RU2006131784A - METHOD FOR STORING PLASMA OR BLOOD SERUM FOR OBTAINING IMMUNOGLOBULIN AND ALBUMIN BIOLOGICAL PRODUCTS - Google Patents

METHOD FOR STORING PLASMA OR BLOOD SERUM FOR OBTAINING IMMUNOGLOBULIN AND ALBUMIN BIOLOGICAL PRODUCTS Download PDF

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Publication number
RU2006131784A
RU2006131784A RU2006131784/15A RU2006131784A RU2006131784A RU 2006131784 A RU2006131784 A RU 2006131784A RU 2006131784/15 A RU2006131784/15 A RU 2006131784/15A RU 2006131784 A RU2006131784 A RU 2006131784A RU 2006131784 A RU2006131784 A RU 2006131784A
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RU
Russia
Prior art keywords
albumin
immunoglobulins
blood serum
biological products
phenol
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RU2006131784/15A
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Russian (ru)
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RU2338375C2 (en
Inventor
Алексей Константинович Барсуков (RU)
Алексей Константинович Барсуков
Андрей Викторович Бармин (RU)
Андрей Викторович Бармин
Ольга Юрьевна Нестерова (RU)
Ольга Юрьевна Нестерова
Флюр Минисалихович Касимов (RU)
Флюр Минисалихович Касимов
Александр Иванович Кузнецов (RU)
Александр Иванович Кузнецов
Светлана Александровна Ушнурцева (RU)
Светлана Александровна Ушнурцева
Евгений Николаевич Желтышев (RU)
Евгений Николаевич Желтышев
Виталий Анатольевич Журавлев (RU)
Виталий Анатольевич Журавлев
Original Assignee
Государственное образовательное учреждение высшего профессионального образовани "Удмуртский государственный университет" (RU)
Государственное образовательное учреждение высшего профессионального образования "Удмуртский государственный университет"
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Application filed by Государственное образовательное учреждение высшего профессионального образовани "Удмуртский государственный университет" (RU), Государственное образовательное учреждение высшего профессионального образования "Удмуртский государственный университет" filed Critical Государственное образовательное учреждение высшего профессионального образовани "Удмуртский государственный университет" (RU)
Priority to RU2006131784/15A priority Critical patent/RU2338375C2/en
Publication of RU2006131784A publication Critical patent/RU2006131784A/en
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Publication of RU2338375C2 publication Critical patent/RU2338375C2/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Claims (5)

1. Способ хранения плазмы или сыворотки крови для получения иммуноглобулиновых и альбуминовых биопрепаратов путем воздействия химическими реагентами, отличающийся тем, что в качестве химических реагентов используют фенол и сульфат аммония, при этом воздействие осуществляют последовательным введением фенола и сульфата аммония, полученную суспензию с иммуноглобулинами в осадке и альбумином в надосадочной жидкости хранят при температуре (10±2)°С, затем избирательно переводят в полуфабрикаты для получения биопрепаратов иммуноглобулинов и альбуминов.1. A method of storing plasma or blood serum to obtain immunoglobulin and albumin biological products by exposure to chemical reagents, characterized in that phenol and ammonium sulfate are used as chemical reagents, the effect being carried out by the sequential introduction of phenol and ammonium sulfate, the resulting suspension with immunoglobulins in the sediment and albumin in the supernatant is stored at a temperature of (10 ± 2) ° C, then selectively transferred to semi-finished products to obtain biological preparations of immunoglobulins and albumin. 2. Способ по п.1, отличающийся тем, что фенол вводят до его конечной концентрации (0,7±0,2)% в заготовке плазмы или сыворотки крови и выдерживают в течение 5 суток.2. The method according to claim 1, characterized in that phenol is administered to its final concentration (0.7 ± 0.2)% in a plasma or blood serum preparation and incubated for 5 days. 3. Способ по п.1, отличающийся тем, что сульфат аммония вносят до концентрации 50% от насыщения.3. The method according to claim 1, characterized in that the ammonium sulfate contribute to a concentration of 50% of saturation. 4. Способ по п.1, отличающийся тем, что перевод в полуфабрикаты для получения биопрепаратов иммуноглобулинов и альбумина осуществляют путем экстракции осадков целевых белков раствором хлорида кальция и переосаждением их из растворов полиэтиленгликолем.4. The method according to claim 1, characterized in that the conversion to semi-finished products for the production of biological products of immunoglobulins and albumin is carried out by extraction of the precipitated target proteins with a solution of calcium chloride and their reprecipitation from solutions of polyethylene glycol. 5. Способ по п.1, отличающийся тем, перевод в полуфабрикаты для получения биопрепаратов иммуноглобулинов и альбумина осуществляют на любом сроке хранения в течение 12 месяцев.5. The method according to claim 1, characterized in that the conversion to semi-finished products for the production of biological products of immunoglobulins and albumin is carried out at any shelf life for 12 months.
RU2006131784/15A 2006-09-04 2006-09-04 Method of plasma or blood serum storage for obtaining of immunoglobulene and albuminous biological preparations RU2338375C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2006131784/15A RU2338375C2 (en) 2006-09-04 2006-09-04 Method of plasma or blood serum storage for obtaining of immunoglobulene and albuminous biological preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2006131784/15A RU2338375C2 (en) 2006-09-04 2006-09-04 Method of plasma or blood serum storage for obtaining of immunoglobulene and albuminous biological preparations

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RU2006131784A true RU2006131784A (en) 2008-03-10
RU2338375C2 RU2338375C2 (en) 2008-11-20

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RU2006131784/15A RU2338375C2 (en) 2006-09-04 2006-09-04 Method of plasma or blood serum storage for obtaining of immunoglobulene and albuminous biological preparations

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2703537C2 (en) * 2016-08-09 2019-10-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Удмуртский государственный университет" Method for making semi-products of immunoglobulin and albumin biopreparations of slaughtered animal blood, abortion and placental human blood
RU2696480C1 (en) * 2018-03-12 2019-08-02 Александр Владимирович Захаров Method of producing a gamma-globulin semi-product with high content of antiviral antibodies from slaughter blood of vaccinated cows

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RU2338375C2 (en) 2008-11-20

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