RU2002124887A - METHOD FOR PRODUCING 4-METHYL-5-FORMILTHIAZOLE - Google Patents

METHOD FOR PRODUCING 4-METHYL-5-FORMILTHIAZOLE

Info

Publication number
RU2002124887A
RU2002124887A RU2002124887/04A RU2002124887A RU2002124887A RU 2002124887 A RU2002124887 A RU 2002124887A RU 2002124887/04 A RU2002124887/04 A RU 2002124887/04A RU 2002124887 A RU2002124887 A RU 2002124887A RU 2002124887 A RU2002124887 A RU 2002124887A
Authority
RU
Russia
Prior art keywords
methyl
formilthiazole
producing
organic solvent
inorganic
Prior art date
Application number
RU2002124887/04A
Other languages
Russian (ru)
Other versions
RU2228332C1 (en
Inventor
Алла Николаевна Яркевич
Зо Викторовна Сафронова
Зоя Викторовна Сафронова
Алексей Николаевич Пушин
Валерий Владимирович Рагулин
Николай Серафимович Зефиров
Original Assignee
Институт физиологически активных веществ РАН
Ниппон Кемикал Индустриал Ко., Лтд. (Jp)
Ниппон Кемикал Индустриал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт физиологически активных веществ РАН, Ниппон Кемикал Индустриал Ко., Лтд. (Jp), Ниппон Кемикал Индустриал Ко., Лтд. filed Critical Институт физиологически активных веществ РАН
Priority to RU2002124887/04A priority Critical patent/RU2228332C1/en
Priority to CNB031569889A priority patent/CN1307165C/en
Priority to JP2003325125A priority patent/JP4440585B2/en
Publication of RU2002124887A publication Critical patent/RU2002124887A/en
Application granted granted Critical
Publication of RU2228332C1 publication Critical patent/RU2228332C1/en

Links

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (3)

1. Способ получения 4-метил-5-формил-тиазола, заключающийся в окислении 4-метил-5-(2-гидроксиэтил)тиазола, отличающийся тем, что в качестве окислителя используют раствор окиси хрома или неорганических бихроматов в водном растворе серной кислоты и реакцию проводят в двухфазной системе вода-органический растворитель при температуре 20-50°С.1. The method of obtaining 4-methyl-5-formylthiazole, which consists in the oxidation of 4-methyl-5- (2-hydroxyethyl) thiazole, characterized in that the oxidizing agent is a solution of chromium oxide or inorganic dichromates in an aqueous solution of sulfuric acid and the reaction is carried out in a two-phase water-organic solvent system at a temperature of 20-50 ° C. 2. Способ по п.1, отличающийся тем, что в качестве органического растворителя используют диэтиловый эфир, бензол и хлористый метилен.2. The method according to claim 1, characterized in that diethyl ether, benzene and methylene chloride are used as the organic solvent. 3. Способ по пп.1 и 2, отличающийся тем, что в качестве неорганического бихромата используют бихромат калия.3. The method according to claims 1 and 2, characterized in that potassium dichromate is used as an inorganic dichromate.
RU2002124887/04A 2002-09-19 2002-09-19 Method for preparing 4-methyl-5-formylthiazole RU2228332C1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
RU2002124887/04A RU2228332C1 (en) 2002-09-19 2002-09-19 Method for preparing 4-methyl-5-formylthiazole
CNB031569889A CN1307165C (en) 2002-09-19 2003-09-17 4-methyl-5-formylthiazole preparation method
JP2003325125A JP4440585B2 (en) 2002-09-19 2003-09-17 Process for producing 4-methyl-5-formylthiazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2002124887/04A RU2228332C1 (en) 2002-09-19 2002-09-19 Method for preparing 4-methyl-5-formylthiazole

Publications (2)

Publication Number Publication Date
RU2002124887A true RU2002124887A (en) 2004-03-20
RU2228332C1 RU2228332C1 (en) 2004-05-10

Family

ID=32294262

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002124887/04A RU2228332C1 (en) 2002-09-19 2002-09-19 Method for preparing 4-methyl-5-formylthiazole

Country Status (3)

Country Link
JP (1) JP4440585B2 (en)
CN (1) CN1307165C (en)
RU (1) RU2228332C1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100360511C (en) * 2006-01-24 2008-01-09 浙江工业大学 Method for synthesizing 4-methyl-5-methyol thiazole
CN104485998A (en) * 2014-12-15 2015-04-01 北京理工大学 Calibration device and method for response time of optical communication transmitting-receiving component

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU979344A1 (en) * 1981-07-06 1982-12-07 Болоховский химический комбинат синтетических полупродуктов и витаминов Process for producing 4-methyl-5-beta-hydroethyl thiazole
DE19547075A1 (en) * 1995-12-18 1997-06-19 Bayer Ag Improved process for the production of 5-formylthiazole
DE19735197A1 (en) * 1997-08-14 1999-02-18 Bayer Ag Process for the preparation of 2-substituted 5-formylthiazoles

Also Published As

Publication number Publication date
CN1307165C (en) 2007-03-28
CN1495176A (en) 2004-05-12
JP2004107346A (en) 2004-04-08
RU2228332C1 (en) 2004-05-10
JP4440585B2 (en) 2010-03-24

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Legal Events

Date Code Title Description
PC4A Invention patent assignment

Effective date: 20071018

PD4A Correction of name of patent owner
QA4A Patent open for licensing

Effective date: 20130611

MM4A The patent is invalid due to non-payment of fees

Effective date: 20160920