RU2004113379A - CONJUGATES OF PROTEIN AND POLYETHYLENE Glycol Derivative, PHARMACEUTICAL COMPOSITION, METHOD FOR COMBATING VIRAL INFECTION - Google Patents

CONJUGATES OF PROTEIN AND POLYETHYLENE Glycol Derivative, PHARMACEUTICAL COMPOSITION, METHOD FOR COMBATING VIRAL INFECTION Download PDF

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RU2004113379A
RU2004113379A RU2004113379/04A RU2004113379A RU2004113379A RU 2004113379 A RU2004113379 A RU 2004113379A RU 2004113379/04 A RU2004113379/04 A RU 2004113379/04A RU 2004113379 A RU2004113379 A RU 2004113379A RU 2004113379 A RU2004113379 A RU 2004113379A
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conjugates
polyethylene glycol
protein
pharmaceutical composition
viral infection
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RU2004113379/04A
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Russian (ru)
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RU2298560C2 (en
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Сергей Николаевич Курочкин (RU)
Сергей Николаевич Курочкин
Антон Александрович Парканский (RU)
Антон Александрович Парканский
ев Тимур Хайдарович Чибил (RU)
Тимур Хайдарович Чибиляев
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Закрытое Акционерное Общество "ВЕРОФАРМ" (RU)
Закрытое акционерное общество "ВЕРОФАРМ"
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Claims (7)

1. Конъюгаты белка и производного полиэтиленгликоля формулы1. Conjugates of a protein and a derivative of polyethylene glycol of the formula
Figure 00000001
Figure 00000001
 где n и n1 составляют от 100 до 500, а средняя молекулярная масса звеньев полиэтиленгликоля составляет от приблизительно 7500 Да до приблизительно 35000 Да.where n and n 1 are from 100 to 500, and the average molecular weight of the polyethylene glycol units is from about 7500 Da to about 35000 Da. 2. Конъюгаты по п.1, где n=n1=120, а молекулярная масса звеньев полиэтиленгликоля составляет приблизительно 10000 Да.2. The conjugates according to claim 1, where n = n 1 = 120, and the molecular weight of the polyethylene glycol units is approximately 10,000 Da. 3. Конъюгаты по любому из пп.1 и 2, в котором конъюгированный белок представляет собой интерферон.3. The conjugates according to any one of claims 1 and 2, in which the conjugated protein is interferon. 4. Конъюгаты по п.3, в котором интерфероном является α-IFN.4. The conjugates according to claim 3, in which the interferon is α-IFN. 5. Конъюгаты по п.3, в котором интерфероном является α-2b IFN.5. The conjugates according to claim 3, in which the interferon is α-2b IFN. 6. Фармацевтическая композиция, обладающая противовирусной активностью, содержащая коньюгат по любому из пп.1-5 и терапевтически инертный носитель.6. A pharmaceutical composition having antiviral activity, comprising the conjugate according to any one of claims 1 to 5 and a therapeutically inert carrier. 7. Способ борьбы с вирусной инфекцией, включающий введение в организм конъюгата по любому из пп.3-5 в эффективном количестве.7. A method of combating a viral infection, comprising introducing into the body the conjugate according to any one of claims 3 to 5 in an effective amount.
RU2004113379/04A 2004-04-30 2004-04-30 Conjugates of protein and polyethylene glycol derivative, pharmaceutical composition, method for control of viral infection RU2298560C2 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125880B2 (en) 2002-12-26 2015-09-08 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency

Families Citing this family (1)

* Cited by examiner, † Cited by third party
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EA019319B1 (en) * 2011-06-06 2014-02-28 Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") Method for producing covalent conjugate of polyethyleneglycol with interferon and method of producing activated peg-agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125880B2 (en) 2002-12-26 2015-09-08 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency

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