CN100360511C - Method for synthesizing 4-methyl-5-methyol thiazole - Google Patents
Method for synthesizing 4-methyl-5-methyol thiazole Download PDFInfo
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Abstract
The present invention relates to a synthetic method for 4-methyl-5-hydroxymethyl thiazole. The present invention comprises the procedures that sodium borohydride or potassium borohydride is used as reducing agents, 4-methyl-5-thiazolyl formic ether carries out reduction reaction in an organic solvent at-20 DGE C to 100 DGE C under the action of base catalyst, and the products are obtained through postprocessing. Compared with the prior art, the present invention has the advantages that process conditions are simple and reasonable, and an anhydrous solvent does not need to be used; reaction can be stopped by filling water, acid or alkali does not need to be used, and the problems of trouble postprocessing, serious three waste pollution, etc. of traditional process reaction are eliminated fundamentally. Thereby, the present invention has the advantages of simple and safe operation, high reaction yield, low cost, no basic three waste, larger implement value and social economic benefit.
Description
(1) technical field
The present invention relates to the synthetic method of a kind of 4-methyl-5-hydroxymethylthiazole.
(2) background technology
4-methyl-5-hydroxymethylthiazole (I) is the important intermediate of synthetic third generation cephalosporin antimicrobial drug Cefditoren pivoxil Cephalosporins (III).
In the prior art, the chemical synthesis process of 4-methyl-5-hydroxymethylthiazole (I) is to make with Lewis acid/sodium borohydride or POTASSIUM BOROHYDRIDE reduction system 4-methylthiazol-5-formic acid ester (II).For example: US0204095 (2003) and Chinese publication CN1628108A have all reported with sodium borohydride/aluminum chloride system and have reduced 4-methylthiazol-5-formic acid ester (II), obtain 4-methyl-5-hydroxymethylthiazole (I), but the limitation of this method mainly is: 1) reaction needed anhydrous condition, the cost height of preparation anhydrous solvent is dangerous big; Need consume a large amount of hydrochloric acid and sodium hydroxide when 2) separating purification, and bother the industrial production cost height because of the aluminium salt that produces a large amount of flockss causes aftertreatment.
(3) summary of the invention
The object of the invention be to provide a kind of easy and simple to handle, production cost is low, reaction yield is high, do not have the chemical synthesis process of the 4-methyl-5-hydroxymethylthiazole of the three wastes substantially.
4-methyl of the present invention-5-hydroxymethylthiazole is suc as formula shown in (I), described synthetic method comprises the steps: with sodium borohydride or POTASSIUM BOROHYDRIDE as reductive agent, carry out reduction reaction in-20～100 ℃ suc as formula the 4-methyl-5-thiazole formic acid ester of (II) in organic solvent under the alkaline catalysts effect, aftertreatment promptly gets described product;
R is C in its Chinese style (II)
1～C
4Alkyl, described alkaline catalysts is inorganic metal alkali or organic amine, as one of following: sodium hydroxide, potassium hydroxide, lithium hydroxide, yellow soda ash, salt of wormwood, Quilonum Retard, sodium bicarbonate, saleratus, Trimethylamine 99, triethylamine, tripropyl amine, diethyl Tri N-Propyl Amine, pyridine, 2-picoline, 3-picoline, 4-picoline, piperidines, N, dinethylformamide, N, N-diethylformamide, N, accelerine, N, N-Diethyl Aniline, N, N-dipropyl aniline.
The reaction formula of described synthetic method is:
Or
It is one of following that described R is preferably: methyl, ethyl, n-propyl, sec.-propyl, cyclopropyl, normal-butyl, isobutyl-, the tertiary butyl.
Described organic solvent can be a hydro carbons, alcohols, halogenated hydrocarbon, the mixture of ether compound or their arbitrary combination, be preferably one of following or more than one arbitrary combination: Skellysolve A, pentamethylene, normal hexane, hexanaphthene, methyl alcohol, ethanol, n-propyl alcohol, Virahol, propyl carbinol, isopropylcarbinol, the trimethyl carbinol, Pentyl alcohol, primary isoamyl alcohol, neopentyl alcohol, methylene dichloride, trichloromethane, tetracol phenixin, 1, the 2-ethylene dichloride, 1,1,2, the 2-tetrachloroethane, ether, positive propyl ether, isopropyl ether, butyl ether, 1, the 4-dioxane, glycol dimethyl ether, one glyme, diglyme, dithiocarbonic anhydride, tetrahydrofuran (THF), benzene, toluene, chlorobenzene, pyridine.Described consumption of organic solvent is generally 2～20 times of 4-methyl-5-thiazole formic acid ester quality, is preferably 5～10 times.
Described reduction reaction temperature is preferably 60～80 ℃; The described reaction times was generally 1～24 hour, was preferably 4～8 hours.
Described 4-methyl-5-thiazole formic acid ester: reductive agent: the molar ratio of alkaline catalysts is generally 1: 1.0～6.0: 0.01～0.2; Further, when described reductive agent is sodium borohydride, described 4-methyl-5-thiazole formic acid ester: sodium borohydride: the molar ratio of alkaline catalysts is preferably 1: 1.0～and 1.5: 0.05～0.1, when described reductive agent was POTASSIUM BOROHYDRIDE, described 4-methyl-5-thiazole formic acid ester: POTASSIUM BOROHYDRIDE: the molar ratio of alkaline catalysts was 1: 1.5～2.0: 0.1～0.15.
Synthetic method of the present invention preferably includes following steps: 4-methyl-5-thiazole formic acid ester is dissolved in described organic solvent, add alkaline catalysts, add sodium borohydride or POTASSIUM BOROHYDRIDE at-20～100 ℃, stirred 1～24 hour, and added the water termination reaction, with ether or ethyl acetate extraction, dry, filter, after decompression steamed organic solvent, underpressure distillation promptly got 4-methyl-5-hydroxymethylthiazole yellow oily liquid again.
The present invention compared with prior art has the following advantages: 1) processing condition are easy, reasonable, do not need to use anhydrous solvent; 2) add water and get final product stopped reaction, do not need to use acid or alkali, and fundamentally eliminated problems such as the traditional technology post-reaction treatment bothers, three-waste pollution is serious.Therefore, the present invention has safety simple to operate, the reaction yield height, and production cost is low, does not have the three wastes substantially, has bigger implementary value and economic results in society.
(4) embodiment
The invention will be further described below in conjunction with embodiment, but protection scope of the present invention is not limited to this.
Embodiment 1
Its molar ratio is a 4-methylthiazol-5-formic acid methyl esters: POTASSIUM BOROHYDRIDE: catalyzer=1: 3.0: 0.2, catalyzer are pyridine, and organic solvent is an ethanol, and its consumption is 10 times of 4-methylthiazol-5-formic acid methyl esters total mass number.
In thermometer, reflux condensing tube and churned mechanically 500mL four-hole boiling flask are housed, add 4-methylthiazol-5-formic acid methyl esters 31.4g (0.2mol), catalyzer 3.16g (0.04mol), ethanol 314g, POTASSIUM BOROHYDRIDE 32.4g (0.6mol) under the room temperature successively, open and stir, 65～70 ℃ of following stirring reactions 6 hours, (developping agent was a sherwood oil to the TLC tracking monitor: ethyl acetate=2: 1).React and finish postcooling to room temperature, in the slow impouring 200ml of reaction solution frozen water, after decompression is reclaimed solvent down, the water layer ethyl acetate extraction (3 * 300mL), the salt water washing of gained organic layer, anhydrous sodium sulfate drying.Behind the decompression and solvent recovery underpressure distillation obtain yellow oil 20.6g (115-118 ℃/5mmHg), yield 80%, HPLC purity 99.5%.
1H?NMR(400MHz，CDCl
3)δ：8.58(s，1H)，4.79(s，2H)，3.78(brs，1H)，2.36(s，3H).
Embodiment 2
Molar ratio is a 4-methylthiazol-5-formic acid methyl esters: POTASSIUM BOROHYDRIDE: catalyzer=1: 1.5: 0.2.4-methylthiazol-5-formic acid methyl esters charging capacity is 31.4g (0.2mol), and the POTASSIUM BOROHYDRIDE charging capacity is 16.2g (0.3mol), and catalyzer is a pyridine, its consumption is 3.16g (0.04mol), ethanol is solvent, and its consumption is 314g, promptly 10 times of 4-methylthiazol-5-formic acid methyl esters total mass number.Temperature of reaction is 65～70 ℃, and the reaction times is 12 hours, and other is operated with embodiment 1, and product yield is 74%, and purity is 99.3%.
Embodiment 3
Molar ratio is a 4-methylthiazol-5-formic acid methyl esters: POTASSIUM BOROHYDRIDE: catalyzer=1: 1.0: 0.2.4-methylthiazol-5-formic acid methyl esters charging capacity is 31.4g (0.2mol), and the POTASSIUM BOROHYDRIDE charging capacity is 10.8g (0.2mol), and catalyzer is a pyridine, its consumption is 3.16g (0.04mol), ethanol is solvent, and its consumption is 314g, promptly 10 times of 4-methylthiazol-5-formic acid methyl esters total mass number.Temperature of reaction is 65～70 ℃, and the reaction times is 12 hours, and other is operated with embodiment 1, and product yield is 70%, and purity is 99.6%.
Embodiment 4
Molar ratio is a 4-methylthiazol-5-formic acid methyl esters: POTASSIUM BOROHYDRIDE: catalyzer=1: 1.5: 0.2.4-methylthiazol-5-formic acid methyl esters charging capacity is 31.4g (0.2mol), and the POTASSIUM BOROHYDRIDE charging capacity is 16.2g (0.3mol), and catalyzer is a pyridine, its consumption is 3.16g (0.04mol), tetrahydrofuran (THF) is a solvent, and its consumption is 314g, promptly 10 times of 4-methylthiazol-5-formic acid methyl esters total mass number.Temperature of reaction is 65～70 ℃, and the reaction times is 12 hours, and other is operated with embodiment 1, and product yield is 74%, and purity is 99.3%.
Embodiment 5
Molar ratio is a 4-methylthiazol-5-formic acid methyl esters: POTASSIUM BOROHYDRIDE: catalyzer=1: 1.0: 0.2.4-methylthiazol-5-formic acid methyl esters charging capacity is 31.4g (0.2mol), the POTASSIUM BOROHYDRIDE charging capacity is 10.8g (0.2mol), catalyzer is a pyridine, its consumption is 3.16g (0.04mol), glycol dimethyl ether is a solvent, its consumption is 157g, promptly 5 times of 4-methylthiazol-5-formic acid methyl esters total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 4 hours, and other is operated with embodiment 1, and product yield is 75%, and purity is 99.1%.
Embodiment 6
Molar ratio is a 4-methylthiazol-5-formic acid ethyl ester: POTASSIUM BOROHYDRIDE: catalyzer=1: 3.0: 0.02.4-methylthiazol-5-formic acid ethyl ester charging capacity is 34.2g (0.2mol), the POTASSIUM BOROHYDRIDE charging capacity is 32.4g (0.6mol), catalyzer is a sodium hydroxide, its consumption is 0.16g (0.004mol), Virahol is a solvent, its consumption is 342g, promptly 10 times of 4-methylthiazol-5-formic acid ethyl ester total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 2 hours, and other is operated with embodiment 1, and product yield is 71%, and purity is 99.3%.
Embodiment 7
Molar ratio is a 4-methylthiazol-5-formic acid ethyl ester: POTASSIUM BOROHYDRIDE: catalyzer=1: 2.0: 0.02.4-methylthiazol-5-formic acid ethyl ester charging capacity is 34.2g (0.2mol), the POTASSIUM BOROHYDRIDE charging capacity is 21.6g (0.4mol), catalyzer is a sodium hydroxide, its consumption is 0.1 6g (0.004mol), Virahol is a solvent, its consumption is 342g, promptly 10 times of 4-methylthiazol-5-formic acid ethyl ester total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 2 hours, and other is operated with embodiment 1, and product yield is 75%, and purity is 99.3%.
Embodiment 8
Molar ratio is a 4-methylthiazol-5-formic acid ethyl ester: POTASSIUM BOROHYDRIDE: catalyzer=1: 1.0: 0.02.4-methylthiazol-5-formic acid ethyl ester charging capacity is 34.2g (0.2mol), the POTASSIUM BOROHYDRIDE charging capacity is 10.8g (0.2mol), catalyzer is a sodium hydroxide, its consumption is 0.16g (0.004mol), Virahol is a solvent, its consumption is 342g, promptly 10 times of 4-methylthiazol-5-formic acid ethyl ester total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 2 hours, and other is operated with embodiment 1, and product yield is 70%, and purity is 99.0%.
Embodiment 9
Molar ratio is a 4-methylthiazol-5-formic acid n-propyl: sodium borohydride: catalyzer=1: 3.0: 0.2.4-methylthiazol-5-formic acid n-propyl charging capacity is 37.0g (0.2mol), and the sodium borohydride charging capacity is 22.8g (0.6mol), and catalyzer is a pyridine, its consumption is 3.16g (0.04mol), propyl alcohol is a solvent, and its consumption is 724g, promptly 20 times of 4-methylthiazol-5-formic acid n-propyl total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 2 hours, and other is operated with embodiment 1, and product yield is 74%, and purity is 99.0%.
Embodiment 10
Molar ratio is a 4-methylthiazol-5-formic acid n-propyl: sodium borohydride: catalyzer=1: 2.0: 0.2.4-methylthiazol-5-formic acid n-propyl charging capacity is 37.0g (0.2mol), and the sodium borohydride charging capacity is 15.2g (0.4mol), and catalyzer is a pyridine, its consumption is 3.16g (0.04mol), propyl alcohol is a solvent, and its consumption is 362g, promptly 10 times of 4-methylthiazol-5-formic acid n-propyl total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 6 hours, and other is operated with embodiment 1, and product yield is 72%, and purity is 99.0%.
Embodiment 11
Molar ratio is a 4-methylthiazol-5-formic acid n-propyl: sodium borohydride: catalyzer=1: 1.0: 0.2.4-methylthiazol-5-formic acid n-propyl charging capacity is 37.0g (0.2mol), and the sodium borohydride charging capacity is 7.6g (0.2mol), and catalyzer is a pyridine, its consumption is 3.16g (0.04mol), propyl alcohol is a solvent, and its consumption is 181g, promptly 5 times of 4-methylthiazol-5-formic acid n-propyl total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 6 hours, and other is operated with embodiment 1, and product yield is 67%, and purity is 99.1%.
Embodiment 12
Molar ratio is a 4-methylthiazol-5-formic acid methyl esters: sodium borohydride: catalyzer=1: 3.0: 0.2.4-methylthiazol-5-formic acid methyl esters charging capacity is 31.4g (0.2mol), and the sodium borohydride charging capacity is 22.8g (0.6mol), and catalyzer is a sodium hydroxide, its consumption is 1.6g (0.04mol), Virahol is a solvent, and its consumption is 628g, promptly 20 times of 4-methylthiazol-5-formic acid methyl esters total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 6 hours, and other is operated with embodiment 1, and product yield is 78%, and purity is 99.2%.
Embodiment 13
Molar ratio is a 4-methylthiazol-5-formic acid methyl esters: sodium borohydride: catalyzer=1: 3.0: 0.1.4-methylthiazol-5-formic acid methyl esters charging capacity is 31.4g (0.2mol), and the sodium borohydride charging capacity is 22.8g (0.6mol), and catalyzer is a sodium hydroxide, its consumption is 0.8g (0.02mol), Virahol is a solvent, and its consumption is 628g, promptly 20 times of 4-methylthiazol-5-formic acid methyl esters total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 8 hours, and other is operated with embodiment 1, and product yield is 79%, and purity is 99.0%.
Embodiment 14
Molar ratio is a 4-methylthiazol-5-formic acid methyl esters: sodium borohydride: catalyzer=1: 3.0: 0.02.4-methylthiazol-5-formic acid methyl esters charging capacity is 31.4g (0.2mol), the sodium borohydride charging capacity is 22.8g (0.6mol), catalyzer is a sodium hydroxide, its consumption is 0.16g (0.004mol), Virahol is a solvent, its consumption is 628g, promptly 20 times of 4-methylthiazol-5-formic acid methyl esters total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 6 hours, and other is operated with embodiment 1, and product yield is 78%, and purity is 99.2%.
Embodiment 15
Molar ratio is a 4-methylthiazol-5-formic acid n-propyl: sodium borohydride: catalyzer=1: 1.5: 0.2.4-methylthiazol-5-formic acid n-propyl charging capacity is 37.0g (0.2mol), the sodium borohydride charging capacity is 11.4g (0.3mol), catalyzer is a sodium hydroxide, its consumption is 1.6g (0.04mol), propyl alcohol is a solvent, its consumption is 362g, promptly 10 times of 4-methylthiazol-5-formic acid n-propyl total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 6 hours, and other is operated with embodiment 1, and product yield is 75%, and purity is 99.4%.
Embodiment 16
Molar ratio is a 4-methylthiazol-5-formic acid n-propyl: sodium borohydride: catalyzer=1: 1.5: 0.2.4-methylthiazol-5-formic acid n-propyl charging capacity is 37.0g (0.2mol), and the sodium borohydride charging capacity is 11.4 (0.3mol), and catalyzer is a sodium hydroxide, its consumption is 1.6g (0.04mol), propyl alcohol is a solvent, and its consumption is 362g, promptly 10 times of 4-methylthiazol-5-formic acid n-propyl total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 6 hours, and other is operated with embodiment 1, and product yield is 78%, and purity is 99.2%.
Embodiment 17
Molar ratio is the 4-methylthiazol-5-formic acid tert-butyl ester: POTASSIUM BOROHYDRIDE: catalyzer=1: 1.5: 0.1.4-methylthiazol-5-formic acid tert-butyl ester charging capacity is 39.8g (0.2mol), the POTASSIUM BOROHYDRIDE charging capacity is 16.2g (0.3mol), catalyzer is a triethylamine, its consumption is 2.02g (0.02mol), the trimethyl carbinol is a solvent, its consumption is 278.6g, promptly 7 times of 4-methylthiazol-5-formic acid tert-butyl ester total mass number.Temperature of reaction is 80～85 ℃, and the reaction times is 24 hours, and other is operated with embodiment 1, and product yield is 78%, and purity is 99.3%.
Embodiment 18
Molar ratio is a 4-methylthiazol-5-formic acid isopropyl ester: sodium borohydride: catalyzer=1: 1.0: 0.2.4-methylthiazol-5-formic acid isopropyl ester charging capacity is 37.0g (0.2mol), the sodium borohydride charging capacity is 11.4g (0.3mol), catalyzer is a piperidines, its consumption is 3.4g (0.04mol), 1, the 4-dioxane is a solvent, and its consumption is 185g, promptly 5 times of 4-methylthiazol-5-formic acid isopropyl ester total mass number.Temperature of reaction is 70～75 ℃, and the reaction times is 6 hours, and other is operated with embodiment 1, and product yield is 75%, and purity is 99.2%.
Embodiment 19
Molar ratio is the positive butyl ester of 4-methylthiazol-5-formic acid: sodium borohydride: catalyzer=1: 2.0: 0.2.The positive butyl ester charging capacity of 4-methylthiazol-5-formic acid is 39.8g (0.2mol), the sodium borohydride charging capacity is 15.2g (0.4mol), catalyzer is a salt of wormwood, its consumption is 3.96g (0.04mol), tetrahydrofuran (THF) is a solvent, its consumption is 398g, promptly 10 times of the positive butyl ester total mass number of 4-methylthiazol-5-formic acid.Temperature of reaction is 60～65 ℃, and the reaction times is 12 hours, and other is operated with embodiment 1, and product yield is 65%, and purity is 99.2%.
Embodiment 20
Molar ratio is the positive butyl ester of 4-methylthiazol-5-formic acid: sodium borohydride: catalyzer=1: 2.0: 0.2.The positive butyl ester charging capacity of 4-methylthiazol-5-formic acid is 39.8g (0.2mol), the sodium borohydride charging capacity is 15.2g (0.4mol), catalyzer is a potassium hydroxide, its consumption is 2.24g (0.04mol), 1, the 4-dioxane is a solvent, and its consumption is 398g, promptly 10 times of the positive butyl ester total mass number of 4-methylthiazol-5-formic acid.Temperature of reaction is 60～65 ℃, and the reaction times is 12 hours, and other is operated with embodiment 1, and product yield is 65%, and purity is 99.2%.
Embodiment 21
Molar ratio is a 4-methylthiazol-5-formic acid isobutyl ester: POTASSIUM BOROHYDRIDE: catalyzer=1: 3.0: 0.2.4-methylthiazol-5-formic acid isobutyl ester charging capacity is 39.8g (0.2mol), the POTASSIUM BOROHYDRIDE charging capacity is 32.4g (0.6mol), catalyzer is a potassium hydroxide, its consumption is 2.24g (0.04mol), 1, the 4-dioxane is a solvent, and its consumption is 398g, promptly 10 times of 4-methylthiazol-5-formic acid isobutyl ester total mass number.Temperature of reaction is 70～75 ℃, and the reaction times is 12 hours, and other is operated with embodiment 1, and product yield is 81%, and purity is 99.2%.
Embodiment 22
Molar ratio is a 4-methylthiazol-5-formic acid cyclopropyl ester: sodium borohydride: catalyzer=1: 1.0: 0.2.4-methylthiazol-5-formic acid cyclopropyl ester charging capacity is 37.0g (0.2mol), the sodium borohydride charging capacity is 11.4g (0.3mol), catalyzer is a piperidines, its consumption is 3.4g (0.04mol), 1, the 4-dioxane is a solvent, and its consumption is 185g, promptly 5 times of 4-methylthiazol-5-formic acid cyclopropyl ester total mass number.Temperature of reaction is 70～75 ℃, and the reaction times is 24 hours, and other is operated with embodiment 1, and product yield is 75%, and purity is 99.3%.
Embodiment 23
Throwing molar ratio is 4-methylthiazol-5-formic acid cyclopropyl ester: sodium borohydride: catalyzer=1: 1.0: 0.2.4-methylthiazol-5-formic acid cyclopropyl ester charging capacity is 37.0g (0.2mol), the sodium borohydride charging capacity is 11.4g (0.3mol), catalyzer is N, dinethylformamide, its consumption is 2.92g (0.04mol), tetrahydrofuran (THF) is a solvent, and its consumption is 185g, promptly 5 times of 4-methylthiazol-5-formic acid cyclopropyl ester total mass number.Temperature of reaction is 70～75 ℃, and the reaction times is 8 hours, and other is operated with embodiment 1, and product yield is 77%, and purity is 99.6%.
Embodiment 24
Molar ratio is a 4-methylthiazol-5-formic acid isopropyl ester: sodium borohydride: catalyzer=1: 1.0: 0.2.4-methylthiazol-5-formic acid isopropyl ester charging capacity is 37.0g (0.2mol), and the sodium borohydride charging capacity is 11.4g (0.3mol), and catalyzer is a yellow soda ash, its consumption is 4.0g (0.04mol), methyl alcohol is solvent, and its consumption is 185g, promptly 5 times of 4-methylthiazol-5-formic acid isopropyl ester total mass number.Temperature of reaction is 60～65 ℃, and the reaction times is 10 hours, and other is operated with embodiment 1, and product yield is 75%, and purity is 99.2%.
Embodiment 25
Molar ratio is a 4-methylthiazol-5-formic acid ethyl ester: POTASSIUM BOROHYDRIDE: catalyzer=1: 3.0: 0.2.4-methylthiazol-5-formic acid ethyl ester charging capacity is 34.2g (0.2mol), and the POTASSIUM BOROHYDRIDE charging capacity is 32.4g (0.6mol), and catalyzer is a strong aqua, its consumption is 1.4g (0.04mol), ethanol is solvent, and its consumption is 342g, promptly 10 times of 4-methylthiazol-5-formic acid ethyl ester total mass number.Temperature of reaction is 75～80 ℃, and the reaction times is 12 hours, and other is operated with embodiment 1, and product yield is 78%, and purity is 99.1%.
Claims (10)
1, a kind of synthetic method of the 4-methyl-5-hydroxymethylthiazole suc as formula (I), comprise the steps: with sodium borohydride or POTASSIUM BOROHYDRIDE as reductive agent, carry out reduction reaction in-20～100 ℃ suc as formula the 4-methyl-5-thiazole formic acid ester of (II) in organic solvent under the alkaline catalysts effect, aftertreatment promptly gets described product;
R is C in its Chinese style (II)
1～C
4Alkyl, described alkaline catalysts is inorganic metal alkali or organic amine.
2, the synthetic method of 4-methyl as claimed in claim 1-5-hydroxymethylthiazole, it is characterized in that described alkaline catalysts is one of following: sodium hydroxide, potassium hydroxide, lithium hydroxide, yellow soda ash, salt of wormwood, Quilonum Retard, sodium bicarbonate, saleratus, Trimethylamine 99, triethylamine, tripropyl amine, diethyl Tri N-Propyl Amine, pyridine, 2-picoline, 3-picoline, 4-picoline, piperidines, N, dinethylformamide, N, N-diethylformamide, N, accelerine, N, N-Diethyl Aniline, N, N-dipropyl aniline.
3, the synthetic method of 4-methyl as claimed in claim 1-5-hydroxymethylthiazole is characterized in that described R is one of following: methyl, ethyl, n-propyl, sec.-propyl, cyclopropyl, normal-butyl, isobutyl-, the tertiary butyl.
4, the synthetic method of 4-methyl as claimed in claim 1-5-hydroxymethylthiazole, it is characterized in that described organic solvent is one of following or more than one arbitrary combination: Skellysolve A, pentamethylene, normal hexane, hexanaphthene, methyl alcohol, ethanol, n-propyl alcohol, Virahol, propyl carbinol, isopropylcarbinol, the trimethyl carbinol, Pentyl alcohol, primary isoamyl alcohol, neopentyl alcohol, methylene dichloride, trichloromethane, tetracol phenixin, 1, the 2-ethylene dichloride, 1,1,2, the 2-tetrachloroethane, ether, positive propyl ether, isopropyl ether, butyl ether, 1, the 4-dioxane, glycol dimethyl ether, one glyme, diglyme, dithiocarbonic anhydride, tetrahydrofuran (THF), benzene, toluene, chlorobenzene, pyridine.
5, the synthetic method of 4-methyl as claimed in claim 1-5-hydroxymethylthiazole is characterized in that described reduction reaction temperature is 60～80 ℃, and the described reaction times is 4～8 hours.
6, as the synthetic method of the described 4-methyl of one of claim 1～5-5-hydroxymethylthiazole, it is characterized in that described 4-methyl-5-thiazole formic acid ester: reductive agent: the molar ratio of alkaline catalysts is 1: 1.0～6.0: 0.01～0.2; Described consumption of organic solvent is 2～20 times of 4-methyl-5-thiazole formic acid ester quality.
7, the synthetic method of 4-methyl as claimed in claim 6-5-hydroxymethylthiazole, it is characterized in that described reductive agent is a sodium borohydride, described 4-methyl-5-thiazole formic acid ester: sodium borohydride: the molar ratio of alkaline catalysts is 1: 1.0～1.5: 0.05～0.1.
8, the synthetic method of 4-methyl as claimed in claim 6-5-hydroxymethylthiazole, it is characterized in that described reductive agent is a POTASSIUM BOROHYDRIDE, described 4-methyl-5-thiazole formic acid ester: POTASSIUM BOROHYDRIDE: the molar ratio of alkaline catalysts is 1: 1.5～2.0: 0.1～0.15.
9, the synthetic method of 4-methyl as claimed in claim 6-5-hydroxymethylthiazole, the consumption that it is characterized in that described organic solvent are 5～10 times of 4-methyl-5-thiazole formic acid ester quality.
10, the synthetic method of 4-methyl as claimed in claim 1-5-hydroxymethylthiazole, it is characterized in that described synthetic method comprises the steps: 4-methyl-5-thiazole formic acid ester is dissolved in described organic solvent, add alkaline catalysts, add sodium borohydride or POTASSIUM BOROHYDRIDE at-20～100 ℃, stirred 1～24 hour, add the water termination reaction, with ether or ethyl acetate extraction, dry, filter, after decompression steamed organic solvent, underpressure distillation promptly got 4-methyl-5-hydroxymethylthiazole yellow oily liquid again.
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| CN1468855A (en) * | 2003-06-27 | 2004-01-21 | 厦门大学 | Heterocyclic carboxylic ester reducing process |
| JP2004026671A (en) * | 2002-06-21 | 2004-01-29 | Daito Kagaku Kk | Method for manufacturing thiazole compounds |
| CN1495176A (en) * | 2002-09-19 | 2004-05-12 | 日本化学工业株式会社 | 4-methyl-5-formylthiazole preparation method |
| CN1628108A (en) * | 2002-04-26 | 2005-06-15 | 欧奇地化学药物有限公司 | Process for the preparation of 4-methyl-thiazole-5-carbaldehyde intermediate |
| WO2005100330A1 (en) * | 2004-04-13 | 2005-10-27 | Ranbaxy Laboratories Limited | Preparation of intermediate for 3-[2-(4-methylthiazole-5-yl)vinyl] cephalosporins |
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| CN1628108A (en) * | 2002-04-26 | 2005-06-15 | 欧奇地化学药物有限公司 | Process for the preparation of 4-methyl-thiazole-5-carbaldehyde intermediate |
| JP2004026671A (en) * | 2002-06-21 | 2004-01-29 | Daito Kagaku Kk | Method for manufacturing thiazole compounds |
| CN1495176A (en) * | 2002-09-19 | 2004-05-12 | 日本化学工业株式会社 | 4-methyl-5-formylthiazole preparation method |
| CN1468855A (en) * | 2003-06-27 | 2004-01-21 | 厦门大学 | Heterocyclic carboxylic ester reducing process |
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