RU2002126396A - IMMUNOGENOUS CHIMER PEPTID LIBRARY MIMING THE GENETIC VARIETY OF HYPERVARIABLE DISTRICT V3 PROTEIN OF THE HUMAN IMMUNODEFICIENCY VIRUS GP120 - Google Patents

IMMUNOGENOUS CHIMER PEPTID LIBRARY MIMING THE GENETIC VARIETY OF HYPERVARIABLE DISTRICT V3 PROTEIN OF THE HUMAN IMMUNODEFICIENCY VIRUS GP120

Info

Publication number
RU2002126396A
RU2002126396A RU2002126396/13A RU2002126396A RU2002126396A RU 2002126396 A RU2002126396 A RU 2002126396A RU 2002126396/13 A RU2002126396/13 A RU 2002126396/13A RU 2002126396 A RU2002126396 A RU 2002126396A RU 2002126396 A RU2002126396 A RU 2002126396A
Authority
RU
Russia
Prior art keywords
library
hypervariable
protein
immunogenous
chimer
Prior art date
Application number
RU2002126396/13A
Other languages
Russian (ru)
Other versions
RU2237065C2 (en
Inventor
Амир Закиевич Максютов
Александр Александрович Колобов
Александр Борисович Рыжиков
Александр Николаевич Канев
Заки Амирович Максютов
Original Assignee
Государственный научный центр вирусологии и биотехнологии "Вектор"
Filing date
Publication date
Application filed by Государственный научный центр вирусологии и биотехнологии "Вектор" filed Critical Государственный научный центр вирусологии и биотехнологии "Вектор"
Priority claimed from RU2002126396/13A external-priority patent/RU2237065C2/en
Priority to RU2002126396/13A priority Critical patent/RU2237065C2/en
Priority to US10/529,885 priority patent/US20060153865A1/en
Priority to AU2003269748A priority patent/AU2003269748A1/en
Priority to EP03751670A priority patent/EP1558628A4/en
Priority to CA002500401A priority patent/CA2500401A1/en
Priority to JP2004541361A priority patent/JP2006519160A/en
Priority to NZ539606A priority patent/NZ539606A/en
Priority to KR1020057005874A priority patent/KR20050067411A/en
Priority to CNA038255375A priority patent/CN1714100A/en
Priority to RU2005108567/04A priority patent/RU2312941C2/en
Priority to PCT/RU2003/000421 priority patent/WO2004031212A1/en
Priority to PCT/RU2003/000423 priority patent/WO2004031226A1/en
Publication of RU2002126396A publication Critical patent/RU2002126396A/en
Publication of RU2237065C2 publication Critical patent/RU2237065C2/en
Application granted granted Critical

Links

Claims (1)

Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие основного гипервариабельного района V3 белка оболочки gp120 ВИЧ-1, способная вызывать протективный гуморальный иммунный ответ против широкого спектра вариантов вируса и связывать ранние антитела к ВИЧ-1, содержащая оптимальное число возможных, в том числе и модифицированных, структур района V3 gp120 ВИЧ-1, имеющая следующую структуру:An immunogenic library of chimeric peptides that mimics the genetic diversity of the main hypervariable region V3 of the HIV-1 gp120 envelope protein, which can induce a protective humoral immune response against a wide range of virus variants and bind early antibodies to HIV-1, containing the optimal number of possible, including modified, structures of the V3 gp120 HIV-1 region, having the following structure: N-N-N-T-R-K-[S(75%), G(18%), R(7%)]-I-[H(60%), P(18%), N(11%), S(11%)]-[I(88%), M(12%)]-[G(97%), A(3%)]-[P(95%), W(5%)]-G-[R(77%), Q(9%), K(8%), S(3%), G(3%)]-[A(93%), T(7%)]-[F(76%), W(15%), L(9%)]-Y-[T(58%), A(42%)]-T-G-[E(39%), D(98%),Q(24%), R(9%)]-I-I-G-[D(88%), N(12%)]-I-R-Q, где в квадратных скобках приведены относительные встречаемости аминокислот в вариабельных позициях последовательности.NNNTRK- [S (75%), G (18%), R (7%)] - I- [H (60%), P (18%), N (11%), S (11%)] - [I (88%), M (12%)] - [G (97%), A (3%)] - [P (95%), W (5%)] - G- [R (77%) , Q (9%), K (8%), S (3%), G (3%)] - [A (93%), T (7%)] - [F (76%), W (15 %), L (9%)] - Y- [T (58%), A (42%)] - TG- [E (39%), D (98%), Q (24%), R (9 %)] - IIG- [D (88%), N (12%)] - IRQ, where the relative occurrences of amino acids in the variable positions of the sequence are given in square brackets.
RU2002126396/13A 2002-10-03 2002-10-03 Chimeric peptide immunogenic library mimicking genetic diversity of hypervariable region of protein v3 of human immunodeficiency virus envelope gp120 RU2237065C2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
RU2002126396/13A RU2237065C2 (en) 2002-10-03 2002-10-03 Chimeric peptide immunogenic library mimicking genetic diversity of hypervariable region of protein v3 of human immunodeficiency virus envelope gp120
US10/529,885 US20060153865A1 (en) 2002-10-03 2003-08-19 Antigenic peptides
NZ539606A NZ539606A (en) 2002-10-03 2003-09-25 Antigenic peptides
EP03751670A EP1558628A4 (en) 2002-10-03 2003-09-25 Antigenic peptides
CA002500401A CA2500401A1 (en) 2002-10-03 2003-09-25 Antigenic peptides
JP2004541361A JP2006519160A (en) 2002-10-03 2003-09-25 Antigenic peptide
AU2003269748A AU2003269748A1 (en) 2002-10-03 2003-09-25 Antigenic peptides
KR1020057005874A KR20050067411A (en) 2002-10-03 2003-09-25 Antigenic peptides
CNA038255375A CN1714100A (en) 2002-10-03 2003-09-25 Antigen peptides
RU2005108567/04A RU2312941C2 (en) 2002-10-03 2003-09-25 Antigenic peptides
PCT/RU2003/000421 WO2004031212A1 (en) 2002-10-03 2003-09-25 Antigenic peptides
PCT/RU2003/000423 WO2004031226A1 (en) 2002-10-03 2003-09-29 Immunogenic library of chimeric peptides mimicking the genetic diversity of the hypervariable region v3 of the protein of the envelope of a virus gp 120 of human immunodeficiency

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2002126396/13A RU2237065C2 (en) 2002-10-03 2002-10-03 Chimeric peptide immunogenic library mimicking genetic diversity of hypervariable region of protein v3 of human immunodeficiency virus envelope gp120

Publications (2)

Publication Number Publication Date
RU2002126396A true RU2002126396A (en) 2004-07-20
RU2237065C2 RU2237065C2 (en) 2004-09-27

Family

ID=32067104

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002126396/13A RU2237065C2 (en) 2002-10-03 2002-10-03 Chimeric peptide immunogenic library mimicking genetic diversity of hypervariable region of protein v3 of human immunodeficiency virus envelope gp120

Country Status (10)

Country Link
US (1) US20060153865A1 (en)
EP (1) EP1558628A4 (en)
JP (1) JP2006519160A (en)
KR (1) KR20050067411A (en)
CN (1) CN1714100A (en)
AU (1) AU2003269748A1 (en)
CA (1) CA2500401A1 (en)
NZ (1) NZ539606A (en)
RU (1) RU2237065C2 (en)
WO (2) WO2004031212A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2601394A1 (en) * 2005-03-17 2006-09-28 Primex Clinical Laboratories, Inc. Immunogens for vaccines against antigenically variable pathogens and diseases
WO2007079755A1 (en) 2006-01-12 2007-07-19 Janus Beierholm Holding Aps Reimmunization and antibody design
WO2007124755A1 (en) * 2006-05-02 2007-11-08 The Antibody Project Aps Method for immunizing an avian species
CA2682206A1 (en) * 2007-03-27 2008-10-02 The Regents Of The University Of California Acute transmitted hiv envelope signatures
KR20100028031A (en) * 2007-06-06 2010-03-11 다니스코 유에스 인크. Methods for improving protein properties
EP2205736B1 (en) * 2007-10-09 2014-04-02 Technologie Integrale Ltd. A method for producing an HIV immunogenic composition based on HIV-specific antibodes
NZ593415A (en) 2008-12-05 2014-04-30 Inviragen Inc Compositions, methods and uses for inducing viral growth
WO2011138032A2 (en) * 2010-05-05 2011-11-10 Artemev, Timur Universal influenza vaccines and methods for their generation
EP2422618A1 (en) * 2010-08-27 2012-02-29 Technologie Integrale Ltd. Animal model for the evaluation of the efficacy of an HIV vaccine
EP2492279A1 (en) * 2011-02-25 2012-08-29 Laboratorios Del. Dr. Esteve, S.A. Rapid immunogen selection method using lentiviral display
WO2013040040A1 (en) * 2011-09-12 2013-03-21 New York University School Of Medicine Peptides mimicking hiv-1 viral epitopes in the v2 loop for the gp120 surface envelope glycoprotein
US10383927B2 (en) 2015-01-09 2019-08-20 Primex Clinical Laboratories, Inc. Variable epitope library compositions and methods of therapeutic and prophylactic use
US20220243360A1 (en) * 2019-06-27 2022-08-04 Roche Sequencing Solutions, Inc. Peptide libraries having enhanced subsequence diversity and methods for use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2260754T3 (en) * 1992-06-18 2006-11-01 Creagen, Inc. METHOD FOR PRODUCING A SET OF COMBINATORY POLIPEPTIDIC ANTIGENS.
WO1994028929A1 (en) * 1993-06-07 1994-12-22 Genentech, Inc. Hiv envelope polypeptides
GB2282378A (en) * 1993-09-30 1995-04-05 Merck & Co Inc Conjugates of epitopes of HIV with a protein complex from Neisseria
CA2175579A1 (en) * 1993-10-26 1995-05-04 Chang Yi Wang Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics
IT1277057B1 (en) * 1995-12-11 1997-11-04 Tecnogen Scpa IMPROVED ANTIGENIC PEPTIDES
MXPA04007646A (en) * 2002-02-08 2005-05-27 Variation Biotechnologies Inc Immunogenic formulations of variable peptidic epitopes and process for preparation thereof.

Similar Documents

Publication Publication Date Title
RU2002126396A (en) IMMUNOGENOUS CHIMER PEPTID LIBRARY MIMING THE GENETIC VARIETY OF HYPERVARIABLE DISTRICT V3 PROTEIN OF THE HUMAN IMMUNODEFICIENCY VIRUS GP120
WO2001047955A3 (en) Improvements in or relating to immune responses to hiv
DK1278534T3 (en) Methods and compositions for attenuating the multiplication of HIV-1
ATE154610T1 (en) SYNTHETIC PEPTIDES DERIVED FROM HIV GP120 ENV PROTEIN AND THEIR APPLICATION
EP1878742A3 (en) HIV peptides, antigens, vaccine compositions, immunoassay and a method of detecting antibodies induced by HIV
CA2363947A1 (en) Hiv peptides, antigens, vaccine compositions, immunoassay kit and a method of detecting antibodies induced by hiv
Zaghouani et al. Induction of antibodies to the envelope protein of the human immunodeficiency virus by immunization with monoclonal anti-idiotypes.
ZA200301742B (en) HIV peptides from tat, rev and nef conserved regions and their application as e.g. vaccine components.
Conley et al. Immunogenicity of synthetic HIV-1 gp120 V3-loop peptide-conjugate immunogens
CA2181590A1 (en) Peptomers with enhanced immunogenicity
PT1417222E (en) Isolated polypeptides based on the neutralizing epitope of the p17 protein of hiv useful as vaccines, and neutralizing anti-p17 antibodies which specifically recognize said neutralizing epitope
WO1994026903A3 (en) Human influenza virus peptides binding hla-i molecule
CA2473163A1 (en) Anti-idiotypic antibody inducing hiv-1 neutralizing antibodies
WO2004073659A3 (en) HIV gp120 MIMOTOPE ANTIGEN
RU2001127439A (en) Peptides from the sequence of the T virus and monospecific antibodies that bind to the TT virus
WO2000078969A1 (en) Hiv tat peptides and multiple peptide conjugate system
Qabar et al. Pharmaceutical applications of peptidomimetics
WO2002069691A3 (en) Immunogenic hiv peptides for use as reagents and vaccines
Gras-Masse et al. Confronting the degeneracy of convergent combinatorial immunogens, or ‘mixotopes’, with the specificity of recognition of the target sequences
AU4712993A (en) New peptides, antibodies raised against peptides and means for blocking said antibodies, application as medicaments, pharmaceutical compositions and utilization methods
ATE247485T1 (en) PEPTIDES FOR USE IN VACCINATION AND INDUCTION OF NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS
US20060275309A1 (en) Peptide oligomers for use as hiv vaccines
WO2003066090A1 (en) Immunogenic formulations of variable peptidic epitopes and process for preparation thereof
WO1991018618A3 (en) Immunotherapeutic compositions for treating and preventing aids, arc and hiv infection
WO2004056316A3 (en) Vaccines against hiv-1 tat protein to generate neutralizing antibodies