RU2002131380A - PHARMACEUTICAL COMPOSITIONS - Google Patents

PHARMACEUTICAL COMPOSITIONS

Info

Publication number
RU2002131380A
RU2002131380A RU2002131380/15A RU2002131380A RU2002131380A RU 2002131380 A RU2002131380 A RU 2002131380A RU 2002131380/15 A RU2002131380/15 A RU 2002131380/15A RU 2002131380 A RU2002131380 A RU 2002131380A RU 2002131380 A RU2002131380 A RU 2002131380A
Authority
RU
Russia
Prior art keywords
composition according
sweeteners
preceding paragraphs
mass ratio
composition
Prior art date
Application number
RU2002131380/15A
Other languages
Russian (ru)
Other versions
RU2241460C2 (en
Inventor
Матильде Ибаньес ФЕРНАНДЕС
Эмилио Санс ГАРРИС
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of RU2002131380A publication Critical patent/RU2002131380A/en
Application granted granted Critical
Publication of RU2241460C2 publication Critical patent/RU2241460C2/en

Links

Claims (12)

1. Композиция, включающая цефуроксим аксетил в форме частиц, в которой частицы имеют сплошные покрытия из липида или смеси липидов, которые нерастворимы в воде и диспергируются или растворяются при контакте с желудочным соком, объемный подсластитель и связующий агент, отличающаяся тем, что композиция дополнительно включает систему подсластителей и модификатор структуры в количествах, достаточных для маскировки горького вкуса цефуроксим аксетила.1. A composition comprising particulate cefuroxime axetil, in which the particles are continuous coatings of a lipid or mixture of lipids that are insoluble in water and disperse or dissolve upon contact with gastric juice, a bulk sweetener and a binding agent, characterized in that the composition further comprises a system of sweeteners and a structure modifier in quantities sufficient to mask the bitter taste of cefuroxime axetil. 2. Композиция по п.1, в которой система подсластителей включает, по меньшей мере, один подсластитель искусственного или природного происхождения, выбранный из сахарина, натрийсахарина, натрийцикламата, ацесульфамкалия, тауматина, неогесперидиндигидрохалкона, аммониевой соли корня солодки и аспартама.2. The composition according to claim 1, in which the sweetener system includes at least one artificial or natural sweetener selected from saccharin, sodium saccharin, sodium cyclamate, acesulfamecal, thaumatin, neohesperidine dihydrochalcone, ammonium salt of licorice root and aspartame. 3. Композиция по п.1 или 2, в которой система подсластителей включает два подсластителя в смеси при массовом соотношении от 1:10 до 10:1.3. The composition according to claim 1 or 2, in which the sweetener system includes two sweeteners in a mixture in a mass ratio of from 1:10 to 10: 1. 4. Композиция по любому из предшествующих пунктов, в которой подсластителями являются ацесульфамкалий и аспартам.4. The composition according to any one of the preceding paragraphs, in which the sweeteners are acesulfamecalcium and aspartame. 5. Композиция по п.4, в которой ацесульфамкалий и аспартам присутствуют в массовом соотношении 1:1.5. The composition according to claim 4, in which acesulfamecal and aspartame are present in a mass ratio of 1: 1. 6. Композиция по любому из предшествующих пунктов, в которой модификатор структуры выбирают из поливинилпирролидона, натрийкарбоксиметилцеллюлозы, гидроксиэтилцеллюлозы, гидроксипропилцеллюлозы, гуаровой камеди, альгинатов, карагенана или ксантановой камеди.6. The composition according to any one of the preceding paragraphs, wherein the structure modifier is selected from polyvinylpyrrolidone, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, guar gum, alginates, carrageenan or xanthan gum. 7. Композиция по п.6, в которой модификатором структуры является ксантановая камедь.7. The composition according to claim 6, in which the structure modifier is xanthan gum. 8. Композиция по любому из предшествующих пунктов, в которой массовое соотношение модификатор структуры:система подсластителей находится в пределах приблизительно от 1:1 до 1:1000.8. The composition according to any one of the preceding paragraphs, in which the mass ratio of the modifier structure: the system of sweeteners is in the range from about 1: 1 to 1: 1000. 9. Композиция по любому из предшествующих пунктов, в которой массовое соотношение частица с липидным покрытием:система подсластителей:модификатор структуры находится в пределах приблизительно от 300:10:1 до 3000:100:1.9. The composition according to any one of the preceding paragraphs, in which the mass ratio of the particle with a lipid coating: system of sweeteners: a structure modifier is in the range from about 300: 10: 1 to 3000: 100: 1. 10. Композиция по любому из предшествующих пунктов, отличающаяся тем, что она дополнительно включает один или более фармацевтически приемлемых носителей или наполнителей.10. A composition according to any one of the preceding paragraphs, characterized in that it further comprises one or more pharmaceutically acceptable carriers or excipients. 11. Фармацевтическая композиция по п.10 в форме водной суспензии.11. The pharmaceutical composition of claim 10 in the form of an aqueous suspension. 12. Фармацевтическая композиция по п.10 в форме гранул.12. The pharmaceutical composition of claim 10 in the form of granules.
RU2002131380/15A 2001-11-23 2002-11-21 Cefuroxime axetyl-containing pharmaceutical composition with masked bitter taste RU2241460C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01500277.7 2001-11-23
EP01500277 2001-11-23

Publications (2)

Publication Number Publication Date
RU2002131380A true RU2002131380A (en) 2004-06-27
RU2241460C2 RU2241460C2 (en) 2004-12-10

Family

ID=8183502

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002131380/15A RU2241460C2 (en) 2001-11-23 2002-11-21 Cefuroxime axetyl-containing pharmaceutical composition with masked bitter taste

Country Status (34)

Country Link
US (1) US20030161888A1 (en)
EP (1) EP1446126B1 (en)
JP (1) JP3497503B2 (en)
KR (1) KR100979328B1 (en)
CN (1) CN1297274C (en)
AT (1) ATE473006T1 (en)
AU (2) AU2002338950A1 (en)
BE (2) BE1014078A6 (en)
BR (1) BR0204767A (en)
CA (1) CA2408198C (en)
CH (1) CH693982A5 (en)
CO (1) CO5580783A2 (en)
CY (1) CY1110778T1 (en)
CZ (1) CZ12993U1 (en)
DE (3) DE20218068U1 (en)
DK (1) DK1446126T3 (en)
ES (2) ES2201932B2 (en)
FR (1) FR2832635B1 (en)
GB (1) GB2383536B (en)
GR (1) GR1004522B (en)
HR (2) HRP20020923A2 (en)
HU (1) HUP0204026A3 (en)
IL (2) IL161972A0 (en)
IT (1) ITMI20022470A1 (en)
MX (1) MXPA02011561A (en)
NO (1) NO335273B1 (en)
NZ (1) NZ533092A (en)
PL (1) PL205325B1 (en)
PT (1) PT1446126E (en)
RU (1) RU2241460C2 (en)
SI (1) SI1446126T1 (en)
TR (1) TR200202559A2 (en)
WO (1) WO2003043638A1 (en)
ZA (1) ZA200209473B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
ES2517244T3 (en) 2004-05-11 2014-11-03 Egalet Ltd. Inflatable pharmaceutical form comprising gellan gum
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
EP1802285B1 (en) 2004-10-21 2013-02-27 Aptalis Pharmatech, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
JP2012107060A (en) * 2004-12-15 2012-06-07 Aska Pharmaceutical Co Ltd Oral formulation in which bitter taste of isosorbide was alleviated, method for producing the same
JP4972311B2 (en) * 2004-12-15 2012-07-11 あすか製薬株式会社 Oral preparation with reduced bitter taste of isosorbide and method for producing the same
DE102005019458A1 (en) * 2005-04-25 2006-10-26 Grünenthal GmbH Composition, useful in the preparation of pellets and the multi-particular-presentation form, comprises cefuroximaxetil and carrageenan of the group of lambda carrageenan, tau carrageenan and kappa carrageenan
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
CN100402035C (en) * 2005-07-07 2008-07-16 石药集团中奇制药技术(石家庄)有限公司 A pharmaceutical composition of microencapsulated cefuroxime axetil
US8637076B2 (en) * 2006-06-01 2014-01-28 Cima Labs Inc. Prednisolone salt formulations
US20070281014A1 (en) * 2006-06-01 2007-12-06 Cima Labs, Inc. Prednisolone salt formulations
CN101756906B (en) * 2009-11-02 2011-11-16 严洁 Pharmaceutical composition of cefcapene pivoxil hydrochloride granules and preparation method thereof
AU2010325746B2 (en) 2009-12-02 2016-02-25 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
TW201127375A (en) * 2010-01-08 2011-08-16 Eurand Inc Taste masked topiramate composition and an orally disintegrating tablet comprising the same
WO2011139254A2 (en) 2010-05-04 2011-11-10 Mahmut Bilgic Pharmaceutical formulations compising cefuroxime axetil
JP5853461B2 (en) * 2010-07-30 2016-02-09 大正製薬株式会社 Oral solution
EP2741750A1 (en) 2011-08-12 2014-06-18 Dhanuka Laboratories Ltd. Pharmaceutical composition comprising cefuroxime
CN102440960A (en) * 2011-09-01 2012-05-09 山东鲁抗医药股份有限公司 Pharmaceutical composition of cefuroxime axetil for suspension and preparation method thereof
CA2852912A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Intellectual Property Limited Pazopanib formulation
CN108338936A (en) * 2017-01-23 2018-07-31 刘全忠 The preparation and use of sensitive skin protective lotion

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1323161A (en) * 1970-02-16 1973-07-11 Wyeth John & Brother Ltd Penicillin composition
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
GB1571683A (en) * 1976-02-16 1980-07-16 Glaxo Operations Ltd Ester derivatives of cefuroxime
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320520D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8524001D0 (en) * 1985-09-30 1985-11-06 Glaxo Group Ltd Pharmaceutical composition
NL193682C (en) * 1987-05-14 2000-07-04 Glaxo Group Ltd Coated Cefuroxime Maxetil Composition.
US4992276A (en) * 1988-12-14 1991-02-12 Warner-Lambert Company Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds and thymol and methods for preparing same
EP0670716B1 (en) * 1992-11-30 2003-03-26 Kv Pharmaceutical Company Tastemasked pharmaceutical materials
IT1277426B1 (en) * 1995-08-03 1997-11-10 Acs Dobfar Spa BIOAVAILABLE CRYSTALLINE FORM OF CEFUROXIMA AXETIL
NZ299077A (en) * 1996-07-26 1998-06-26 Apotex Inc Preparation of amorphous cefuroxime axetil (a cephalosporin derivative) by dissolving crystalline cefuroxim axetil in a highly polar solvent, typically dmso and/or dmf
DE69730982T2 (en) * 1996-10-28 2005-09-01 General Mills, Inc., Minneapolis Encapsulation and encapsulation of particles for controlled release
CA2209868C (en) * 1997-08-15 2001-08-14 Bernard Charles Sherman Pharmaceutical compositions comprising cefuroxime axetil
GB9726781D0 (en) * 1997-12-19 1998-02-18 Glaxo Group Ltd Pharmaceutical composition
AT413647B (en) * 1998-11-26 2006-04-15 Sandoz Ag USE OF A COPOLYMERISATE OF 1-VINYL-2-PYRROLIDONE AND VINYL ACETATE FOR THE PREPARATION OF CEFUROXIMAXETIL-SUBJECTED TABLETS

Similar Documents

Publication Publication Date Title
RU2002131380A (en) PHARMACEUTICAL COMPOSITIONS
DE20218068U1 (en) drug
US4760094A (en) Spray dried acetaminophen
ES2215223T3 (en) LIQUID SUSPENSIONS OF MASKED FLAVOR.
KR920702215A (en) Pharmaceutical compositions that rapidly form suspensions in water
PT1276469E (en) Taste masking coating composition
BRPI0820308B1 (en) PHARMACEUTICAL COMPOSITION UNDERSTANDING HIGH LOAD IRON OXYHYDROXIDE, ITS USES AND PREPARATION PROCESSES, AND TABLET
JPH11178539A (en) Granular sweetener
WO2000002536A1 (en) Croscarmellose taste masking
GB2192790A (en) Acetylcysteine compositions
US4767789A (en) Spray dried acetaminophen
ES2288152T3 (en) SOLID PREPARATIONS CONTAINING CHITOSANE POWDER AND ASSOCIATED PRODUCTION PROCEDURE.
US6726928B2 (en) Process for preparing solid dosage forms for unpalatable pharmaceuticals
EP0331385B1 (en) Aqueous suspension of sucralfate
PT94987A (en) PROCESS FOR THE PREPARATION OF AN INSOLUBLE DRUG IN WATER, ANTI-INFLAMMATORY, NON-STEROID, MICROENCAPSULATED
US20040091536A1 (en) Telithromycin suspension with masked taste
JP2726498B2 (en) Oral solid preparation
ES2307099T3 (en) CO-PRECIPITATE QUITOSAN-SILICON DIOXIDE AND USE AS EXCIPIENT IN SOLID DOSAGE FORMS.
JPH0322874B2 (en)
JPWO2021119456A5 (en)
TH23580A (en) A new pharmaceutical formulation containing trymbutene and a process for preparing it.