RU2002116255A

RU2002116255A - Aminoheterocycclamide derivatives with pesticidal activity

Info

Publication number: RU2002116255A
Application number: RU2002116255/04A
Authority: RU
Inventors: Пьер ДЮКРЕ; Жак БУВЬЕ; Урс МЮЛЛЕР
Original assignee: Новартис Аг
Priority date: 1999-11-18
Filing date: 2000-11-16
Publication date: 2003-12-20

Claims

1. Compounds of the formula

where R ₁ is hydrogen, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkyl or unsubstituted or substituted with 1-5 phenyl substituents, where the substituents are selected from the group consisting of C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, aryloxy, halogen, cyano and nitro, moreover, if the number of substituents exceeds 1, then the substituents may be the same or different;

R ₂ is hydrogen, C ₁ -C ₆ alkyl, (C ₁ -C ₆ alkylene) phenyl, pyridyl, COOR ₆ , CONR ₇ R ₈ , SOK ₆ , allyl or CH ₂ -O-R ₆ ;

X ₁ is N;

X ₂ is C (CN), C (COOR ₆ ), C (COR ₆ ), C (SOR ₆ ), C (CONR ₇ R ₈ ) or C (NO ₂ );

X ₃ is O or S;

Q is CH or N;

R ₃ and R _{4 are} independently hydrogen, C ₁ -C ₆ alkyl, or together with the carbon atom to which they are attached form a C ₃ -C ₇ cycloalkyl ring;

R ₅ is a substituent selected from the group consisting of C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, aryloxy, halogen, cyano , hydroxy, amino, nitro, and phenyl substituted with 1-5 substituents, where the substituents are selected from the group consisting of C ₁ -C ₆ alkyl, C ₂ -C ₆ alkeyyl, C ₂ -C ₆ alkynyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, aryloxy, halogen, cyano, hydroxy, amino and nitro, and if the number of phenyl substituents exceeds 1, then they can be the same or different, and if m is greater than 1, then the substituents R ₅ can be the same or different;

R ₆ is C ₁ -C ₆ alkyl, phenyl or benzyl;

R ₇ and R _{8 are} independently hydrogen or C ₁ -C ₆ alkyl;

m is 1,2 or 3; and

n is 0 or 1.

2. A method of obtaining compounds of formula I according to claim 1, which consists in the fact that the compound of the formula

which is known or which can be obtained analogously to the corresponding known compounds, and in which R ₁ , R ₂ , X ₁ and X ₂ have the meanings indicated for formula I, are reacted with a compound of the formula

which is known or which can be prepared analogously to the corresponding known compounds, and in which X ₃ , R ₃ , R ₄ , R ₅ , m, n and Q have the meanings indicated for formula I, and Z represents a leaving group, optionally in the presence of a basic the catalyst and optionally obtained as a result of this process or in any other way, the compound of formula I or its enantiomer is converted into another compound of formula I or its enantiomer, the mixture of enantiomers that can be obtained from this process is separated and isolated uemy enantiomer.

3. A pest control composition that includes, as an active substance, at least one compound of formula I according to claim 1 in combination with carriers and / or dispersing agents.

4. The use of compounds of formula I according to claim 1 for pest control.

5. A method of controlling pests, which consists in treating pests or their habitat with an effective amount of at least one compound of formula I according to claim 1 as an pesticide.

6. The use of the compounds of formula I according to claim 1 in a method for controlling parasites of warm-blooded animals.

7. The use of the compounds of formula I according to claim 1 for the preparation of a pharmaceutical composition for controlling parasites.