RU2001130047A - Rapidly dispersible fish gelatin formulations - Google Patents

Rapidly dispersible fish gelatin formulations

Info

Publication number
RU2001130047A
RU2001130047A RU2001130047/14A RU2001130047A RU2001130047A RU 2001130047 A RU2001130047 A RU 2001130047A RU 2001130047/14 A RU2001130047/14 A RU 2001130047/14A RU 2001130047 A RU2001130047 A RU 2001130047A RU 2001130047 A RU2001130047 A RU 2001130047A
Authority
RU
Russia
Prior art keywords
composition
active ingredient
fish gelatin
carrier
dosage form
Prior art date
Application number
RU2001130047/14A
Other languages
Russian (ru)
Other versions
RU2242969C2 (en
Inventor
Оуэн МЮРРЕЙ
Майкл ХОЛЛ
Ричард ГРИН
Патрик Керни
Original Assignee
Ар. Пи. ШЕРЕР КОРПОРЕЙШН
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9908014.5A external-priority patent/GB9908014D0/en
Application filed by Ар. Пи. ШЕРЕР КОРПОРЕЙШН filed Critical Ар. Пи. ШЕРЕР КОРПОРЕЙШН
Publication of RU2001130047A publication Critical patent/RU2001130047A/en
Application granted granted Critical
Publication of RU2242969C2 publication Critical patent/RU2242969C2/en

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Claims (26)

1. Фармацевтическая композиция в виде быстро диспергируемой лекарственной формы, включающая носитель и активный ингредиент, где указанный носитель представляет собой рыбий желатин, а указанная лекарственная форма быстро высвобождает активный ингредиент при контакте с жидкостью.1. A pharmaceutical composition in the form of a rapidly dispersible dosage form comprising a carrier and an active ingredient, wherein said carrier is fish gelatin and said dosage form quickly releases the active ingredient upon contact with the liquid. 2. Композиция по п.1, где указанная композиция дезинтегрируется в течение 1 - 60 с после контакта с жидкостью.2. The composition according to claim 1, where the specified composition is disintegrated within 1 to 60 seconds after contact with the liquid. 3. Композиция по п.1, где указанная композиция предназначена для перорального введения и быстро высвобождает активный ингредиент в полости рта.3. The composition according to claim 1, where the specified composition is intended for oral administration and quickly releases the active ingredient in the oral cavity. 4. Композиция по п.1, где указанная композиция представлена в твердом состоянии и ее получают путем сублимации растворителя из смеси в твердом состоянии, в котором смесь включает активный ингредиент, носитель и растворитель.4. The composition according to claim 1, where the specified composition is presented in the solid state and it is obtained by sublimation of the solvent from the mixture in the solid state, in which the mixture includes the active ingredient, a carrier and a solvent. 5. Композиция по п.1, где активный ингредиент присутствует в количестве от приблизительно 0,2 до приблизительно 95 мас.% от массы композиции в сухой лекарственной форме.5. The composition according to claim 1, where the active ingredient is present in an amount of from about 0.2 to about 95 wt.% By weight of the composition in dry dosage form. 6. Композиция по п.5, где активный ингредиент присутствует в количестве от приблизительно 1 до приблизительно 20 мас.% от массы композиции в сухой лекарственной форме.6. The composition according to claim 5, where the active ingredient is present in an amount of from about 1 to about 20 wt.% By weight of the composition in dry dosage form. 7. Композиция по п.1, где рыбий желатин представляет собой не превращающийся в гель рыбий желатин.7. The composition according to claim 1, where the fish gelatin is a non-gelable fish gelatin. 8. Композиция по п.7, где рыбий желатин не гидролизован.8. The composition according to claim 7, where the fish gelatin is not hydrolyzed. 9. Композиция по п.8, где рыбий желатин является высушенным распылением.9. The composition of claim 8, where the fish gelatin is a spray dried. 10. Композиция по п.1, также включающая дополнительный ингредиент, выбранный из группы, состоящей из матрицеобразующих агентов, сахаров, циклических сахаров, аминокислот, консервантов, поверхностно-активных веществ, загустителей, красящих агентов, корригентов, модификаторов рН, подсластителей, агентов, маскирующих вкус, а также их комбинаций.10. The composition according to claim 1, also comprising an additional ingredient selected from the group consisting of matrix-forming agents, sugars, cyclic sugars, amino acids, preservatives, surfactants, thickeners, coloring agents, flavoring agents, pH modifiers, sweeteners, agents, masking the taste, as well as their combinations. 11. Способ получения фармацевтической композиции в виде быстро диспергируемой лекарственной формы, содержащей активный ингредиент и носитель из рыбьего желатина, включающий стадию образования сетчатой структуры активного ингредиента и носителя из рыбьего желатина сублимацией растворителя из смеси в твердом состоянии, в котором смесь включает активный ингредиент, носитель и растворитель для носителя.11. A method of obtaining a pharmaceutical composition in the form of a rapidly dispersible dosage form containing the active ingredient and a fish gelatin carrier, comprising the step of forming a net structure of the active ingredient and a fish gelatin carrier by sublimating the solvent from a solid mixture in which the mixture comprises the active ingredient, a carrier and carrier solvent. 12. Фармацевтическая композиция в виде быстро диспергируемой лекарственной формы, включающая активный ингредиент и носитель из рыбьего желатина, который быстро высвобождает активный ингредиент при контакте с жидкостью, при этом указанная лекарственная форма имеет сетчатую структуру активного ингредиента и рыбьего желатина, полученную в результате сублимации растворителя: из смеси в твердом состоянии, в котором смесь включает активный ингредиент, носитель и растворитель.12. A pharmaceutical composition in the form of a rapidly dispersible dosage form comprising an active ingredient and a fish gelatin carrier that rapidly releases the active ingredient in contact with a liquid, wherein the dosage form has a network structure of the active ingredient and fish gelatin obtained by sublimation of the solvent : from a solid state mixture in which the mixture comprises an active ingredient, a carrier and a solvent. 13. Композиция по п.12, где указанная композиция дезинтегрируется в течение 1 - 60 с после контакта с жидкостью.13. The composition of claim 12, wherein said composition is disintegrated within 1-60 seconds after contact with the liquid. 14. Композиция по п.12, где указанная композиция предназначена для перорального введения и быстро высвобождает активный ингредиент в полости рта.14. The composition of claim 12, wherein said composition is for oral administration and rapidly releases the active ingredient in the oral cavity. 15. Композиция по п.12, где активный ингредиент присутствует в количестве от приблизительно 0,2 до приблизительно 95 мас.% от массы композиции в сухой лекарственной форме.15. The composition according to item 12, where the active ingredient is present in an amount of from about 0.2 to about 95 wt.% By weight of the composition in dry dosage form. 16. Композиция по п.15, где активный ингредиент присутствует в количестве от приблизительно 1 до приблизительно 20 мас.% от массы композиции в сухой лекарственной форме.16. The composition according to clause 15, where the active ingredient is present in an amount of from about 1 to about 20 wt.% By weight of the composition in dry dosage form. 17. Композиция по п.12, где рыбий желатин представляет собой не превращающийся в гель рыбий желатин.17. The composition according to item 12, where the fish gelatin is a non-gelable fish gelatin. 18. Композиция по п.11, где рыбий желатин не гидролизован.18. The composition according to claim 11, where the fish gelatin is not hydrolyzed. 19. Композиция по п.18, где рыбий желатин является высушенным распылением.19. The composition of claim 18, wherein the fish gelatin is spray dried. 20. Композиция по п.12, также включающая дополнительный ингредиент, выбранный из группы, состоящей из матрицеобразующих агентов, сахаров, циклических сахаров, аминокислот, консервантов, поверхностно-активных веществ, загустителей, красящих агентов, корригентов, модификаторов рН, подсластителей, агентов, маскирующих вкус, а также их комбинаций.20. The composition according to p. 12, also comprising an additional ingredient selected from the group consisting of matrix forming agents, sugars, cyclic sugars, amino acids, preservatives, surfactants, thickeners, coloring agents, flavoring agents, pH modifiers, sweeteners, agents, masking the taste, as well as their combinations. 21. Способ применения рыбьего желатина в качестве носителя в фармацевтической композиции, включающий: а) добавление рыбьего желатина в растворителе к активному ингредиенту для получения смеси; b) замораживание указанной смеси; и c) сублимацию растворителя из замороженной смеси, в котором композиция представляет быстро диспергируемую лекарственную форму, быстро высвобождающую активный ингредиент при контакте с жидкостью.21. A method of using fish gelatin as a carrier in a pharmaceutical composition, comprising: a) adding fish gelatin in a solvent to the active ingredient to obtain a mixture; b) freezing said mixture; and c) sublimation of the solvent from the frozen mixture, in which the composition is a rapidly dispersible dosage form, quickly releasing the active ingredient upon contact with the liquid. 22. Способ по п.21, где композиция дезинтегрируется в течение 1 - 60 с после контакта с жидкостью.22. The method according to item 21, where the composition is disintegrated within 1 to 60 seconds after contact with the liquid. 23. Способ по п.21, где композиция предназначена для перорального введения и быстро высвобождает активный ингредиент в полости рта.23. The method according to item 21, where the composition is intended for oral administration and quickly releases the active ingredient in the oral cavity. 24. Способ по п.21, где рыбий желатин представляет собой не превращающийся в гель рыбий желатин.24. The method according to item 21, where the fish gelatin is a non-gelable fish gelatin. 25. Способ по п.24, где рыбий желатин не гидролизован.25. The method according to paragraph 24, where the fish gelatin is not hydrolyzed. 26. Способ по п.25, где рыбий желатин является высушенным распылением.26. The method according A.25, where the fish gelatin is a spray dried.
RU2001130047/15A 1999-04-08 2000-04-07 Piscine gelatin-containing rapidly dispersing medicinal formulations RU2242969C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9908014.5A GB9908014D0 (en) 1999-04-08 1999-04-08 Pharmaceutical compositions
GB9908014.5 1999-04-08

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RU2001130047A true RU2001130047A (en) 2003-06-20
RU2242969C2 RU2242969C2 (en) 2004-12-27

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US (2) US6709669B1 (en)
EP (1) EP1165053B1 (en)
JP (1) JP4838939B2 (en)
KR (1) KR100767076B1 (en)
CN (1) CN1224381C (en)
AT (1) ATE262890T1 (en)
AU (1) AU761439B2 (en)
BR (1) BR0009609A (en)
CA (1) CA2369715C (en)
CZ (1) CZ295324B6 (en)
DE (1) DE60009472T2 (en)
DK (1) DK1165053T3 (en)
ES (1) ES2215645T3 (en)
GB (1) GB9908014D0 (en)
HK (1) HK1039066B (en)
HU (1) HU229892B1 (en)
IL (2) IL145783A0 (en)
IS (1) IS2403B (en)
MX (1) MXPA01010094A (en)
NO (1) NO330196B1 (en)
NZ (1) NZ515230A (en)
PL (1) PL196572B1 (en)
PT (1) PT1165053E (en)
RO (1) RO122011B1 (en)
RU (1) RU2242969C2 (en)
TR (1) TR200102881T2 (en)
WO (1) WO2000061117A1 (en)
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