RU2002133458A - Compounds of piperazine and piperidine - Google Patents

Compounds of piperazine and piperidine

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Publication number
RU2002133458A
RU2002133458A RU2002133458/04A RU2002133458A RU2002133458A RU 2002133458 A RU2002133458 A RU 2002133458A RU 2002133458/04 A RU2002133458/04 A RU 2002133458/04A RU 2002133458 A RU2002133458 A RU 2002133458A RU 2002133458 A RU2002133458 A RU 2002133458A
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RU
Russia
Prior art keywords
compound according
alkyl
compound
compounds
hydrogen
Prior art date
Application number
RU2002133458/04A
Other languages
Russian (ru)
Other versions
RU2261250C2 (en
Inventor
Рулоф В. Фенстра
ДЕР ХЕЙДЕН Йоханнес А. М. ВАН
Корнелис Г. Крюсе
Стефен К. ЛОНГ
СХАРРЕНБЮРГ Густаф Й. М. ВАН
Original Assignee
Солвей Фармасьютикалс Б.В.
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Application filed by Солвей Фармасьютикалс Б.В. filed Critical Солвей Фармасьютикалс Б.В.
Publication of RU2002133458A publication Critical patent/RU2002133458A/en
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Publication of RU2261250C2 publication Critical patent/RU2261250C2/en

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Claims (10)

1. Соединения формулы (I)1. The compounds of formula (I)
Figure 00000001
Figure 00000001
 где Y является водородом, галогеном, С1-С3-алкилом или CN, CF3, OCF3, SCF3, С1-С3-алкоксигруппой, аминогруппой или моно- или ди(С1-С3-алкил)замещенной аминогруппой или гидроксигруппой;where Y is hydrogen, halogen, C 1 -C 3 -alkyl or CN, CF 3 , OCF 3 , SCF 3 , C 1 -C 3 -alkoxy, amino or mono- or di (C 1 -C 3 -alkyl) substituted an amino group or a hydroxy group; Х является O, S, SO или SO2;X is O, S, SO or SO 2 ; Z представляет -C,=C, -N;Z is —C, = C, —N; R1 и R2 независимо представляют водород или С1-С3-алкил;R 1 and R 2 independently represent hydrogen or C 1 -C 3 alkyl; Q является бензилом или 2-, 3- или 4-пиридилметилом, группы которых могут быть замещены одним или более заместителями, выбранными из группы, содержащей галоген, нитро, циано, моно- или ди(С1-С3-алкил)аминогруппу, С1-С3-алкоксигруппу, CF3, OCF3, SCF3, С1-С4-алкил, С1-С3-алкилсульфонил или гидроксигруппу,Q is benzyl or 2-, 3- or 4-pyridylmethyl, the groups of which can be substituted with one or more substituents selected from the group consisting of halogen, nitro, cyano, mono- or di (C 1 -C 3 -alkyl) amino group, A C 1 -C 3 alkoxy group, CF 3 , OCF 3 , SCF 3 , C 1 -C 4 alkyl, C 1 -C 3 alkylsulfonyl or a hydroxy group, а также их соли и пролекарства.as well as their salts and prodrugs. 2. Соединения по п.1, где Y, R1 и R2 являются водородом, Х представляет кислород, Q является (замещенным) бензилом и Z имеет значения, указанные в п.1.2. The compounds of claim 1, wherein Y, R 1, and R 2 are hydrogen, X is oxygen, Q is (substituted) benzyl, and Z is as defined in claim 1. 3. Соединения по п.2, где Q является бензилом, а Z представляет -N.3. The compound of claim 2, wherein Q is benzyl and Z is —N. 4. Способ получения соединений по п.1 взаимодействием соединения формулы (I), в котором Q является водородом, с соединением Q-Hal, в котором Q имеет значения, указанные в п.1, и Hal является галогеном.4. The method for producing compounds according to claim 1 by reacting a compound of formula (I) in which Q is hydrogen with a Q-Hal compound in which Q is as defined in claim 1, and Hal is halogen. 5. Фармацевтическая композиция, содержащая, по меньшей мере, одно соединение по п.1 в качестве активного компонента.5. A pharmaceutical composition containing at least one compound according to claim 1 as an active component. 6. Способ получения фармацевтической композиции, отличающийся тем, что соединение по п.1 приводят в форму пригодную для введения.6. A method of obtaining a pharmaceutical composition, characterized in that the compound according to claim 1 is brought into a form suitable for administration. 7. Способ лечения нарушений центральной нервной системы, отличающийся тем, что используют соединение по п.1.7. A method of treating disorders of the central nervous system, characterized in that the compound according to claim 1 is used. 8. Способ лечения состояния страха и/или депрессии, отличающийся тем, что используют соединение по п.1.8. A method of treating a state of fear and / or depression, characterized in that the compound according to claim 1 is used. 9. Способ лечения болезни Паркинсона, отличающийся тем, что используют соединение по п.1.9. A method of treating Parkinson's disease, characterized in that the compound according to claim 1 is used. 10. Способ лечения наркомании (алкоголизма), отличающийся тем, что используют соединение, заявленное по п.1.10. A method for the treatment of drug addiction (alcoholism), characterized in that the compound according to claim 1 is used.
RU2002133458/04A 2000-05-12 2001-05-10 Piperazine and piperidine compounds RU2261250C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00201699,6 2000-05-12
EP00201699 2000-05-12

Publications (2)

Publication Number Publication Date
RU2002133458A true RU2002133458A (en) 2004-08-20
RU2261250C2 RU2261250C2 (en) 2005-09-27

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Country Status (28)

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US (2) US6911448B2 (en)
EP (1) EP1283838B1 (en)
JP (1) JP2003532729A (en)
CN (1) CN1174979C (en)
AR (1) AR028443A1 (en)
AT (1) ATE255578T1 (en)
AU (2) AU6392701A (en)
BR (1) BR0110592A (en)
CA (1) CA2405971C (en)
CZ (1) CZ301464B6 (en)
DE (1) DE60101386T2 (en)
DK (1) DK1283838T3 (en)
DZ (1) DZ3370A1 (en)
ES (1) ES2211809T3 (en)
HK (1) HK1055952A1 (en)
HU (1) HUP0302016A2 (en)
IL (2) IL152177A0 (en)
MX (1) MXPA02011084A (en)
NO (1) NO323778B1 (en)
NZ (1) NZ522116A (en)
PL (1) PL198857B1 (en)
PT (1) PT1283838E (en)
RU (1) RU2261250C2 (en)
SK (1) SK286778B6 (en)
TR (1) TR200302294T4 (en)
UA (1) UA72337C2 (en)
WO (1) WO2001085725A1 (en)
ZA (1) ZA200208537B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ3370A1 (en) * 2000-05-12 2001-11-15 Solvay Pharm Bv PIPERAZINE AND PIPERIDINE COMPOUNDS
EP1408976B3 (en) 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
WO2004000837A1 (en) * 2002-06-25 2003-12-31 Sumitomo Pharmaceuticals Co., Ltd. Novel benzoxazolinone derivative
ES2232292B1 (en) * 2003-07-30 2006-11-01 Laboratorios Del Dr. Esteve, S.A. SULFONAMIDIC COMPOUNDS DERIVED FROM BENZOXAZINONA, ITS PREPARATION AND USE AS MEDICATIONS.
EP1595542A1 (en) * 2004-03-26 2005-11-16 Solvay Pharmaceuticals B.V. Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
US7596407B2 (en) 2004-03-26 2009-09-29 Solvay Pharmaceuticals, B.V. Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
AR058022A1 (en) * 2005-08-22 2008-01-23 Solvay Pharm Bv DERIVATIVES OF BENZOOXAZOLES, PHARMACEUTICAL COMPOSITIONS AND ITS USE FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS.
US7750013B2 (en) 2005-08-22 2010-07-06 Solvay Pharmaceuticals, B.V. N-oxides as prodrugs of piperazine and piperidine derivatives
DK1919883T3 (en) * 2005-08-22 2009-04-14 Solvay Pharm Bv N-oxides as profarmacones from piperazine and piperidine derivatives
US20070275977A1 (en) * 2006-05-02 2007-11-29 Van Aar Marcel P N-oxides of pyridylmethyl -piperazine and -piperidine derivatives
US8106056B2 (en) 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
CN101541797A (en) 2006-12-07 2009-09-23 弗·哈夫曼-拉罗切有限公司 Spiro-piperidine derivatives
ATE469900T1 (en) 2006-12-07 2010-06-15 Hoffmann La Roche SPIROPIPERIDEN DERIVATIVES AS ANTAGONISTS OF THE VIA RECEPTOR
CA2671324A1 (en) 2006-12-08 2008-06-12 F. Hoffmann-La Roche Ag Indoles which act as via receptor antagonists
JP2010511659A (en) 2006-12-08 2010-04-15 エフ．ホフマン−ラ ロシュ アーゲー Indole
WO2008077810A2 (en) 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives
US20110105523A1 (en) * 2008-01-15 2011-05-05 Van Stuivenberg Herman H Bifeprunox derivatives
WO2018039642A1 (en) 2016-08-26 2018-03-01 Exciva Ug (Haftungsbeschränkt) Compositions and methods thereof
EP3831898A4 (en) * 2018-07-27 2022-04-06 Chugoku Marine Paints, Ltd. Antifouling paint composition, antifouling coating, substrate with antifouling coating, ?production method thereof, and repair method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60126275A (en) * 1983-12-13 1985-07-05 Otsuka Pharmaceut Co Ltd Benzothiazole derivative
FR2567884B1 (en) 1984-07-19 1987-03-06 Roussel Uclaf NEW INDOLE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
ATE81975T1 (en) * 1984-12-21 1992-11-15 Duphar Int Res MEDICATIONS WITH PSYCHOTROPIC EFFECTS.
DE3571436D1 (en) 1984-12-21 1989-08-17 Duphar Int Res New pharmaceutical compositions having anti-psychotic properties
NZ331860A (en) * 1996-03-29 2000-04-28 Duphar Int Res Piperazine and piperidine compounds with affinity for both dopamine D2 and seratonin 5-HT1A receptors
GB9811879D0 (en) * 1998-06-03 1998-07-29 Knoll Ag Therapeutic agents
UA71590C2 (en) * 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
US20030186838A1 (en) * 2000-05-12 2003-10-02 Feenstra Roelof W. Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders
DZ3370A1 (en) * 2000-05-12 2001-11-15 Solvay Pharm Bv PIPERAZINE AND PIPERIDINE COMPOUNDS

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