RU2003106194A - NEW Phenylpiperazines - Google Patents

NEW Phenylpiperazines

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Publication number
RU2003106194A
RU2003106194A RU2003106194/04A RU2003106194A RU2003106194A RU 2003106194 A RU2003106194 A RU 2003106194A RU 2003106194/04 A RU2003106194/04 A RU 2003106194/04A RU 2003106194 A RU2003106194 A RU 2003106194A RU 2003106194 A RU2003106194 A RU 2003106194A
Authority
RU
Russia
Prior art keywords
formula
compound
compound according
phenylpiperazines
new
Prior art date
Application number
RU2003106194/04A
Other languages
Russian (ru)
Other versions
RU2279431C2 (en
Inventor
Рулоф В. Фенстра
Эрик РОНКЕН
Корнелис Г. Крюсе
Эндрю С. Маккрири
СХАРРЕНБУРГ Густаф Й. М. ВАН
Original Assignee
Солвей Фармасьютикалс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Солвей Фармасьютикалс Б.В. filed Critical Солвей Фармасьютикалс Б.В.
Publication of RU2003106194A publication Critical patent/RU2003106194A/en
Application granted granted Critical
Publication of RU2279431C2 publication Critical patent/RU2279431C2/en

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Claims (5)

1. Производные фенилпиперазина, имеющие формулу (1)1. Derivatives of phenylpiperazine having the formula (1)
Figure 00000001
Figure 00000001
 где R означает группу формулы (а) или (b)where R is a group of formula (a) or (b)
Figure 00000002
Figure 00000003
Figure 00000002
Figure 00000003
 и их соли.and their salts. 2. Способ получения соединений по п.1, отличающийся тем, что соединение, имеющее формулу (2)2. A method of producing compounds according to claim 1, characterized in that the compound having the formula (2)
Figure 00000004
Figure 00000004
 подвергают взаимодействию в основных условиях с соединением формулыsubjected to basic conditions with a compound of the formula L-(а) или L-(b)L- (a) or L- (b) где L означает отщепляемую группу, а (а) и (b) имеют значения, приведенные в п.1.where L means a leaving group, and (a) and (b) have the meanings given in claim 1. 3. Фармацевтическая композиция, содержащая, по меньшей мере, одно соединение по п.1 в качестве активного компонента.3. A pharmaceutical composition comprising at least one compound according to claim 1 as an active component. 4. Способ лечения болезни Паркинсона, отличающийся тем, что применяют соединение по п.1.4. A method of treating Parkinson's disease, characterized in that the compound according to claim 1 is used. 5. Способ лечения расстройств ЦНС, таких, как шизофрения, состояние тревоги и депрессия, отличающийся тем, что применяют соединение по п.1.5. A method of treating CNS disorders, such as schizophrenia, anxiety and depression, characterized in that the compound according to claim 1 is used.
RU2003106194/04A 2001-02-21 2002-02-19 Derivatives of benzoxazolone, pharmaceutical composition and treatment methods RU2279431C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200609 2001-02-21
EP01200609.4 2001-02-21

Publications (2)

Publication Number Publication Date
RU2003106194A true RU2003106194A (en) 2004-08-20
RU2279431C2 RU2279431C2 (en) 2006-07-10

Family

ID=8179908

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003106194/04A RU2279431C2 (en) 2001-02-21 2002-02-19 Derivatives of benzoxazolone, pharmaceutical composition and treatment methods

Country Status (29)

Country Link
US (1) US6828325B2 (en)
EP (1) EP1395583B1 (en)
JP (1) JP4178033B2 (en)
KR (1) KR100848482B1 (en)
CN (1) CN1190433C (en)
AR (1) AR032711A1 (en)
AT (1) ATE289604T1 (en)
AU (1) AU2002253043B2 (en)
BR (1) BR0205220A (en)
CA (1) CA2411973A1 (en)
CZ (1) CZ299487B6 (en)
DE (1) DE60203042T2 (en)
DK (1) DK1395583T3 (en)
DZ (1) DZ3441A1 (en)
ES (1) ES2235029T3 (en)
HK (1) HK1059781A1 (en)
HU (1) HUP0303329A3 (en)
IL (1) IL153176A (en)
MX (1) MXPA03004242A (en)
NO (1) NO323781B1 (en)
NZ (1) NZ523135A (en)
PL (1) PL359650A1 (en)
PT (1) PT1395583E (en)
RU (1) RU2279431C2 (en)
SI (1) SI1395583T1 (en)
SK (1) SK286064B6 (en)
UA (1) UA74426C2 (en)
WO (1) WO2002066472A1 (en)
ZA (1) ZA200209897B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2246494C2 (en) * 1999-08-23 2005-02-20 Солвей Фармасьютикалс Б.В. New phenylpiperazines
AR032712A1 (en) 2001-02-21 2003-11-19 Solvay Pharm Bv A MESILATE OF PHENYLPIPERAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
CA2453837C (en) * 2001-07-20 2011-10-04 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder using eltoprazine and related compounds
EP1683790A1 (en) * 2005-01-24 2006-07-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands
GB0708818D0 (en) * 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
CA2335711A1 (en) * 1998-06-19 1999-12-29 Ivan Mikkelsen 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR020773A1 (en) 1998-10-16 2002-05-29 Duphar Int Res COMPOUND DERIVED FROM 3- (TETRAHYDROPIRIDIN-4-IL) INDOL, METHOD TO PREPARE IT, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, METHOD TO PREPARE SUCH COMPOSITION AND USE OF THE COMPOUND
RU2246494C2 (en) 1999-08-23 2005-02-20 Солвей Фармасьютикалс Б.В. New phenylpiperazines
EP1336406A1 (en) 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity

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