RU2001131570A - The method of obtaining L-amino acids using bacteria belonging to the genus Escherichia - Google Patents

The method of obtaining L-amino acids using bacteria belonging to the genus Escherichia

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Publication number
RU2001131570A
RU2001131570A RU2001131570/13A RU2001131570A RU2001131570A RU 2001131570 A RU2001131570 A RU 2001131570A RU 2001131570/13 A RU2001131570/13 A RU 2001131570/13A RU 2001131570 A RU2001131570 A RU 2001131570A RU 2001131570 A RU2001131570 A RU 2001131570A
Authority
RU
Russia
Prior art keywords
bacterium
amino acid
increased
amino acids
activity
Prior art date
Application number
RU2001131570/13A
Other languages
Russian (ru)
Other versions
RU2229513C2 (en
Inventor
Виталий Аркадьевич Лившиц
Мария Вячеславовна Витушкина
Михаил Маркович Гусятинер
Михаил Харисович Зиятдинов
Валерий Завенович Ахвердян
Екатерина Алексеевна Саврасова
Вера Георгиевна Дорошенко
Сергей Владимирович Машко
Original Assignee
Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика"
Filing date
Publication date
Application filed by Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" filed Critical Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика"
Priority claimed from RU2001131570/13A external-priority patent/RU2229513C2/en
Priority to RU2001131570/13A priority Critical patent/RU2229513C2/en
Priority to MXPA04004872A priority patent/MXPA04004872A/en
Priority to CNB028274784A priority patent/CN100469875C/en
Priority to EP06009979A priority patent/EP1688482A1/en
Priority to KR1020047007782A priority patent/KR101023924B1/en
Priority to AT02788635T priority patent/ATE334190T1/en
Priority to JP2003545812A priority patent/JP4305183B2/en
Priority to PL369776A priority patent/PL207851B1/en
Priority to PCT/JP2002/012202 priority patent/WO2003044191A1/en
Priority to DK02788635T priority patent/DK1449917T3/en
Priority to CA2468178A priority patent/CA2468178C/en
Priority to DE60213456T priority patent/DE60213456T2/en
Priority to BRPI0214329-1A priority patent/BR0214329B1/en
Priority to ES02788635T priority patent/ES2269788T3/en
Priority to EP02788635A priority patent/EP1449917B1/en
Priority to AU2002355021A priority patent/AU2002355021C1/en
Priority to ARP020104507A priority patent/AR037583A1/en
Priority to US10/302,983 priority patent/US7259003B2/en
Publication of RU2001131570A publication Critical patent/RU2001131570A/en
Publication of RU2229513C2 publication Critical patent/RU2229513C2/en
Application granted granted Critical
Priority to US11/761,465 priority patent/US7531332B2/en

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Claims (8)

1. Бактерия - продуцент L-аминокислоты, принадлежащая к роду Escherichia, в которой продукция L-аминокислоты упомянутой бактерией увеличена за счет повышения активности белков, описанных в пунктах (А) или (В), в клетке упомянутой бактерии:1. A bacterium is an L-amino acid producer belonging to the genus Escherichia, in which the production of an L-amino acid by said bacterium is increased by increasing the activity of the proteins described in (A) or (B) in the cell of said bacterium: (A) белок, который представлен аминокислотной последовательностью, приведенной в списке последовательностей под номером 2;(A) a protein that is represented by the amino acid sequence shown in sequence listing number 2; (B) белок, который представлен аминокислотной последовательностью, включающей делеции, замены, вставки или добавление одной или нескольких аминокислот в аминокислотную последовательность, приведенную в списке последовательностей под номером 2, и который обладает активностью, придающей бактерии повышенную устойчивость к L-аминокислотам, таким как фенилаланин, треонин, гомосерин или цистеин, и/или их аналогам, таким как п-фторфенилаланин, 5-фтор-DL-триптофан, S-(2-аминоэтил)цистеин или 4-аза-DL-лейцин;(B) a protein that is represented by an amino acid sequence including deletions, substitutions, insertions, or the addition of one or more amino acids to the amino acid sequence listed in sequence number 2, and which has an activity that confers bacteria an increased resistance to L-amino acids, such as phenylalanine, threonine, homoserine or cysteine, and / or their analogues, such as p-fluorophenylalanine, 5-fluoro-DL-tryptophan, S- (2-aminoethyl) cysteine or 4-aza-DL-leucine; 2. Бактерия по п.1, отличающаяся тем, что активности белков, описанных в пунктах (А) или (В), повышены путем трансформации бактерии с помощью ДНК, кодирующей белки, описанные в пунктах (А) или (В), или путем изменения регуляции экспрессии указанной ДНК в хромосоме упомянутой бактерии.2. The bacterium according to claim 1, characterized in that the activity of the proteins described in points (A) or (B) is increased by transforming the bacterium using DNA encoding the proteins described in points (A) or (B), or by changes in the regulation of expression of said DNA in the chromosome of said bacterium. 3. Бактерия по п.2, отличающаяся тем, что трансформация осуществляется с использованием многокопийного вектора.3. The bacterium according to claim 2, characterized in that the transformation is carried out using a multi-copy vector. 4. Способ получения L-аминокислоты, включающий стадии: выращивания бактерии по любому из пп.1-3 в питательной среде, и выделения из культуральной жидкости полученной и накопленной в ней L-аминокислоты.4. A method for producing an L-amino acid, comprising the steps of: growing a bacterium according to any one of claims 1 to 3 in a nutrient medium, and isolating the obtained and accumulated L-amino acid from the culture fluid. 5. Способ по п.4, отличающийся тем, что L-аминокислотой является L-фенилаланин.5. The method according to claim 4, characterized in that the L-amino acid is L-phenylalanine. 6. Способ по п.5, отличающийся тем, что у указанной бактерии повышена экспрессия генов биосинтеза фенилаланина.6. The method according to claim 5, characterized in that said bacterium has increased expression of phenylalanine biosynthesis genes. 7. Способ по п.4, отличающийся тем, что L-аминокислотой является L-треонин.7. The method according to claim 4, characterized in that the L-amino acid is L-threonine. 8. Способ по п.7, отличающийся тем, что у указанной бактерии повышена экспрессия генов треонинового оперона.8. The method according to claim 7, characterized in that said bacterium has increased expression of threonine operon genes.
RU2001131570/13A 2001-11-23 2001-11-23 Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants) RU2229513C2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
RU2001131570/13A RU2229513C2 (en) 2001-11-23 2001-11-23 Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)
CA2468178A CA2468178C (en) 2001-11-23 2002-11-21 Method for producing l-amino acid using bacteria belonging to the genus escherichia
BRPI0214329-1A BR0214329B1 (en) 2001-11-23 2002-11-21 L-AMINO ACID PRODUCING BACTERIA, AND METHODS FOR THE PRODUCTION OF L-AMINO ACID AND LOWER ALTERINE ALPHA-L-PHENYL-ALANINE ALTERIN ESTER
EP06009979A EP1688482A1 (en) 2001-11-23 2002-11-21 Method for producing L-amino acid using bacteria belonging to the genus Escherichia
KR1020047007782A KR101023924B1 (en) 2001-11-23 2002-11-21 Process for producing L-amino acid using Escherichia
AT02788635T ATE334190T1 (en) 2001-11-23 2002-11-21 PROCESS FOR L-AMINO ACID PRODUCTION WITH ESCHERICHIA
JP2003545812A JP4305183B2 (en) 2001-11-23 2002-11-21 Method for producing L-amino acid using Escherichia bacterium
PL369776A PL207851B1 (en) 2001-11-23 2002-11-21 Process for producing l-amino acid using escherichia
PCT/JP2002/012202 WO2003044191A1 (en) 2001-11-23 2002-11-21 Process for producing l-amino acid using escherichia
DK02788635T DK1449917T3 (en) 2001-11-23 2002-11-21 Process for L-Amino Acid Preparation Using Escherichia
MXPA04004872A MXPA04004872A (en) 2001-11-23 2002-11-21 Process for producing l-amino acid using escherichia.
DE60213456T DE60213456T2 (en) 2001-11-23 2002-11-21 PROCESS FOR L-AMINO ACID PRODUCTION WITH ESCHERICHIA
CNB028274784A CN100469875C (en) 2001-11-23 2002-11-21 Process for producing L-amino acid using escherichia
ES02788635T ES2269788T3 (en) 2001-11-23 2002-11-21 PROCEDURE FOR THE PRODUCTION OF L-AMINO ACIDS USING ESCHERICHIA.
EP02788635A EP1449917B1 (en) 2001-11-23 2002-11-21 Process for producing l-amino acid using escherichia
AU2002355021A AU2002355021C1 (en) 2001-11-23 2002-11-21 Process for producing L-amino acid using escherichia
ARP020104507A AR037583A1 (en) 2001-11-23 2002-11-22 METHOD TO PRODUCE L-AMINO ACIDS USING BACTERIA THAT BELONG TO THE GENERO ESCHERICHIA
US10/302,983 US7259003B2 (en) 2001-11-23 2002-11-25 Escherichia bacteria transformed with a yedA homolog to enhance L-amino acid producing activity, and methods for producing an L-amino acid using same
US11/761,465 US7531332B2 (en) 2001-11-23 2007-06-12 Method for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine using Escherichia bacteria

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2001131570/13A RU2229513C2 (en) 2001-11-23 2001-11-23 Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)

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RU2001131570A true RU2001131570A (en) 2003-08-20
RU2229513C2 RU2229513C2 (en) 2004-05-27

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US (2) US7259003B2 (en)
EP (2) EP1688482A1 (en)
JP (1) JP4305183B2 (en)
KR (1) KR101023924B1 (en)
CN (1) CN100469875C (en)
AR (1) AR037583A1 (en)
AT (1) ATE334190T1 (en)
AU (1) AU2002355021C1 (en)
BR (1) BR0214329B1 (en)
CA (1) CA2468178C (en)
DE (1) DE60213456T2 (en)
DK (1) DK1449917T3 (en)
ES (1) ES2269788T3 (en)
MX (1) MXPA04004872A (en)
PL (1) PL207851B1 (en)
RU (1) RU2229513C2 (en)
WO (1) WO2003044191A1 (en)

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