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) piperidine-2-carboxamide, Compound 89 (S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 90 (R) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 91 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 92 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-bromobenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 93 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2-phenylethyl) -2-amino-2-methylpropanamide, Compound 94 (R) -N- (2- (1H-indol-3-yl) -1- (5-phenethyl-4- (thiophen-2-ylmethyl) -4H-1,2,4-triazol-3-yl) ethyl) piperidine-4-carboxamide, Compound 95 (R) -N- (1- (4- (2- (1H-indol-3-yl) ethyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-2-methylpropanamide, Compound 96 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4-methyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole -3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 97 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-methyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 98 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl ) ethyl) -2-amino-2-methylpropanamide, Compound 99 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 100 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-methyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 101 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 102 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 103 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1W-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 104 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole -3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 105 (R) -N- (1- (5-benzyl-4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino -2-methylpropanamide, Compound 106 (R) -N- (1- (5-benzyl-4- (2,2-diphenylethyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 107 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,2-diphenylethyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 108 (R) -N- (1- (4- (3,5-dimethoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 109 (R) -N- (1- (4,5-dibenzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2 methylpropanamide Compound 110 (R) -N- (1- (5-benzyl-4-hexyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino -2-methylpropanamide, Compound 111 (R) -N- (1- (4- (2- (1H-indol-3-yl) ethyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 112 (S) -N- (1- (4- (2,4-dimethoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 113 (R) -N- (1- (4- (3,5-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 114 (R) -N- (1- (4- (4-bromobenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 115 (R) -N- (1- (4- (2-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 116 (S) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 117 (R) -N- (1- (4,5-diphenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2 methylpropanamide Compound 118 (R) -N- (1- (4- (3,4-dichlorobenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 119 (R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) -2 - (1H-indol-3-yl) ethanamine, Compound 120 (R) -N- (1- (4- (4-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2-phenylethyl) -2-amino-2-methylpropanamide, Compound 121 (R) -N- (1- (4- (4-fluorobenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 122 (R) -N- (1- (4- (3,4-dichlorobenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 124 (R) -N- (1- (4- (4-methylbenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 125 (S) -N- (1- (4- (4-methoxybenzyl) -5- (3-phenylpropyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indole-3- il) ethyl) -2-amino-2-methylpropanamide, Compound 126 (S) -N- (1- (4- (4-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 128 N - ((R) -1- (4- (4-nitrobenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 129 (S) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 130 (R) -N- (1- (4- (4-methoxyphenethyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 131 (R) -N- (2- (1H-indol-3-yl) -1- (5-phenethyl-4- (thiophen-2-ylmethyl) -4H-1,2,4-triazol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 132 (R) -N- (2- (1H-indol-3-yl) -1- (5-phenethyl-4- (pyridin-2-ylmethyl) -4H-1,2,4-triazol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 133 (R) -N- (2- (1H-indol-3-yl) -1- (5-phenethyl-4- (pyridin-2-ylmethyl) -4H-1,2,4-triazol-3-yl) ethyl) piperidine-3-carboxamide, Compound 134 (S) -N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) pyrrolidin-2-carboxamide, Compound 135 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-thiazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 136 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2- (pyridn-4-yl) acetamide, Compound 137 (2R) -N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-2-carboxamide, Compound 138 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) picolinamide Compound 139 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminopyridine-3-carboxamide, Compound 140 (2S) -N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) -2-aminopropanamide, Compound 141 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) isonicotinamide, Compound 142 N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) piperidin-4- carboxamide Compound 143 (2S) -N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) pyrrolidine-2-carboxamide, Compound 144 N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) -2-aminoacetamide , Compound 145 N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) -2- ( pyridin-2-yl) acetamide, Compound 146 N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) picolinamide, Compound 147 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-ethylphenyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) picolinamide, Compound 148 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-ethylphenyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 149 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-ethylphenyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 150 (2S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-ethylphenyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 152 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 153 N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-trans-aminocyclohexanecarboxamide, Compound 154 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-3-yl) acetamide, Compound 155 (3S) -N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-3-carboxamide, Compound 156 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminobenzamide, Compound 157 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4-phenyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) picolinamide, Compound 158 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4-phenyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) piperidin-4-carboxamide, Compound 159 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) picolinamide, Compound 160 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 161 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) pyrazine-2-carboxamide, Compound 162 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) -2-aminoacetamide, Compound 163 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) piperidine-4-carboxamide, Compound 164 N - ((R) -1- (5-benzyl-4 - ((pyridin-2-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) picolinamide, Compound 165 N - ((R) -1- (5-benzyl-4 - ((pyridin-2-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-acetamide, Compound 166 N - ((R) -1- (5-benzyl-4 - ((pyridin-2-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) piperidine-4-carboxamide, Compound 167 N - ((R) -1- (5-benzyl-4 - ((pyridin-4-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-2-methylpropanamide, Compound 168 N - ((R) -1- (5- (4-methoxybenzyl) -4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 169 N - ((R) -1- (5-benzyl-4 - ((pyridin-4-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) picolinamide, Compound 170 N - ((R) -1- (5-benzyl-4 - ((pyridin-4-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) 2-amino-acetamide, Compound 171 (R) -benzyl-3- (2-aminoisobutyramido) -3- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4- triazol-3-yl) propanoate, Compound 172 N - ((R) -1- (5-benzyl-4 - ((pyridin-3-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-2-methylpropanamide, Compound 173 N - ((R) -1- (4-benzyl-5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino -2-methylpropanamide, Compound 174 N - ((R) -2- (1H-indol-3-yl) -1- (4-methyl-5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) picolinamide, Compound 175 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4-phenyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 176 N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) benzamide, Compound 177 (R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) -N- phenylmethanesulfonylamine, Compound 178 (R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) -N- tosilethanamine, Compound 179 N - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 180 N-1 - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) ethane-1,2-diamine, Compound 181 N - ((R) -1- (4 - ((furan-2-yl) methyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-2-methylpropanamide, Compound 182 N - ((R) -1- (4 - ((furan-2-yl) methyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) picolinamide, Compound 183 N - ((R) -1- (4 - ((furan-2-yl) methyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) piperidine-4-carboxamide, Compound 184 N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) tetrahydro-2H-pyran-4-carboxamide, Compound 185 N - ((R) -1- (5 - ((1H-indol-3-yl) methyl) -4- (3-methoxybenzyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 186 (2S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) -2-amino-3-phenylpropanamide, Compound 187 (R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) -2 - (1H-indol-3-yl) -N-tosilethanamine, Compound 188 N - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -4-azidobenzamide, Compound 189 N-benzyl- (R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl ) ethanamine, Compound 190 (2S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) -2,5-dihydro-1H-pyrrole-2-carboxamide. 10. The use according to claim 1, in which the antagonist of SSHR receptors is selected from the group of compounds comprising compound 1, 3, 12, 13, 14, 18, 20, 22, 23, 33, 36, 37, 38, 41, 46 , 47, 48, 49, 50, 51, 52, 53, 57, 58, 59, 60, 61, 63, 64, 65, 66, 68, 69, 70, 71, 72, 73, 74, 75, 76 , 77, 79, 80, 82, 85, 86, 87, 88, 89, 90, 91, 93, 101, 102, 109, 114, 116, 119, 134, 135, 136, 137, 138, 139, 140 , 145, 146, 147, 148, 150, 152, 153, 154, 156, 157, 159, 160, 161, 164, 171, 174, 176, 178, 179, 182, 184, 186, 188 and / or the compound 190. 11. The use according to claim 5, in which the agonist of SSHR receptors is selected from the group comprising compound 2, 4, 5, 6, 7, 8, 9, 10, 11, 15, 16, 17, 19, 21, 24, 25, 26, 27, 28, 29, 30, 31, 32, 34, 39, 40, 42, 43, 44, 45, 54, 55, 56, 62, 67, 78, 81, 83, 84, 87, 92, 94, 99, 103, 104, 105, 106, 107, 108, 110, 111, 115, 117, 118, 121, 122, 124, 130, 131, 142, 155, 158, 163, 173, 175, 180, 181, 183, 185 and / or compound 187. 12. The use according to claim 1, in which the SSHR receptors are selected from the group comprising GHS receptors type 1, GHS-R 1a, GHS-R 1b, motilin receptor, motilin receptor 1a, neurotensin receptor, TRH receptor, GPR38 ( FM1), GPR39 (FM2), FM3, subtype GHS-R, CGH-binding site, GHS-R of heart muscle, GHS-R of the mammary gland, preferably selected from the group comprising GHS receptors type 1, GHS-R 1a, GHS -R 1b, and most preferably GHS-R 1a. 13. The use according to claim 1, in which physiological and / or pathophysiological conditions are selected from the group including acute fatigue syndrome and loss of muscle mass after selective surgery, adipogenesis, obesity, age-related weakening of the thymus function, age-related functional deviation (ARFD ) in the elderly, age-related deviations in domestic animals, Alzheimer's disease, anorexia (for example, associated with cachexia or aging); anxiety, low blood pressure, decrease / increase in body weight, restoration of bones after fractures (acceleration of the process), stimulation of bone remodeling, cachexia and loss of proteins due to chronic diseases such as cancer or AIDS, dysfunctions of the cardiovascular system (e.g. associated with valve disease, myocardial infarction, cardiac muscle hypertrophy or congestive heart failure), cardiomyopathy, stimulation of cartilage growth, catabolic disorders associated with pulmonary dysfunction and dependence on the mechanical ventilation system, catabolic side effects of glucocorticoid use, catabolic state of aging, central nervous system disorders (together with antidepressants), chronic dialysis, chronic fatigue syndrome, improved cognitive function (for example, with dementia or Alzheimer's disease), complicated fractures (e.g., osteogenesis disorders) associated with transplantation complications, congestive heart failure (can be treated in conjunction with an antagonist and corticotropin-releasing factor), Crohn’s disease and ulcerative colitis, Cushing's syndrome, dementia, depression, short-term, medium-term and / or long-term regulation of energy balance, short-term, medium-term and / or long-term regulation of food intake (stimulation and / or inhibition), fragility bones (e.g., in the elderly), gastrectomy (ghrelin replacement therapy), gastric postoperative obstruction, improved glycemic control, stimulation of the release of growth hormone in the elderly, hormone replacement growth in stressed patients, growth stimulation in livestock, growth retardation associated with Prader-Willi syndrome and Turner syndrome, growth retardation due to Crohn's disease, growth retardation, hair / nail growth support, hip fractures, hunger, hypercortisolism , hyperinsulinemia, including nezidioblastosis, hypothermia, immune deficiency in people with a reduced T4 / T8 cell ratio, improved immune response during vaccination, stimulation of the immune system in pets, stimulation immune system suppression, immune system suppression in patients with such suppression, inflammation or inflammatory effects, intestinal inflammation, insulin resistance in the heart, insulin resistance in patients with type 2 diabetes, insulin resistance, including NIDDM, diabetes, type 1 diabetes, type 2 diabetes, intrauterine growth retardation, irritable bowel syndrome, lipodystrophy (e.g., HIV-induced), maintenance of metabolic homeostasis, increased milk yield in cattle, increased m cervical mass / strength, improving muscle mobility, increasing muscle strength, maintaining muscle strength / functioning in the elderly, muscle atrophy, musculoskeletal disorders (e.g. in the elderly), Noonan syndrome, obesity and its associated growth retardation, stimulation of osteoblasts, osteochondrodysplasia, osteoporosis, ovulation induction (adjuvant treatment), physiological short stature, including growth hormone deficiency in children, postoperative obstruction, weakening of the protein catabolic response after extensive surgery surgical intervention or trauma, increased activity of protein kinase B, psychosocial deprivation syndrome, pulmonary dysfunction and dependence on mechanical ventilation devices, improved lung function, pulsating induction of growth hormone secretion, treatment of burns and shorter hospitalization of burned patients (accelerated healing), renal insufficiency caused by stunted growth, maintenance of renal homeostasis and elderly people with increased fragility, sarcopenia, schizophrenia, under retention of sensory function (e.g., hearing, vision, smell and taste), short bowel syndrome associated with a short illness of small stature, skeletal dysplasia, maintaining skin thickness, sleep disturbances, improving sleep quality, thrombocytopenia, stimulating the development of thymus, restoring or growing teeth tumor cell proliferation, ventricular dysfunction or cases of reperfusion, AIDS-related exhaustion, chronic liver disease exhaustion, chronic obstructive exhaustion lung disease, depletion associated with multiple sclerosis or other neurodegenerative diseases, depletion caused by fractures, stimulation of hair growth in sheep, accelerated wound healing and / or delayed wound healing. 14. The application of item 13, in which physiological and / or pathophysiological conditions are selected from the group including growth retardation, cachexia, short-term, medium-term and / or long-term regulation of energy balance; short-term, medium-term and / or long-term regulation (stimulation and / or inhibition) of food intake; adipogenesis, obesity and / or obesity; increase and / or decrease in body weight; diabetes, type 1 diabetes, type 2 diabetes, tumor cell proliferation; inflammation, effects of inflammation, gastric postoperative obstruction, postoperative obstruction and / or gastrectomy (ghrelin-replacement therapy). 15. The use according to claim 1, in which the drug contains at least one additional pharmacologically active substance. 16. The use according to clause 15, in which the additional pharmacologically active substance is a CCG receptor antagonist and an endocannabinoid receptor antagonist, preferably a CB1 receptor antagonist, most preferably rimonabant [1H-pyrazole-3-carboxamide, 5- (4- chlorophenyl) -1- (2,4-dichlorophenyl) -4-methyl-N-1-piperidinyl-, monohydrochloride]. 17. The use according to claim 1, in which the drug is used before, during and / or after treatment with at least one additional pharmacologically active substance. 18. The use according to claim 17, wherein the drug comprises an SSHR receptor antagonist, and the additional pharmacologically active substance is an endocannabinoid receptor antagonist, preferably a CB1 receptor antagonist, most preferably rimonabant [1H-pyrazole-3-carboxamide, 5 - (4-chlorophenyl) -1- (2,4-dichlorophenyl) -4-methyl-N-1-piperidinyl-, monohydrochloride]. 19. Triazoles selected from the group including Compound 1 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 2 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 3 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 4 (R) -N- (1- (5-benzyl-4- (naphthalen-1-ylmethyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 5 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (naphthalen-1-ylmethyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 6 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (3-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 7 (R) -N- (1- (4- (3-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 8 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 9 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 10 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (3-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 11 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (naphthalen-1-ylmethyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 12 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 13 (R) -N- (1- (4- (4-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 14 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (4-bromobenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 15 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-hexyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 16 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4-hexyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 17 (R) -N- (1- (4,5-bis (2- (1H-indol-3-yl) ethyl) -4H-1,2,4-triazol-3-yl) -2- (1H- indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 18 (S) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 19 (R) -N- (1- (4- (3-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 20 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 21 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (3,5-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 22 (R) -N- (1- (4- (4-methoxybenzyl) -5- (3-phenylpropyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indole-3- il) ethyl) -2-amino-2-methylpropanamide, Compound 23 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 24 (R) -N- (1- (4- (2- (1H-indol-3-yl) ethyl) -5- (3- (1H-indol-3-yl) propyl) -4H-1,2, 4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 25 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2-methoxy) benzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 26 (R) -N- (1- (4- (2-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 27 (R) -N- (2- (1H-indol-3-yl) -1- (4- (naphthalen-1-ylmethyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 28 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (3,4-dichlorobenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 29 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-fluorobenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 30 (R) -N- (1- (4- (4-fluorobenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 31 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) piperidin-4-carboxamide, Compound 32 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) piperidin-3-carboxamide, Compound 33 (R) -N- (1- (4- (4-methylbenzyl) -5- (3-phenylpropyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) -2-amino-2-methylpropanamide, Compound 34 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methylbenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 36 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) piperidin-2-carboxamide, Compound 37 (R) -N- (1- (4- (4-methylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 38 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-aminobenzamide, Compound 39 (R) -N- (1- (5-benzyl-4- (pyridin-2-ylmethyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 40 (2S, 4R) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole- 3-yl) ethyl) -4-hydroxypyrrolidin-2-carboxamide, Compound 41 (S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-3-carboxamide, Compound 42 (R) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-3-carboxamide, Compound 43 (R) -N- (1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 44 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperidine-4-carboxamide, Compound 45 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) piperidin-4-carboxamide, Compound 46 (S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) pyrrolidin-2-carboxamide, Compound 47 (R) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) pyrrolidin-2-carboxamide, Compound 48 (S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-2-carboxamide, Compound 49 (R) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-2-carboxamide, Compound 50 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 51 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 52 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-4-yl) acetamide, Compound 53 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) cyclohexanecarboxamide, Compound 54 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) piperidin-4-carboxamide, Compound 55 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) piperidin-3-carboxamide, Compound 56 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -3-aminopropanamide, Compound 57 (S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) -2-aminopropanamide, Compound 58 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-3-yl) acetamide, Compound 59 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -3- (pyridin-3-yl) propanamide, Compound 60 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 61 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 62 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperidine-4-carboxamide, Compound 63 (R) -N - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole- 3-yl) ethyl) piperidin-2-carboxamide, Compound 64 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) picolinamide, Compound 65 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) isonicotinamide, Compound 66 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) pyrazine-2-carboxamide, Compound 67 (R) -N-1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl ) piperazine-2-carboxamide, Compound 68 (S) -N - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole- 3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 69 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 70 (S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazole -3-yl) -2- (1H-indol-3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 71 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) pyrazin-2-carboxamide, Compound 72 (R) -N-1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperazine-2-carboxamide, Compound 73 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) picolinamide, Compound 74 (R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) -2 - (1H-indol-3-yl) ethanamine, Compound 75 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 76 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) pyrazine-2-carboxamide, Compound 77 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) isonicotinamide, Compound 78 (R) -N-1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperazine -2-carboxamide, Compound 79 (R) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) picolinamide Compound 80 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) picolinamide, Compound 81 (R) -N- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) -2- ( 1W-indol-3-yl) ethyl) piperazin-2-carboxamide, Compound 82 (R) -N- (1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 83 (R) -N- (1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperidine-4-carboxamide, Compound 84 (R) -N-1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) piperazine -2-carboxamide, Compound 85 (R) -N- (1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) pyrazine-2-carboxamide, Compound 86 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-cis-aminocyclohexanecarboxamide, Compound 87 (S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) piperidin-3-carboxamide, Compound 88 (R) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) piperidine-2-carboxamide, Compound 89 (S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 90 (R) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 91 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 92 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-bromobenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 93 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2-phenylethyl) -2-amino-2-methylpropanamide, Compound 94 (R) -N- (2- (1H-indol-3-yl) -1- (5-phenethyl-4- (thiophen-2-ylmethyl) -4H-1,2,4-triazol-3-yl) ethyl) piperidine-4-carboxamide, Compound 95 (R) -N- (1- (4- (2- (1H-indol-3-yl) ethyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-2-methylpropanamide, Compound 96 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4-methyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole -3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 97 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4-methyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 98 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl ) ethyl) -2-amino-2-methylpropanamide, Compound 99 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 100 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-methyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 101 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 102 (R) -N- (1- (4- (2,4-dimethoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 103 (R) -N- (1- (5- (3- (1H-indol-3-yl) propyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl ) -2- (1W-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 104 (R) -N- (1- (5 - ((1H-indol-3-yl) methyl) -4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indole -3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 105 (R) -N- (1- (5-benzyl-4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino -2-methylpropanamide, Compound 106 (R) -N- (1- (5-benzyl-4- (2,2-diphenylethyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 107 (R) -N- (1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,2-diphenylethyl) -4H-1,2,4-triazol-3-yl ) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 108 (R) -N- (1- (4- (3,5-dimethoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 109 (R) -N- (1- (4,5-dibenzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2 methylpropanamide Compound 110 (R) -N- (1- (5-benzyl-4-hexyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino -2-methylpropanamide, Compound 111 (R) -N- (1- (4- (2- (1H-indol-3-yl) ethyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 112 (S) -N- (1- (4- (2,4-dimethoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 113 (R) -N- (1- (4- (3,5-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 114 (R) -N- (1- (4- (4-bromobenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 115 (R) -N- (1- (4- (2-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 116 (S) -N- (1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 117 (R) -N- (1- (4,5-diphenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2 methylpropanamide Compound 118 (R) -N- (1- (4- (3,4-dichlorobenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 119 (R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) -2 - (1H-indol-3-yl) ethanamine, Compound 120 (R) -N- (1- (4- (4-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2-phenylethyl) -2-amino-2-methylpropanamide, Compound 121 (R) -N- (1- (4- (4-fluorobenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 122 (R) -N- (1- (4- (3,4-dichlorobenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 124 (R) -N- (1- (4- (4-methylbenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 125 (S) -N- (1- (4- (4-methoxybenzyl) -5- (3-phenylpropyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indole-3- il) ethyl) -2-amino-2-methylpropanamide, Compound 126 (S) -N- (1- (4- (4-methoxybenzyl) -5-benzyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 128 N - ((R) -1- (4- (4-nitrobenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 129 (S) -N- (1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 130 (R) -N- (1- (4- (4-methoxyphenethyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 131 (R) -N- (2- (1H-indol-3-yl) -1- (5-phenethyl-4- (thiophen-2-ylmethyl) -4H-1,2,4-triazol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 132 (R) -N- (2- (1H-indol-3-yl) -1- (5-phenethyl-4- (pyridin-2-ylmethyl) -4H-1,2,4-triazol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 133 (R) -N- (2- (1H-indol-3-yl) -1- (5-phenethyl-4- (pyridin-2-ylmethyl) -4H-1,2,4-triazol-3-yl) ethyl) piperidine-3-carboxamide, Compound 134 (S) -N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) pyrrolidin-2-carboxamide, Compound 135 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 136 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2- (pyridn-4-yl) acetamide, Compound 137 (2R) -N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-2-carboxamide, Compound 138 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) picolinamide Compound 139 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminopyridine-3-carboxamide, Compound 140 (2S) -N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) -2-aminopropanamide, Compound 141 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) isonicotinamide, Compound 142 N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) piperidin-4- carboxamide Compound 143 (2S) -N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) pyrrolidine-2-carboxamide, Compound 144 N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) -2-aminoacetamide , Compound 145 N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) -2- ( pyridin-2-yl) acetamide, Compound 146 N - ((R) -2- (1H-indol-3-yl) -1- (5-phenethyl-4-phenyl-4H-1,2,4-triazol-3-yl) ethyl) picolinamide, Compound 147 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-ethylphenyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) picolinamide, Compound 148 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-ethylphenyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 149 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-ethylphenyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 150 (2S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-ethylphenyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) pyrrolidin-2-carboxamide, Compound 152 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3-yl) - 2- (1H-indol-3-yl) ethyl) -2-aminoacetamide, Compound 153 N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-trans-aminocyclohexanecarboxamide, Compound 154 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2- (pyridin-3-yl) acetamide, Compound 155 (3S) -N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) piperidine-3-carboxamide, Compound 156 N - ((R) -1- (4- (4-ethylbenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-aminobenzamide, Compound 157 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4-phenyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) picolinamide, Compound 158 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4-phenyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) piperidin-4-carboxamide, Compound 159 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) picolinamide, Compound 160 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) -2- (pyridin-2-yl) acetamide, Compound 161 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) pyrazine-2-carboxamide, Compound 162 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) -2-aminoacetamide, Compound 163 N - ((R) -2- (1H-indol-3-yl) -1- (4- (2,4-dimethoxyphenyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) piperidine-4-carboxamide, Compound 164 N - ((R) -1- (5-benzyl-4 - ((pyridin-2-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) picolinamide, Compound 165 N - ((R) -1- (5-benzyl-4 - ((pyridin-2-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-acetamide, Compound 166 N - ((R) -1- (5-benzyl-4 - ((pyridin-2-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) piperidine-4-carboxamide, Compound 167 N - ((R) -1- (5-benzyl-4 - ((pyridin-4-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-2-methylpropanamide, Compound 168 N - ((R) -1- (5- (4-methoxybenzyl) -4-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 169 N - ((R) -1- (5-benzyl-4 - ((pyridin-4-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) picolinamide, Compound 170 N - ((R) -1- (5-benzyl-4 - ((pyridin-4-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) 2-amino-acetamide, Compound 171 (R) -benzyl-3- (2-aminoisobutyramido) -3- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4- triazol-3-yl) propanoate, Compound 172 N - ((R) -1- (5-benzyl-4 - ((pyridin-3-yl) methyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-2-methylpropanamide, Compound 173 N - ((R) -1- (4-benzyl-5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino -2-methylpropanamide, Compound 174 N - ((R) -2- (1H-indol-3-yl) -1- (4-methyl-5-phenethyl-4H-1,2,4-triazol-3-yl) ethyl) picolinamide, Compound 175 N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4-phenyl-4H-1,2,4-triazol-3-yl) -2- (1H -indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 176 N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) benzamide, Compound 177 (R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) -N- phenylmethanesulfonylamine, Compound 178 (R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) -N- tosilethanamine, Compound 179 N - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 180 N-1 - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) ethane-1,2-diamine, Compound 181 N - ((R) -1- (4 - ((furan-2-yl) methyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) -2-amino-2-methylpropanamide, Compound 182 N - ((R) -1- (4 - ((furan-2-yl) methyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) picolinamide, Compound 183 N - ((R) -1- (4 - ((furan-2-yl) methyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3 -yl) ethyl) piperidine-4-carboxamide, Compound 184 N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) tetrahydro-2H-pyran-4-carboxamide, Compound 185 N - ((R) -1- (5 - ((1H-indol-3-yl) methyl) -4- (3-methoxybenzyl) -4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -2-amino-2-methylpropanamide, Compound 186 (2S) -N - ((R) -1- (4- (4-methoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3- il) ethyl) -2-amino-3-phenylpropanamide, Compound 187 (R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (2,4-dimethoxybenzyl) -4H-1,2,4-triazol-3-yl) -2 - (1H-indol-3-yl) -N-tosilethanamine, Compound 188 N - ((R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl) ethyl) -4-azidobenzamide, Compound 189 N-benzyl- (R) -1- (4- (2,4-dimethoxybenzyl) -5-phenethyl-4H-1,2,4-triazol-3-yl) -2- (1H-indol-3-yl ) ethanamine, Compound 190 (2S) -N - ((R) -1- (5- (2- (1H-indol-3-yl) ethyl) -4- (4-methoxybenzyl) -4H-1,2,4-triazol-3 -yl) -2- (1H-indol-3-yl) ethyl) -2,5-dihydro-1H-pyrrole-2-carboxamide. 20. A pharmaceutical composition, characterized in that it contains at least one compound according to claim 19 in a pharmacologically effective amount. 21. The pharmaceutical composition according to claim 20, characterized in that the active ingredient is present in a unit dose of from 0.001 to 100 mg per kg of body weight of the patient. 22. The pharmaceutical composition according to claim 20, characterized in that it further comprises at least one pharmaceutically acceptable carrier and / or excipient. 23. The pharmaceutical composition according to claim 20, characterized in that it contains at least one additional pharmacologically active substance. 24. The pharmaceutical composition according to claim 23, wherein the additional pharmacologically active substance is an endocannabinoid receptor antagonist, preferably a CB1 receptor antagonist, most preferably rimonabant [1H-pyrazole-3-carboxamide, 5- (4-chlorophenyl) -1- (2,4-dichlorophenyl) -4-methyl-N-1-piperidinyl-, monohydrochloride].