RU2000130159A - METHOD FOR PRODUCING A MEDICAL DIAGNOSTIC DEVICE CONTAINING REAGENT AND DEVICE - Google Patents

METHOD FOR PRODUCING A MEDICAL DIAGNOSTIC DEVICE CONTAINING REAGENT AND DEVICE

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Publication number
RU2000130159A
RU2000130159A RU2000130159/14A RU2000130159A RU2000130159A RU 2000130159 A RU2000130159 A RU 2000130159A RU 2000130159/14 A RU2000130159/14 A RU 2000130159/14A RU 2000130159 A RU2000130159 A RU 2000130159A RU 2000130159 A RU2000130159 A RU 2000130159A
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RU
Russia
Prior art keywords
substrate
sample
reagent
region
application
Prior art date
Application number
RU2000130159/14A
Other languages
Russian (ru)
Other versions
RU2256167C2 (en
Inventor
Ян А. ХАРДИНГ
Роберт Джастис ШАРТЛ
Original Assignee
Лайфскен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/454,196 external-priority patent/US6830934B1/en
Application filed by Лайфскен, Инк. filed Critical Лайфскен, Инк.
Publication of RU2000130159A publication Critical patent/RU2000130159A/en
Application granted granted Critical
Publication of RU2256167C2 publication Critical patent/RU2256167C2/en

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Claims (20)

1. Способ изготовления содержащего реагент медицинского диагностического устройства, при котором (a) обеспечивают неабсорбирующий субстрат, имеющий на своей поверхности, по меньшей мере, одну гидрофильную область-мишень, (b) обеспечивают пульсирующую струю микрокапель жидкости, содержащую диагностический реагент, из неударной печатающей головки в точку в пределах области-мишени, (c) осуществляют движение струи относительно субстрата, и (d) повторяют этапы (b) и (с), по меньшей мере, столько раз, сколько достаточно для создания практически однородного слоя жидкости на области-мишени.1. A method of manufacturing a reagent-containing medical diagnostic device in which (a) a non-absorbent substrate is provided having at least one hydrophilic target region on its surface, (b) a pulsating jet of liquid droplets containing a diagnostic reagent is provided from a non-impact printing heads to a point within the target region, (c) move the jet relative to the substrate, and (d) repeat steps (b) and (c) at least as many times as enough to create almost one native fluid layer on the target area. 2. Способ по п. 1, при котором субстрат содержит практически плоский листок. 2. The method according to claim 1, wherein the substrate contains a substantially flat sheet. 3. Способ по п. 1, при котором субстрат содержит термопластичный листок. 3. The method according to claim 1, wherein the substrate contains a thermoplastic sheet. 4. Способ по п. 1, при котором каждая из, по меньшей мере, одной областей-мишеней имеет угол контакта с водой не более приблизительно 60o.4. The method of claim 1, wherein each of the at least one target regions has a contact angle with water of not more than about 60 ° . 5. Способ по п. 1, при котором печатающая головка представляет собой термографическую струйную печатающую головку. 5. The method of claim 1, wherein the printhead is a thermographic inkjet printhead. 6. Способ по п. 1, при котором реакционная жидкость содержит тромбопластин. 6. The method of claim 1, wherein the reaction liquid contains thromboplastin. 7. Способ по п. 2, при котором осуществляют движение потока в направлении, практически перпендикулярном субстрату, и поток передвигают относительно субстрата путем перемещения субстрата в направлении, практически перпендикулярном направлению движения потока. 7. The method according to p. 2, in which the flow is carried out in a direction almost perpendicular to the substrate, and the flow is moved relative to the substrate by moving the substrate in a direction almost perpendicular to the direction of flow. 8. Способ по п. 1, при котором поток проходит через отверстие в листке, расположенное между дозатором и субстратом. 8. The method according to claim 1, wherein the flow passes through an opening in the sheet located between the dispenser and the substrate. 9. Способ по п. 8, при котором листок имеет гидрофобную поверхность, обращенную к дозатору. 9. The method according to claim 8, wherein the leaf has a hydrophobic surface facing the dispenser. 10. Способ по п. 9, при котором реагент содержит краситель. 10. The method according to p. 9, in which the reagent contains a dye. 11. Содержащее реагент медицинское диагностическое устройство для измерения концентрации анализируемого вещества или характеристики биологической жидкости, включающее в себя (a) область нанесения образца для приема образца биологической жидкости для анализа и (b) заранее предопределенную гидрофильную реакционную область, на которую путем неударной печати наносится жидкость, содержащая диагностический реагент, взаимодействующий с образцом, вызывая физически измеримое изменение в образце, связанное с концентрацией анализируемого вещества или характеристикой жидкости. 11. A reagent-containing medical diagnostic device for measuring the concentration of an analyte or a characteristic of a biological fluid, including (a) a sample application area for receiving a sample of a biological fluid for analysis and (b) a predetermined hydrophilic reaction region to which a liquid is applied by printing containing a diagnostic reagent that interacts with the sample, causing a physically measurable change in the sample associated with the concentration of the analyte or characterization of the fluid. 12. Устройство по п. 11, в котором область нанесения образца и реакционная область практически совпадают. 12. The device according to p. 11, in which the region of application of the sample and the reaction region are practically the same. 13. Устройство по п. 11, дополнительно содержащее средство проведения образца от области нанесения в реакционную область. 13. The device according to p. 11, additionally containing means for conducting the sample from the area of application to the reaction region. 14. Устройство по п. 11, в котором область нанесения образца является гидрофильной. 14. The device according to claim 11, in which the area of application of the sample is hydrophilic. 15. Устройство по п. 11, в котором субстрат содержит практически прозрачный плоский листок. 15. The device according to claim 11, in which the substrate contains an almost transparent flat sheet. 16. Устройство по п. 11, в котором субстрат содержит практически прозрачный термопластичный листок. 16. The device according to claim 11, in which the substrate contains an almost transparent thermoplastic sheet. 17. Устройство по п. 11, в котором реакционная жидкость содержит тромбопластин. 17. The device according to claim 11, in which the reaction liquid contains thromboplastin. 18. Устройство по п. 11, в котором реакционная жидкость содержит краситель. 18. The device according to p. 11, in which the reaction liquid contains a dye. 19. Устройство по п. 13, в котором средство проведения образца от области нанесения в реакционную область включает в себя верхний слой, отделенный от субстрата промежуточным слоем, который имеет сквозное отверстие и примыкающий канал, врезанный в него, верхний слой, промежуточный слой и субстрат, образующий камеру, которая, будучи сжатой, а затем высвобожденной, способна создавать в канале пониженное давление для продвижения крови в реакционную область. 19. The device according to p. 13, in which the means of conducting the sample from the area of application to the reaction region includes an upper layer separated from the substrate by an intermediate layer, which has a through hole and an adjacent channel embedded in it, the upper layer, the intermediate layer and the substrate forming a chamber, which, being compressed and then released, is able to create a reduced pressure in the channel to move blood into the reaction region. 20. Устройство по п. 19, в котором верхний слой имеет гидрофобную поверхность, обращенную к субстрату, по меньшей мере, в канале и реакционной области. 20. The device according to p. 19, in which the upper layer has a hydrophobic surface facing the substrate, at least in the channel and the reaction region.
RU2000130159/14A 1999-12-03 2000-12-01 Method and device for producing medical diagnostic device containing reagent RU2256167C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/454,196 US6830934B1 (en) 1999-06-15 1999-12-03 Microdroplet dispensing for a medical diagnostic device
US09/454,196 1999-12-03

Publications (2)

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RU2000130159A true RU2000130159A (en) 2002-10-10
RU2256167C2 RU2256167C2 (en) 2005-07-10

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US (3) US6830934B1 (en)
EP (1) EP1107004B1 (en)
JP (1) JP2001201504A (en)
KR (1) KR20010062005A (en)
CN (1) CN1213302C (en)
AR (1) AR026703A1 (en)
AT (1) ATE325342T1 (en)
AU (1) AU775559B2 (en)
BR (1) BR0005697A (en)
CA (1) CA2327305A1 (en)
DE (1) DE60027677T2 (en)
DK (1) DK1107004T3 (en)
ES (1) ES2264921T3 (en)
HK (2) HK1036838A1 (en)
IL (1) IL139789A (en)
MX (1) MXPA00011830A (en)
NO (1) NO320095B1 (en)
PT (1) PT1107004E (en)
RU (1) RU2256167C2 (en)
SG (1) SG89361A1 (en)
TW (1) TW539546B (en)

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