RU2003102627A - IMPROVED METHOD FOR SYNTHESIS OF COMPLEX 6-ETHERS OF SUGAROSE - Google Patents
IMPROVED METHOD FOR SYNTHESIS OF COMPLEX 6-ETHERS OF SUGAROSEInfo
- Publication number
- RU2003102627A RU2003102627A RU2003102627/04A RU2003102627A RU2003102627A RU 2003102627 A RU2003102627 A RU 2003102627A RU 2003102627/04 A RU2003102627/04 A RU 2003102627/04A RU 2003102627 A RU2003102627 A RU 2003102627A RU 2003102627 A RU2003102627 A RU 2003102627A
- Authority
- RU
- Russia
- Prior art keywords
- sucrose
- distillation
- reaction mixture
- ester
- removing water
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title claims 2
- 238000003786 synthesis reaction Methods 0.000 title claims 2
- 230000002194 synthesizing Effects 0.000 title claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
- 239000005720 sucrose Substances 0.000 claims 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 5
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 5
- 238000004821 distillation Methods 0.000 claims 5
- 239000011541 reaction mixture Substances 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 2
- WFDIJRYMOXRFFG-UHFFFAOYSA-N acetic anhydride Chemical group CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 2
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003880 polar aprotic solvent Substances 0.000 claims 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N tin hydride Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 2
- BAQAVOSOZGMPRM-JVFSCRHWSA-N (2R,3R,4R,5R,6R)-2-[(2S,3R,4R,5R)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@]1(CCl)[C@H](O)[C@@H](O)[C@H](CCl)O1 BAQAVOSOZGMPRM-JVFSCRHWSA-N 0.000 claims 1
- CPBZARXQRZTYGI-UHFFFAOYSA-N 3-cyclopentylpropylcyclohexane Chemical compound C1CCCCC1CCCC1CCCC1 CPBZARXQRZTYGI-UHFFFAOYSA-N 0.000 claims 1
- 239000004376 Sucralose Substances 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- 238000004876 x-ray fluorescence Methods 0.000 claims 1
Claims (13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0018784A GB2365424B (en) | 2000-07-31 | 2000-07-31 | An improved method for the synthesis of sucrose-6-esters |
GB0018784.9 | 2000-07-31 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005120725/04A Division RU2005120725A (en) | 2000-07-31 | 2005-06-30 | METHOD FOR SYNTHESIS OF SUCRALOSE |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2003102627A true RU2003102627A (en) | 2004-07-27 |
RU2261252C2 RU2261252C2 (en) | 2005-09-27 |
Family
ID=9896697
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2003102627/04A RU2261252C2 (en) | 2000-07-31 | 2001-07-19 | Improved method for synthesis of sucrose 6-esters |
RU2005120725/04A RU2005120725A (en) | 2000-07-31 | 2005-06-30 | METHOD FOR SYNTHESIS OF SUCRALOSE |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005120725/04A RU2005120725A (en) | 2000-07-31 | 2005-06-30 | METHOD FOR SYNTHESIS OF SUCRALOSE |
Country Status (17)
Country | Link |
---|---|
US (1) | US6939962B2 (en) |
EP (1) | EP1305326B1 (en) |
JP (1) | JP4536321B2 (en) |
KR (2) | KR20070094671A (en) |
CN (1) | CN1210286C (en) |
AT (1) | ATE292139T1 (en) |
AU (2) | AU2001270875B2 (en) |
BR (1) | BR0111624A (en) |
CA (1) | CA2417404C (en) |
DE (1) | DE60109787T2 (en) |
ES (1) | ES2239149T3 (en) |
GB (1) | GB2365424B (en) |
IL (2) | IL152599A0 (en) |
MX (1) | MXPA03000986A (en) |
PT (1) | PT1305326E (en) |
RU (2) | RU2261252C2 (en) |
WO (1) | WO2002010180A1 (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1295237C (en) * | 2003-10-01 | 2007-01-17 | 常州市牛塘化工厂 | Method for preparing sucrose-6-ethyl ester |
GB0702854D0 (en) * | 2007-01-09 | 2007-03-28 | Tate & Lyle Plc | Method for the synthesis of sucrose-6-esters |
CN101293902B (en) * | 2007-04-25 | 2011-05-11 | 吉安市新琪安科技有限公司 | Process for synthesizing sucrose-6- ethyl ester |
US20080300401A1 (en) * | 2007-06-04 | 2008-12-04 | Polymed Therapeutics, Inc. | Novel chlorination process for preparing sucralose |
US20080300392A1 (en) * | 2007-06-04 | 2008-12-04 | Polymed Therapeutics, Inc. | Novel chlorination process for preparing sucralose |
US20090076261A1 (en) * | 2007-09-13 | 2009-03-19 | Polymed Therapeutics, Inc. | Novel process for preparing sucrose-6-esters |
AR070082A1 (en) * | 2008-01-04 | 2010-03-10 | Tate & Lyle Technology Ltd | METHOD FOR THE PRODUCTION OF SUCRALOSE |
US8476424B2 (en) * | 2008-03-20 | 2013-07-02 | Tate & Lyle Technology Limited | Removal of acids from tertiary amide solvents |
US8436157B2 (en) * | 2008-03-26 | 2013-05-07 | Tate & Lyle Technology Limited | Method for the production of sucralose |
KR20100127875A (en) * | 2008-04-03 | 2010-12-06 | 테이트 앤드 라일 테크놀러지 리미티드 | Effect of carbohydrate concentration on sucralose extraction efficiency |
AR071134A1 (en) * | 2008-04-03 | 2010-05-26 | Tate & Lyle Technology Ltd | CRYSTALLIZATION OF SUCRALOSE FROM SQURALOSA CONTAINING |
US20090259036A1 (en) * | 2008-04-03 | 2009-10-15 | Tate & Lyle Technology Limited | Extraction of less polar impurities from sucralose containing aqueous feed streams |
US8497367B2 (en) * | 2008-04-03 | 2013-07-30 | Tate & Lyle Technology Limited | Sucralose purification process |
GB2469157B (en) | 2009-03-30 | 2011-07-06 | John Kerr | Process for removing dimethylamine during sucralose production |
GB2469158B (en) * | 2009-03-31 | 2011-09-28 | Peter J Seaberg | Base-assisted formation of tin-sucrose adducts |
GB2471348B (en) | 2009-06-22 | 2011-12-14 | Tate & Lyle Technology Ltd | A method for producing sucralose-6-acylate |
GB2474311B (en) | 2009-10-12 | 2012-10-17 | Tate & Lyle Technology Ltd | Low temperature, single solvent process for the production of sucrose-6-ester |
GB2474310B (en) * | 2009-10-12 | 2012-02-29 | Tate & Lyle Technology Ltd | Process for the production of sucrose-6-ester |
GB201110520D0 (en) | 2011-05-10 | 2011-08-03 | Tate & Lyle Technology Ltd | Extraction of carboxylic acids with tin compounds |
CN104098617A (en) * | 2013-04-08 | 2014-10-15 | 南京工业大学 | Preparation method of sucrose-6-acetate |
CN105829332B (en) | 2013-12-16 | 2018-10-02 | 塔特和莱利技术有限公司 | The chlorination of sucrose-6-ester |
GB2544217B (en) | 2014-08-08 | 2020-03-25 | Tate & Lyle Tech Ltd | Chlorination of sucrose-6-esters |
GB2536480B (en) | 2015-03-17 | 2019-09-04 | Tate & Lyle Tech Ltd | DMF Distillation |
CN104817597A (en) * | 2015-05-22 | 2015-08-05 | 盐城捷康三氯蔗糖制造有限公司 | Preparation method of sucrose-6-ester |
CN105601665B (en) * | 2015-12-30 | 2018-07-17 | 浙江新和成股份有限公司 | A kind of processing method of Dibutyltin oxide and its application in sucrose-6-ethyl ester synthesis |
GB2551591B (en) | 2016-06-23 | 2019-08-07 | Tate & Lyle Tech Ltd | Liquid-liquid extraction of DMF |
CN109438533A (en) * | 2018-12-10 | 2019-03-08 | 安徽金禾实业股份有限公司 | A kind of method of Sucralose production high temperature continuous acylation |
CN112808048B (en) * | 2021-01-04 | 2022-05-31 | 安徽金禾实业股份有限公司 | Equipment and method for manufacturing sucrose-6-ester |
CN113039001B (en) * | 2021-02-19 | 2022-10-18 | 安徽金禾实业股份有限公司 | Production equipment and production method of sucrose-6-ester |
CN112915565B (en) * | 2021-03-04 | 2022-04-08 | 安徽金禾实业股份有限公司 | Rotary continuous production equipment and production method for sucrose-6-ester |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0629198B2 (en) * | 1984-10-19 | 1994-04-20 | 武田薬品工業株式会社 | Chemical dehydration method |
US5023329A (en) * | 1990-04-23 | 1991-06-11 | Noramco, Inc. | Sucrose-6-ester production process |
GR910100356A (en) * | 1990-08-27 | 1992-08-31 | Mcneil Ppc Inc | Catalysed sucrose -6- ester process |
US5470969A (en) | 1990-08-27 | 1995-11-28 | Mcneil-Ppc, Inc. | Catalyzed sucrose-6-ester process |
DE69625989T2 (en) * | 1995-11-28 | 2003-11-13 | Mcneil Ppc Inc | Manufacturing process for sucrose-6-esters |
-
2000
- 2000-07-31 GB GB0018784A patent/GB2365424B/en not_active Expired - Fee Related
-
2001
- 2001-07-19 DE DE60109787T patent/DE60109787T2/en not_active Expired - Fee Related
- 2001-07-19 RU RU2003102627/04A patent/RU2261252C2/en not_active IP Right Cessation
- 2001-07-19 AU AU2001270875A patent/AU2001270875B2/en not_active Ceased
- 2001-07-19 JP JP2002515909A patent/JP4536321B2/en not_active Expired - Fee Related
- 2001-07-19 IL IL15259901A patent/IL152599A0/en active IP Right Grant
- 2001-07-19 WO PCT/GB2001/003245 patent/WO2002010180A1/en active IP Right Grant
- 2001-07-19 AU AU7087501A patent/AU7087501A/en active Pending
- 2001-07-19 PT PT01949760T patent/PT1305326E/en unknown
- 2001-07-19 MX MXPA03000986A patent/MXPA03000986A/en active IP Right Grant
- 2001-07-19 CN CNB018136842A patent/CN1210286C/en not_active Expired - Fee Related
- 2001-07-19 US US10/343,378 patent/US6939962B2/en not_active Expired - Lifetime
- 2001-07-19 CA CA002417404A patent/CA2417404C/en not_active Expired - Fee Related
- 2001-07-19 KR KR1020077019987A patent/KR20070094671A/en not_active Application Discontinuation
- 2001-07-19 ES ES01949760T patent/ES2239149T3/en not_active Expired - Lifetime
- 2001-07-19 AT AT01949760T patent/ATE292139T1/en not_active IP Right Cessation
- 2001-07-19 BR BR0111624-0A patent/BR0111624A/en not_active IP Right Cessation
- 2001-07-19 EP EP01949760A patent/EP1305326B1/en not_active Expired - Lifetime
- 2001-07-19 KR KR1020027016897A patent/KR100769532B1/en not_active IP Right Cessation
-
2002
- 2002-11-03 IL IL152599A patent/IL152599A/en not_active IP Right Cessation
-
2005
- 2005-06-30 RU RU2005120725/04A patent/RU2005120725A/en not_active Application Discontinuation
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