RU2000122618A - SURFACE-ACTIVE COPOLYMERS BASED ON METHILIDENMALONATE - Google Patents

SURFACE-ACTIVE COPOLYMERS BASED ON METHILIDENMALONATE

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Publication number
RU2000122618A
RU2000122618A RU2000122618/04A RU2000122618A RU2000122618A RU 2000122618 A RU2000122618 A RU 2000122618A RU 2000122618/04 A RU2000122618/04 A RU 2000122618/04A RU 2000122618 A RU2000122618 A RU 2000122618A RU 2000122618 A RU2000122618 A RU 2000122618A
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paragraphs
fragment
copolymers according
poly
copolymers
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RU2000122618/04A
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Russian (ru)
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RU2216551C2 (en
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Николь БРЮ-МАНЬЕ
Виржини ЛАРРА
Жерар РЬЕСС
Паскаль БРЕТОН
Патрик КУВРЕР
Клод РОК-КАРМ
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Вирсоль
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Priority claimed from FR9801001A external-priority patent/FR2774096B1/en
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Claims (1)

1. Биосовместимые сополимеры, включающие по меньшей мере один фрагмент, имеющий гидрофильный характер, и по меньшей мере один фрагмент, имеющий гидрофобный характер, отличающиеся тем, что фрагмент гидрофобного характера образован либо гомополимером, состоящим из повторяющихся звеньев общей формулы (I):
Figure 00000001

в которой R1 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода, или группу (СН2)m-СООR3, в которой m является целым числом от 1 до 5, а R3 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода;
R2 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода; а
n является целым числом от 1 до 5;
либо статистическим сополимером, состоящим из разных повторяющихся звеньев указанной выше формулы (I):
либо статистическим сополимером, большей частью состоящим из звеньев указанной выше формулы (I).1. Biocompatible copolymers comprising at least one fragment having a hydrophilic character and at least one fragment having a hydrophobic character, characterized in that the fragment of a hydrophobic character is formed by either a homopolymer consisting of repeating units of the general formula (I):
Figure 00000001

in which R 1 represents an alkyl group having from 1 to 6 carbon atoms, or a group (CH 2 ) m —COOR 3 , in which m is an integer from 1 to 5, and R 3 represents an alkyl group having from 1 up to 6 carbon atoms;
R 2 represents an alkyl group having from 1 to 6 carbon atoms; but
n is an integer from 1 to 5;
or a statistical copolymer consisting of different repeating units of the above formula (I):
or a statistical copolymer, mostly consisting of units of the above formula (I). 2. Сополимеры по п. 1, отличающиеся тем, что фрагмент гидрофобного характера состоит из повторяющихся звеньев указанной выше общей формулы (I), в которой R1 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода, R2 представляет собой алкильную группу, имеющую от 1 до 6 атомов углерода, а n является целым числом, равным единице.2. Copolymers according to claim 1, characterized in that the fragment of a hydrophobic character consists of repeating units of the aforementioned general formula (I) in which R 1 is an alkyl group having from 1 to 6 carbon atoms, R 2 is an alkyl group , having from 1 to 6 carbon atoms, and n is an integer equal to one. 3. Сополимеры по п. 1, отличающиеся тем, что фрагмент гидрофобного характера состоит из повторяющихся звеньев формулы:
Figure 00000002

4. Сополимеры по какому-либо из пп. 1-3, отличающиеся тем, что фрагмент гидрофильного характера выбирается из поли(оксиэтилена), поли(винилового спирта), поли(винилпирролидона, поли(N-2-гидроксипропилметакриламида), поли(гидроксиэтилметакрилата), гидрофильной поли(аминокислоты), такой как полилизин, полисахарид.3. Copolymers under item 1, characterized in that the fragment of a hydrophobic character consists of repeating units of the formula:
Figure 00000002

4. Copolymers according to any of paragraphs. 1-3, characterized in that the fragment of hydrophilic character is selected from poly (oxyethylene), poly (vinyl alcohol), poly (vinyl pyrrolidone, poly (N-2-hydroxypropyl methacrylamide), poly (hydroxy ethyl methacrylate), hydrophilic poly (amino acid), such polylysine, polysaccharide. 5. Сополимеры по какому-либо из пп. 1-4, отличающиеся тем, что они имеют блочную структуру, предпочтительно двухблочную или трехблочную, или привитую структуру. 5. Copolymers according to any of paragraphs. 1-4, characterized in that they have a block structure, preferably a two-block or three-block, or a graft structure. 6. Сополимеры по какому-либо из пп. 1-5, отличающиеся тем, что массовое содержание фрагмента гидрофобного характера в них составляет 5 - 95%, предпочтительно 10 - 90%. 6. Copolymers according to any of paragraphs. 1-5, characterized in that the mass content of a fragment of a hydrophobic character in them is 5 - 95%, preferably 10 - 90%. 7. Сополимеры по какому-либо из пп. 1-6, отличающиеся тем, что общая молекулярная масса фрагментов гидрофобного характера составляет 1,000 - 80,000 г/моль и предпочтительно, 1,000 - 50,000 г/моль. 7. Copolymers according to any of paragraphs. 1-6, characterized in that the total molecular weight of fragments of a hydrophobic nature is 1,000 to 80,000 g / mol, and preferably 1,000 to 50,000 g / mol. 8. Сополимеры по какому-либо из пп. 1-7 для получения мицеллярных систем, эмульсий, для получения или стабилизации наночастиц или для инкапсулирования активных веществ. 8. Copolymers according to any of paragraphs. 1-7 for obtaining micellar systems, emulsions, for obtaining or stabilizing nanoparticles or for encapsulating active substances. 9. Сополимеры по любому из пп. 1-7 в качестве агентов для поверхностной обработки материалов или биоматериалов, в частности, для придания гидрофильного характера обрабатываемым поверхностям путем закрепления названных сополимеров на обрабатываемых поверхностях. 9. Copolymers according to any one of paragraphs. 1-7 as agents for the surface treatment of materials or biomaterials, in particular, to impart a hydrophilic character to the treated surfaces by fixing the mentioned copolymers on the treated surfaces. 10. Сополимеры по любому из пп. 1-7 в качестве агентов для поверхностной обработки материалов или биоматериалов, способных входить в контакт с тканями животных, с клетками или биомолекулами, в частности, для снижения межфазного сцепления с названными тканями животных, с клетками или биомолекулами. 10. Copolymers according to any one of paragraphs. 1-7 as agents for the surface treatment of materials or biomaterials that can come into contact with animal tissues, with cells or biomolecules, in particular, to reduce the interfacial adhesion with these animal tissues, cells or biomolecules.
RU2000122618/04A 1998-01-29 1999-01-29 Methylidenemalonate-base surface-active copolymers RU2216551C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801001A FR2774096B1 (en) 1998-01-29 1998-01-29 NOVEL SURFACTANT COPOLYMERS BASED ON METHYLIDENE MALONATE
FR98/01001 1998-01-29

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RU2216551C2 RU2216551C2 (en) 2003-11-20

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EP (1) EP1051436B1 (en)
JP (1) JP2002501953A (en)
KR (1) KR20010040476A (en)
CN (1) CN1114633C (en)
AR (1) AR018536A1 (en)
AT (1) ATE253602T1 (en)
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CA (1) CA2318828A1 (en)
CZ (1) CZ294928B6 (en)
DE (1) DE69912578T2 (en)
ES (1) ES2211028T3 (en)
FR (1) FR2774096B1 (en)
HK (1) HK1034525A1 (en)
HU (1) HUP0100238A3 (en)
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WO (1) WO1999038898A1 (en)
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Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4611561B2 (en) * 2000-04-12 2011-01-12 Ｄｉｃ株式会社 Novel vinyl resin and method for producing the same
WO2001077238A1 (en) * 2000-04-12 2001-10-18 Dainippon Ink And Chemicals, Inc. Antifouling coating composition and novel resin
JP4786053B2 (en) * 2000-04-12 2011-10-05 中国塗料株式会社 Antifouling paint composition, antifouling coating, substrate coated with the coating, antifouling method
KR100427725B1 (en) * 2001-03-22 2004-04-27 광주과학기술원 Manufacturing Process of Nanocomposites Using Nanoparticles And Copolymers
EP1451234B1 (en) * 2001-12-07 2006-07-26 Hercules Incorporated Composition comprising cellulose fiber and a water-soluble anionic copolymer as well as method of making said composition
JP3961312B2 (en) 2002-02-26 2007-08-22 株式会社デンソー Control device for internal combustion engine
DE10217439A1 (en) * 2002-04-18 2003-10-30 Basf Ag Process for the production of polyamides
WO2004043425A1 (en) * 2002-11-14 2004-05-27 Universität Duisburg-Essen Implant, therapeutic agent and micelle
DE102004004209A1 (en) * 2004-01-27 2005-08-18 Merck Patent Gmbh Use of random copolymer with hydrophobic and hydrophilic groups in different structural units as emulsifier is useful for producing polymer-modified nanoparticles, e.g. of silica, silver or metal sulfide or carbonate for use in polymer
EP1709092A1 (en) * 2004-01-27 2006-10-11 MERCK PATENT GmbH Use of statistical copolymers
ITRM20060682A1 (en) * 2006-12-19 2008-06-20 Sicit Chemitech S P A NEW BIODEGRADABLE POLYMER DERIVATIVES
US8993795B2 (en) 2009-05-07 2015-03-31 Optmed Inc Methylidene malonate process
US8106234B2 (en) * 2009-05-07 2012-01-31 OptMed, Inc Methylidene malonate process
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9279022B1 (en) * 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
CN103502198B (en) 2010-10-20 2016-07-06 瑟拉斯公司 Use in the presence of coolant and quickly reclaim synthesis methylene malonate
FR2969619B1 (en) * 2010-12-23 2013-01-04 Arkema France FILAMENTARY POLYMERIC PARTICLES AND PROCESS FOR THE PREPARATION OF SAID PARTICLES BY EMULSION CONTROLLED RADICAL POLYMERIZATION.
EP2768917B1 (en) 2011-10-19 2018-12-05 Sirrus, Inc. Multifunctional monomers and methods for making them
EP2831185B1 (en) 2012-03-30 2019-09-25 Sirrus, Inc. Ink and coating formulations and polymerizable systems for producing the same
CA2869108A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
CA2869112A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Composite and laminate articles and polymerizable systems for producing the same
US10047192B2 (en) 2012-06-01 2018-08-14 Sirrus, Inc. Optical material and articles formed therefrom
CN105008438B (en) 2012-11-16 2019-10-22 拜奥福米克斯公司 Plastics bonding system and method
EP3712928A1 (en) 2012-11-30 2020-09-23 Sirrus, Inc. Composite compositions for electronics applications
EP2943462B1 (en) 2013-01-11 2018-06-27 Sirrus, Inc. Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
JP2019522064A (en) * 2016-06-03 2019-08-08 シラス・インコーポレイテッド Water-absorbing or water-soluble polymers, intermediate compounds, and methods thereof
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US10428177B2 (en) * 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
CA3064314A1 (en) 2017-06-02 2018-12-06 Arkema France Curable compositions and uses thereof
CN114127220B (en) 2019-07-19 2024-01-19 阿科玛法国公司 Curable composition useful for obtaining a non-sensitized cured product

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR940003548U (en) * 1992-08-14 1994-02-21 김형술 Laundry dryer
FR2722411B1 (en) * 1994-07-18 1996-10-04 Union Pharma Scient Appl IMMUNONANOPARTICLES COATED WITH ANTI-BETA2 MICROGLOBULIN MONOCLONAL ANTIBODIES AND THEIR USE FOR PROPHYLAXIS AND / OR THE TREATMENT OF PATHOLOGIES DUE TO HIV VIRUS INFECTION
DE19508049C2 (en) * 1995-02-23 1997-02-06 Schering Ag Use of methylene malon diester derivatives for the production of gas-containing microparticles
FR2755136B1 (en) * 1996-10-25 1999-01-22 Virsol PROCESS FOR THE PREPARATION OF METHYLIDENE MALONATE NANOPARTICLES, NANOPARTICLES CONTAINING ONE OR MORE BIOLOGICALLY ACTIVE MOLECULES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2789314B1 (en) * 1999-02-09 2001-04-27 Virsol WOUND SUTURE MATERIAL BASED ON METHYLIDENE MALONATE

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