RU2003123907A - METHOD FOR PRODUCING N-PHTHALIMIDOALKylADAMANTHANE OR ITS DERIVATIVES - Google Patents

METHOD FOR PRODUCING N-PHTHALIMIDOALKylADAMANTHANE OR ITS DERIVATIVES Download PDF

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RU2003123907A
RU2003123907A RU2003123907/04A RU2003123907A RU2003123907A RU 2003123907 A RU2003123907 A RU 2003123907A RU 2003123907/04 A RU2003123907/04 A RU 2003123907/04A RU 2003123907 A RU2003123907 A RU 2003123907A RU 2003123907 A RU2003123907 A RU 2003123907A
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phthalyl
derivatives
derivative
cooc
phthalimidoalkyl
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RU2003123907/04A
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Russian (ru)
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RU2247114C1 (en
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Геннадий Михайлович Бутов (RU)
Геннадий Михайлович Бутов
Владимир Михайлович Мохов (RU)
Владимир Михайлович Мохов
Евгений Николаевич Вишневский (RU)
Евгений Николаевич Вишневский
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Волгоградский государственный технический университет (ВолгГТУ) (RU)
Волгоградский государственный технический университет (ВолгГТУ)
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Priority to RU2003123907/04A priority Critical patent/RU2247114C1/en
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Способ получения N-фталимидоалкиладамантанов и их производных общей формулыThe method of obtaining N-phthalimidoalkylamantanes and their derivatives of the General formula
Figure 00000001
Figure 00000001
 где Х - одинарная связь, R1 - H: R - С6Н5, С6Н4COOC2Н5; R1 - СН3: R - СН3; R1 - COOC2H5: R - СН2СН2SCH3, (СН2)3СН3 where X is a single bond, R 1 - H: R - C 6 H 5 , C 6 H 4 COOC 2 H 5 ; R 1 is CH 3 ; R is CH 3 ; R 1 - COOC 2 H 5 : R - CH 2 CH 2 SCH 3 , (CH 2 ) 3 CH 3 Х=СН2СН2, R1=R=COOC2H5;X = CH 2 CH 2 , R 1 = R = COOC 2 H 5 ; X,
Figure 00000002
X
Figure 00000002
 с использованием производного адамантана, отличающийся тем, что способ заключается в присоединении к производному адамантана соответствующего N-фталимидоалкила или его производного, причем в качестве производного адамантана используют 1,3-дегидроадамантан, а в качестве N-фталимидоалкила или его производного используют N-бензилфталимид, N-изопропилфталимид, этиловые эфиры N-фталил-D,L-метионина, N-фталил-D,L-норлейцина, N-фталил-4-аминометил-1-бензойной кислоты, N-фталил-4-аминоциклогексан-1-карбоновой кислоты, диэтиловый эфир 2-(N-фтали-мидо)этилмалоновой кислоты, а процесс проводят при мольных соотношениях реагентов соответственно 1:2-3 в среде инертного растворителя или в расплаве N-фталимидоалкилов или их производных при температуре 80-120°С в течение 4-6 ч.using an adamantane derivative, characterized in that the method comprises attaching to the adamantane derivative the corresponding N-phthalimidoalkyl or its derivative, wherein 1,3-dehydroadamantane is used as the adamantane derivative and N-benzylphthalimide is used as the N-phthalimidoalkyl or derivative, N-isopropylphthalimide, ethyl esters of N-phthalyl-D, L-methionine, N-phthalyl-D, L-norleucine, N-phthalyl-4-aminomethyl-1-benzoic acid, N-phthalyl-4-aminocyclohexane-1-carboxylic acid acids, diethyl ether 2- (N-phthalimido) ethyl alonovoy acid, and the process is conducted at a mole ratio of reactants respectively 1: 2-3 in an inert solvent or in the melt-N-ftalimidoalkilov or their derivatives at a temperature of 80-120 ° C for 4-6 hours.
RU2003123907/04A 2003-07-30 2003-07-30 Method for preparing n-phthalimidoalkyladamantane or its derivatives RU2247114C1 (en)

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