RU2000107825A - PHARMACEUTICAL SUSPENSION CONTAINING NEVIRAPINE HEMIDATE - Google Patents
PHARMACEUTICAL SUSPENSION CONTAINING NEVIRAPINE HEMIDATEInfo
- Publication number
- RU2000107825A RU2000107825A RU2000107825/14A RU2000107825A RU2000107825A RU 2000107825 A RU2000107825 A RU 2000107825A RU 2000107825/14 A RU2000107825/14 A RU 2000107825/14A RU 2000107825 A RU2000107825 A RU 2000107825A RU 2000107825 A RU2000107825 A RU 2000107825A
- Authority
- RU
- Russia
- Prior art keywords
- nevirapine
- hemidate
- suspension containing
- pharmaceutical suspension
- propylparaben
- Prior art date
Links
- NQDJXKOVJZTUJA-UHFFFAOYSA-N Nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 title claims 4
- 229960000689 Nevirapine Drugs 0.000 title claims 4
- 239000007971 pharmaceutical suspension Substances 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N Methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229940068968 Polysorbate 80 Drugs 0.000 claims 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N Propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- 229960004793 Sucrose Drugs 0.000 claims 2
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960002216 methylparaben Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960003415 propylparaben Drugs 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims 1
- 229960001631 Carbomer Drugs 0.000 claims 1
- 102000000801 Human immunodeficiency virus 1 reverse transcriptase Human genes 0.000 claims 1
- 108010001522 Human immunodeficiency virus 1 reverse transcriptase Proteins 0.000 claims 1
- 229940083608 Sodium Hydroxide Drugs 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920001888 polyacrylic acid Polymers 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 235000011121 sodium hydroxide Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Claims (2)
Невирапин-полугидрат - 0,1-50
Карбомер 934Р - 0,17-0,22
Полисорбат 80 - 0,01-0,2
Раствор сорбитола - 5-30
Сахароза - 5-30
Метилпарабен - 0,15-0,2
Пропилпарабен - 0,02-0,24
Гидроксид натрия (в виде 20%-ного раствора - До рН 5,5-6,0
Очищенная вода - До объема 100,0 мл2. The pharmaceutical composition according to claim 1, characterized in that it further comprises carbomer 934P, polysorbate 80, sorbitol solution, sucrose, methylparaben, propylparaben and sodium hydroxide in the following ratio of ingredients g / 100 ml
Nevirapine hemihydrate - 0.1-50
Carbomer 934Р - 0.17-0.22
Polysorbate 80 - 0.01-0.2
Sorbitol solution - 5-30
Sucrose - 5-30
Methylparaben - 0.15-0.2
Propylparaben - 0.02-0.24
Sodium hydroxide (in the form of a 20% solution - Up to pH 5.5-6.0
Purified Water - Up to 100.0 ml
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5680397P | 1997-08-25 | 1997-08-25 | |
| US60/056,803 | 1997-08-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000107825A true RU2000107825A (en) | 2002-01-10 |
| RU2196584C2 RU2196584C2 (en) | 2003-01-20 |
Family
ID=22006658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000107825/14A RU2196584C2 (en) | 1997-08-25 | 1998-08-11 | Nevirapine semihydrate-containing pharmaceutical composition |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US6172059B1 (en) |
| EP (1) | EP1019058B1 (en) |
| JP (1) | JP3472261B2 (en) |
| KR (1) | KR100426516B1 (en) |
| CN (1) | CN1197578C (en) |
| AR (2) | AR016869A1 (en) |
| AT (1) | ATE326971T1 (en) |
| AU (1) | AU742761B2 (en) |
| BG (1) | BG64337B1 (en) |
| BR (1) | BR9811994B1 (en) |
| CA (1) | CA2301646C (en) |
| CL (1) | CL2008003111A1 (en) |
| CO (1) | CO4970742A1 (en) |
| CY (1) | CY1105228T1 (en) |
| CZ (1) | CZ290667B6 (en) |
| DE (1) | DE69834655T2 (en) |
| DK (1) | DK1019058T3 (en) |
| EG (1) | EG24075A (en) |
| ES (1) | ES2265666T3 (en) |
| HK (1) | HK1027975A1 (en) |
| HR (1) | HRP980461B1 (en) |
| HU (1) | HU226063B1 (en) |
| ID (1) | ID21650A (en) |
| IL (1) | IL134185A (en) |
| MY (1) | MY122272A (en) |
| NO (1) | NO326226B1 (en) |
| NZ (1) | NZ503414A (en) |
| PE (1) | PE105799A1 (en) |
| PL (1) | PL192361B1 (en) |
| PT (1) | PT1019058E (en) |
| RS (1) | RS49808B (en) |
| RU (1) | RU2196584C2 (en) |
| SA (1) | SA98190680B1 (en) |
| TR (1) | TR200000490T2 (en) |
| TW (1) | TW450812B (en) |
| UA (1) | UA44370C2 (en) |
| WO (1) | WO1999009990A1 (en) |
| ZA (1) | ZA987623B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002092095A1 (en) * | 2001-05-11 | 2002-11-21 | Boehringer Ingelheim International Gmbh | Use of nevirapine to treat or prevent lipid pathology in patients with hiv that is resistant to nevirapine |
| EP1504040A1 (en) * | 2002-04-23 | 2005-02-09 | Boehringer Ingelheim Pharmaceuticals Inc. | Method for reduction of residual organic solvent in carbomer |
| KR20080053317A (en) * | 2005-08-31 | 2008-06-12 | 씨아이피엘에이 엘티디. | Pharmaceutical combinations containing lamivudine, stavudine and nevirapine |
| US20110082161A1 (en) * | 2008-06-30 | 2011-04-07 | Lieven Elvire Colette Baert | Powders for reconstitution |
| BR112012011095A2 (en) * | 2009-11-10 | 2015-10-06 | Univ Northwest | method for increasing the solubility of a transcriptase inhibiting composition |
| DE112010004862T5 (en) * | 2009-12-17 | 2012-12-06 | North West University | Polymorphic form of nevirapine and its preparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366972A (en) | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| CA2030056C (en) * | 1989-11-17 | 1995-10-17 | Karl D. Hargrave | 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection |
| US5571912A (en) * | 1990-10-19 | 1996-11-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines |
| DE4403311C1 (en) * | 1994-02-03 | 1995-04-20 | Boehringer Ingelheim Kg | Process for the preparation of nevirapine (11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-d iazepin]-6-one) |
-
1998
- 1998-08-11 UA UA2000031668A patent/UA44370C2/en unknown
- 1998-08-11 AT AT98939312T patent/ATE326971T1/en active
- 1998-08-11 AU AU87771/98A patent/AU742761B2/en not_active Ceased
- 1998-08-11 WO PCT/US1998/016581 patent/WO1999009990A1/en active IP Right Grant
- 1998-08-11 US US09/131,829 patent/US6172059B1/en not_active Expired - Lifetime
- 1998-08-11 BR BRPI9811994-0B1A patent/BR9811994B1/en not_active IP Right Cessation
- 1998-08-11 KR KR10-2000-7001889A patent/KR100426516B1/en not_active IP Right Cessation
- 1998-08-11 CA CA002301646A patent/CA2301646C/en not_active Expired - Fee Related
- 1998-08-11 TR TR2000/00490T patent/TR200000490T2/en unknown
- 1998-08-11 RU RU2000107825/14A patent/RU2196584C2/en not_active IP Right Cessation
- 1998-08-11 DK DK98939312T patent/DK1019058T3/en active
- 1998-08-11 NZ NZ503414A patent/NZ503414A/en not_active IP Right Cessation
- 1998-08-11 HU HU0003093A patent/HU226063B1/en not_active IP Right Cessation
- 1998-08-11 PL PL338828A patent/PL192361B1/en unknown
- 1998-08-11 EP EP98939312A patent/EP1019058B1/en not_active Expired - Lifetime
- 1998-08-11 JP JP2000507380A patent/JP3472261B2/en not_active Expired - Fee Related
- 1998-08-11 CN CNB988084899A patent/CN1197578C/en not_active Expired - Fee Related
- 1998-08-11 ES ES98939312T patent/ES2265666T3/en not_active Expired - Lifetime
- 1998-08-11 DE DE69834655T patent/DE69834655T2/en not_active Expired - Lifetime
- 1998-08-11 PT PT98939312T patent/PT1019058E/en unknown
- 1998-08-11 CZ CZ2000694A patent/CZ290667B6/en not_active IP Right Cessation
- 1998-08-11 IL IL13418598A patent/IL134185A/en not_active IP Right Cessation
- 1998-08-11 RS YUP-98/00A patent/RS49808B/en unknown
- 1998-08-11 PE PE1998000718A patent/PE105799A1/en not_active Application Discontinuation
- 1998-08-21 MY MYPI98003819A patent/MY122272A/en unknown
- 1998-08-23 EG EG98398A patent/EG24075A/en active
- 1998-08-24 HR HR980461A patent/HRP980461B1/en not_active IP Right Cessation
- 1998-08-24 ID IDP981156A patent/ID21650A/en unknown
- 1998-08-24 TW TW087113878A patent/TW450812B/en not_active IP Right Cessation
- 1998-08-24 CO CO98048247A patent/CO4970742A1/en unknown
- 1998-08-24 ZA ZA9807623A patent/ZA987623B/en unknown
- 1998-08-25 AR ARP980104200A patent/AR016869A1/en not_active Ceased/Invalidation/Refusal/Rejection/Nullification
- 1998-11-01 SA SA98190680A patent/SA98190680B1/en unknown
-
2000
- 2000-02-07 BG BG104133A patent/BG64337B1/en active Active
- 2000-02-24 NO NO20000906A patent/NO326226B1/en not_active IP Right Cessation
- 2000-03-02 US US09/517,564 patent/US6255481B1/en not_active Expired - Lifetime
- 2000-11-20 HK HK00107393A patent/HK1027975A1/en not_active IP Right Cessation
-
2006
- 2006-08-11 CY CY20061101147T patent/CY1105228T1/en unknown
-
2008
- 2008-10-21 CL CL2008003111A patent/CL2008003111A1/en unknown
-
2011
- 2011-10-14 AR ARP110103815A patent/AR083451A2/en active Pending
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