RU2004119947A - GENES AND PROTEINS OF VIRULENCE AND THEIR USE - Google Patents

GENES AND PROTEINS OF VIRULENCE AND THEIR USE Download PDF

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Publication number
RU2004119947A
RU2004119947A RU2004119947/13A RU2004119947A RU2004119947A RU 2004119947 A RU2004119947 A RU 2004119947A RU 2004119947/13 A RU2004119947/13 A RU 2004119947/13A RU 2004119947 A RU2004119947 A RU 2004119947A RU 2004119947 A RU2004119947 A RU 2004119947A
Authority
RU
Russia
Prior art keywords
strain according
mutation
strain
gram
streptococcal
Prior art date
Application number
RU2004119947/13A
Other languages
Russian (ru)
Inventor
Энда Элизабет КЛАРК (GB)
Энда Элизабет КЛАРК
Ликуинг ЗХОУ (GB)
Ликуинг ЗХОУ
Жаклин Элизабет ШИА (GB)
Жаклин Элизабет ШИА
Роберт Грэхэм ФЕЛДМАН (GB)
Роберт Грэхэм ФЕЛДМАН
Дэвид Вилль м ХОЛДЕН (GB)
Дэвид Вилльям ХОЛДЕН
Original Assignee
Вмакс Лимитед (Gb)
Вмакс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9930474.3A external-priority patent/GB9930474D0/en
Priority claimed from GBGB9930466.9A external-priority patent/GB9930466D0/en
Priority claimed from GBGB9930462.8A external-priority patent/GB9930462D0/en
Priority claimed from GBGB9930463.6A external-priority patent/GB9930463D0/en
Priority claimed from GBGB9930472.7A external-priority patent/GB9930472D0/en
Priority claimed from GBGB9930469.3A external-priority patent/GB9930469D0/en
Priority claimed from GBGB9930476.8A external-priority patent/GB9930476D0/en
Priority claimed from GB0003726A external-priority patent/GB0003726D0/en
Priority claimed from GB0003728A external-priority patent/GB0003728D0/en
Priority claimed from GB0003731A external-priority patent/GB0003731D0/en
Priority claimed from GB0003730A external-priority patent/GB0003730D0/en
Priority claimed from GB0003733A external-priority patent/GB0003733D0/en
Priority claimed from GB0010587A external-priority patent/GB0010587D0/en
Application filed by Вмакс Лимитед (Gb), Вмакс Лимитед filed Critical Вмакс Лимитед (Gb)
Publication of RU2004119947A publication Critical patent/RU2004119947A/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (9)

1. Стрептококковый штамм группы А, содержащий мутацию, которая нарушает экспрессию любой из нуклеотидных последовательностей, идентифицированных как SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59 и 61 S.pyogenes, или родственной молекулой в стрептококковой или грам-положительной бактерии.1. A group A streptococcal strain containing a mutation that disrupts the expression of any of the nucleotide sequences identified as SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, and 61 S. pyogenes, or a related molecule in a streptococcal or gram-positive bacterium. 2. Штамм по п.1, отличающийся тем, что мутацией является инсерционная инактивация или делеция гена.2. The strain according to claim 1 , characterized in that the mutation is insertional inactivation or deletion of the gene. 3. Штамм по п.1 или 2, включающий мутацию в дополнительной нуклеотидной последовательности.3. The strain according to claim 1 or 2, comprising a mutation in an additional nucleotide sequence. 4. Штамм по любому из пп.1-3, содержащий гетерологичный антиген, терапевтический пептид или нуклеиновую кислоту.4. The strain according to any one of claims 1 to 3, containing a heterologous antigen, therapeutic peptide or nucleic acid. 5. Штамм по любому из пп.1-4, используемый для изготовления лекарственного средства для лечения или профилактики состояния, ассоциированного с инфицированием стрептококком или грам-положительной бактерией.5. The strain according to any one of claims 1 to 4, used for the manufacture of a medicament for the treatment or prophylaxis of a condition associated with infection with streptococcus or gram-positive bacterium. 6. Штамм по п.5, отличающийся тем, что состоянием является пневмония.6. The strain according to claim 5, characterized in that the condition is pneumonia. 7. Штамм по п.5 или 6, используемый в ветеринарии.7. The strain according to claim 5 or 6, used in veterinary medicine. 8. Штамм по любому из пп.1-4, используемый в анализе-скрининге для идентификации противомикробного лекарственного средства.8. The strain according to any one of claims 1 to 4, used in a screening assay to identify an antimicrobial drug. 9. Вакцина, включающая штамм по любому из пп.1-4.9. A vaccine comprising a strain according to any one of claims 1 to 4.
RU2004119947/13A 1999-12-23 2004-06-30 GENES AND PROTEINS OF VIRULENCE AND THEIR USE RU2004119947A (en)

Applications Claiming Priority (38)

Application Number Priority Date Filing Date Title
GB9930463.6 1999-12-23
GB9930469.3 1999-12-23
GB9930472.7 1999-12-23
GBGB9930462.8A GB9930462D0 (en) 1999-12-23 1999-12-23 Virulence gene and protein and their use
GBGB9930463.6A GB9930463D0 (en) 1999-12-23 1999-12-23 Virulence gene and protein and their use
GBGB9930472.7A GB9930472D0 (en) 1999-12-23 1999-12-23 Virulence gene and protein,and their use
GB9930475.0 1999-12-23
GB9930467.7 1999-12-23
GBGB9930469.3A GB9930469D0 (en) 1999-12-23 1999-12-23 Virulence gene and protein,and their use
GB9930473.5 1999-12-23
GB9930474.3 1999-12-23
GBGB9930474.3A GB9930474D0 (en) 1999-12-23 1999-12-23 Virulence gene and protein, and their use
GB9930466.9 1999-12-23
GB9930476.8 1999-12-23
GB9930471.9 1999-12-23
GB9930464.4 1999-12-23
GBGB9930476.8A GB9930476D0 (en) 1999-12-23 1999-12-23 Virulence gene and protein,and their use
GBGB9930466.9A GB9930466D0 (en) 1999-12-23 1999-12-23 Virulence gene and protein,and their use
GB9930462.8 1999-12-23
GB0003727.5 2000-02-17
GB0003726A GB0003726D0 (en) 2000-02-17 2000-02-17 Virulence gene and protein and their use
GB0003728.3 2000-02-17
GB0003735.8 2000-02-17
GB0003726.7 2000-02-17
GB0003728A GB0003728D0 (en) 2000-02-17 2000-02-17 Virulence gene and protein, and their use
GB0003732.5 2000-02-17
GB0003725.9 2000-02-17
GB0003736.6 2000-02-17
GB0003733.3 2000-02-17
GB0003731.7 2000-02-17
GB0003731A GB0003731D0 (en) 2000-02-17 2000-02-17 Virulence gene and protein, and their use
GB0003730.9 2000-02-17
GB0003730A GB0003730D0 (en) 2000-02-17 2000-02-17 Virulence gene and protein, and their use
GB0003733A GB0003733D0 (en) 2000-02-17 2000-02-17 Virulence gene and protein, and their use
GB0003729.1 2000-02-17
GB0010585.8 2000-05-02
GB0010587A GB0010587D0 (en) 2000-05-02 2000-05-02 Virulence gene and protein, and their use
GB0010587.4 2000-05-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2002119589/13A Division RU2240327C2 (en) 1999-12-23 2000-12-22 Gene and protein of virulence and their using

Publications (1)

Publication Number Publication Date
RU2004119947A true RU2004119947A (en) 2006-01-10

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Application Number Title Priority Date Filing Date
RU2002119589/13A RU2240327C2 (en) 1999-12-23 2000-12-22 Gene and protein of virulence and their using
RU2004119947/13A RU2004119947A (en) 1999-12-23 2004-06-30 GENES AND PROTEINS OF VIRULENCE AND THEIR USE

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU2002119589/13A RU2240327C2 (en) 1999-12-23 2000-12-22 Gene and protein of virulence and their using

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RU2240327C2 (en) 2004-11-20
RU2002119589A (en) 2004-02-10

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FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20080804