RU2006147263A - Терапевтическое перепрограммирование, гибридные стволовые клетки и созревание - Google Patents
Терапевтическое перепрограммирование, гибридные стволовые клетки и созревание Download PDFInfo
- Publication number
- RU2006147263A RU2006147263A RU2006147263/14A RU2006147263A RU2006147263A RU 2006147263 A RU2006147263 A RU 2006147263A RU 2006147263/14 A RU2006147263/14 A RU 2006147263/14A RU 2006147263 A RU2006147263 A RU 2006147263A RU 2006147263 A RU2006147263 A RU 2006147263A
- Authority
- RU
- Russia
- Prior art keywords
- cell
- stem
- cells
- specified
- stem cells
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title claims abstract 31
- 230000008672 reprogramming Effects 0.000 title claims abstract 18
- 230000001225 therapeutic effect Effects 0.000 title claims abstract 18
- 230000035800 maturation Effects 0.000 title claims 3
- 210000004027 cell Anatomy 0.000 claims abstract 48
- 238000000034 method Methods 0.000 claims abstract 31
- 230000004936 stimulating effect Effects 0.000 claims abstract 11
- 210000004602 germ cell Anatomy 0.000 claims abstract 8
- 239000000284 extract Substances 0.000 claims abstract 7
- 210000001671 embryonic stem cell Anatomy 0.000 claims abstract 5
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000013043 chemical agent Substances 0.000 claims abstract 4
- 230000018109 developmental process Effects 0.000 claims abstract 4
- 238000002955 isolation Methods 0.000 claims abstract 3
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims abstract 2
- RTKIYFITIVXBLE-UHFFFAOYSA-N Trichostatin A Natural products ONC(=O)C=CC(C)=CC(C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-UHFFFAOYSA-N 0.000 claims abstract 2
- 210000000577 adipose tissue Anatomy 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 210000000604 fetal stem cell Anatomy 0.000 claims abstract 2
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims abstract 2
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims abstract 2
- 210000001988 somatic stem cell Anatomy 0.000 claims abstract 2
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims abstract 2
- 230000004927 fusion Effects 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 3
- 230000007159 enucleation Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 210000005036 nerve Anatomy 0.000 claims 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 238000000520 microinjection Methods 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/061—Sperm cells, spermatogonia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/04—Cells produced using nuclear transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/864,788 US20050090004A1 (en) | 2003-01-16 | 2004-06-08 | Stem cell maturation for all tissue lines |
| US10/864,788 | 2004-06-08 | ||
| US58814604P | 2004-07-15 | 2004-07-15 | |
| US60/588,146 | 2004-07-15 | ||
| PCT/US2005/005052 WO2005123123A2 (en) | 2004-06-08 | 2005-02-16 | Therapeutic reprogramming, hybrid stem cells and maturation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006147263A true RU2006147263A (ru) | 2008-07-20 |
Family
ID=35355246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006147263/14A RU2006147263A (ru) | 2004-06-08 | 2005-02-16 | Терапевтическое перепрограммирование, гибридные стволовые клетки и созревание |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1758989A2 (enExample) |
| JP (1) | JP2008501795A (enExample) |
| AU (1) | AU2005253923A1 (enExample) |
| BR (1) | BRPI0511889A (enExample) |
| CA (1) | CA2567692A1 (enExample) |
| RU (1) | RU2006147263A (enExample) |
| WO (1) | WO2005123123A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090252711A1 (en) * | 2006-05-11 | 2009-10-08 | Andrew Craig Boquest | Stem Cells And Methods Of Making And Using Stem Cells |
| WO2008104994A2 (en) | 2007-02-28 | 2008-09-04 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
| CN101679365A (zh) | 2007-06-08 | 2010-03-24 | 艾德维纳斯医疗私人有限公司 | 作为葡萄糖激酶激活剂的新型吡咯-2-甲酰胺衍生物、它们的制造方法和药学应用 |
| EP2090649A1 (en) | 2008-02-13 | 2009-08-19 | Fondazione Telethon | Method for reprogramming differentiated cells |
| EP2402327B1 (en) | 2010-06-29 | 2018-03-07 | Impetis Biosciences Ltd. | Acetamide compounds as glucokinase activators, their process and medicinal applications |
| EP2796873A1 (en) * | 2013-04-25 | 2014-10-29 | QGel SA | Method for a cell-based drug screening assay and the use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9912662A (pt) * | 1998-07-31 | 2001-06-05 | Genzyme Corp | Melhoria de função cardìaca por transplante de célula de ramo mesenquimal |
| US20020136709A1 (en) * | 2000-12-12 | 2002-09-26 | Nucleus Remodeling, Inc. | In vitro-derived adult pluripotent stem cells and uses therefor |
| JP2004248505A (ja) * | 2001-09-21 | 2004-09-09 | Norio Nakatsuji | 移植抗原の一部または全てを欠除したｅｓ細胞由来の未分化な体細胞融合細胞およびその製造 |
| CA2474766A1 (en) * | 2002-01-16 | 2003-07-31 | Chauncey Sayre | Stem cell maturation for all tissue types |
| AU2003229388A1 (en) * | 2002-05-31 | 2003-12-19 | Apollo Life Sciences Limited | Cell recovery |
| AU2003295444A1 (en) * | 2002-11-15 | 2004-06-15 | The Board Of Trustees Of The University Of Illinois | Methods for in vitro expansion of hematopoietic stem cells |
-
2005
- 2005-02-16 RU RU2006147263/14A patent/RU2006147263A/ru unknown
- 2005-02-16 AU AU2005253923A patent/AU2005253923A1/en not_active Abandoned
- 2005-02-16 BR BRPI0511889-1A patent/BRPI0511889A/pt not_active IP Right Cessation
- 2005-02-16 JP JP2007527196A patent/JP2008501795A/ja not_active Withdrawn
- 2005-02-16 EP EP05723204A patent/EP1758989A2/en not_active Withdrawn
- 2005-02-16 CA CA002567692A patent/CA2567692A1/en not_active Abandoned
- 2005-02-16 WO PCT/US2005/005052 patent/WO2005123123A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2567692A1 (en) | 2005-12-29 |
| EP1758989A2 (en) | 2007-03-07 |
| WO2005123123A2 (en) | 2005-12-29 |
| WO2005123123A3 (en) | 2006-03-02 |
| AU2005253923A1 (en) | 2005-12-29 |
| BRPI0511889A (pt) | 2008-01-15 |
| JP2008501795A (ja) | 2008-01-24 |
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