RU2003102627A - IMPROVED METHOD FOR SYNTHESIS OF COMPLEX 6-ETHERS OF SUGAROSE - Google Patents

IMPROVED METHOD FOR SYNTHESIS OF COMPLEX 6-ETHERS OF SUGAROSE

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Publication number
RU2003102627A
RU2003102627A RU2003102627/04A RU2003102627A RU2003102627A RU 2003102627 A RU2003102627 A RU 2003102627A RU 2003102627/04 A RU2003102627/04 A RU 2003102627/04A RU 2003102627 A RU2003102627 A RU 2003102627A RU 2003102627 A RU2003102627 A RU 2003102627A
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RU
Russia
Prior art keywords
sucrose
distillation
reaction mixture
ester
removing water
Prior art date
Application number
RU2003102627/04A
Other languages
Russian (ru)
Other versions
RU2261252C2 (en
Inventor
Джейсон Д. КЛАРК
Ричард Р. Мл. ЛЕМЭЙ
Original Assignee
Тейт Энд Лайл Паблик Лимитед Компани
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Priority claimed from GB0018784A external-priority patent/GB2365424B/en
Application filed by Тейт Энд Лайл Паблик Лимитед Компани filed Critical Тейт Энд Лайл Паблик Лимитед Компани
Publication of RU2003102627A publication Critical patent/RU2003102627A/en
Application granted granted Critical
Publication of RU2261252C2 publication Critical patent/RU2261252C2/en

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Claims (13)

1. Способ получения сложного 6-эфира сахарозы, включающий а) взаимодействие смеси, содержащей сахарозу и полярный апротонный растворитель, с активатором ацилирования на основе оловоорганического соединения, с добавлением растворителя, способного удалять воду путем совместной перегонки, и удаление воды совместной перегонкой для получения первой реакционной смеси, по существу свободной от воды, и далее (b) добавление ангидрида карбоновой кислоты к указанной первой реакционной смеси для получения второй реакционной смеси, и выдерживание указанной второй реакционной смеси при температуре и в течение времени, достаточных для образования сложного 6-эфира сахарозы, отличающийся тем, что стадию (a) проводят при температуре 85-125°C и под давлением 20-80 KPa.1. A method for producing sucrose 6-ester, comprising a) reacting a mixture containing sucrose and a polar aprotic solvent with an acylation activator based on an organotin compound, adding a solvent capable of removing water by co-distillation, and removing water by co-distillation to obtain the first a reaction mixture substantially free of water, and further (b) adding carboxylic acid anhydride to said first reaction mixture to obtain a second reaction mixture, and holding at azannoy second reaction mixture at a temperature and for a time sufficient to form a complex of sucrose 6-ester, characterized in that step (a) is carried out at a temperature of 85-125 ° C and a pressure of 20-80 KPa. 2. Способ по п.1, где указанный полярный апротонный растворитель представляет собой диметилформамид.2. The method according to claim 1, where the specified polar aprotic solvent is dimethylformamide. 3. Способ по п.1 или 2, где указанный растворитель, способный удалять воду путем совместной перегонки, представляет собой циклогексан.3. The method according to claim 1 or 2, wherein said solvent capable of removing water by co-distillation is cyclohexane. 4. Способ по любому из пп.1-3, где указанный активатор ацилирования на основе оловоорганического соединения, представляет собой 1,3-диацилокси-1,1,3,3-тетра-(гидрокарбил)дистанноксан.4. The method according to any one of claims 1 to 3, wherein said acylating activator based on an organotin compound is 1,3-diacyloxy-1,1,3,3-tetra- (hydrocarbyl) distannoxane. 5. Способ по п.4, где указанный 1,3-диацилокси-1,1,3,3-тетра(гидрокарбил)дистанноксан представляет собой 1,3-диацилокси-1,1,3,3-тетрабутилдистанноксан.5. The method of claim 4, wherein said 1,3-diacyloxy-1,1,3,3-tetra (hydrocarbyl) distannoxane is 1,3-diacyloxy-1,1,3,3-tetrabutyl distannoxane. 6. Способ по любому из пп.1-5, где в конце стадии (а) массовое соотношение олова к воде в первой реакционной смеси составляет 26-28, при этом содержание олова измеряют рентгенофлюоресцентным анализатором, а содержание воды измеряют по методу Карла Фишера.6. The method according to any one of claims 1 to 5, where at the end of stage (a) the mass ratio of tin to water in the first reaction mixture is 26-28, while the tin content is measured by an X-ray fluorescence analyzer, and the water content is measured by the Karl Fischer method. 7. Способ по любому из пп.1-6, где стадию (а) проводят при температуре приблизительно 97°C.7. The method according to any one of claims 1 to 6, where stage (a) is carried out at a temperature of approximately 97 ° C. 8. Способ по любому из пп.1-7, где стадию (а) проводят под давлением приблизительно 50 KPa.8. The method according to any one of claims 1 to 7, where stage (a) is carried out under a pressure of approximately 50 KPa. 9. Способ по любому из пп.1-8, где указанный сложный 6-эфир сахарозы представляет собой сахароза-6-ацетат, и указанный ангидрид карбоновой кислоты представляет собой уксусный ангидрид.9. The method according to any one of claims 1 to 8, wherein said sucrose 6-ester is sucrose-6-acetate and said carboxylic anhydride is acetic anhydride. 10. Способ по любому из пп.1-9, где растворитель, способный удалять воду путем совместной перегонки, регенерируют и используют повторно.10. The method according to any one of claims 1 to 9, where a solvent capable of removing water by co-distillation is regenerated and reused. 11. Способ по любому из пп.1-9, где растворитель, способный удалять воду путем совместной перегонки, рециркулируют в течение реакции.11. The method according to any one of claims 1 to 9, where a solvent capable of removing water by co-distillation is recycled during the reaction. 12. Способ по любому из пп.4-11, где 1,3-диацилокси-1,1,3,3-тетра(гидрокарбил)дистанноксан регенерируют и используют повторно.12. The method according to any one of claims 4-11, wherein 1,3-diacyloxy-1,1,3,3-tetra (hydrocarbyl) distannoxane is regenerated and reused. 13. Способ синтеза сукралозы из сахарозы с использованием сложного эфира 6-сахарозы в качестве промежуточного продукта, отличающийся тем, что сложный эфир 6-сахарозы получен в соответствии со способом по любому из пп.1-13.13. A method for the synthesis of sucralose from sucrose using a 6-sucrose ester as an intermediate product, characterized in that the 6-sucrose ester is obtained in accordance with the method according to any one of claims 1 to 13.
RU2003102627/04A 2000-07-31 2001-07-19 Improved method for synthesis of sucrose 6-esters RU2261252C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0018784A GB2365424B (en) 2000-07-31 2000-07-31 An improved method for the synthesis of sucrose-6-esters
GB0018784.9 2000-07-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2005120725/04A Division RU2005120725A (en) 2000-07-31 2005-06-30 METHOD FOR SYNTHESIS OF SUCRALOSE

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RU2003102627A true RU2003102627A (en) 2004-07-27
RU2261252C2 RU2261252C2 (en) 2005-09-27

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RU2005120725/04A RU2005120725A (en) 2000-07-31 2005-06-30 METHOD FOR SYNTHESIS OF SUCRALOSE

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US (1) US6939962B2 (en)
EP (1) EP1305326B1 (en)
JP (1) JP4536321B2 (en)
KR (2) KR20070094671A (en)
CN (1) CN1210286C (en)
AT (1) ATE292139T1 (en)
AU (2) AU2001270875B2 (en)
BR (1) BR0111624A (en)
CA (1) CA2417404C (en)
DE (1) DE60109787T2 (en)
ES (1) ES2239149T3 (en)
GB (1) GB2365424B (en)
IL (2) IL152599A0 (en)
MX (1) MXPA03000986A (en)
PT (1) PT1305326E (en)
RU (2) RU2261252C2 (en)
WO (1) WO2002010180A1 (en)

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