RU2002100738A - The method of obtaining 6-substituted uracils - Google Patents

The method of obtaining 6-substituted uracils

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Publication number
RU2002100738A
RU2002100738A RU2002100738/04A RU2002100738A RU2002100738A RU 2002100738 A RU2002100738 A RU 2002100738A RU 2002100738/04 A RU2002100738/04 A RU 2002100738/04A RU 2002100738 A RU2002100738 A RU 2002100738A RU 2002100738 A RU2002100738 A RU 2002100738A
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RU
Russia
Prior art keywords
substituted
obtaining
thiouracil
substituted uracils
methyloxyran
Prior art date
Application number
RU2002100738/04A
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Russian (ru)
Other versions
RU2212406C1 (en
Inventor
Иван Александрович Новаков
Борис Семенович Орлинсон
Максим Борисович Навроцкий
Original Assignee
Волгоградский государственный технический университет
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Priority to RU2002100738A priority Critical patent/RU2212406C1/en
Priority claimed from RU2002100738A external-priority patent/RU2212406C1/en
Application granted granted Critical
Publication of RU2212406C1 publication Critical patent/RU2212406C1/en
Publication of RU2002100738A publication Critical patent/RU2002100738A/en

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Claims (1)

Способ получения 6-замещенных урацилов общей формулыThe method of obtaining 6-substituted uracils of the General formula
Figure 00000001
Figure 00000001
 где R = СН3, С6Н5СН2, 2,6-F2С6Н3СН2 where R = CH 3 , C 6 H 5 CH 2 , 2,6-F 2 C 6 H 3 CH 2 с использованием 6-замещенных 2-тиоурацилов в присутствии водного раствора гидроксида натрия, отличающийся тем, что в качестве 6-замещенных 2-тиоурацилов используют 6-метил-2-тиоурацил, 6-бензил-2-тиоурацил или 6-(2,6-дифторбензил)-2-тиоурацил, которые подвергают взаимодействию с 2-метилоксираном при мольном соотношении 6-замещенный 2-тиоурацил:2-метилоксиран:гидроксид натрия равном 1:1,0-1,2:1 с последующим выделением целевого продукта.using 6-substituted 2-thiouracils in the presence of an aqueous solution of sodium hydroxide, characterized in that 6-methyl-2-thiouracil, 6-benzyl-2-thiouracil or 6- (2,6) are used as 6-substituted 2-thiouracils -difluorobenzyl) -2-thiouracil, which is reacted with 2-methyloxyran in a 6-substituted 2-thiouracil: 2-methyloxyran: sodium hydroxide molar ratio of 1: 1.0-1.2: 1, followed by isolation of the target product.
RU2002100738A 2002-01-08 2002-01-08 Method for preparing 6-substituted uracil RU2212406C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2002100738A RU2212406C1 (en) 2002-01-08 2002-01-08 Method for preparing 6-substituted uracil

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Application Number Priority Date Filing Date Title
RU2002100738A RU2212406C1 (en) 2002-01-08 2002-01-08 Method for preparing 6-substituted uracil

Publications (2)

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RU2212406C1 RU2212406C1 (en) 2003-09-20
RU2002100738A true RU2002100738A (en) 2003-10-10

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